The N-aryl pyrrolidine diphosphine (R,R)-N-phenyl-3,4-bis(diphenylphosphino)pyrrolidine was obtained from natural tartaric acid. Contrary to our preliminary expectations, this new chiral ligand proved to be less selective than the corresponding N-benzyl pyrrolidine diphosphine. An attempted expl...
The Mn(I) cationic carbyne complexes [Cp(CO)2Mn+≡C–R]BX4 (R = Ph, Tol, Me, Bn; X = F, Cl, Ph) react with bis(diphenylphosphino)methane to afford selectively either cyclic λ5-1,3-diphosphetium semi-ylides [RC–P+Ph2CH2P+Ph2)]BPh4 ([R4]BPh4; R = Ph, Tol), or Mn(I) complexes [Cp(CO)Mn(η3-(P,C,C...
2-Oxoglutaric acid (1) underwent facile indium mediated allylation with allyl bromide (2), and ethyl 4-bromocrotonate (3), cinnamyl bromide (4) and subsequent in situ dehydration to provide respective 5-oxotetrahydrofuran-2-carboxylic acids 5–7 (90–95%). The reaction of 1 with 3 and 4 proceede...
An efficient approach to the syntheses of cinatrins C1 and C3 has been developed and used to establish the absolute configurations of these natural products. The construction of each molecule has been achieved in a five-step reaction sequence (overall yield 43% for cinatrin C1, 33% for cinatrin ...
Multi-component reactions (MCRs) are some of the most significant processes of highly functionalised organic compound synthesis in modern synthetic chemistry. This is a strong artifice for the rapid preparation of diverse heterocyclic scaffolds. This study involves two steps: first, fabricating ...
Multi-component reactions (MCRs) are some of the most significant processes of highly functionalised organic compound synthesis in modern synthetic chemistry. This is a strong artifice for the rapid preparation of diverse heterocyclic scaffolds. This study involves two steps: first, fabricating ...
The Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) is an enzyme that has been implicated as an important drug target in various therapeutic areas, including neurological disorders (Down syndrome, Alzheimer's disease), oncology, and diabetes (pancreatic β-cell expans...
Heme‐based sensors are a recently discovered functional class of heme proteins that serve to detect physiological fluctuations in oxygen (O2), carbon monoxide (CO), or nitric oxide (NO). Many of these modular sensors detect heme ligands by coupling a histidine‐protein kinase to a heme‐binding...
Spr1814 belongs to the NarL/FixJ subfamily of signal transduction response regulators (RR), and has been predicted to regulate the neighboring ABC transporter, which translocates antibiotic molecules in Streptococcus pneumoniae. Here, we report the crystal structure of full-length unphosphorylat...
FixL proteins are bacterial heme-containing signal transduction proteins responsible for sensing the O2 concentration in the organism’s environment. In Sinorhizobium meliloti FixL is a protein histidine kinase that, together with its response regulator FixJ, constitute an oxygen-sensitive switc...
The FixL/FixJ two-component regulatory system of Sinorhizobium meliloti controls the expression of nitrogen fixation genes in response to O2. When phosphorylated, the transcription factor FixJ binds to the nifA and fixK promoters in S. meliloti and induces expression of the corresponding genes, ...
Background: A variety of bacterial adaptative cellular responses to environmental stimuli are mediated by two-component signal transduction pathways. In these phosphorelay cascades, histidine kinases transphosphorylate a conserved aspartate in the receiver domain, a conserved module in the respo...
Background: Two-component signal transduction pathways are sophisticated phosphorelay cascades widespread in prokaryotes and also found in fungi, molds and plants. FixL/FixJ is a prototypical system responsible for the regulation of nitrogen fixation in the symbiotic bacterium Sinorhizobium meli...
Two-component regulatory systems mediate most of the bacterial cells responses to a variety of signals. In Sinorhizobium meliloti, the FixL–FixJ couple controls the expression of the nitrogen fixation genes through the binding of the two-domains response regulator FixJ to the fixK and nifA prom...
FixL and FixJ belong to a two-component regulatory system in Rhizobium meliloti that induces the expression of numerous nitrogen-fixation genes during symbiosis with alfalfa. FixJ is a positive activator required for transcription of the regulatory genes nifA andfixK, while FixL is an oxygen-bin...
The phosphorylated FixJ transcriptional activator is key to nitrogen fixation in Sinorhizobium meliloti, switching both the nifA and fixK genes on. Previously no consensus picture emerged concerning the nature of FixJ binding sites. Here we used in vitro DNA selection in order to systematically ...
The “two-component” FixLJ system activates nitrogen fixation genes via nifA and fixK in Sinorhizobium meliloti. Like other response regulators, the FixJ protein can be decomposed into an N-terminal phosphorylatable “receiver” domain FixJN and a C-terminal transcriptional activator domain Fix...
The prolactin (PRL)-like activity released into synthetic culture medium from concanavalin-A (Con-A)-stimulated mouse splenocytes was bioassayed using 3H thymidine incorporation into Nb2 lymphoma cells. At low cell density (1.0 × 106 cells/ml medium) Con-A-stimulated splenocytes from Balb/c mic...
Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC rem...
ObjectiveTo investigate the differential protein expression before and after menopause in women with nonalcoholic fatty liver disease (NAFLD) and to explore novel markers for menopausal NAFLD.
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