Aspergillus niger EBK-9 was isolated from soil sample. This isolate was evaluated for production of (R)-1-(4-Bromo-phenyl)-ethanol 2 from 1-(4-Bromo-phenyl)-ethanone 1. In this work, the production of the 2 was achieved via fermenter. Glucose, yeast extract and ram horn peptone as medium in ferm...
The title compound (6bR,14bR,15R,15aR)-ethyl 5-bromo-14b-phenyl-1,6b,8,9,14,14b,15,15a- octahydrochromeno [3′,4′:2,3] indolizino [8,7-b] indole-15-carboxylate belongs to an indole derivative. The compound crystallizes in the triclinic crystal system with the space group P1̅. The asymmetric uni...
High expression of the aldo-keto reductase enzyme AKR1C3 in the human prostate and breast has implicated it in the development and progression of leukemias and of prostate and breast cancers. Inhibitors are thus of interest as potential drugs. Most inhibitors of AKR1C3 are carboxylic acids, whos...
N-ω-[18F]fluoroethylketanserin ([18F]FEK), an 18F-labeled analogue of the serotonin S2 antagonist ketanserin, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon brain following injection of [18F]FEK indicated that the fluorinated ligand rapidly localized in v...
The conformations of d-glucono-, d-mannono-, d-gulono-, and d-galactono-1,4-lactone in solution were studied by 1H- and 13C-n.m.r. spectroscopy. The two equilibrating, envelope forms [3E(D) and E3(D)] of the lactone ring are weighted strongly in favor of the conformation having the OH-2 group qu...
Four studies of the 1H NMR spectrum for the aromatic protons of 4-fluoroaniline between 1958 and 1974 give three very different solutions to the second-order, AA′BB′X, spectrum. A re-evaluation of the second-order spectrum was done at 300 MHz. Simultaneous simulations of the 1H NMR spectrum an...
Two new natural pteridines have been isolated from the cultured medium of Rhodopseudomonas sphaeroides GM-1. The compounds are tentatively identified as 2-amino-4-hydroxy-6-(1,2,3,4-tetrahydroxybutyl)pteridine and 2-amino-4-hydroxy-6-(3-hydroxy-4-phosphonoxy-1-butenyl)pteridine by degradative ex...
Functionalized 2-(arylthio)benzoates are prepared by formal [3+3] cyclizations of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 3-silyloxy-2-en-1-ones and 1,1-diacylcyclopropanes.
A novel and practical synthetic route is presented for the preparation of methyl-(E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate, the key intermediate of Montelukast, a leukotriene antagonist. The main diarylpropane framework was prepared via a polarity conversation re...
The mechanism of T-cell transformation by human T-cell lymphotropic virus type I (HTLV-I), though not completely understood, appears to involve the interactions of several viral and cellular proteins. One of these viral proteins, p12I, encoded by HTLV-I orfI, is a weak oncogene that binds the 16...
New series of [Ln2 (pydc)2(SO4) (H2O)x]·yH2O (H2pydc = 2,5-pyridinedicarboxylic acid), differing in number of the coordinating (x) and the crystallizing (y) water, have been hydrothermally synthesized and characterized: (i) x = 2, y = 6, and Ln = La, Pr and Nd; (ii) x = 3, y = 2 and Ln = Pr and...
Sulfate is a primary component of industrial wastewater and the existing wastewater treatment methods cannot effectively recover the chemical energy of pollutants. Sulfate radicals (SO4−•), as a strong oxidant, have obvious advantages in the degradation of refractory pollutants compared with hyd...
This study aimed to enhance treatment of wastewater containing nitrobenzene (NB) and sulfate using biocathode enriched with sulfate-reducing bacteria in microbial electrolysis cell (MEC). Artificial wastewater with 50 mg L−1 NB and 200 mg L−1 sulfate was used as the catholyte. With 0.8 V applied...
Biological sulfate removal is challenging in cold climates due to the slower metabolism of mesophilic bacteria; however, cold conditions also offer the possibility to isolate bacteria that have adapted to low temperatures. The present research focused on the cold acclimation and characterization...
Heparan sulfate (HS) 6-O-endosulfatases (Sulfs) have emerged recently as critical regulators of many physiological and pathological processes. By removing 6-O-sulfates from specific HS sequences, they modulate the activities of a variety of growth factors and morphogens, including fibroblast gro...
Chondroitin sulfate/dermatan sulfate (CS/DS) were isolated and purified for the first time from the bone of corb (Sciaena umbra) (CBG) and their chemical composition and anticoagulant activity were assessed. Infrared spectrum and agarose-gel electrophoresis for extracted CS/DS were also investig...
During the process of preparing furfural by straw depolymerization with dilute sulfuric acid, large amounts of high temperature sulfate-rich organic wastewater were produced. It cannot be treated directly by anaerobic digestion and converted to bioenergy due to high concentrations of sulfate. In...
A practical synthesis of (R)-homopipecolinic acid methyl ester 1 and (R)-homoproline methyl ester 2 was performed utilizing (i) a direct intramolecular cyclization of ω-chloro-β-enamino esters 11 and 12, which were prepared from available (S)-1-phenylethylamine or (S)-1-(1-naphthyl)ethylamine ...
The (+) and (−) enantiomers of the isotopically chiral sulfoxide, perdeuteriophenyl-phenyl-sulfoxide, 1, have been synthesized by the reaction of the diastereomers of O-menthyl benzenesulfinate with C6D5MgBr. Their absolute configurations have been determined by comparison of the vibrational cir...
Reaction of β-mesyloxy (or acetoxy) sulfoxides, derived from alkyl (or arylmethyl) phenyl sulfoxides and carbonyl compounds in two steps, with alkylmetals (n-BuLi, t-BuLi, or EtMgBr) at low temperature gave olefins in good to excellent yields. When the β-hydroxy sulfoxides derived from arylald...
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