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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3,4,5-Trifluorobenzoic Acid with high purity

Cas:121602-93-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:Shanghai, Qingdao

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3,4,5-Trifluorobenzoic Acid

Cas:121602-93-5

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

CSA NO.:121602-93-5 3,4,5-Trifluorobenzoic acid 1.Large qty in stock 2.High quality 3.Lowest price 4.Best service Our Advantage 1. Risk-free guarantee,15days refund 2. Most of the products in stock,can ship within 7days after the

CSA NO.:121602-93-5 3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3, 4, 5-Trifluorobenzoic Acid CAS No. 121602-93-5

Cas:121602-93-5

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 121602-93-5 with fast shipping

Cas:121602-93-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: 3,4,5-Trifluorobenzoic acid CAS: 121602-93-5 MF: C7H3F3O2 MW: 176.09 EINECS: 624-063-4 Mol File: 121602-93-5.mol 3,4,5-Trifluorobenzoic acid Structure 3,4,5-Trifluorobenzoic acid Chemical Properties Melting point

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:5 Gram

FOB Price: $675.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3,4,5-Trifluorobenzoic Acid CAS No.:121602-93-5 Molecule Formula:C7H2F3O2 Molecule Weight:175.09 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TES

High Quality 3,4,5-Trifluorobenzoic Acid on stock

Cas:121602-93-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Price3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,4,5-Trifluorobenzoic Acid cas no. 121602-93-5 98%

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 3,4,5-Trifluorobenzoic acid 100g

Cas:121602-93-5

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3,4,5-Trifluorobenzoic Acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3,4,5-Trifluorobenzoic acid

Cas:121602-93-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

carbon dioxide
124-38-9

carbon dioxide

3,4,5-trifluoro-1-bromobenzene
138526-69-9

3,4,5-trifluoro-1-bromobenzene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
With n-butyllithium In diethyl ether; hexane at -75℃; for 0.25h;93%
Stage #1: 3,4,5-trifluoro-1-bromobenzene With magnesium Metallation;
Stage #2: carbon dioxide Carboxylation; Grignard reaction;
4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

A

2,3,4,5-tetrafluorobenzoic acid
1201-31-6

2,3,4,5-tetrafluorobenzoic acid

B

3,4-Difluorobenzoic acid
455-86-7

3,4-Difluorobenzoic acid

C

2,4,5-trifluorobenzoic acid
446-17-3

2,4,5-trifluorobenzoic acid

D

2,3,4,-trifluorobenzoic acid
61079-72-9

2,3,4,-trifluorobenzoic acid

E

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

F

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With fluorine In sulfuric acid Product distribution; various substrate to fluorine ratios; also in 98percent HCOOH;
Pentafluorobenzoic acid
602-94-8

Pentafluorobenzoic acid

A

2,3,4,5-tetrafluorobenzoic acid
1201-31-6

2,3,4,5-tetrafluorobenzoic acid

B

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
With 1,10-Phenanthroline; nickel dichloride; zinc In water; N,N-dimethyl-formamide at 50℃; for 6h; Product distribution; Further Variations:; Reagents; Temperatures; reaction time; Hydrodefluorination;
1,2,3-trifluorobenzene
1489-53-8

1,2,3-trifluorobenzene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 91 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -75 °C
2: 95 percent / bromine / CCl4 / Heating
3: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
4: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
5: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 6 steps
1: 91 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -75 °C
2: 95 percent / bromine / CCl4 / Heating
3: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
4: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
5: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
6: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 91 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -75 °C
2.1: 95 percent / bromine / CCl4 / Heating
3.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
4.1: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
1,2-dibromo-3,4,5-trifluorobenzene
17299-94-4

1,2-dibromo-3,4,5-trifluorobenzene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
2: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
1,5-dibromo-2,3,4-trifluorobenzene
17299-95-5

1,5-dibromo-2,3,4-trifluorobenzene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
2: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
3: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 4 steps
1: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
2: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
3: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
4: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
1.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
2.1: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
1,2,3-tribromo-4,5,6-trifluoro-benzene
34628-01-8

1,2,3-tribromo-4,5,6-trifluoro-benzene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
2: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
3: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
1-bromo-2,3,4-trifluorobenzene
176317-02-5

1-bromo-2,3,4-trifluorobenzene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
2: 93 percent / bromine / CCl4 / 36 h / Heating
3: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
4: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
5: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 6 steps
1: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
2: 93 percent / bromine / CCl4 / 36 h / Heating
3: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
4: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
5: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
6: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
2.1: 93 percent / bromine / CCl4 / 36 h / Heating
3.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
4.1: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
(5-bromo-2,3,4-trifluorophenyl)triethylsilane
530145-56-3

(5-bromo-2,3,4-trifluorophenyl)triethylsilane

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / bromine / CCl4 / 36 h / Heating
2: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
4: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 5 steps
1: 93 percent / bromine / CCl4 / 36 h / Heating
2: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
3: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
4: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
5: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 93 percent / bromine / CCl4 / 36 h / Heating
2.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
3.1: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
2,3,4-trifluoro-1,5-phenylenebis(triethylsilane)
530145-55-2

2,3,4-trifluoro-1,5-phenylenebis(triethylsilane)

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / bromine / CCl4 / Heating
2: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
4: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 5 steps
1: 95 percent / bromine / CCl4 / Heating
2: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
3: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
4: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
5: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 95 percent / bromine / CCl4 / Heating
2.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
3.1: 93 percent / butyllithium / diethyl ether; hexane / 0.25 h / -75 °C
View Scheme
3,4,5-trifluoro aniline
163733-96-8

3,4,5-trifluoro aniline

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: Mg
View Scheme
3,4,5-trifluorobenzaldehyde

3,4,5-trifluorobenzaldehyde

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Stage #1: 3,4,5-trifluorobenzaldehyde With potassium permanganate In water; acetone at 20℃; for 6.5h;
Stage #2: With hydrogenchloride; sodium hydrogensulfite In water; acetone
C22H17F3O4

C22H17F3O4

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
In ethanol; dichloromethane at 25℃; Kinetics;
methyl 3,4,5-trifluorobenzoate
773873-72-6

methyl 3,4,5-trifluorobenzoate

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Stage #1: methyl 3,4,5-trifluorobenzoate With sodium hydroxide In methanol; water for 2h; Reflux;
Stage #2: With hydrogenchloride
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

tert-butyl 3,4,5-trifluorobenzoate
863562-09-8

tert-butyl 3,4,5-trifluorobenzoate

Conditions
ConditionsYield
dmap In tert-butyl alcohol at 40℃; for 18h;100%
4,4-difluorocyclohexanol
22419-35-8

4,4-difluorocyclohexanol

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

4-((4,4-difluorocyclohexyl)oxy)-3,5-difluorobenzoic acid

4-((4,4-difluorocyclohexyl)oxy)-3,5-difluorobenzoic acid

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 6h;100%
tri(p-tolyl)antimony
5395-43-7

tri(p-tolyl)antimony

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

(CH3C6H4)3Sb(OCOC6H2F3)2
460752-07-2

(CH3C6H4)3Sb(OCOC6H2F3)2

Conditions
ConditionsYield
With dihydrogen peroxide In diethyl ether; water byproducts: H2O; react. of antimony compd. and acid with aq. H2O2 at room temp. in ether; elem. anal.;99%
triphenylantimony
603-36-1

triphenylantimony

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

(C6H5)3Sb(OCOC6H2F3)2
460752-06-1

(C6H5)3Sb(OCOC6H2F3)2

Conditions
ConditionsYield
With dihydrogen peroxide In diethyl ether; water byproducts: H2O; react. of antimony compd. and acid with aq. H2O2 at room temp. in ether; elem. anal.;99%
tri(p-tolyl)antimony
5395-43-7

tri(p-tolyl)antimony

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

tri-p-tolylantimony bis(3,4,5-trifluorobenzoate)

tri-p-tolylantimony bis(3,4,5-trifluorobenzoate)

Conditions
ConditionsYield
With H2O2 In diethyl ether (C6F3H2)COOH and 30% aq. H2O2 added to soln. of (p-tolyl)3Sb in ether; kept at 20°C for 12 h; crystals filtered off; dried; elem. anal.;99%
triphenylantimony
603-36-1

triphenylantimony

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

triphenylantimony bis(3,4,5-trifluorobenzoate)

triphenylantimony bis(3,4,5-trifluorobenzoate)

Conditions
ConditionsYield
With H2O2 In diethyl ether (C6F3H2)COOH and 30% aq. H2O2 added to soln. of Ph3Sb in ether; kept at 20°C for 12 h; crystals filtered off; dried; elem. anal.;99%
3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

2-(((tert-butyldimethylsilyl)oxy)methyl)-6-hydroxy-2H-pyran-3(6H)-one
359435-59-9

2-(((tert-butyldimethylsilyl)oxy)methyl)-6-hydroxy-2H-pyran-3(6H)-one

6-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxo-5,6-dihydro-2H-pyran-2-yl 3,4,5-trifluorobenzoate

6-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxo-5,6-dihydro-2H-pyran-2-yl 3,4,5-trifluorobenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 1.5h;99%
6-(((tert-butyldimethylsilyl)oxy)methyl)-6-hydroxy-2-methyl-2H-pyran-3(6H)-one

6-(((tert-butyldimethylsilyl)oxy)methyl)-6-hydroxy-2-methyl-2H-pyran-3(6H)-one

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

2-(((tert-butyldimethylsilyl)oxy)methyl)-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl3,4,5-trifluorobenzoate

2-(((tert-butyldimethylsilyl)oxy)methyl)-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl3,4,5-trifluorobenzoate

Conditions
ConditionsYield
With dmap In dichloromethane at 0℃; for 0.5h; Inert atmosphere;98%
para-xylene
106-42-3

para-xylene

triphenylbismuthane
603-33-8

triphenylbismuthane

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Bi4(O)2(O2CC6H2F3)8(C6H4(CH3)2)2

Bi4(O)2(O2CC6H2F3)8(C6H4(CH3)2)2

Conditions
ConditionsYield
In xylene mixt. of BiPh3 and 3,4,5-trifluorobenzoic acid in p-xylene stored in sealed tube in air for 16 h at 20°C; elem. anal.;97%
triphenylbismuthane
603-33-8

triphenylbismuthane

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

benzene
71-43-2

benzene

Bi4(O)2(O2CC6H2F3)8(C6H6)2

Bi4(O)2(O2CC6H2F3)8(C6H6)2

Conditions
ConditionsYield
In benzene mixt. of BiPh3 and 3,4,5-trifluorobenzoic acid in benzene stored in sealed tube in air for 16 h at 20°C; elem. anal.;95%
N-tert-butyl-N'-phenyl-S-phenylisothiourea

N-tert-butyl-N'-phenyl-S-phenylisothiourea

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

3,4,5-trifluoro-N-phenylbenzamide
1274669-24-7

3,4,5-trifluoro-N-phenylbenzamide

Conditions
ConditionsYield
With iron(III)-acetylacetonate In o-xylene at 130℃; for 24h; Microwave irradiation;95%
triphenylbismuthane
603-33-8

triphenylbismuthane

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

tris(3,4,5-trifluorobenzoato)bismuth(III)

tris(3,4,5-trifluorobenzoato)bismuth(III)

Conditions
ConditionsYield
In benzene Reflux;93%
3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

2,6-difluorophenol
28177-48-2

2,6-difluorophenol

Conditions
ConditionsYield
With water; lithium carbonate at 180 - 185℃; for 12h; Sealed tube;92.1%
oxygen
80937-33-3

oxygen

triphenylbismuthane
603-33-8

triphenylbismuthane

toluene
108-88-3

toluene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

Bi4(O)2(O2CC6H2F3-3,4,5)8*2η6-toluene
727990-94-5

Bi4(O)2(O2CC6H2F3-3,4,5)8*2η6-toluene

Conditions
ConditionsYield
In toluene mixt. of Ph3Bi and 3,4,5-trifluorobenzoic acid in toluene kept in sealedglass tube with air (20°C, 16 h); crystals filtered off; dried;92%
penta(p-tolyl)antimony(V)
13328-67-1, 51017-91-5

penta(p-tolyl)antimony(V)

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

tetra(p-tolyl)antimony 3,4,5-trifluorobenzoate
460752-10-7

tetra(p-tolyl)antimony 3,4,5-trifluorobenzoate

Conditions
ConditionsYield
In benzene at 80℃; for 1h; Sealed tube;91%
triphenylbismuthane
603-33-8

triphenylbismuthane

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

phenylbismuth bis(3,4,5-trifluorobenzoate)

phenylbismuth bis(3,4,5-trifluorobenzoate)

Conditions
ConditionsYield
In o-xylene byproducts: C6H6; mixt. of Ph3Bi and 3,4,5-trifluorobenzoic acid (1:2 molar ratio) kept (20°C, 16 h) in sealed glass tube containing atmospheric O2; crystals filtered off; dried; elem. anal.;90%
6-hydroxy-3,6-dihydro-2H-pyran-3-one
35436-57-8

6-hydroxy-3,6-dihydro-2H-pyran-3-one

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

5-oxo-5,6-dihydro-2H-pyran-2-yl 3,4,5-trifluorobenzoate
1638116-03-6

5-oxo-5,6-dihydro-2H-pyran-2-yl 3,4,5-trifluorobenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 1.5h; Inert atmosphere;89%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 1.5h;58%
carbon dioxide
124-38-9

carbon dioxide

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

C8H3F3O4

C8H3F3O4

Conditions
ConditionsYield
Stage #1: 3,4,5-trifluorobenzoic acid With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 20℃;
89%
3-amino-N-cyclopropyl-4-methylbenzamide
623155-19-1

3-amino-N-cyclopropyl-4-methylbenzamide

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3,4,5-trifluorobenzamide
857355-27-2

N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3,4,5-trifluorobenzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) for 16h;88%
3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

benzyl alcohol
100-51-6

benzyl alcohol

4-(benzyloxy)-3,5-difluorobenzoic acid
1408143-67-8

4-(benzyloxy)-3,5-difluorobenzoic acid

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃;88%
2,2,2,-trichloroethoxycarbonyl azide

2,2,2,-trichloroethoxycarbonyl azide

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

2,2,2-trichloroethyl (3,4,5-trifluorophenyl)carbamate

2,2,2-trichloroethyl (3,4,5-trifluorophenyl)carbamate

Conditions
ConditionsYield
With dmap; copper diacetate In acetonitrile at 100℃; for 6h; Schlenk technique; Sealed tube; Inert atmosphere;85%
1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

methyl iodide
74-88-4

methyl iodide

methyl 3,4,5-trifluoro-2,6-bis[(triisopropylsilyl)ethynyl]benzoate

methyl 3,4,5-trifluoro-2,6-bis[(triisopropylsilyl)ethynyl]benzoate

Conditions
ConditionsYield
Stage #1: 1-bromo-2-(triisopropylsilyl)acetylene; 3,4,5-trifluorobenzoic acid With [Ru(O2CMes)2(p-cymene)] In 1,4-dioxane at 120℃; for 16h; Inert atmosphere; Schlenk technique;
Stage #2: methyl iodide With potassium carbonate In 1,4-dioxane; acetonitrile at 50℃; for 2h; Inert atmosphere; Schlenk technique;
84%
(3S,4R,5R)-clausenamidone
114376-13-5

(3S,4R,5R)-clausenamidone

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

C26H20F3NO4

C26H20F3NO4

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;80.1%
1-(diphenylmethyl)-3-hydroxyazetidine
18621-17-5

1-(diphenylmethyl)-3-hydroxyazetidine

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

4-((1-benzhydrylazetidin-3-yl)oxy)-3,5-difluorobenzoic acid

4-((1-benzhydrylazetidin-3-yl)oxy)-3,5-difluorobenzoic acid

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 50℃; for 19h;79%
(4-(9-(4-hydroxyphenyl)nonyl)phenyl 4-cyanobenzoate)

(4-(9-(4-hydroxyphenyl)nonyl)phenyl 4-cyanobenzoate)

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

4-(9-(4-((4-cyanobenzoyl)oxy)phenyl)nonyl)phenyl 3,4,5-trifluorobenzoate

4-(9-(4-((4-cyanobenzoyl)oxy)phenyl)nonyl)phenyl 3,4,5-trifluorobenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 2h; Inert atmosphere;76%
triphenylbismuthane
603-33-8

triphenylbismuthane

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

triphenylbismuth bis(3,4,5-trifluorobenzoate)

triphenylbismuth bis(3,4,5-trifluorobenzoate)

Conditions
ConditionsYield
With H2O2 In diethyl ether byproducts: H2O; 3,4,5-trifluorobenzoic acid + 37% H2O2 added to soln. of Ph3Bi (2:1:1); kept (12 h, 20°C); crystals filtered off; dried;74%
3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

3,4,5-trifluoro-2-nitrobenzoic acid
121579-85-9

3,4,5-trifluoro-2-nitrobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 90℃; for 1h; oil bath;73%
3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

3,4,5-trifluoro-2-iodobenzoic acid

3,4,5-trifluoro-2-iodobenzoic acid

Conditions
ConditionsYield
Stage #1: 3,4,5-trifluorobenzoic acid With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 3h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran; hexane at -78 - 25℃; Inert atmosphere;
Stage #3: With hydrogenchloride In water
72%
Stage #1: 3,4,5-trifluorobenzoic acid With n-butyllithium In tetrahydrofuran at -78℃; for 2.5h;
Stage #2: With iodine In tetrahydrofuran at -78℃; for 0.5h;
65.6%
3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

1-(2.3.4-Trimethoxybenzoyl)piperazin
93896-51-6

1-(2.3.4-Trimethoxybenzoyl)piperazin

C21H21F3N2O5

C21H21F3N2O5

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h;70%

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