SummaryThe synthesis of acrylic acid and its derivatives with the use of CO2 and ethylene feedstock is an exciting yet extremely challenging reaction. In addition to the inherent stability of CO2, other challenges arise, such as the elimination of β-hydride from metallalactone to release free a...
Aedes albopictus (Skuse) (Diptera: Culicidae), an aggressive and annoying vector of several arbovirus including Chikungunya and Zika, is a serious health problem worldwide. Control of this mosquito is difficult because of high adaptability, egg resistance to dehydration and ability to exploit ma...
It has been found that aromatic aldehydes with electron-withdrawing as well as electron-donating substituents are oxidized to arenecarboxylic acids using tert-butyl hydroperoxide in the presence of ebselen (2-phenylbenzisoselenazol-3(2H)-one) as a catalyst. The reaction is highly chemoselective ...
Heterogeneous ethylene polymerization catalysts were prepared by supporting tetrakis(dimethylamino)zirconium on chemically modified silica surface. The silica was modified with a silane coupling agent, Cp(CH2)3Si(OEt)3, using ALCVD-technique. On the resulting cyclopentadienyl surface zirconium a...
Tetrakis(dimethylamino)zirconium (3a) and -hafnium (3b) react with cyclopentadiene-indene ligand precursors to form new η5 : η5-metallocenes1c,d of the amido-type. A cyclopentadiene-fluorene ligand eliminates only one amide ligand from 3a to yield a tris(amide) complex 5, with the fluorenyl li...
Room-temperature atomic layer deposition (ALD) of ZrO2 is developed with tetrakis(ethylmethylamino)zirconium (TEMAZ) and a plasma-excited humidified argon. A growth per cycle of 0.17 nm/cycle at room temperature is confirmed, and the TEMAZ adsorption and its oxidization on ZrO2 are characterized...
Experimental and theoretical investigations on the molecular structure, electronic and vibrational characteristics of 2-Amino-3-bromo-5-nitropyridine are presented. The vibrational frequencies were obtained by DFT/B3LYP calculations employing 6–311 ++ G (d, p) basis set. This was compared with ...
Formulation of liposome delivery system loaded with water insoluble 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II), LipoTHP–C11 was carried out. The particle size distributions were determined by dynamic light scattering and asymmetrical flow field-flow fra...
Publisher SummaryThis chapter describes the coordination chemistry of technetium focusing on technetium(−I), technetium(0), technetium(I), technetium(II), technetium(III), technetium(IV), technetium(V), technetium(VI), and technetium(VII). Technetium(III) complexes with aminocarboxylato ligands ...
A new hexadentate aminethiol ligand (TACNS) derived from triazacyclononane was synthesized and characterized for the development of technetium radiopharmaceuticals. The ligand formed a neutral, lipophilic and stable complex with [99mTc]pertechnetate in the presence of tin(II)tartarate as a reduc...
Labelling of a homologous series of 2,3-dioximinoalkanes in Tween 40 formulations with 99mTc has been achieved in aqueous medium using the solubilized method earlier reported for the 2,3-diamine ligand series. The 99mTc-dioxime complexes were anionic, and their formations were more facile than t...
The progress in diagnostic nuclear medicine over the years since the discovery of 99mTc is indeed phenomenal. Over 80% of the radiopharmaceuticals currently being used make use of this short-lived, metastable radionuclide, which has reigned as the workhorse of diagnostic nuclear medicine. The pr...
The chemistry behind the development of technetium-99m (Tc-99m) complexes useful for determining renal (kidney) function is discussed. The design of these compounds so that they will be (1) stable in vivo, (2) actively taken up by the kidney and (3) excreted from the body without being metaboliz...
The symmetrically connected spiro[[2]benzopyran-1,4′-piperidines] 1 are highly potent and selective σ1 receptor ligands. Changing the position of the spirocyclic nitrogen atom led to the unsymmetrically connected spiro[[2]benzopyran-1,3′-piperidines] 2 with a reduced distance between the arom...
A series of 1- and 2-naphthamides has been prepared and tested for in vitro binding to D2L, D4.2, and 5-HT2A receptors. Different compounds display selectivity for D4.2 and 5-HT2A receptors versus D2L receptors. N-(1-Arylalkyl-piperidin-4-yl) carboxamides have higher affinities than the correspo...
Glutamate-induced excitotoxicity via the N-methyl-d-aspartate (NMDA) receptor is an important factor in the pathogenesis of perinatal brain injury. The sigma-1 receptor on the endoplasmic reticulum (ER) has been known to affect the function of the NMDA receptor. 4-Phenyl-1-(4-phenylbutyl)piperid...
2-(4-Chloro-2-cyano-2-phenylbutyl)aziridines were employed for the one-step stereoselective construction of both endo- and exo-2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes as new azaheterobicyclic scaffolds via a double LiAlH4-induced reductive cyclization protocol. Antiplasmodial assessme...
In adult stroke models, 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP), a sigma receptor agonist, attenuates activity of neuronal nitric oxide synthase (nNOS), blunts ischemia-induced nitric oxide production, and provides neuroprotection. Here, we tested the hypothesis that PPBP attenuates neurona...
Premature birth represents a clinical situation of risk for brain injury. The diversity of pathophysiological processes complicates efforts to find effective therapeutic strategies. Excitotoxicity is one important factor in the pathogenesis of preterm brain injury. The observation that sigma-1 r...
The antioxidant activities of three new Schiff base compounds, 1–3, were studied through their direct scavenging ability to eliminate free radicals using DPPH and ABTS methods and also through their indirect antioxidant activity as measured using the ferric thiocyanate (FTC) method. The number ...
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