Products

Refine

Country

Business Type

Certificate

Display

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]Benzonitrile

Cas:906673-24-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

1. High quality: CP.EP 2. Big capacity: 50mt per month 3. A lower price with high quality 4. Certificate: GMP, COA 5. Package: Packed with multi-layer paper bags, with polyethylene inner bag, net weight 25kg per bag. 6. Storage should be stored

Crisaborole 906673-24-3

Cas:906673-24-3

Min.Order:25 Kilogram

FOB Price: $200.0

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Crisaborole Cas 906673-24-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10g/100g/1kg/foil bag Application:medic

Manufacturer high quality Crisaborole Cas 906673-24-3 with good price

Cas:906673-24-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile CAS No.:906673-24-3 Name: 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile Synonyms: AN 2728 Molecular Structure

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Crisaborole 906673-24-3 GMP Manufacturer

Cas:906673-24-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile

Cas:906673-24-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Crisaborole

Cas:906673-24-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-((1-HYDROXY-1,3-DIHYDROBENZO[C][1,2]OXABOROL-5-YL)OXY)BENZONITRILE

Cas:906673-24-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Crisaborole

Cas:906673-24-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 906673-24-3 with competitive price

Cas:906673-24-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

AN 2728

Cas:906673-24-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High q

Value 99% Purity Pharmaceutical API Crisaborole 906673-24-3

Cas:906673-24-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Crisaborole CAS 906673-24-3

Cas:906673-24-3

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

AN 2728

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Crisaborole manufacturer with low price

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

CrisaboroleCAS:906673-24-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

CrisaboroleCAS:906673-24-3

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

AN 2728/ LIDE PHARMA- Factory supply / Best price

Cas:906673-24-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:906673-24-3

Cas:906673-24-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Crisaborole cas:906673-24-3

Cas:906673-24-3

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Crisaborole

Cas:906673-24-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments Pharmaceutical acti

High Quality API Crisaborole 906673-24-3 GMP

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d

Crisaborole cas 906673-24-3

Cas:906673-24-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

AN2728 Crisaborole 906673-24-3

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Crisaborole CAS 906673-24-3 with Fast Shipment

Cas:906673-24-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Crisaborole cas 906673-24-3 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control sys

Crisaborole cas 906673-24-3

Cas:906673-24-3

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis (AD) in patients aged two year

Crisaborole

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Crisaborole (AN2728)

Cas:906673-24-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole

Cas:906673-24-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Crisaborole

Cas:906673-24-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole/High quality/Best price

Cas:906673-24-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Synthetic route

4-Cyanochlorobenzene
623-03-0

4-Cyanochlorobenzene

1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane
1187190-70-0

1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 60℃; Reagent/catalyst; Temperature; Solvent;95%
1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane
1187190-70-0

1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane

4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 12h; Reagent/catalyst; Temperature;95%
With potassium carbonate In dimethyl sulfoxide at 60 - 70℃; for 4h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;76.9%
1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane
1187190-70-0

1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane

4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 60℃; Reagent/catalyst; Solvent; Temperature;93.3%
5-(4-cyanophenoxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

5-(4-cyanophenoxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 40℃; Reagent/catalyst; Solvent; Temperature;93%
With sodium hydroxide at 15 - 45℃;91%
4-(3-(hydroxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile

4-(3-(hydroxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With hydrogenchloride In water at 80℃; for 4h;93%
C25H30BNO5

C25H30BNO5

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With methanesulfonic acid In ethanol; water at 20 - 30℃; for 24h; Solvent; Reagent/catalyst;92%
2,6-dichloro-4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile

2,6-dichloro-4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; potassium hydroxide In ethanol; water under 760.051 - 3800.26 Torr; for 1h;90%
pinacol 4-(4-cyanophenoxy)-2-bromomethylphenylborate

pinacol 4-(4-cyanophenoxy)-2-bromomethylphenylborate

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With water; potassium hydroxide at 55 - 65℃; for 2h; Inert atmosphere;90%
4-(3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile

4-(3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile

water
7732-18-5

water

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Stage #1: 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-formylphenoxy]benzonitrile With sodium tetrahydroborate; ethanol at 0 - 5℃; for 1h; Inert atmosphere;
Stage #2: water With hydrogenchloride at 40 - 45℃; for 0.5h; Inert atmosphere;
89.4%
Stage #1: 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-formylphenoxy]benzonitrile With methanol; sodium tetrahydroborate at 0 - 15℃; for 1h; Inert atmosphere;
Stage #2: water With hydrogenchloride pH=4 - 6; Temperature;
76.5%
C26H36BNO4Si

C26H36BNO4Si

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 40℃; for 5h;87%
C26H36BNO4Si

C26H36BNO4Si

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 40℃; for 5h;87%
diisobutyl 4-(4-cyanophenoxy)-2-bromomethylbenzeneborate

diisobutyl 4-(4-cyanophenoxy)-2-bromomethylbenzeneborate

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With water; potassium hydroxide at 40 - 50℃; for 6h; Inert atmosphere;85%
4-(4-cyanophenoxy)-2-chloromethylbenzeneboronic acid

4-(4-cyanophenoxy)-2-chloromethylbenzeneboronic acid

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With triethylamine In water at 50 - 60℃; for 10h; Inert atmosphere;84%
Triisopropyl borate
5419-55-6

Triisopropyl borate

[5-(4-nitrylphenoxy)-2-bromophenyl-1-methoxy]trimethylsilane

[5-(4-nitrylphenoxy)-2-bromophenyl-1-methoxy]trimethylsilane

water
7732-18-5

water

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Stage #1: Triisopropyl borate; [5-(4-nitrylphenoxy)-2-bromophenyl-1-methoxy]trimethylsilane With n-hexyllithium In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
Stage #2: water With hydrogenchloride In tetrahydrofuran; hexane pH=1 - 2; Inert atmosphere;
82%
4-(4-cyanophenoxy)-2-formylbenzeneboronic acid

4-(4-cyanophenoxy)-2-formylbenzeneboronic acid

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 4℃; for 25h;81%
pinacol 4-(4-cyanophenoxy)-2-methylphenylborate

pinacol 4-(4-cyanophenoxy)-2-methylphenylborate

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Stage #1: pinacol 4-(4-cyanophenoxy)-2-methylphenylborate With 5,5-dibromohydantoin In chlorobenzene at 75℃; for 2h;
Stage #2: With water; sodium hydroxide In chlorobenzene at 45℃; for 1h;
80.9%
tetrahydroxydiboron
13675-18-8

tetrahydroxydiboron

4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
906673-45-8

4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With (chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II)); potassium acetate; ethylene glycol; XPhos In methanol at 64 - 66℃; Reagent/catalyst; Inert atmosphere; Sealed tube;80%
tetrahydroxydiboron
13675-18-8

tetrahydroxydiboron

4-(4-amino-3-(hydroxymethyl)phenoxy)benzonitrile

4-(4-amino-3-(hydroxymethyl)phenoxy)benzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Stage #1: 4-(4-amino-3-(hydroxymethyl)phenoxy)benzonitrile With hydrogenchloride; sodium nitrite In methanol; water at 0℃; for 0.5h;
Stage #2: tetrahydroxydiboron In methanol; water for 1h;
75%
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1195-66-0

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

[5-(4-nitrylphenoxy)-2-bromophenyl-1-methoxy]trimethylsilane

[5-(4-nitrylphenoxy)-2-bromophenyl-1-methoxy]trimethylsilane

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Stage #1: [5-(4-nitrylphenoxy)-2-bromophenyl-1-methoxy]trimethylsilane With isopropylmagnesium chloride In tetrahydrofuran at -20 - 20℃; for 3h; Inert atmosphere;
Stage #2: 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran at 0 - 25℃; for 8h; Inert atmosphere;
72%
C25H32BNO5

C25H32BNO5

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; for 3h;
With hydrogenchloride In methanol at 20 - 30℃; for 24h;
Reaxys ID: 32488018

Reaxys ID: 32488018

AN2728
906673-24-3

AN2728

4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
906673-45-8

4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile

Trimethyl borate
121-43-7

Trimethyl borate

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -78℃;Ca. 17 g
4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
906673-45-8

4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile

Triisopropyl borate
5419-55-6

Triisopropyl borate

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -78℃;Ca. 1.8 g
4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
906673-45-8

4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap / tetrahydrofuran / 1 h / 20 °C
2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 85 °C / Inert atmosphere
3: hydrogenchloride / tetrahydrofuran; water / 40 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 20 °C
2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
3: sodium hydroxide / 15 - 45 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 20 °C
2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
3: sodium hydroxide; methanol / 20 °C
4: hydrogenchloride / water / 4 h / 80 °C
View Scheme
4-(3-(hydroxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile

4-(3-(hydroxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile

water
7732-18-5

water

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
With hydrogenchloride at 0℃;0.4 g
4-(4-bromo-3-formaldehydephenoxy)benzonitrile
906673-54-9

4-(4-bromo-3-formaldehydephenoxy)benzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; water; sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere
2: potassium acetate; XPhos; (chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II)); ethylene glycol / methanol / 64 - 66 °C / Inert atmosphere; Sealed tube
View Scheme
Multi-step reaction with 3 steps
1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 2-methyltetrahydrofuran / 2 h / 80 °C / Inert atmosphere
2: methanol; sodium tetrahydroborate / 0.5 h / 0 - 20 °C
3: hydrogenchloride / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; methanol / 10 - 30 °C
2: pyridine / dichloromethane / 20 °C
3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
4: sodium hydroxide / 15 - 45 °C
View Scheme
2-bromo-5-hydroxybenzaldehyde
2973-80-0

2-bromo-5-hydroxybenzaldehyde

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / 8 h / 115 °C / Inert atmosphere
2: sodium hydroxide; water; sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere
3: potassium acetate; XPhos; (chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II)); ethylene glycol / methanol / 64 - 66 °C / Inert atmosphere; Sealed tube
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / 8 h / 115 °C / Inert atmosphere
2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 2-methyltetrahydrofuran / 2 h / 80 °C / Inert atmosphere
3: methanol; sodium tetrahydroborate / 0.5 h / 0 - 20 °C
4: hydrogenchloride / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 75 - 85 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 8 h / 65 - 70 °C
3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 15 °C / Inert atmosphere
3.2: pH 4 - 6
View Scheme
4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / 8 h / 115 °C / Inert atmosphere
2: sodium hydroxide; water; sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere
3: potassium acetate; XPhos; (chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II)); ethylene glycol / methanol / 64 - 66 °C / Inert atmosphere; Sealed tube
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / 8 h / 115 °C / Inert atmosphere
2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 2-methyltetrahydrofuran / 2 h / 80 °C / Inert atmosphere
3: methanol; sodium tetrahydroborate / 0.5 h / 0 - 20 °C
4: hydrogenchloride / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 75 - 85 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 8 h / 65 - 70 °C
3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 15 °C / Inert atmosphere
3.2: pH 4 - 6
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 80 - 90 °C
2.1: toluene-4-sulfonic acid / dichloromethane / 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -75 - 80 °C / Inert atmosphere
3.2: -75 - 80 °C
4.1: hydrogenchloride / methanol / 24 h / 20 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 80 - 90 °C
2: toluene-4-sulfonic acid / dichloromethane / 20 °C
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 20 h / 90 - 100 °C / Autoclave; Inert atmosphere
4: methanesulfonic acid / ethanol; water / 24 h / 20 - 30 °C
View Scheme
4-cyanophenol
767-00-0

4-cyanophenol

AN2728
906673-24-3

AN2728

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water; 1,4-dioxane / 0.5 h / 20 °C
1.2: 3 h / 55 °C
2.1: hydrogenchloride / 1 h / 20 °C
3.1: sodium tetrahydroborate / tetrahydrofuran
4.1: sodium nitrite; hydrogenchloride / methanol; water / 0.5 h / 0 °C
4.2: 1 h
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water; 1,4-dioxane / 0.5 h / 20 °C
1.2: 3 h / 55 °C
2.1: hydrogenchloride / 1 h / 20 °C
3.1: sodium tetrahydroborate / tetrahydrofuran
4.1: sodium nitrite; hydrogenchloride / methanol; water / 0.5 h / 0 °C
4.2: 1 h
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 95 - 100 °C
2.1: potassium carbonate / methanol; water / 1 h / 40 °C
3.1: 1H-imidazole / dichloromethane / 3 h / 25 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h
4.2: 20 - 30 °C
5.1: cesium acetate; pyridine / ethyl acetate / 20 h / 30 - 35 °C / Inert atmosphere; Irradiation
6.1: hydrogenchloride / water; tetrahydrofuran / 5 h / 40 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 95 - 100 °C
2.1: potassium carbonate / methanol; water / 1 h / 40 °C
3.1: 1H-imidazole / acetone / 4 h / 30 - 40 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 1 h
4.2: 5 h / 20 - 30 °C
5.1: cesium acetate; picoline / ethyl acetate / 16 h / 30 - 35 °C / Inert atmosphere; Irradiation
6.1: hydrogenchloride / water; tetrahydrofuran / 5 h / 40 °C
View Scheme
AN2728
906673-24-3

AN2728

4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzoic acid

4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; water In 1,4-dioxane; methanol for 144h; Reflux;79%
With sodium hydroxide In ethanol for 3h; Heating / reflux;8%
Stage #1: AN2728 With sodium hydroxide In ethanol for 3h; Heating / reflux;
Stage #2: With hydrogenchloride Product distribution / selectivity;
8%
With water; sodium hydroxide In ethanol for 3h; Solvent; Temperature; Time; Reflux;8%
Stage #1: AN2728 With sodium hydroxide In ethanol; water for 3h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water
8%
AN2728
906673-24-3

AN2728

butyric acid
107-92-6

butyric acid

C18H16BNO4

C18H16BNO4

Conditions
ConditionsYield
Stage #1: butyric acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: AN2728 In tetrahydrofuran for 2h;
76.32%
AN2728
906673-24-3

AN2728

dimethylphosphoric acid
813-78-5

dimethylphosphoric acid

C16H15BNO6P

C16H15BNO6P

Conditions
ConditionsYield
Stage #1: dimethylphosphoric acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: AN2728 In tetrahydrofuran for 2h;
66.58%
AN2728
906673-24-3

AN2728

isobutyric Acid
79-31-2

isobutyric Acid

C18H16BNO4

C18H16BNO4

Conditions
ConditionsYield
Stage #1: isobutyric Acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: AN2728 In tetrahydrofuran for 2h;
62.46%
AN2728
906673-24-3

AN2728

3-Phenylpropionic acid
501-52-0

3-Phenylpropionic acid

C23H18BNO4

C23H18BNO4

Conditions
ConditionsYield
Stage #1: 3-Phenylpropionic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: AN2728 In tetrahydrofuran for 2h;
62.06%
AN2728
906673-24-3

AN2728

diphenyl hydrogen phosphate
838-85-7

diphenyl hydrogen phosphate

C26H19BNO6P

C26H19BNO6P

Conditions
ConditionsYield
Stage #1: diphenyl hydrogen phosphate With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: AN2728 In tetrahydrofuran for 2h;
43.38%
AN2728
906673-24-3

AN2728

5-(4-(1H-tetrazol-5-yl)phenoxy)benzo[c][1,2]oxaborol-1(3H)-ol
947162-19-8

5-(4-(1H-tetrazol-5-yl)phenoxy)benzo[c][1,2]oxaborol-1(3H)-ol

Conditions
ConditionsYield
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 80℃; for 48h;23%
AN2728
906673-24-3

AN2728

1-hydroxy-5-[4-(tetrazole-1-yl)phenoxy]-2,1-benzoxaborole

1-hydroxy-5-[4-(tetrazole-1-yl)phenoxy]-2,1-benzoxaborole

Conditions
ConditionsYield
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 80℃; for 48h;23%
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 80℃; for 48h;23%
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 80℃; for 48h;23%
AN2728
906673-24-3

AN2728

4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzamide

4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; water / ethanol / 3 h / Reflux
2: 1,1'-carbonyldiimidazole; ammonium bicarbonate / N,N-dimethyl-formamide / 20 °C
View Scheme
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View