Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activ...

Platinum drugs (cisplatin, oxaliplatin, and carboplatin) and arsenic trioxide are the only commercial inorganic non-radioactive anticancer drugs approved by the US Food and Drug Administration. Numerous efforts are underway to take advantage of the synergy between the anticancer activity of cisp...

ObjectivesCisplatin is commonly used in the treatment of head and neck squamous cell carcinoma (HNSCC), and the repair of cisplatin-induced DNA damage involves activation of the DNA damage response protein ataxia telangiectasia and Rad3-related (ATR). Resistance to cisplatin therapy exacerbates ...

ObjectiveTo investigate effect of cisplatin on biochemical parameter and histology of pancreas and testis in Wistar rats.

BackgroundCisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activit...

A series of α,β-unsaturated hydroxamic acid derivatives as novel HDAC inhibitors (HDACi) with structural modifications of the connecting unit and the CAP group was synthesized. The in vitro evaluation against the human cancer cell lines A2780 and Cal27 identified 6e and 7j as the most potent c...

Cisplatin is one of the most frequently used chemotherapeutic agents for treatment of a wide range of cancer types. Nevertheless, the intrinsic or acquired resistance to cisplatin remains a major obstacle for cancer therapy. There are a number of factors contributing to the onset of this phenoty...

This paper assesses the mechanical stability and dehydration behaviour of a new composite material constituted by magnesium sulphate hepta-hydrate, used as filler at vary contents, and a porous silicone, used as matrix in order to evaluate its applicability in sorption thermal energy storage fie...

An easily performed stepwise injection (SWIA) procedure based on on-line dilution of biodiesel samples and the formation of color-forming calcium (II) and magnesium (II) complexes with Eriochrome Black T (EBT) in an organic medium followed by spectrophotometric determination is presented. A samp...

A cheap and simple procedure for the simultaneous colorimetric determination of glycerol, magnesium and calcium in biodiesel samples using a paper-based analytical device (PAD) was developed. A reversed-phase air-assisted dispersive liquid-liquid microextraction (RP-AA-DLLME) approach was propos...

The chemical transformation of lactic acid derivatives to industrially important fine chemicals is crucial for the development of new techniques in the medical, cosmetics, and food sectors. Much research has been devoted to the preparation of polylactides (PLAs), which are promising biodegradabl...

In order to improve the activity, selectivity and physical properties of iron antimonate fluid-bed catalysts, the reactions which take place during preparation are clarified and promoter effects have been investigated. Selecting appropriate promoters leads to practical iron antimonate fluid-bed ...

We investigated the adsorption performance of five Fe-based MOFs (Fe-BTC, MIL-100(Fe), MIL-101(Fe), MIL-53(Fe) and MIL-88C(Fe)) for removal of antimonite (Sb(III)) and antimonate (Sb(V)) from water. Among these MOFs, MIL-101(Fe) exhibited the best adsorption capacities for both Sb(III) and Sb(V)...

ABSTRACTIron impurities in clays degrade the quality in many aspects, but available Fe oxides can significantly improve adsorption affinity of clays to anionic particles. Two natural Fe-rich clays (kaolin and bentonite) were treated in 0.5 M HCl (pH = 1.1) and 0.15 M (COOH)2 (pH = 1.2), and then...

Eighteen glazed objects from Nimrud, Hasanlu and Borsippa dated to a period from the ninth to sixth century BCE were analysed by micro X-ray fluorescence (μ-XRF), X-ray diffractometry (XRD), scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDS) and micro-Ram...

The redox properties of vanadium and mixed vanadium and iron have been studied by electrical conductivity measurements. The solids which are active catalysts in the ammoxidation of propane, were shown to be n-type semiconductors with electrons as the main charge carriers. The changes in the elec...

The role of organic matter (OM) in antimonate (further denoted as Sb(OH)6) mobility in soil is unclear. The objective of this study was to evaluate Sb(OH)6–OM interaction. Antimonate solid:liquid distribution coefficients (KD) were measured at low Sb concentrations in soil samples with a natura...

This work is aiming at achieving antimonate (Sb(V)) bio-reduction in a methane (CH4) based membrane biofilm reactor (MBfR), and elucidating the effect of oxygen (O2) on the performance of the biofilm. Scanning electron microscope (SEM), energy dispersive X-ray (EDS) and X-ray photoelectron spect...

ATP sulfurylase (ATPS, EC: 2.7.7.4) is a crucial enzyme for sulfate assimilation pathway in both plastids and cytosol in plants. In this study, genome-wide and comparative analyses of ATPSs in 11 higher plant species, including sequence and structural analyses have been performed. Expression of ...

Cadmium (Cd), a hazardous environmental contaminant with irreversible toxicity to fish, has been detected in aquatic environment of many countries. The common carp is one of the most widely distributed fish in the world, so we used common carp to assess environmental contaminant risk. In present...