Targeting of tyrosinase has proven to be the best means of identifying safe, efficacious, and potent tyrosinase inhibitors for whitening skin. We designed and synthesized ten NAB (N-(acryloyl)benzamide) derivatives (1a–1j) using the Horner-Wadsworth-Emmons olefination of diethyl (2-benzamido-2-...
N-Heterocyclic carbenes (NHCs) have been employed as highly efficient organocatalysts for fluorinated silyl-Reformatsky reaction of carbonyl compounds. In the presence of 5–10 mol % NHC A, various aldehydes and 2,2,2–trifluoroacetophenone reacted with difluoro (trimethylsilyl) acetate to produ...
Azidonitration of 3,4-di-O-benzoyl-1,5-anhydro-5-thio-d-threo-pent-1-enitol (3,4-di-O-benzoyl-5-thio-d-xylal) afforded a 1:1 mixture of 2-azido-3,4-di-O-benzoyl-2-deoxy-1-O-nitro-5-thio-α-d-xylo- and lyxo-pyranosides, which were converted after separation into their 1-O-acetyl derivatives 8 and...
Tri-O-acetyl-5-thio-d-ribopyranosyl bromide was converted into 3,4-di-O-benzoyl-1,5-anhydro-5-thio-d-erythro-pent-1-enitol (3,4-di-O-benzoyl-5-thio-d-ribal), the azidonitration of which afforded an unstable mixture of 2-azido-3,4-di-O-benzoyl-2-deoxy-1-O-nitro-5-thio-d-pentopyranoside isomers. T...
l-Arabinose diethyl dithioacetal was converted, via its 4-azido-5-S-benzoyl-4-deoxy-2,3-O-isopropylidene-5-thio-d-xylose diethyl dithioacetal, into 4-azido-4-deoxy-5-thio-α-d-xylopyranose triacetate 29. Glycosidation of 29 with 4-cyanothiophenol in the presence of trimethylsilyl triflate gave t...
N,N′-Bis(4-cyanophenyl)-1,4,5,8-naphthalenediimide (CN-NDI) and N,N′-bis(4-cyanophenyl)-3,4,9,10-perylenebis(dicarboximide) (CN-PDI) have been synthesized under special conditions in high yield. The compounds are characterized by UV-Vis, IR, NMR, MS, DSC, TGA and CV measurements. The fluoresce...
A series of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives was designed, synthesized and evaluated for inhibitory potency in vitro against xanthine oxidase. The isonicotinamide series was considerably more effective than the nicotinamide series. SARs analysis revealed that th...
Wastewater from petroleum refineries contains toxic, carcinogenic and recalcitrant chlorophenols. This comes with the mandatory environmental aspect of the recycling of the organic wastes. This work aimed to prepare; fluorapatite (FAP) by a simple calcination process of waste animal bones (ABs),...
Chlorinated phenols are considered a critical environmental problem, due to their extreme toxicity and their widespread use both in industrial and agricultural activities.In this study, aerobic granular sludge was initially developed into an acetate-fed Granulated Sequencing Batch Reactor (GSBR)...
Functionalized 4-chlorophenols and 1,4-dihydroquinones were prepared by [3+3] cyclization of 1,3-bis-silyl enol ethers with 2-chloro- and 2-acyloxy-3-(silyloxy)alk-2-en-1-ones.
Experimental partition coefficient data have been compiled from the published literature for the water/methyl acetate, water/ethyl acetate and water/butyl acetate partition systems, log P data, and for the gas/methyl acetate, gas/ethyl acetate and gas/butyl acetate partition systems, log K data....
Chlorophenols (CPs) are synthetic chemicals that are generated and used widely by different industries such as textile, pharmaceutical, metallurgic, oil, and pulp and paper manufacturing. Except water, most of the solvents used in these industries are volatile and toxic. Therefore, there is an i...
Acetate can be used as an electron donor to stimulate 2,4-dichlorophenoxyacetic acid (2,4-D), which has not been determined under methanogenic condition. This study applied high-throughput sequencing and methanogenic inhibition approaches to investigate the 2,4-D degradation process using the en...
Practical application of metallurgical microbial electrolysis cells (MECs) requires efficient removal of metals and organics in larger reactors. A 40 L cylindrical single-chamber MEC fed acetate was used to achieve high removals of W(VI) and Mo(VI). In the presence of both metals, there were nea...
Acetate is a common electron donor that can drive microbial reductive processes in anaerobic environments. Apart from acting as a terminal electron acceptor, chlorinated organic pollutant of pentachlorophenol (PCP) has antimicrobial properties but little is known about its effect on anaerobic mi...
The microwave spectra of isotopic nitromethanes are presently being reinvestigated in order to increase our understanding of the interaction between the almost free internal rotation and the vibrations.The presence of relaxation terms depending on cos3p proves that the symmetry of Heff is D3h an...
Thin films of homogeneously mixed nitromethane (CH3NO2) and D3-nitromethane (CD3NO2) ices were exposed to energetic electrons and Lyman α photons. The isotopically mixed reaction products were probed in situ via reflectron time-of-flight mass spectrometry coupled with pulsed photoionization dur...
An automated synthesis system for the production of 5-[18F]fluoro-2′-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem co...
A novel biodegradable AB-type diblock copolymer poly(L-lactic- co-glycolic acid)-block-poly(l-glutamic acid) (PLGA-b-PGA) was synthesized by a macromolecular coupling reaction between carboxyl-terminated PLGA and amino-terminated poly(γ-benzyl-glutamate) (PBLG) and the subsequent elimination of...
Chemotherapy has had limited success in the treatment of cancer over the years, due, in part, to the untoward toxicity of the therapeutic agent to normal cells. The design of tailor-made polymer conjugates provides a synthetic approach that can overcome some of the problems. Several synthetic po...
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