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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 120067-83-6 with competitive price

Cas:120067-83-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

FIPRONIL-SULFIDE CAS:120067-83-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

FIPRONIL-SULFIDE CAS:120067-83-6

Cas:120067-83-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Pyrazole-3-carbonitrile,5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)thio]-

Cas:120067-83-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

Fipronil Disulfide/ Fipronil Sulfide CAS 120067-83-6

Cas:120067-83-6

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

FIPRONIL-SULFIDE CAS 120067-83-6 in stock AKS

Cas:120067-83-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

FIPRONIL SULFIDE

Cas:120067-83-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1H-Pyrazole-3-carbonitrile,5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)thio]-

Cas:120067-83-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthio-1H-pyrazole-3-carbonitrile

Cas:120067-83-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Chemsigma International Co.,Ltd.

bulk production Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine ch

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Trading Company

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

FIPRONIL-SULFIDE CAS No.120067-83-6

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Trading Company

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DB BIOTECH CO., LTD

best seller Application:API

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

1H-Pyrazole-3-carbonitrile,5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)thio]-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by a

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

FIPRONIL-SULFIDE

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

120067-83-6 Application:intermediate

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:1ml Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Fipronil-Sulfide

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

fipronil-sulfide

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

120067-83-6

Cas:120067-83-6

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

Langlois reagent
2926-29-6

Langlois reagent

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
120068-79-3

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Stage #1: Langlois reagent; 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole With C7H16O3P(1-)*C6H11N2O(1+) In toluene at -2℃; for 0.0833333h;
Stage #2: With phosphorus trichloride In toluene at 50℃; for 5h; Temperature;
96%
Stage #1: Langlois reagent; 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole; dimethylamine p-toluenesulfonate In N,N-dimethyl-formamide; toluene at 20 - 25℃; for 0.75h;
Stage #2: With phosphorus trichloride In N,N-dimethyl-formamide; toluene at 0 - 70℃; for 8h; Product distribution / selectivity;
66.7%
Stage #1: Langlois reagent; 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole; dimethylamine p-toluenesulfonate In N,N-dimethyl-formamide; toluene at 25℃; for 0.75h; Industry scale;
Stage #2: With phosphorus trichloride In N,N-dimethyl-formamide; toluene at 0 - 70℃; for 10h; Product distribution / selectivity;
5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile
120069-10-5

5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile

Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile With sulfur dioxide; sodium formate In DMF (N,N-dimethyl-formamide) at 20℃; for 0.0833333h;
Stage #2: Bromotrifluoromethane In DMF (N,N-dimethyl-formamide) at 20 - 45℃; under 8625.86 Torr; for 1.5h; Product distribution / selectivity;
90.8%
Stage #1: 5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile With sulfur dioxide In DMF (N,N-dimethyl-formamide) at 20℃; for 0.0333333h;
Stage #2: Bromotrifluoromethane With sodium formate In DMF (N,N-dimethyl-formamide) at 20 - 54℃; for 2.33333h; Product distribution / selectivity;
84.7%
With sulfur dioxide; potassium formate In DMF (N,N-dimethyl-formamide); water at -60 - 55℃; for 3h; Product distribution / selectivity;81%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]
130755-46-3

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With sulfur dioxide; sodium formate In N,N-dimethyl-formamide at 60℃; under 9000.7 - 9750.8 Torr; for 4h; Mechanism; Product distribution; other reagent, other perhalogenoalkanes, other disulfide;85%
With sulfur dioxide; sodium formate In N,N-dimethyl-formamide at 60℃; under 9000.7 - 9750.8 Torr; for 4h;85%
With disodium hydrogenphosphate; sodium dithionite In water; N,N-dimethyl-formamide at 20℃; for 4h;51%
Trifluoromethylsulfenyl chloride
421-17-0

Trifluoromethylsulfenyl chloride

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
120068-79-3

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
In dichloromethane at 18 - 20℃; for 12h; Large scale;68%
With sodium hydroxide In dichloromethane at 10 - 20℃; for 12h; Large scale;68%
In dichloromethane for 2h; Heating;
Reaxys ID: 12045767

Reaxys ID: 12045767

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With copper dichloride In chlorobenzene at 100℃; for 4h;65%
fipronil
120068-37-3

fipronil

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With trifluoroacetic anhydride; sodium iodide In acetone at 0℃; for 10h;60%
5-amino-3-cyano-4-(trifluoromethylsulfenyl)-1-(2,6-dinitro-4-trifluoromethylphenyl)pyrazole
183288-98-4

5-amino-3-cyano-4-(trifluoromethylsulfenyl)-1-(2,6-dinitro-4-trifluoromethylphenyl)pyrazole

aminosulfonic acid
5329-14-6

aminosulfonic acid

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With lithium chloride In 1-methyl-pyrrolidin-2-one; water48%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

sulfur dioxide
7446-09-5

sulfur dioxide

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]
130755-46-3

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With sodium formate; sodium hydrogencarbonate In water; N,N-dimethyl-formamide
CF3 Br

CF3 Br

sodium hydrogen phosphate 12H2 O

sodium hydrogen phosphate 12H2 O

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]
130755-46-3

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
In N-methyl-acetamide; water
2,6-dichloro-4-(trifluoromethyl)aniline
24279-39-8

2,6-dichloro-4-(trifluoromethyl)aniline

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: nitrosylsulfuric acid; acetic acid / 30 - 55 °C
1.2: 0 - 15 °C
2.1: dichloromethane
View Scheme
1,2-dichloro-4-(trifluoromethyl)benzene
328-84-7

1,2-dichloro-4-(trifluoromethyl)benzene

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dimethylsulfone; potassium fluoride; ammonia / 6 h / 30 - 235 °C / 18751.9 - 19502 Torr / Autoclave
2.1: sulfuryl dichloride; 1-methyl-pyrrolidin-2-one / 1-methyl-pyrrolidin-2-one; chlorobenzene / 8 h / 55 - 60 °C
3.1: nitrosylsulfuric acid; acetic acid / 30 - 55 °C
3.2: 0 - 15 °C
4.1: dichloromethane
View Scheme
Multi-step reaction with 4 steps
1.1: 1-methyl-pyrrolidin-2-one; potassium fluoride; ammonia / 10 h / 245 - 250 °C / 22502.3 - 30003 Torr / Autoclave
2.1: sulfuryl dichloride; 1-methyl-pyrrolidin-2-one / 1-methyl-pyrrolidin-2-one; chlorobenzene / 8 h / 55 - 60 °C
3.1: nitrosylsulfuric acid; acetic acid / 30 - 55 °C
3.2: 0 - 15 °C
4.1: dichloromethane
View Scheme
chlorothio-trichloro-methane
594-42-3

chlorothio-trichloro-methane

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
120068-79-3

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
In dichloromethane225 g
2-chloro-4-(trifluoromethyl)aniline
39885-50-2

2-chloro-4-(trifluoromethyl)aniline

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuryl dichloride; 1-methyl-pyrrolidin-2-one / 1-methyl-pyrrolidin-2-one; chlorobenzene / 8 h / 55 - 60 °C
2.1: nitrosylsulfuric acid; acetic acid / 30 - 55 °C
2.2: 0 - 15 °C
3.1: dichloromethane
View Scheme
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
120068-79-3

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With dimethylamine p-toluenesulfonate; Langlois reagent; trichlorophosphate In N,N-dimethyl-formamide; toluene at 0 - 45℃; for 20h; Reagent/catalyst; Temperature; Solvent;4.95 g
2-bromo-1,3-dichloro-5-(trifluoromethyl)benzene
118754-53-3

2-bromo-1,3-dichloro-5-(trifluoromethyl)benzene

5-amino-4-((trifluoromethyl)thio)-1H-pyrazole-3-carbonitrile
183288-97-3

5-amino-4-((trifluoromethyl)thio)-1H-pyrazole-3-carbonitrile

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With 1,10-Phenanthroline; copper In tetrahydrofuran; dimethyl sulfoxide at 60℃; for 8h; Temperature;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

fipronil
120068-37-3

fipronil

Conditions
ConditionsYield
Stage #1: 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile With dichloro-acetic acid; sulfuric acid at 15℃; for 0.5h;
Stage #2: With dihydrogen peroxide In water at 15℃; Product distribution / selectivity;
98%
With caro's acid In dichloromethane at 0 - 5℃; Reagent/catalyst; Industrial scale;97.9%
With dihydrogen peroxide In dichloro-acetic acid; water; trichloroacetic acid at 20℃; for 2h; Product distribution / selectivity;95%
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

A

fipronil
120068-37-3

fipronil

B

fipronil sulfone
120068-36-2

fipronil sulfone

Conditions
ConditionsYield
With dihydrogen peroxide; trifluoroacetic acid In dichloromethane at 10 - 12℃; for 3h;A 96%
B n/a
Stage #1: 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile With trifluoroacetic acid for 0.25h;
Stage #2: With Oxone at -15℃; Product distribution / selectivity;
A 55.4%
B n/a
Stage #1: 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile With trifluoroacetic acid for 0.25h; Industry scale;
Stage #2: With Oxone at -15℃; Product distribution / selectivity; Industry scale;
sulfure de methyle et de 2-chloroethyle
542-81-4

sulfure de methyle et de 2-chloroethyle

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-(N-methyl-N-(2-methylthioethyl)amino)-4-trifluoromethylthiopyrazole
847779-93-5

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-(N-methyl-N-(2-methylthioethyl)amino)-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With potassium phosphate In acetonitrile at 20 - 30℃; for 8h; Conversion of starting material; Heating / reflux;89%
With potassium phosphate In 1-methyl-pyrrolidin-2-one at 20 - 30℃; for 8h; Conversion of starting material; Heating / reflux;7 %Spectr.
With sodium hydride In dimethyl sulfoxide; N,N-dimethyl-formamide at 20 - 30℃; for 8h; Conversion of starting material; Heating / reflux;10 %Spectr.
With sodium hydride In N,N-dimethyl-formamide at 20 - 30℃; for 8h; Conversion of starting material; Heating / reflux;10 %Spectr.
dimethyl cis-but-2-ene-1,4-dioate
624-48-6

dimethyl cis-but-2-ene-1,4-dioate

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

C18H11ClF6N4O4S

C18H11ClF6N4O4S

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 50℃; for 3h;84%
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthio-1H-pyrazole-3-carboxylic acid

5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthio-1H-pyrazole-3-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid In water at 135℃; for 7h;82%
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

5-(2'-bromo-2'-carbomethoxy)ethyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthio-1H-pyrazole-3-carbonitrile
192988-64-0

5-(2'-bromo-2'-carbomethoxy)ethyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthio-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
With tert.-butylnitrite; copper(I) bromide In acetonitrile78%
With tert.-butylnitrite; copper(ll) bromide In acetonitrile at 0 - 20℃; for 12h;
Methoxyacetyl chloride
38870-89-2

Methoxyacetyl chloride

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfenyl-5-(methoxyacetamido)pyrazole

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfenyl-5-(methoxyacetamido)pyrazole

Conditions
ConditionsYield
With dmap; triethylamine In chloroform52%
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

fipronil sulfone
120068-36-2

fipronil sulfone

Conditions
ConditionsYield
With potassium permanganate; magnesium sulfate In water; acetone at 20℃;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-trifluoromethylthio-1H-pyrazole-3-carboxaldehyde
120068-75-9

5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-trifluoromethylthio-1H-pyrazole-3-carboxaldehyde

Conditions
ConditionsYield
aluminum nickel In formic acid
aluminum nickel In formic acid
Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-(ethoxycarbonyl)carbonylamino-4-trifluoromethylthiopyrazole

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-(ethoxycarbonyl)carbonylamino-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With dmap; triethylamine In tetrahydrofuran at 50 - 70℃; for 8h; Heating / reflux;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

3-chloropropionylamino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

3-chloropropionylamino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With zinc(II) chloride In toluene for 4h; Heating / reflux;
2-chloropropionyl chloride
7623-09-8

2-chloropropionyl chloride

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

5-(2-chloropropionylamino)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

5-(2-chloropropionylamino)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With zinc(II) chloride In toluene for 16h; Heating / reflux;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

isopropyl alcohol
67-63-0

isopropyl alcohol

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-isopropyloxymethylamino-4-trifluoromethylthiopyrazole

1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-isopropyloxymethylamino-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
Stage #1: 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile; isopropyl alcohol for 0.0833333h;
Stage #2: With formaldehyd at 20℃; for 120h;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

dimethyl amine
124-40-3

dimethyl amine

5-amino-3-cyano-1-[2,6-bis(dimethylamino)-4-trifluoromethylphenyl]-4-trifluoromethylthiopyrazole
865854-41-7

5-amino-3-cyano-1-[2,6-bis(dimethylamino)-4-trifluoromethylphenyl]-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
In 1,4-dioxane; water at 200℃; for 0.666667h; Microwave irradiation;
ethanol
64-17-5

ethanol

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

5-amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole
865854-38-2

5-amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With copper(I) bromide; sodium t-butanolate In DMF (N,N-dimethyl-formamide) at 90℃; for 7h;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

methylamine
74-89-5

methylamine

5-amino-1-(2-chloro-6-methylamino-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole
865854-36-0

5-amino-1-(2-chloro-6-methylamino-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
In 1,4-dioxane; water at 200℃; for 0.666667h; Microwave irradiation;
N-Ethylmethylamine
624-78-2

N-Ethylmethylamine

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

A

5-amino-3-cyano-1-[2-chloro-6-(ethyl-methylamino)-4-trifluoromethylphenyl]-4-trifluoromethylthiopyrazole
865854-58-6

5-amino-3-cyano-1-[2-chloro-6-(ethyl-methylamino)-4-trifluoromethylphenyl]-4-trifluoromethylthiopyrazole

B

5-amino-3-cyano-1-[2,6-bis(ethyl-methylamino)-4-trifluoromethylphenyl]-4-trifluoromethylthiopyrazole
865854-42-8

5-amino-3-cyano-1-[2,6-bis(ethyl-methylamino)-4-trifluoromethylphenyl]-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
In 1,4-dioxane at 140 - 145℃; under 12751.3 - 13501.4 Torr; Microwave irradiatio;
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

5-(dichlorophosphorylamino)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

5-(dichlorophosphorylamino)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; trichlorophosphate In 1,2-dichloro-ethane for 7h; Heating / reflux;
sulfur dioxide
7446-09-5

sulfur dioxide

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

fipronil
120068-37-3

fipronil

Conditions
ConditionsYield
With dihydrogen peroxide; boric acid; trifluoroacetic acid In chlorobenzene
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethoxymethylideneamino-4-trifluoromethylthiopyrazole

3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethoxymethylideneamino-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With hydrogenchloride In orthoformic acid triethyl ester
With hydrogenchloride In orthoformic acid triethyl ester
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile
120067-83-6

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

acetyl chloride
75-36-5

acetyl chloride

5-acetamido-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole
120068-03-3

5-acetamido-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole

Conditions
ConditionsYield
With pyridine In dichloromethane; acetonitrile
With pyridine In dichloromethane; acetonitrile

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