In recent years, there has been concern in the soft body armor community that copolymer fibers based on 5-amino-2-(p-aminophenyl)-benzimidazole can release hydrochloric acid, which is present in these fibers as a by-product of the manufacturing process. The presence of acids could potentially be...

This chapter is intended to give an overview on the recent developments in the field of the palladium-catalyzed synthesis of carbonylated heterocycles by the direct introduction of carbon monoxide (carbonylation) into an acyclic precursor. This chapter is divided into two main sections: The firs...

The characteristics of host–guest complexation between p-sulfonated calix [G. Arena, S. Gentile, F. G. Gulino, D. Sciotto, C. Sgarlata, Tetrahedron Lett. 45 (2004) 7091] arene (SC6A) and cationic surfactant cetyltrimethylammonium bromide (CTAB) were studied by fluorescence spectrometry. A 1:1 s...

An inorganic/organic hybrid adsorbent for phosphate adsorption was synthesized by introducing lanthanum (La) onto diamino modified MCM-41. The adsorbent was characterized by XRD, SEM, BET, TGA, and FTIR spectroscopy. A series of batch tests were conducted to investigate the influence of contact ...

The purpose of this study was to investigate the transformation of brushite (dicalcium phosphate dihydrate, DCPD, CaHPO4·2H2O) powders at 36.5 °C in DMEM (Dulbecco's Modified Eagle Medium) solutions. Two sets of brushite powders with different particle shapes were synthesized to use in th...

A series of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride have been synthesized. Their physicochemical properties were also investigated. The critical micelle concentrat...

The separation of different ring numbered polyaromatic hydrocarbons (PAHs) was accomplished by using cetyltrimethylammonium bromide (CTAB) in capillary electrokinetic chromatography. In order to increase the solubilities and selectivities of PAHs, acetonitrile (ACN) was used as an organic modifi...

It is therefore difficult to develop anionic imprinted polymers due to its intrinsic properties of anionic templates, which have much smaller charge size ratio, species diversity, and irregular geometry than cationic templates. Moreover, its synthesis is not suitable for traditional apolar media...

Calcium phosphate is applied in many products in biomedicine, but also in toothpastes and cosmetics. In some cases, it is present in nanoparticulate form, either on purpose or after degradation or mechanical abrasion. Possible concerns are related to the biological effect of such nanoparticles. ...

Surfactant molecular self-assemblies solubilize and shelter the drugs from adverse conditions. As membrane mimetic they serve as a powerful tool to understand the consequences of drug membrane interactions. In this study the interaction modulation of fixed dose combination (FDC) having norfloxac...

Hydrogen phosphate imprinted polymer was prepared via emulsion polymerization. An oil in water emulsion, stabilized with cetyltrimethylammonium bromide molecules, was used as the polymerization media. Acrylic acid and divinyl benzene, dissolved in chloroform, were used as the functional monomer ...

The isolation and characterisation of methyl piperitol, (+)-epieudesmin and (+)-episesamin from the stem bark of Zanthoxylum acanthapodium is reported. The 1H and 13C NMR spectra are correlated with those of other known lignans and it is shown that 13C NMR shifts can be used to assign unambiguou...

A simple, rapid, sensitive, robust, stability-indicating RP-HPLC-PDA analytical protocol was developed and validated for the analysis of zileuton racemate in bulk and in tablet formulation. Development of method and resolution of degradation products from forced; hydrolytic (acidic, basic, neutr...

Novel, simple, rapid and reliable High-Performance Thin-Layer Chromatographic (HPTLC) and UV-spectroscopic area under curve (UV-AUC) methods were developed and validated for the analysis of zileuton racemate in bulk and in in-house tablet formulation. HPTLC quantitation of zileuton was done by U...

Background5-Lipoxygenase is an enzyme involved in the synthesis of leukotriene eicosanoids from arachidonic acid. The therapeutic potential of zileuton, an inhibitor of 5-lipoxygenase, and montelukast, a cysteinyl leukotriene receptor antagonist, for the treatment of ischemia/reperfusion (I/R) i...

BackgroundRecent studies demonstrated beneficial effects of zileuton, a 5-lipoxygenase (5LO) inhibitor, on some brain diseases in animal models, but the role of zileuton in the depression remains unknown.

ObjectiveThe current study investigated for the first time the possible beneficial effect of zileuton, a selective 5-lipoxygenase inhibitor (5-LOX), against cisplatin-induced acute renal failure.

Osteoporosis is one of the most common diseases worldwide. In osteoporosis, vertebral fractures represent a major burden. Lipoxygenase (LOX) inhibitors such as baicalein and zileuton may represent a promising therapeutic option owing to their antioxidative effects and suppression of various infl...

For the first time, a modified carbon paste electrode by using molecularly imprinted polymer (MIP) was designed and prepared as a high performance selective sensor for Zileuton determination. The MIP was synthetized by noncovalent mechanism via bulk polymerization in presence of Zileuton as temp...

Zileuton is a reversible inhibitor of 5-lipoxygenase, an iron containing enzyme which is synonymous with arachidonate 5-lipoxygenase. Zileuton is approved as a prophylactic agent for chronic treatment of asthma in adults and children 12 years of age or older. Zileuton is not used in an acute ast...