Two optimized and validated spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in commercial dosage forms. Method A is based on the reaction of tertiary amino group of the drug with N-bromosuccinimide in methanol–acetone medium resulting in the form...
The preferential solvation parameters (δx1,3) of amiodarone hydrochloride (AMDH) in three binary solvent mixtures of ethanol (1) + water (2), N-methyl pyrrolidone (NMP) (1) + water (2) and propylene glycol (1) + water (2) were derived from their available solubility data by using the inverse Ki...
In this work, for the first time, RESS, RESOLV, and ultrasonic-assisted RESOLV methods were applied to produce amiodarone hydrochloride (AMH) drug nanoparticles. Design of experiments was accomplished by Taguchi method (robust design) to obtain optimized process conditions. Water-soluble polymer...
Solubility measurement of solid solute components in supercritical carbon dioxide (SC-CO2) provides essential information for forming pharmaceutical particles of smaller size with a desired size distribution, so as to achieve a better dissolution rate. In this study, for the first time, solubili...
The quasi square pyramidal tricarbonyl-η5:1-(2-cyclopentadiendiyl)ethyl-tungsten (1) reacts photochemically with 1,3-butadiene (a), 2,3-dimethyl-2,4-butadiene (b), E,E-2,4-hexadiene (c), 4-methyl-1,3-pentadiene (d), and 2,5-dimethyl-2,4-hexadiene (e). Replacement of one CO ligand by a diene giv...
Publisher SummaryThis chapter discusses the preparation of amino sugars and amino cyclitols through cyclization of dialdehydes with nitromethane. Two new asymmetric carbon atoms are formed in the cyclization step, a third on the acidification of the aci-nitro salt; thus, depending on the type of...
β-(1→4)-Thiodisaccharides formed by a pentopyranose unit as reducing or non reducing end have been synthesized using a sugar enone derived from a hexose or pentose as Michael acceptor of a 1-thiopentopyranose or 1-thiohexopyranose derivatives. Thus, 2-propyl per-O-acetyl-3-deoxy-4-S-(β-d-Xylp...
Michael addition of common thiols to the enone system of (2S)-2-benzyloxy-2H-pyran-3(6H)-one (1) afforded the corresponding 3-deoxy-4-thiopentopyranosid-2-ulose derivatives (2–4). The reaction was highly diastereoselective, and the addition was governed by the quasiaxially disposed 2-benzyloxy ...
An efficient and practical route for the large-scale synthesis of 2-deoxy-l-erythro-pentose (2-deoxy-l-ribose) starting from l-arabinose was developed using Barton-type free-radical deoxygenation reaction as a key step. The radical precursor, a phenoxythiocarbonyl ester, was prepared in situ, an...
1,2,3,4-Tetra-O-acetyl-5-thio-d-ribopyranose as well as its 1-bromide were used as donors in the reaction with 4-cyano- and 4-nitrobenzenethiol, to give the corresponding thioglycosides in different anomeric ratios depending on the reaction conditions. Zemplén deacetylation afforded 4-cyanophen...
The base catalyzed conjugate Michael addition of the 1-thiosugar, 2,3,4,6-tetra-O-acetyl-β-d-glucopyranose, 1, to a new highly reactive enone 4-deoxy-1,2-O-isopropylidene-l-glycero-pent-4-enopyranos-3-ulose, 2, proceeds steroselectively with formation of adduct 3 in 94% yield. Convenient stereo...
Treatment of the 2,3-isopropylidene acetal of the title dithioxyloside with 2,4,5-triiodoimidazole–PPh3 caused replacement of the 4-hydroxyl group by iodine to afford 82% of the 4-axial iodide 6, converted by base into 4-cyanophenyl 2,3-O-isopropylidene-1,5-dithio-β-d-glycero-pent-3-enopyranos...
Octyl p-methoxycinnamate (OMC) is one of the most widely used sunscreen agents. However, the efficiency of OMC as UV filter over time is affected due to the formation of the cis-isomer which presents a markedly lower extinction coefficient (εcis = 12,600 L mol− 1 cm− 1 at 291 nm) than the origi...
Catalytic properties of various microporous zeolites consisted of different acidic properties and pore topologies were studied in the synthesis of octyl glucoside from D-glucose with 1-octanol by single-step direct glucosidation. The influences of acidic properties and pore topologies of the zeo...
Cholesterol is an important lipid molecule and is needed for all mammalian cells. In various cell types, excess cholesterol is stored as cholesteryl esters; acyl-CoA:cholesterol acyltransferase 1 (ACAT1) plays an essential role in this storage process. ACAT1 is located at the endoplasmic reticul...
The effect of 1‑octyl‑3‑methylimidazolium salicylate, [OMIm][Sal] and 1‑octyl‑3‑methylimidazolium ibuprofenate, [OMIm][Ibu] as active pharmaceutical ingredient ionic liquids (API-ILs) on the solvation properties of l-alanine in aqueous media have been investigated by thermophysical properties de...
The influence of two innovative ionic liquids consisting ibuprofenate anion as active pharmaceutical ingredient ionic liquids (API-ILs) on the volumetric, ultrasonic, viscometric, conductometric and refractometric properties of aqueous solutions of glycine has been surveyed. To reach this purpos...
Cutinase has been shown to be a promising biocatalyst for applications in processes targeted for industrial scale. This work aims to further contribute for highlighting such role, by bestowing detailed insight on the application of cutinase for the synthesis of value added compounds in miniemuls...
The most engineering application for the molecular self-assembly of sulfydryl compounds on solid surfaces is froth flotation. In this work, the hydrophobic mechanism of 3-hexyl-4-amino-1,2,4-triazole-5-thione (HATT) on chalcopyrite (CuFeS2) was first investigated by in situ atomic force microsco...
The activity coefficients at infinite dilution,γi∞, for 33 solutes, including alkanes, cycloalkanes, alkenes, aromatic hydrocarbons, acetonitrile, acetone, tetrahydrofuran, ethyl acetate, 1,4-dioxane, chloromethanes, alcohols in the ionic liquid 1-hexyl-3-methylimidazolium chloride, [HMIM][Cl]...
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