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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmeth/ LIDE PHARMA- Factory supply / Best price

Cas:763114-26-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Biobond Pharmaceutical Co.,Ltd

The product is the key intermediate for producing the Olaparib. and we have produced it for several times from 1-50kg per batch with high quality of above 99% purity . At the same time, the related impurities have been studied in detail. For the

5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-

Cas:763114-26-7

Min.Order:1 Kilogram

FOB Price: $770.0 / 950.0

Type:Lab/Research institutions

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Shangdong Shinning Pharm co.ltd

100% owned factory, regulatory compliance and be audited.Appearance:Off- white powder Application:Commercial

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid in stock

Cas:763114-26-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product description: Product name 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid CAS number 763114-26-7 Assay ≥99% Appearance White powder Capacity 200mt/year A

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid

Cas:763114-26-7

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid CAS No.:763114-26-7 Name: 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid Molecular Structure

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid

Cas:763114-26-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)-methyl]-benzoic acid

Cas:763114-26-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid CAS NO 763114-26-7

Cas:763114-26-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C16H11FN2O3 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7

Cas:763114-26-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 763114-26-7 with competitive price

Cas:763114-26-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Olaparib intermediate CAS# 763114-26-7 Pharmaceutical Intermediate & API

Cas:763114-26-7

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid 763114-26-7

Cas:763114-26-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid CAS:763114-26-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermedi

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid CAS:763114-26-7

Cas:763114-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2-fluoro-5 -((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid

Cas:763114-26-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Cas:763114-26-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

Olaparib Intermediate (AZD2281) 763114-26-7

Cas:763114-26-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to pink solid Storage:Room temperature, Keep in Dark Place.

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

Cas:763114-26-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Olaparib Intermediate 763114-26-7

Cas:763114-26-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS763114-26-7 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

Cas:763114-26-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-fluoro-5 -((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid

Cas:763114-26-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-FLUORO-5-((4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)METHYL)BENZOIC ACID

Cas:763114-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid

Cas:763114-26-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

High purity 763114-26-7 low price 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid good supplier 5-[(3, 4-dihydro-4-oxo-1-phthalazinyl) methyl]-2-fluorobenzoic acid is an intermediate in organic synthesis and pharmaceutical interme

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid/High quality/Best price

Cas:763114-26-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-

Cas:763114-26-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-fluoro-5 -((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid

Cas:763114-26-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Fluoro-5-((4-Oxo-3,4-Dihydrophthalazin-1-yl)Methyl)Benzoic Acid CAS No.:763114-26-7 Molecule Formula:C16H11FN2O3 Molecule Weight:298.27 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards

High Quality 2-Fluoro-5-((4-Oxo-3,4-Dihydrophthalazin-1-yl)Methyl)Benzoic Acid in stock

Cas:763114-26-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

Cas:763114-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one
1062292-60-7

4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one

carbon dioxide
124-38-9

carbon dioxide

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one With n-butyllithium In diethyl ether; hexane at -40 - -30℃; for 0.5h;
Stage #2: carbon dioxide In diethyl ether; hexane for 0.333333h;
Stage #3: With hydrogenchloride In water at 20℃; for 0.5h; Temperature;
95.1%
methyl 2-fluoro-5-(3-oxo-3H-isobenzofuran-1-ylmethylene)benzoate

methyl 2-fluoro-5-(3-oxo-3H-isobenzofuran-1-ylmethylene)benzoate

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: methyl 2-fluoro-5-(3-oxo-3H-isobenzofuran-1-ylmethylene)benzoate With hydrazine hydrate In tetrahydrofuran; water at 8 - 25℃; for 4h;
Stage #2: With sodium hydroxide In tetrahydrofuran; water; acetone at 40℃; for 3.3h;
95%
2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile
763114-25-6

2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With water; sodium hydroxide at 90℃; for 1h;
Stage #2: With hydrazine hydrate at 70℃; for 18h;
93.7%
Stage #1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With sodium hydroxide In water at 90℃; for 1h;
Stage #2: With hydrazine hydrate In water at 70℃; for 18h;
93.69%
Stage #1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With hydrazine hydrate at 8 - 25℃; for 4h;
Stage #2: With water; sodium hydroxide In acetone at 20 - 90℃; for 1h;
91%
methyl 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoate

methyl 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoate

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃;93%
C18H15FN2O3

C18H15FN2O3

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol for 6h; Reflux;90.5%
ethyl 2-(2-(4-fluoro-3-carboxyphenyl)acetyl)benzoate

ethyl 2-(2-(4-fluoro-3-carboxyphenyl)acetyl)benzoate

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; hydrazinium sulfate In water; isopropyl alcohol Reflux;85.1%
dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate
61260-15-9

dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate

2-fluoro-5-formyl-benzoic acid
550363-85-4

2-fluoro-5-formyl-benzoic acid

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate; 2-fluoro-5-formyl-benzoic acid With triethylamine In tetrahydrofuran at 0 - 20℃; for 5h;
Stage #2: With hydrazine hydrate In tetrahydrofuran at 70℃; for 3h;
83%
(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle

(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle

2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle; 2-fluoro-5-[(E)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzonitrile With sodium hydroxide In water at 90℃; for 0.5h;
Stage #2: With hydrazine In water at 70℃; for 18h;
Stage #3: With hydrogenchloride at 20℃; for 0.166667h; pH=4;
77%
(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle

(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; hydrazine hydrate In water77%
Stage #1: (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle With water; sodium hydroxide at 90℃; for 16h; Inert atmosphere;
Stage #2: With hydrazine hydrate at 70℃; for 16h; Inert atmosphere;
2-fluoro-4-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-fluoro-4-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: 2-fluoro-4-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile With water; sodium hydroxide at 90℃; for 1h;
Stage #2: With hydrazine hydrate at 70℃; for 18h;
77%
4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one
1062292-60-7

4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one

carbon monoxide
201230-82-2

carbon monoxide

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; ethanol at 110℃; under 9120.61 Torr; for 6h; Autoclave;71.1%
(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzoic acid

(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzoic acid

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With hydrazine hydrate In tetrahydrofuran Heating;
methyl phosphite
96-36-6, 868-85-9

methyl phosphite

o-carboxybenzaldehyde
119-67-5

o-carboxybenzaldehyde

A

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

B

dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate
61260-15-9

dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate

Conditions
ConditionsYield
With methanesulfonic acid; sodium methylate In methanolA 95%, 95%
B n/a
2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzonitrile
1021298-68-9

2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzonitrile With sodium hydroxide; water at 20 - 90℃;
Stage #2: With hydrogenchloride; water at 60℃; for 0.666667h;
With hydrogenchloride; water at 20℃;
With sodium hydroxide In water
C16H9FO4

C16H9FO4

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With hydrazine hydrate at 70℃; for 18h; Inert atmosphere;30.1 g
With hydrazine hydrate at 70℃; for 72h; Inert atmosphere;2 g
o-carboxybenzaldehyde
119-67-5

o-carboxybenzaldehyde

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium; methanol / 0.5 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / tetrahydrofuran / 15 - 20 °C
3.1: sodium hydroxide; water / 1 h / 90 °C
3.2: 70 °C
3.3: 20 °C / pH 3 - 4
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / methanol / 0.08 h / 0 °C / Inert atmosphere
1.2: 1 h / 20 °C
1.3: 10 °C / Cooling with ice
2.1: triethylamine / tetrahydrofuran / 1 h / 15 - 20 °C
3.1: sodium hydroxide / water / 1 h / 100 °C
3.2: 24 h / 70 °C
3.3: pH 4
View Scheme
Multi-step reaction with 5 steps
1: sodium / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 15 - 20 °C
3: sodium hydroxide; water / 1 h / 90 °C
4: hydrazine hydrate / water / 70 °C
5: water; hydrogenchloride / 20 °C
View Scheme
2-fluoro-5-formylbenzonitrile
218301-22-5

2-fluoro-5-formylbenzonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 15 - 20 °C
2.1: sodium hydroxide; water / 1 h / 90 °C
2.2: 70 °C
2.3: 20 °C / pH 3 - 4
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / tetrahydrofuran / 15 - 20 °C
2: sodium hydroxide; water / 1 h / 90 °C
3: hydrazine hydrate / water / 70 °C
4: water; hydrogenchloride / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: Dimethyl phosphite; hydrogenchloride / water / 20 °C
1.2: 20 °C
2.1: sodium hydroxide / water / 20 - 70 °C
2.2: 20 - 70 °C / pH 4 - 6
View Scheme
3-bromo-4-fluorobenzaldehyde
77771-02-9

3-bromo-4-fluorobenzaldehyde

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-methyl-pyrrolidin-2-one / 24 h / 170 °C
1.2: celite / 1 h / 80 °C
2.1: triethylamine / tetrahydrofuran / 15 - 20 °C
3.1: sodium hydroxide; water / 1 h / 90 °C
3.2: 70 °C
3.3: 20 °C / pH 3 - 4
View Scheme
Multi-step reaction with 5 steps
1: 1-methyl-pyrrolidin-2-one / 24 h / 170 °C
2: triethylamine / tetrahydrofuran / 15 - 20 °C
3: sodium hydroxide; water / 1 h / 90 °C
4: hydrazine hydrate / water / 70 °C
5: water; hydrogenchloride / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 6 h / 30 °C
2.1: hydrazine hydrate / tetrahydrofuran / 1 h / 30 °C
2.2: 7 h / Reflux
3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -40 - -30 °C
3.2: 0.33 h
3.3: 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 6 h / 30 °C
2.1: hydrazine hydrate / tetrahydrofuran / 1 h / 30 °C
2.2: 7 h / Reflux
3.1: bis-triphenylphosphine-palladium(II) chloride; ethanol / 6 h / 110 °C / 9120.61 Torr / Autoclave
View Scheme
dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate
61260-15-9

dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 15 - 20 °C
2.1: sodium hydroxide; water / 1 h / 90 °C
2.2: 70 °C
2.3: 20 °C / pH 3 - 4
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 1 h / 15 - 20 °C
2.1: sodium hydroxide / water / 1 h / 100 °C
2.2: 24 h / 70 °C
2.3: pH 4
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / tetrahydrofuran / 15 - 20 °C
2: sodium hydroxide; water / 1 h / 90 °C
3: hydrazine hydrate / water / 70 °C
4: water; hydrogenchloride / 20 °C
View Scheme
C16H10FNO3

C16H10FNO3

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / water / 70 °C
2: water; hydrogenchloride / 20 °C
View Scheme
2-fluoro-5-bromomethyl benzoic acid methyl ester
709-45-5

2-fluoro-5-bromomethyl benzoic acid methyl ester

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: magnesium; triethylamine / acetonitrile / 2 h / 65 °C
2: sodium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / methanol; water / 4 h / Inert atmosphere; Reflux
3: sodium hydroxide / water; tetrahydrofuran / 20 °C
View Scheme
C9H10BFO4

C9H10BFO4

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / methanol; water / 4 h / Inert atmosphere; Reflux
2: sodium hydroxide / water; tetrahydrofuran / 20 °C
View Scheme
2,3-dihydrophthalazine-1,4-dione
1445-69-8

2,3-dihydrophthalazine-1,4-dione

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trichlorophosphate / 4 h / 110 °C
2.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 0 °C
2.2: 2 h / 80 °C / Inert atmosphere
3.1: potassium hydroxide / methanol / 6 h / Reflux
View Scheme
1-chloro-4-phthalazinone
2257-69-4

1-chloro-4-phthalazinone

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 0 °C
1.2: 2 h / 80 °C / Inert atmosphere
2.1: potassium hydroxide / methanol / 6 h / Reflux
View Scheme
3-hydroxy-1(3H)-isobenzofuranone
16859-59-9

3-hydroxy-1(3H)-isobenzofuranone

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 0.42 h / 100 °C
2: triethylamine / dichloromethane / 0.33 h / 15 °C
3: sodium hydroxide; hydrazine hydrate / ethanol / 0.17 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / methanol / 0.17 h / 0 °C
1.2: 1 h / 0 - 25 °C
2.1: triethylamine / tetrahydrofuran / 10 - 20 °C
3.1: sodium hydroxide; water / 1 h / 90 °C / Inert atmosphere
3.2: 18 h / 70 °C / Inert atmosphere
3.3: 0.17 h / 25 °C / pH 4 / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine; methanesulfonic acid / dichloromethane / 0.5 h
2.1: triethylamine / dichloromethane / 4 h / 6 - 20 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; carbon monoxide / methanol / 8 h / 80 °C / 2585.81 Torr / Inert atmosphere
4.1: hydrazine hydrate / water; tetrahydrofuran / 4 h / 8 - 25 °C
4.2: 3.3 h / 40 °C
View Scheme
phthalonitrile
91-15-6

phthalonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / toluene / 5 h / 50 - 80 °C
1.2: 5 h / 90 - 95 °C
2.1: hydrazine hydrate; hydrogenchloride / water / 10 h / 65 - 70 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / toluene / 5 h / 50 - 80 °C
1.2: 5 h / 90 - 95 °C
2.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
3.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
3.2: 1 h / 20 - 25 °C
View Scheme
methyl 4-fluoro-3-cyanophenylacetate

methyl 4-fluoro-3-cyanophenylacetate

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / toluene / 3 h / 55 - 85 °C
1.2: 4 h / 50 - 95 °C
2.1: hydrazine hydrate; hydrogenchloride / water / 10 h / 65 - 70 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate / toluene / 4 h / 50 - 85 °C
1.2: 4 h / 50 - 85 °C
2.1: hydrazine hydrate; hydrogenchloride / water / 10 h / 65 - 70 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / toluene / 3 h / 55 - 85 °C
1.2: 4 h / 50 - 95 °C
2.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
3.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
3.2: 1 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / toluene / 4 h / 50 - 85 °C
1.2: 4 h / 50 - 85 °C
2.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
3.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
3.2: 1 h / 20 - 25 °C
View Scheme
2-(4-fluoro-3-carboxyphenyl)acetylbenzoic acid

2-(4-fluoro-3-carboxyphenyl)acetylbenzoic acid

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; hydrazine hydrate In water at 65 - 70℃; for 10h; pH=2.5 - 3; Temperature; Reagent/catalyst;27.8 g
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
2.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
2.2: 1 h / 20 - 25 °C
View Scheme
ethyl 4-fluoro-3-cyanobenzeneacetate

ethyl 4-fluoro-3-cyanobenzeneacetate

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium ethanolate / 1,2-dichloro-ethane / 6 h / 50 - 83 °C
1.2: 4 h / 50 - 83 °C
2.1: hydrazine hydrate; hydrogenchloride / water / 10 h / 65 - 70 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 3 steps
1.1: sodium ethanolate / 1,2-dichloro-ethane / 6 h / 50 - 83 °C
1.2: 4 h / 50 - 83 °C
2.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
3.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
3.2: 1 h / 20 - 25 °C
View Scheme
5-(cyanomethyl)-2-fluorobenzonitrile
519059-09-7

5-(cyanomethyl)-2-fluorobenzonitrile

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / toluene / 5 h / 50 - 80 °C
1.2: 5 h / 90 - 95 °C
2.1: hydrazine hydrate; hydrogenchloride / water / 10 h / 65 - 70 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 8 h / 50 - 64 °C
1.2: 5 h / 50 - 95 °C
2.1: hydrazine hydrate; hydrogenchloride / water / 10 h / 65 - 70 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / toluene / 5 h / 50 - 80 °C
1.2: 5 h / 90 - 95 °C
2.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
3.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
3.2: 1 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / 8 h / 50 - 64 °C
1.2: 5 h / 50 - 95 °C
2.1: toluene-4-sulfonic acid / toluene; water / 7 h / 74 - 80 °C
3.1: hydrazine hydrate / toluene; water / 4 h / 30 - 45 °C
3.2: 1 h / 20 - 25 °C
View Scheme
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

tert-butyl 1,6-diazaspiro[3.3]heptane-6-carboxylate
1272412-72-2

tert-butyl 1,6-diazaspiro[3.3]heptane-6-carboxylate

tert-butyl 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-1,6-diazaspiro[3.3]heptane-6-carboxylate

tert-butyl 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-1,6-diazaspiro[3.3]heptane-6-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 60℃; for 12h;98%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

tert-butyl 1,4-diazepine-1-carboxylate
112275-50-0

tert-butyl 1,4-diazepine-1-carboxylate

tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-1,4-diazepane-1-carboxylate
874116-49-1

tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-1,4-diazepane-1-carboxylate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;97%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 24h;
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h;
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(4-fluoro-3-(4-hydroxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one
1174043-15-2

4-(4-fluoro-3-(4-hydroxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl acetamide at 20℃; for 17h; Product distribution / selectivity;97%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In ISOPROPYLAMIDE at 20℃; for 16h; Product distribution / selectivity;
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-[2’-fluoro-5’-[(4’’-oxo-3’’H-phthalazin-1’’-yl)methyl]benzoyl]piperazine-1-carboxylate
763114-04-1

tert-butyl 4-[2’-fluoro-5’-[(4’’-oxo-3’’H-phthalazin-1’’-yl)methyl]benzoyl]piperazine-1-carboxylate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;96%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;96%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 15 - 25℃; for 2h; Product distribution / selectivity;78%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

methyl 2-(2-(pyrrolidin-1-yl)ethylamino)propanoate
1069136-13-5

methyl 2-(2-(pyrrolidin-1-yl)ethylamino)propanoate

3-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)-5-methyl-1-(2-(pyrrolidin-1-yl)ethyl)imidazolidine-2,4-dione
1069135-92-7

3-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)-5-methyl-1-(2-(pyrrolidin-1-yl)ethyl)imidazolidine-2,4-dione

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In acetonitrile at 85℃; for 1.25h;95%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

1-(cyclopropylcarbonyl)piperazine
59878-57-8

1-(cyclopropylcarbonyl)piperazine

olaparib

olaparib

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.5h;
Stage #2: 1-(cyclopropylcarbonyl)piperazine In tetrahydrofuran at 20℃; for 3h;
95%
With pivaloyl chloride; triethylamine In ethanol; dichloromethane at 20℃; for 4h;91.5%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 30 - 50℃;81.9%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

cyclopropyl (piperazin-1-yl)methanone hydrochloride
1021298-67-8

cyclopropyl (piperazin-1-yl)methanone hydrochloride

olaparib

olaparib

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 25℃; for 1h;
Stage #2: cyclopropyl (piperazin-1-yl)methanone hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20 - 25℃; for 5.5h; Reagent/catalyst; Temperature; Solvent;
94.5%
With triethylamine In dichloromethane at -10 - 20℃; for 4h; Solvent;92.2%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 5 - 20℃; Product distribution / selectivity;
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 8h; Solvent; Temperature; Reagent/catalyst;18.92 g
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

N-cyclopropanoylpiperazinium p-toluenesulfonate

N-cyclopropanoylpiperazinium p-toluenesulfonate

olaparib

olaparib

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid With pivaloyl chloride; N-ethyl-N,N-diisopropylamine In acetone at 0 - 20℃; for 3h;
Stage #2: N-cyclopropanoylpiperazinium p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In acetone at 0 - 20℃; for 3h;
89.5%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(2-(pyrrolidin-1-yl)ethoxy)piperidine
1094533-75-1

4-(2-(pyrrolidin-1-yl)ethoxy)piperidine

4-(4-fluoro-3-(4-(2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one
1174044-05-3

4-(4-fluoro-3-(4-(2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 2h;89%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

1-(piperidin-1-yl)-2-(piperidin-4-yloxy)ethanone
902836-10-6

1-(piperidin-1-yl)-2-(piperidin-4-yloxy)ethanone

4-(4-fluoro-3-(4-(2-oxo-2-(piperidin-1-yl)ethoxy)piperidine-1-carbonyl)benzyl)phthalazin-1 (2H)-one
1174044-06-4

4-(4-fluoro-3-(4-(2-oxo-2-(piperidin-1-yl)ethoxy)piperidine-1-carbonyl)benzyl)phthalazin-1 (2H)-one

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In ISOPROPYLAMIDE for 2h;89%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(4-chloro-6-morpholinyl-1,3,5-triazin-2-yl)piperazine hydrochloride

4-(4-chloro-6-morpholinyl-1,3,5-triazin-2-yl)piperazine hydrochloride

C27H26ClFN8O3

C27H26ClFN8O3

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 6h;88%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃;87.7%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

N-(4-((4-methoxyphenyl)carbamoyl)phenyl)piperazine-1-carboxamide hydrochloride

N-(4-((4-methoxyphenyl)carbamoyl)phenyl)piperazine-1-carboxamide hydrochloride

4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-N-(4-((4-methoxyphenyl)carbamoyl)phenyl)piperazine-1-carboxamide

4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-N-(4-((4-methoxyphenyl)carbamoyl)phenyl)piperazine-1-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;84.6%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

(S)-4-(4-chloro-6-(piperazin-1-yl)-1,3,5-triazin-2-yl)-3-methylmorpholine hydrochloride

(S)-4-(4-chloro-6-(piperazin-1-yl)-1,3,5-triazin-2-yl)-3-methylmorpholine hydrochloride

C28H28ClFN8O3

C28H28ClFN8O3

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 8h;84.6%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

N-(4-((4-fluorophenyl)carbamoyl)phenyl)piperazine-1-carboxamide hydrochloride

N-(4-((4-fluorophenyl)carbamoyl)phenyl)piperazine-1-carboxamide hydrochloride

4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-N-(4-((4-fluorophenyl)carbamoyl)phenyl)piperazine-1-carboxamide

4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-N-(4-((4-fluorophenyl)carbamoyl)phenyl)piperazine-1-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;83%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(piperidin-4-yl)butan-1-ol
57614-92-3

4-(piperidin-4-yl)butan-1-ol

C25H28FN3O3

C25H28FN3O3

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 25℃; Inert atmosphere;83%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(2-chloro-7-methyl-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine hydrochloride

4-(2-chloro-7-methyl-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine hydrochloride

4-(3-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

4-(3-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 6h;82.5%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

trans-2,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester

trans-2,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-trans-2,5-dimethylpiperazine-1-carboxylate

tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-trans-2,5-dimethylpiperazine-1-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;81.3%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

4-[3-(1H-benzotriazol-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one

4-[3-(1H-benzotriazol-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one

Conditions
ConditionsYield
With thionyl chloride; triethylamine In dichloromethane at 0 - 20℃; Reagent/catalyst;81%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester
896464-16-7

2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester

tert-butyl 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-1,7-diazaspiro[3.5]nonane-7-carboxylate

tert-butyl 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-1,7-diazaspiro[3.5]nonane-7-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 60℃; for 12h;81%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(2-propenoxy)piperidine
68848-53-3

4-(2-propenoxy)piperidine

C24H24FN3O3
1174043-46-9

C24H24FN3O3

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 2h;80%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

(±)-tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate

(±)-tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate

tert-butyl 7-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

tert-butyl 7-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 60℃; for 12h;79%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

2,8-diazaspiro[4,5]decane-8-carboxylic acid tert-butyl ester
236406-39-6

2,8-diazaspiro[4,5]decane-8-carboxylic acid tert-butyl ester

tert-butyl 2-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-2,8-diazaspiro[4.5]decane-8-carboxylate

tert-butyl 2-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)benzoyl)-2,8-diazaspiro[4.5]decane-8-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 60℃; for 12h;79%
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

4-(4-chloro-6-(piperazin-1-yl)pyrimidin-2-yl)morpholine hydrochloride

4-(4-chloro-6-(piperazin-1-yl)pyrimidin-2-yl)morpholine hydrochloride

C28H27ClFN7O3

C28H27ClFN7O3

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 4h;79%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃;78.9%
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