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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Azacyclonol supplier in China

Cas:115-46-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

α,α-Diphenyl-4-piperidinemethanol CAS NO.115-46-8

Cas:115-46-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Azacyclonol

Cas:115-46-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 4-Piperidinemethanol, a,a-diphenyl- 115-46-8 ISO Producer

Cas:115-46-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Azacyclonol (base and/or unspecified salts)

Cas:115-46-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:alpha,alpha-Diphenyl-4-piperidinomethanol CAS NO:115-46-8 Grade:Medical scientific research and export Molecular formula:267.3654 Molecular weight:null Product Quality 12 years of chemical raw materials Mature operation of the industry

alpha,alpha-Diphenyl-4-piperidinomethanol/ CAS:115-46-8/raw material/ high-quality

Cas:115-46-8

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

alpha,alpha-Diphenyl-4-piperidinemethanol

Cas:115-46-8

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 115-46-8 with fast shipping

Cas:115-46-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Piperidinemethanol, a,a-diphenyl- 115-46-8

Cas:115-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Kilogram

FOB Price: $62.0 / 69.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

alpha,alpha-Diphenyl-4-piperidinomethanol CAS:115-46-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

alpha,alpha-Diphenyl-4-piperidinomethanol CAS:115-46-8

Cas:115-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Piperidinemethanol, a,a-diphenyl-

Cas:115-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Piperidinemethanol, a,a-diphenyl-

Cas:115-46-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:White to light beige solid Storage:Store below +30°C Application:Anxiolytic;H1 antagonist α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E. Port:QINGDAO

alpha,alpha-diphenyl-4-piperidinemethano

Cas:115-46-8

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Azacyclonol 115-46-8

Cas:115-46-8

Min.Order:50 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Diphenyl(piperidin-4-yl)methanol

Cas:115-46-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Azacyclonol

Cas:115-46-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used for Pesticide intermediates T

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

alpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Alpha,Alpha-Diphenyl-4-Piperidinemethanol CAS No.:115-46-8 Molecule Formula:C18H21NO Molecule Weight:267.37 Purity: 98.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

High Quality Alpha,Alpha-Diphenyl-4-Piperidinemethanol

Cas:115-46-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Azacyclonol (base and/or unspecified salts)

Cas:115-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Top Purity Supplieralpha,alpha-Diphenyl-4-piperidinomethanol

Cas:115-46-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol
114399-88-1

α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol at 70℃; under 2585.7 Torr;99%
palladium In ethanol
N-acetyl-α,α-diphenyl-4-piperidinemethanol
58113-28-3

N-acetyl-α,α-diphenyl-4-piperidinemethanol

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 65 - 97℃; for 12h;95%
(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)diphenylmethanol

(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)diphenylmethanol

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
With hydrogen; palladium(II) hydroxide In methanol at 10 - 20℃; under 258.581 Torr; for 5h; Reagent/catalyst; Autoclave;95%
benzyl 4-(hydroxydiphenylmethyl)-piperidine-1-carboxylate
96067-93-5

benzyl 4-(hydroxydiphenylmethyl)-piperidine-1-carboxylate

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal In ethanol at 25℃; under 3102.89 Torr; for 2.5h; Hydrogenolysis;88%
ethyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate
112818-77-6

ethyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 24h; Heating;75%
In ethanol for 24h; Reflux; Inert atmosphere; Alkaline conditions;75%
diphenyl(pyridin-4-yl)methanol
1620-30-0

diphenyl(pyridin-4-yl)methanol

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
With acetic acid; platinum Hydrogenation;
Multi-step reaction with 5 steps
1: acetone / 20 °C
2: sodium tetrahydroborate / methanol / 4 h / 20 °C
3: cyclohexanol / 2 h / Reflux
4: potassium carbonate / chloroform / 20 °C
5: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / Reflux
2: potassium borohydride / methanol / 3 h / 10 - 20 °C
3: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / Reflux
2: lithium borohydride / methanol / 3 h / 10 - 20 °C
3: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
4-carbethoxypiperidine
1126-09-6

4-carbethoxypiperidine

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / triethylamine / tetrahydrofuran; H2O / 2 h / 25 °C
2: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C
3: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr
View Scheme
1-benzyl 4-ethyl piperidine-1,4-dicarboxylate
160809-38-1

1-benzyl 4-ethyl piperidine-1,4-dicarboxylate

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C
2: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr
View Scheme
VUF 4589
6071-92-7

VUF 4589

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / K2CO3 / CH2Cl2 / Ambient temperature
2: 75 percent / 50percent KOH / ethanol / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / chloroform / 20 °C
2: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions
View Scheme
(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)diphenylmethanol
20735-04-0

(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)diphenylmethanol

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / Ra-Ni / various solvent(s) / 2 h / Heating
2: 70 percent / K2CO3 / CH2Cl2 / Ambient temperature
3: 75 percent / 50percent KOH / ethanol / 24 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: cyclohexanol / 2 h / Reflux
2: potassium carbonate / chloroform / 20 °C
3: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions
View Scheme
bromobenzene
108-86-1

bromobenzene

radioactive bromine

radioactive bromine

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) Mg / 1) THF, reflux; 2) THF, room temperature, overnight
2: 99 percent / H2 / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr
View Scheme
N-benzyl isonipecotic acid ethyl ester
24228-40-8

N-benzyl isonipecotic acid ethyl ester

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) Mg / 1) THF, reflux; 2) THF, room temperature, overnight
2: 99 percent / H2 / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr
View Scheme
α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol
114399-88-1

α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol

di-isopropyl ether
108-20-3

di-isopropyl ether

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
palladium-carbon In ethanol
palladium In ethanol
4-(hydroxy-diphenyl-methyl)-1-methyl-pyridinium iodide
113012-26-3

4-(hydroxy-diphenyl-methyl)-1-methyl-pyridinium iodide

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 4 h / 20 °C
2: cyclohexanol / 2 h / Reflux
3: potassium carbonate / chloroform / 20 °C
4: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions
View Scheme
4-Benzoylpyridine
14548-46-0

4-Benzoylpyridine

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tetrahydrofuran / 20 °C / Inert atmosphere
2: acetone / 20 °C
3: sodium tetrahydroborate / methanol / 4 h / 20 °C
4: cyclohexanol / 2 h / Reflux
5: potassium carbonate / chloroform / 20 °C
6: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions
View Scheme
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tetrahydrofuran / 20 °C / Inert atmosphere
2: acetone / 20 °C
3: sodium tetrahydroborate / methanol / 4 h / 20 °C
4: cyclohexanol / 2 h / Reflux
5: potassium carbonate / chloroform / 20 °C
6: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions
View Scheme
isonipecotic acid
498-94-2

isonipecotic acid

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 4 h / Reflux
2.1: thionyl chloride / toluene / 6 h / 40 °C
3.1: aluminum (III) chloride / 10 h / 70 °C
4.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
4.2: 10 - 30 °C / Inert atmosphere
5.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 4 h / Reflux
2.1: thionyl chloride / toluene / 6 h / 40 °C
3.1: aluminum (III) chloride / 10 h / 70 °C
4.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
4.2: 10 - 30 °C / Inert atmosphere
5.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 6 h / Reflux
2.1: thionyl chloride / toluene / 6 h / 40 °C
3.1: aluminum (III) chloride / 10 h / 70 °C
4.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
4.2: 10 - 30 °C / Inert atmosphere
5.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 6 h / Reflux
2.1: thionyl chloride / toluene / 6 h / 40 °C
3.1: aluminum (III) chloride / 10 h / 70 °C
4.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
4.2: 10 - 30 °C / Inert atmosphere
5.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
1-acetyl-piperidine-4-carboxylic acid
25503-90-6

1-acetyl-piperidine-4-carboxylic acid

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 6 h / 40 °C
2.1: aluminum (III) chloride / 10 h / 70 °C
3.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
3.2: 10 - 30 °C / Inert atmosphere
4.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 6 h / 40 °C
2.1: aluminum (III) chloride / 10 h / 70 °C
3.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
3.2: 10 - 30 °C / Inert atmosphere
4.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
1-(4-benzoylpiperidin-1-yl)ethanone
25519-79-3

1-(4-benzoylpiperidin-1-yl)ethanone

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
1.2: 10 - 30 °C / Inert atmosphere
2.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
1-acetylpiperidine-4-carbonyl chloride
59084-16-1

1-acetylpiperidine-4-carbonyl chloride

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 10 h / 70 °C
2.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
2.2: 10 - 30 °C / Inert atmosphere
3.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 10 h / 70 °C
2.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux
2.2: 10 - 30 °C / Inert atmosphere
3.1: hydrogenchloride / water; ethanol / 12 h / 65 - 97 °C
View Scheme
isonipecotic acid
498-94-2

isonipecotic acid

bromobenzene
108-86-1

bromobenzene

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Stage #1: bromobenzene With magnesium In tetrahydrofuran Reflux;
Stage #2: isonipecotic acid In tetrahydrofuran; toluene at 50 - 120℃; under 304.02 - 1140.08 Torr; for 11h; Inert atmosphere;
415 g
pyridine-4-carbonitrile
100-48-1

pyridine-4-carbonitrile

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium / 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
2: acetonitrile / Reflux
3: potassium borohydride / methanol / 3 h / 10 - 20 °C
4: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
Multi-step reaction with 4 steps
1: lithium / 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
2: acetonitrile / Reflux
3: lithium borohydride / methanol / 3 h / 10 - 20 °C
4: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
benzophenone
119-61-9

benzophenone

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium / 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
2: acetonitrile / Reflux
3: potassium borohydride / methanol / 3 h / 10 - 20 °C
4: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
Multi-step reaction with 4 steps
1: lithium / 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
2: acetonitrile / Reflux
3: lithium borohydride / methanol / 3 h / 10 - 20 °C
4: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
N-benzyl-alpha,alpha-diphenyl-4-pyridinemethanol chloride

N-benzyl-alpha,alpha-diphenyl-4-pyridinemethanol chloride

C18H21NO
115-46-8

C18H21NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium borohydride / methanol / 3 h / 10 - 20 °C
2: hydrogen; palladium(II) hydroxide / methanol / 5 h / 10 - 20 °C / 258.58 Torr / Autoclave
View Scheme
C18H21NO
115-46-8

C18H21NO

4-(diphenylmethylene)piperidine
50706-57-5

4-(diphenylmethylene)piperidine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃;100%
With trifluoroacetic acid In dichloromethane for 7h; Inert atmosphere;96%
With trifluoroacetic acid In dichloromethane at 20℃; for 9h;95%
[4-(4-chloro-1-oxobutyl)phenyl]methyl-propanedioic acid diethyl ester
254453-61-7

[4-(4-chloro-1-oxobutyl)phenyl]methyl-propanedioic acid diethyl ester

C18H21NO
115-46-8

C18H21NO

[4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]phenyl]methyl-propanedioic acid diethyl ester

[4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]phenyl]methyl-propanedioic acid diethyl ester

Conditions
ConditionsYield
With potassium carbonate In water; toluene for 168h; Heating / reflux;99%
With potassium carbonate In water; toluene for 168h; Reflux;99%
C18H21NO
115-46-8

C18H21NO

4-(hydroxydiphenylmethyl)piperidine-1-sulfamoyl fluoride

4-(hydroxydiphenylmethyl)piperidine-1-sulfamoyl fluoride

Conditions
ConditionsYield
With [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 0.166667h; Reagent/catalyst; Solvent;98%
With [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 0.166667h;96%
With dmap; fluorosulfonyl fluoride; magnesium oxide In dichloromethane; water at 20℃;94%
4-bromobut-1-yne
38771-21-0

4-bromobut-1-yne

C18H21NO
115-46-8

C18H21NO

A

azacyclonol hydrobromide

azacyclonol hydrobromide

B

C22H25NO
476468-82-3

C22H25NO

Conditions
ConditionsYield
In tetrahydrofuran at 68℃; for 20h; Heating / reflux;A n/a
B 96.1%
methanesulfonic acid but-3-ynyl ester
72486-09-0

methanesulfonic acid but-3-ynyl ester

C18H21NO
115-46-8

C18H21NO

A

azacyclonol methanesulfonate

azacyclonol methanesulfonate

B

C22H25NO
476468-82-3

C22H25NO

Conditions
ConditionsYield
In tetrahydrofuran at 68℃; for 20h; Heating / reflux;A n/a
B 95.5%
C18H21NO
115-46-8

C18H21NO

4-bromobutanenitrile
5332-06-9

4-bromobutanenitrile

1-(3-Cyanopropyl)-4-(hydroxydiphenylmethyl)piperidine
118419-86-6

1-(3-Cyanopropyl)-4-(hydroxydiphenylmethyl)piperidine

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In butanone for 5h; Heating;95%
C18H21NO
115-46-8

C18H21NO

4-(Diphenylmethyl)piperidine
19841-73-7

4-(Diphenylmethyl)piperidine

Conditions
ConditionsYield
With sodium tetrahydroborate; trifluoroacetic acid at 0℃; for 0.75h;95%
With sodium tetrahydroborate; trifluoroacetic acid In dichloromethane at 0℃; for 0.833333h;88%
With sodium tetrahydroborate In trifluoroacetic acid
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C
2: trimethylsilan / dichloromethane / 72 h / 20 °C
View Scheme
1-(4-(tert-butyl)phenyl)-3-chloropropan-1-one
28547-33-3

1-(4-(tert-butyl)phenyl)-3-chloropropan-1-one

C18H21NO
115-46-8

C18H21NO

1-(4-(tert-butyl)phenyl)-3-(4-(hydroxydiphenylmethyl)piperidin-1-yl)propan-1-one

1-(4-(tert-butyl)phenyl)-3-(4-(hydroxydiphenylmethyl)piperidin-1-yl)propan-1-one

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; butanone at 85℃; for 16h;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

C18H21NO
115-46-8

C18H21NO

(1-(2-(trifluoromethyl)benzyl)piperidin-4-yl)diphenylmethanol

(1-(2-(trifluoromethyl)benzyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;95%
methyl 2-bromomethylbenzoate
2417-73-4

methyl 2-bromomethylbenzoate

C18H21NO
115-46-8

C18H21NO

methyl 2-((4-(hydroxydiphenylmethyl)piperidin-1-yl)methyl)benzoate

methyl 2-((4-(hydroxydiphenylmethyl)piperidin-1-yl)methyl)benzoate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;95%
formaldehyd
50-00-0

formaldehyd

C18H21NO
115-46-8

C18H21NO

VUF 4589
6071-92-7

VUF 4589

Conditions
ConditionsYield
With sodium tetrahydroborate94%
2-(3-chloropropyl)-1,3-dioxolane
16686-11-6

2-(3-chloropropyl)-1,3-dioxolane

C18H21NO
115-46-8

C18H21NO

{1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol
185454-47-1

{1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol

Conditions
ConditionsYield
With sodium hydrogencarbonate; potassium iodide In N,N-dimethyl-formamide at 50 - 68℃; Alkylation;94%
C18H21NO
115-46-8

C18H21NO

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

4-nitrophenyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate
1209468-67-6

4-nitrophenyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 1h;94%
With triethylamine In dichloromethane for 2h; Inert atmosphere;32%
(2-bromoethyl)-4-fluorobenzene
332-42-3

(2-bromoethyl)-4-fluorobenzene

C18H21NO
115-46-8

C18H21NO

(1-(4-fluorophenethyl)piperidin-4-yl)diphenylmethanol

(1-(4-fluorophenethyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;94%
With triethylamine In acetonitrile at 85℃; for 19h;94%
C18H21NO
115-46-8

C18H21NO

1-bromomethyl-4-iodobenzene
16004-15-2

1-bromomethyl-4-iodobenzene

(1-(4-iodobenzyl)piperidin-4-yl)diphenylmethanol

(1-(4-iodobenzyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;94%
Methyl 4-(bromomethyl)benzoate
2417-72-3

Methyl 4-(bromomethyl)benzoate

C18H21NO
115-46-8

C18H21NO

methyl 4-((4-(hydroxydiphenylmethyl)piperidin-1-yl)methyl)benzoate

methyl 4-((4-(hydroxydiphenylmethyl)piperidin-1-yl)methyl)benzoate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;92%
C18H21NO
115-46-8

C18H21NO

2-(6-(tert-butyl)pyridin-3-yl)ethyl 4-methylbenzenesulfonate

2-(6-(tert-butyl)pyridin-3-yl)ethyl 4-methylbenzenesulfonate

(1-(2-(6-(tert-butyl)pyridin-3-yl)ethyl)piperidin-4-yl)diphenylmethanol

(1-(2-(6-(tert-butyl)pyridin-3-yl)ethyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;92%
With triethylamine In acetonitrile at 50℃; for 20h;92%
C18H21NO
115-46-8

C18H21NO

3-(benzyloxy)-6-bromo-2,4,5-trimethylpyridine
1444336-77-9

3-(benzyloxy)-6-bromo-2,4,5-trimethylpyridine

(1-(5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)piperidin-4-yl)diphenylmethanol

(1-(5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 3h; Reflux;92%
perfluoro-1-butanesulfonyl fluoride
2386-60-9

perfluoro-1-butanesulfonyl fluoride

C18H21NO
115-46-8

C18H21NO

[1-(butane-1-sulfonyl)piperidin-4-yl]diphenylmethanol
1164112-42-8

[1-(butane-1-sulfonyl)piperidin-4-yl]diphenylmethanol

Conditions
ConditionsYield
Stage #1: C18H21NO With triethylamine In dichloromethane at 0 - 5℃; for 0.166667h;
Stage #2: perfluoro-1-butanesulfonyl fluoride In dichloromethane at 0 - 20℃;
91%
o-fluorobenzyl bromide
446-48-0

o-fluorobenzyl bromide

C18H21NO
115-46-8

C18H21NO

(1-(2-fluorobenzyl)piperidin-4-yl)diphenylmethanol

(1-(2-fluorobenzyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;91%
2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile
169280-06-2

2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile

C18H21NO
115-46-8

C18H21NO

2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile
394222-36-7

2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

Conditions
ConditionsYield
With lithium perchlorate In toluene at 150℃; for 4h; Reagent/catalyst; Temperature; Concentration; Solvent;91%
C18H21NO
115-46-8

C18H21NO

2-Nitrobenzenesulfonyl chloride
1694-92-4

2-Nitrobenzenesulfonyl chloride

[1-(2-nitrobenzenesulfonyl)piperidin-4-yl](diphenyl)methanol
1152785-34-6

[1-(2-nitrobenzenesulfonyl)piperidin-4-yl](diphenyl)methanol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;90%
Stage #1: C18H21NO With triethylamine In dichloromethane at 0 - 5℃; for 0.166667h;
Stage #2: 2-Nitrobenzenesulfonyl chloride In dichloromethane at 0 - 20℃;
87%
C18H21NO
115-46-8

C18H21NO

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol
852860-46-9

diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;90%
Stage #1: C18H21NO With triethylamine In dichloromethane at 0 - 5℃; for 0.166667h;
Stage #2: p-toluenesulfonyl chloride In dichloromethane at 0 - 20℃;
90%
C18H21NO
115-46-8

C18H21NO

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

(1-benzenesulfonylpiperidin-4-yl)diphenylmethanol
950054-08-7

(1-benzenesulfonylpiperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
Stage #1: C18H21NO With triethylamine In dichloromethane at 0 - 5℃; for 0.166667h;
Stage #2: benzenesulfonyl chloride In dichloromethane at 0 - 20℃;
90%
2-chloro-3-((4-chlorobenzyl)thio)naphthalene-1,4-dione
1347739-33-6

2-chloro-3-((4-chlorobenzyl)thio)naphthalene-1,4-dione

C18H21NO
115-46-8

C18H21NO

2-((4-chlorobenzyl)thio)-3-(4-(hydroxydiphenylmethyl)piperidin-1-yl)naphthalene-1,4-dione
1404074-76-5

2-((4-chlorobenzyl)thio)-3-(4-(hydroxydiphenylmethyl)piperidin-1-yl)naphthalene-1,4-dione

Conditions
ConditionsYield
With sodium carbonate In dichloromethane for 4 - 6h;90%
C18H21NO
115-46-8

C18H21NO

4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-diphenylmethanol

[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-diphenylmethanol

Conditions
ConditionsYield
Stage #1: C18H21NO With triethylamine In dichloromethane for 0.166667h;
Stage #2: 4-chlorobenzenesulfonyl chloride In dichloromethane at 20℃; for 5h; Further stages.;
89%
Stage #1: C18H21NO With triethylamine In dichloromethane at 0 - 5℃; for 0.166667h;
Stage #2: 4-chlorobenzenesulfonyl chloride In dichloromethane at 0 - 20℃;
83%
isoxazole-4-sulfonyl chloride
80466-79-1

isoxazole-4-sulfonyl chloride

C18H21NO
115-46-8

C18H21NO

(1-(3,5-dimethyl-2,3-dihydro-isoxazole-4-sulfonyl)-piperidin-4-yl)-diphenyl-methanol
1164112-38-2

(1-(3,5-dimethyl-2,3-dihydro-isoxazole-4-sulfonyl)-piperidin-4-yl)-diphenyl-methanol

Conditions
ConditionsYield
Stage #1: C18H21NO With triethylamine In dichloromethane at 0 - 5℃; for 0.166667h;
Stage #2: isoxazole-4-sulfonyl chloride In dichloromethane at 0 - 20℃;
89%
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