4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Co...

The polydopamine (PDA) coating was used to modify the surface of the PbO2/TiO2 nanotube arrays (PTNAs) by impregnation method. The obtained PDA-PbO2/TiO2 nanotube arrays (PPTNAs) coating exhibited a sandwich structure and used as anode for photoelectrochemical degradation of toluene. Generally, ...

SummaryBackgroundValproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs. 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA) is an inactive cyclopropyl analogue of VPA that serves as a starting material for the synthesis of CNS-active compounds.

With an aim to develop new curcumin inspired analogues as potent anticancer agents, we synthesized a series of (1E,4E)-1-phenyl-5-(3-phenylimidazo[1,2-a]pyridin-2-yl)penta-1,4-dien-3-ones (12a–t) as tubulin polymerization inhibitors. An initial screening was carried out to evaluate their cytoto...

Thiosemicarbazones (TSC) are a subclass of iron-chelating agents that are believed to have an anticancer activity. The high potential for the application of this compound class can be illustrated by a fact that three TSC have entered clinical trials. The ability to chelate metal ions results in ...

In trying to develop new anticancer agents, a series of 1H-pyrazolo[3,4-b]pyridine derivatives was designed and synthesized. Fifteen compounds were evaluated in vitro for their anti-proliferative activity against HePG-2, MCF-7, HCT-116, and PC-3 cell lines. Additionally, DNA binding affinity of ...

This work provides the synthesis, structural characterization, electrochemical and photophysical features, as well as the application in light-emitting electrochemical cells (LECs) of a novel small molecule belonging to the pyridilimidazo[1,5-a]pyridine family, namely 3-(2-methoxyphenyl)-5-methy...

Further optimization of the trimethoxyphenyl scaffold of parent chalcone compound (2a) by introducing a pyridine ring afforded a series of novel pyridine-chalcone derivatives as potential anti-tubulin agents. All the target compounds were evaluated for their antiproliferative activities. Among t...

BackgroundAlpinia nantoensis (Zingiberaceae) is an aromatic plant endemic to Taiwan, which is used as food flavoring and traditional herbal medicine. The biological activities of compounds isolated from this plant are rarely investigated.

Ascorbic acid (AsA) and melatonin (Mel) are known molecules participating in stress resistance, however, their combined role in counteracting the impact of salinity in plants is still unknown. In this work the effect of exogenous application of 0.50 mΜ AsA, 1 μΜ Mel and their combination (AsA...

Neuropeptide Y (NPY) is a member of the pancreatic polypeptide family which is a potent orexigenic peptide known to date in mammals and teleost. This study was carried out to investigate the effects of NPY on food intake and growth of orange-spotted grouper (Epinephelus coioides). Synthetic grou...

Salinity is a foremost environmental threat that challenges agriculture and food security worldwide. In the present work, physiological, biochemical and anatomical strategies adopted by the xero-halophyte Haloxylon salicornicum in response to salinity was investigated. H. salicornicum plant with...

In the present study, artificial neural network (ANN) method was applied for predicting osmotic pretreatment based on the energy and exergy analyses in microwave drying of orange slices. For this purpose, the oranges were cut into slices with a thickness of 4 mm and treated with salt (NaCl) and ...

ABSTRACTThe periparturient period is the most critical period during the lactation cycle of dairy cows and is characterized by increased oxidative stress status. The objective of this experiment was to evaluate the effect of supplementing rumen-protected methionine on nuclear factor erythroid 2-...

The requirement for cobalamin (vitamin B12) in microalgae is primarily a function of the type of methionine synthase present within their gene repertoires. Our study validates this concept through analysis of the distribution of B12-independent methionine synthase in ecologically relevant diatom...

Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to ...

The aim of the study was to analyse the effects of different dietary methionine (Met) concentrations on the mechanisms of fish muscle growth (hyperplasia and hypertrophy) by using cellular and molecular approaches. Three plant-based diets differing by their Met level (MD, Met-deficient; MC, Met-...

Redox reactions of the aromatic amino acids tyrosine (Tyr) and tryptophan (Trp) are crucial for the biological functions of many metalloproteins. An important question is how biological systems can use the protein environment to move electrons through proteins in a controlled manner. Methionine ...

ABSTRACTThe periparturient period is the most critical phase in the productive cycle of dairy cows and is characterized by impairment of the immune system. Our objective was to evaluate the effect of feeding ethyl-cellulose rumen-protected methionine (RPM) starting at d −28 from expected parturi...

Campylobacter is an important pathogen commonly found in chickens that can cause severe acute gastroenteritis in humans. Despite intensive efforts to inhibit food-borne transmission of Campylobacter no effective strategy exists to reduce Campylobacter loads in farmed broilers. This study examine...