By using iridium catalyst based on chiral spiro phosphine–oxazoline ligands, the hydrogenation of α-arylcinnamic acids was accomplished under ambient pressure and low catalyst loading (as low as 0.01 mol %), providing useful 2,3-diarylpropionic acids in high yields with excellent enantioselect...
A series of novel combretastatin A-4 (CA-4) thio derivatives containing different molecular cores, namely α-phenylcinnamic acids (core 1), (Z)-stilbenes (core 2), 4,5-disubstituted oxazoles (core 3), and 4,5-disubstituted N-methylimidazoles (core 4), as cis-restricted analogues were designed an...
A series of 4-hydroxybenzene acrylic acid derivatives were designed and synthesized based on the ferulic acid of natural active ingredients. The tested compound 5a, 5f and 6a have significant anti-inflammatory activity with suppression rates of 45.29%, 44.75% and 24.11%, respectively, compared w...
A mild and convenient one-pot two-step synthesis of hydroxystilbenes with trans selectivity has been developed through a modified Perkin reaction between benzaldehydes and phenylacetic acids bearing 4- or 2-hydroxy substitution at the aromatic ring, in the presence of piperidine–methylimidazole...
The 13C NMR spectra of para-substituted α-phenylcinnamic and 3- and 4-pyridylacrylic acids, with a wide range of substituents effects, were determined in deuterated dimethylsulfoxide (DMSO-d6). The effect of substituents in both the α-phenyl and β-pyridine groups in these acids is investigate...
Modification of the cap group of biphenylacrylohydroxamic acid-based HDAC inhibitors led to the identification of a new derivative (3) characterized by an indolyl-substituted 4-phenylcinnamic skeleton. Molecular docking was used to predict the optimal conformation in the class I HDACs active sit...
To investigate the influence of the adamantyl group on the biological properties of known HDAC inhibitors with a 4-phenylcinnamic skeleton, a series of compounds having the adamantyl moiety in the cap structure were synthesized and compared to the corresponding hydroxamic acids lacking this grou...
Preparation, characterisation and application of europium(III) chelate-incorporated polystyrene–acrylic acid (AAc) nanoparticle labels featuring diverse AAc proportions is described. Emulsion copolymerisation of styrene and AAc was used to synthesise uniform-sized nanoparticles, approximately 5...
Interactions between poly(acrylic acid) labeled with pyrene (PAA–Py) and succinylated calfskin collagen (type I) (SCSC) were studied by fluorescence spectroscopy. PAA–Py exhibits a strong emission from pyrene monomer (intensity, IM) when it exists in an extended conformation. It exhibits anoth...
A microspheres-based microbial optosensor for NO2− ion quantitation was constructed by using immobilized Raoutella planticola (R. planticola), the bacterium expressing NAD(P)H nitrite reductase (NiR) enzyme, which was isolated from local edible bird’s nest (EBN) via microbial technique. The who...
Monomers possessing hydrolytically-labile bonds to the bioactive agent β-naphthol (βN) were prepared for incorporation into hydrophilic copolymers. β-Naphthyl acrylate was synthesized by an esterification reaction of β-naphthol with acryloyl chloride. 5-Acrylamido(β-naphthyl)valerate, 2-acr...
A new optosensor for visual quantitation of nitrite (NO2−) ion has been fabricated by physically immobilizing Safranine O (SO) reagent onto a self-adhesive poly(n-butyl acrylate) [poly(nBA)] microspheres matrix, which was synthesized via facile microemulsion UV lithography technique. Evaluation ...
In this study, spectroscopic properties of (E)-3-(4-dimethylamino-naphthalen-1-yl)-acrylic acid (DMANAA) have been explored using absorption and emission spectroscopy in combination with quantum chemical calculations. In addition to the local emission, the molecule shows a red-shifted emission f...
The self-development of associates between naphthalene labeled poly(acrylic acid) (PAA25Np42) and dodecyltrimethylammonium chloride (C12TAC) was studied using measurements of surface tension, pH, turbidity, electrophoretic mobility, dynamic light scattering and fluorescence. A peculiar surface t...
1-(1-Naphthyl) ethanol is an important chiral building block for the synthesis of active pharmaceutical intermediates (APIs). In this work, lipase catalyzed kinetic resolution of (RS)-1-(1-naphthyl) ethanol via transesterification was studied under microwave irradiation with different acyl donor...
The (4+2) cycloaddition of methyl 1-diethylamino-2-ethyl-1,3-butadiene-1-carboxylate was performed with acrylonitrile. The cycloadduct bridges over to form 1-diethylamino-6-ethyl-bicyclo [2.2.1] hept-5-ene-7-one-2-carbonitrile 3. We demonstrate that this latter product underoges facile [1,3] sig...
The effect of temperature, pressure, and solvent on 1-butene oligomerization was studied over H-ferrierite. Two-dimensional GC (GC×GC–MS) was used to analyze the olefin, paraffin, aromatic, and cycloalkane products of the C4 olefin conversion. The reaction product mixture revealed H-ferrierite...
The adsorption of 3-ethyl-3-hexanol and 4-octanol was studied at the dodecane/water interface using from 0 to 0.02 mole fraction alcohol in the dodecane, and from 20 to 40°C. Standard Gibbs energies of adsorption from the dodecane at 25°C were −21.10 and −21.37 kJ/mole for 3-ethyl-3-hexanol an...
In this work, the sophisticated thermodynamic techniques: thermodynamic and thermophysical properties of binary mixtures of 1-ethyl-3-methylimidazolium [C2mim][MeSO4] with various organic solvents were determined at different temperatures and under ambient pressure. Experimental densities and sp...
Hydnocarpus alpina Wt. (Flacourtiaceae) (H. alpina) is a large tree traditionally used to treat leprosy; it also posses antidiabetic property. The present study was undertaken to isolate, characterize and to evaluate the antidiabetic effect of 2R, 3R taxifolin 3-O-rhamnoside. (rhamnoside) and it...
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