4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius r...
The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.
We describe herein a diastereoselective approach to access substituted-4-aminopiperidines from pyridine precursors. This methodology has successfully been applied to synthesize 2-alkyl substrates as well as more complex molecular entities of interest to the pharmaceutical industry.
An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives were obtained in good to excellent yields using DavePhos as optimal ligand ...
Critical micelle concentration (CMC) of sodium dodecyl sulfate (SDS), an anionic surfactant, has been investigated in aqueous solutions of a variety of room temperature ionic liquids (RTILs): 1,3-dimethylimidazolium iodide (Me2IM-I, 2), 1-butyl-3-methylimidazolium chloride (BMIM-Cl, 3), 1-hexyl-...
Industrial surfactants such as the sodium salt of naphthalenesulfonic acid, formaldehyde polymer are widely used in manufacturing for process control. These water-soluble materials are eliminated with the waste water. This necessitates sensitive and accurate determinations of surfactant concentr...
In this study, a novel and rapid procedure for the salicylic acid assisted cloud point extraction of molybdenum(VI) is presented. Preconcentration of the substrate has been suggested prior to its spectrophotometric determination method. The method involves the complexation of Mo(VI) with 6,7-dih...
Screening was carried out for microorganisms able to produce N-(l-α-l-aspartyl)-l-phenylalanine methyl ester [APM] from l-isoasparagine and l-phenylalanine methyl ester hydrochloride. Of the 422 strains examined, 44 strains belonging to the family Enterobacteriaceae were found to produce APM. T...
In this study, we developed an efficient approach for hydrophobic amino acids polymerization in aqueous solution. We compared the catalysis efficiency of papain and bromelain in catalyzing l-phenylalanine methyl ester (l-Phe-Me) for oligomer peptides synthesis. A set of reaction conditions (such...
Ceramide is a lipid mediator in cell proliferation, differentiation, and apoptosis in many cell lines. However, the molecular mechanisms for ceramide have not been clarified in HC11 mouse mammary epithelial cells. Under phase contrast microscope, C2-ceramide-treated cells clearly showed morpholo...
A series of radiolabelled ceramides (d-erythro and l-threo) and dihydroceramides (dl-erythro and dl-threo) with 2, 4 or 6 carbon N-acyl groups were synthesized. These analogues were incubated with cultured CHO cells and radioactive products isolated and analyzed. In addition to synthesis of shor...
Transbilayer lipid motion in membranes may be important in certain physiological events, such as ceramide signaling. In this study, the transbilayer redistribution of lipids induced either by ceramide addition or by enzymatic ceramide generation at one side of the membrane has been monitored usi...
The biological activity of ceramide, an intermediate in the synthesis and catabolism of sphingolipids, has been shown to be mimicked by short-chain N-acyl analogues. A potential role for ceramide in modulating cholesterol esterification was investigated using a series of short-chain ceramides an...
Solid-phase synthesis of a small combinatorial library of dihydroceramide analogues as mixtures of erythro and threo diastereomers is described. Some dihydroceramide analogues cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. This activity is likely...
Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from l-aspartic acid via l-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but consid...
Sphingolipids are a wide family of lipids that share common sphingoid backbones, including (2S,3R)-2-amino-4-octadecane-1,3-diol (dihydrosphingosine) and (2S,3R,4E)-2-amino-4-octadecene-1,3-diol (sphingosine). The metabolism and biological functions of sphingolipids derived from sphingosine have...
The pathogenic relevance of sphingolipid metabolism is increasingly being recognised. Here we elaborate on a new player within the sphingolipid field: the degs1 enzyme, a recently discovered enzyme that catalyses the final step in the de novo biosynthesis of ceramides controlling the step from d...
The apoptotic activities of non-natural ceramide homologues, C2-homo-ceramide, C2-homo-dihydroceramide, C2-bishomo-ceramide and C2-bishomo-dihydroceramide, were examined using human leukemia HL-60 cells. The apoptotic activity was in order of C2-ceramide>C2-homo-ceramide≈C2-bishomo-ceramide and...
A series of N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide derivatives and their corresponding BF2 complexes were synthesized, and their photophysical properties were determined. The effect of the derivatives with various substituents on the benzamide ring and phenyl-1, 3, 4-thiadiazole ring were e...
2-bromo-N-(2,4-difluorobenzyl)benzamide was synthesized in 92% yield by the reaction of commercial 2-bromobenzoic acid with (2,4-difluorophenyl)methanamine. The new title compound was characterized by 1H and 13C NMR, EI-MS and FT-IR. The crystal structure was stablished by single-crystal X-ray d...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View