Three new Schiff bases have been synthesised from the reaction of salicylaldehyde with the plant amino acids l-2-amino-3-methylaminopropanoic acid (l-MeDAP), dl-2,4-diaminobutanoic acid (dl-DAB) and dl-2,3-diaminopropanoic acid (dl-DAP). The reaction of salicylaldehyde with l-MeDAP gave only the...
Six new Pt(II) complexes are described having the general formula PtCl2(LL), in which LL is a chelating diamine ligand bearing an amino acid as substituent. The amino acids chosen are l-alanine and its methyl ester, and l-phenylalanine. The compounds have been characterized using analytical and ...
A number of new Pt(II) complexes is described having the general formula PtCl2(LL), where LL is a chelating diamine ligand. Ligands LL were chosen as d,l-2,3-diaminopropionic acid and its ethyl ester, and d,l-2,4-diaminobutyric acid and its ethyl ester. The compounds were characterized using ana...
2,3-Diaminopropionic acid (Dap) and N-terminal Dap peptides have been found to inhibit in vitro protein-modifications by methylglyoxal (MG), one of the highly reactive α-dicarbonyl compounds. MG scavenging potency of the newly synthesized N-terminal Dap peptides is demonstrated by RP-HPLC, SDS–...
ABSTRACTSome Lactobacillus strains have been reported to have antioxidative activity. In our previous work, we screened Lactobacillus plantarum Y44 for its antioxidative activity. In this study, we further studied the antioxidative activities of L. plantarum Y44 using chemical antioxidant method...
Orally disintegrating tablets and oral lyophilisates are novel attractive dosage forms that disintegrate or dissolve in the buccal cavity within seconds without necessity of drinking. The major limitation in designing of these dosage forms is unpleasant taste of the drug substance. Cetirizine di...
A stability-indicating high-performance liquid chromatography (HPLC) of hydrophilic interactions was developed and validated for the determination of cetirizine dihydrochloride in bulk substance and in pharmaceutical dosage form. The separation was achieved on a Poroshell 120 Hilic (4.6 × 150 m...
Cetirizine dihydrochloride, a pharmaceutical drug of the class antihistamines is frequently detected in wastewater samples. In the present work, the degradation of Cetirizine dihydrochloride is carried out using a novel technique of laccase enzyme as a catalyst under the influence of ultrasound ...
Trichomoniasis is the most common non-viral sexually transmitted disease. It is associated with a wide spectrum of complications, including infertility and increased susceptibility to human immunodeficiency virus (HIV). A rising number of reports of Trichomonas vaginalis strains resistant to met...
Two simple and rapid analytical assay methods were developed and validated utilizing spectroscopic techniques for sensitive and selective estimation of daclatasvir dihydrochloride in pharmaceutical preparations based on anion pair complex formation with eosin Y. The maximum absorbance of the for...
SummaryOutbreaks due to multidrug-resistant Candida auris have emerged as a large threat to modern medicine. Since skin colonization and environmental contamination have been identified as a precursor for outbreaks, we evaluated the antifungal activity of ultraviolet-C light using mercury vapour...
Substituent variations on the pyrrolidinyl nitrogen of sulpiride, a selective D2 dopamine antagonist, showed that in vitro and in vivo activities are concentrated in the (S) optical series for N-alkyl analogs and in the (R) series for N-benzyl analogs. To account for these unusual structure-acti...
Mild reaction conditions are described for the preparation of a number of 2-alkyl- and 2-arylaminobenzoxazoles and benzothiazoles from 2-chlorobenzoxazole and 2-chlorobenzothiazole and N-methyl or other simple N-alkyl tertiary amines. The reaction proceeds neat or in THF solution and involves de...
In recent years, the potential application of plasma-activated water (PAW) in the food industry has received increasing attention as a promising alternative to traditional sanitizers. The objective of this work was to evaluate the effect of organic matters in the form of beef extract or peptone ...
The building blocks of the Metal–Organic Frameworks (MOFs) may have different chemical groups or atoms, thus these solids have quite diversified properties. The understanding at the molecular level of the MOFs in possible applications may allow the design of new optimized materials with specifi...
Elastic moduli of the crystalline regions (crystal modulus) of poly(lactic acid)s (PLA), poly (l-lactic acid) (PLLA), poly(d-lactic acid) (PDLA) and their stereocomplex (scPLA) in the directions parallel (El) and perpendicular (Et) to the chain axis were measured by X-ray diffraction. The El val...
Amiodarone is a very effective drug for some patients in cardiology, we must always consider its frequent adverse effects, which can significantly affect the quality of patients’ lives. We describe a relatively rare adverse effect of amiodarone in our case report of a 61-year-old man, who was e...
The USP monograph describes an HPLC method for seven impurities in the amiodarone drug substance using a L1 column, 4.6 mm × 150 mm, 5 μm packing (PF listed ODS2 GL-Science, Inertsil column) at 30 °C with detection at 240 nm. The standard contains 0.01 mg/mL of amiodarone, and USP specified i...
Amiodarone is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis. Accumulating evidence has demonstrated that myofibroblast differentiation is related to the pathogenesis of pulmonary fibrosis. In the present study, we treated human embryonic lung fibro...
SummaryAmiodarone hydrochloride, a class III antiarrhythmic agent, shows ß blocker-like and potassium channel blocker-like actions on the sinuatrial and atrioventricular nodes. It is given by mouth in the treatment of all forms of atrial, junctional and ventricular arrhythmias. Capsules for paed...
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