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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4-Difluorobenzoic acid and derivatives supplier in China

Cas:1583-58-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of custome Port:shanghai

1583-58-0 2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 1583-58-0 2,4-Difluorobenzoic acid Manufacturer

Cas:1583-58-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,4-Difluorobenzoic Acid

Cas:1583-58-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

2,4-Difluorobenzoic acid 1583-58-0 2,4-Difluorobenzoic acid Basic information Product Name: 2,4-Difluorobenzoic acid Synonyms: 2,4-DFBA;2,4-DIFLUOROBENZOIC ACID;RARECHEM AL BO 0245;2,4

2,4-Difluorobenzoic acid 1583-58-0

Cas:1583-58-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 1583-58-0 with fast shipping

Cas:1583-58-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS1583-58-0 2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

high quality cas 1583-58-0 2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:100 Gram

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Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4-Difluorobenzoic acid 1583-58-0

Cas:1583-58-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 2,4-Difluorobenzoic acid CAS: 1583-58-0 MF: C7H4F2O2 MW: 158.1 EINECS: 216-430-9 Mol File: 1583-58-0.mol 2,4-Difluorobenzoic acid Structure 2,4-Difluorobenzoic acid Chemical Properties Melting point 188-190 °

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2,4-Difluorobenzoic acid CAS:1583-58-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

2,4-Difluorobenzoic acid CAS:1583-58-0

Cas:1583-58-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,4-difluoro benzoic acids

Cas:1583-58-0

Min.Order:0

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Type:Manufacturers

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Triumph International Development Limilted

Appearance:white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

2,4-Difluorobenzoic Acid

Cas:1583-58-0

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 1583-58-0 2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,4-DIFLUOROBENZOIC ACID

Cas:1583-58-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,4-Difluorobenzoic Acid

Cas:1583-58-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,4-Difluorobenzoic acid and the derivatives

Cas:1583-58-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,4-Difluorobenzoic Acid

Cas:1583-58-0

Min.Order:0 Metric Ton

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Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,4-Difluorobenzoic acid/High quality/Best price

Cas:1583-58-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,4-Difluorobenzoic acid CAS NO.1583-58-0

Cas:1583-58-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 2,4-Difluorobenzoic Acid CAS No.:1583-58-0 Molecule Formula:C7H3F2O2 Molecule Weight:157.09 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING

Best Quality 2,4-Difluorobenzoic Acid with good supplier

Cas:1583-58-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,4-Difluorobenzoic acid

Cas:1583-58-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Synthetic route

2,4-difluoro-3-(triethylsilyl)benzoic acid
651027-06-4

2,4-difluoro-3-(triethylsilyl)benzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 2h; Heating;98%
N-(4-cyanophenyl)-2,4-difluorobenzamide

N-(4-cyanophenyl)-2,4-difluorobenzamide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 18h;98%
2,4-difluoro-6-bromo-isopropylbenzene

2,4-difluoro-6-bromo-isopropylbenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With 1,3-Dichloro-2-propanol; boron trifluoride diethyl etherate; water at 50℃; for 1.83333h; Temperature;97%
carbon dioxide
124-38-9

carbon dioxide

2,4-difluoro-1-iodobenzene
2265-93-2

2,4-difluoro-1-iodobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -75℃;92%
Stage #1: 2,4-difluoro-1-iodobenzene With copper In tetrahydrofuran at 25℃; for 0.5h;
Stage #2: carbon dioxide In tetrahydrofuran for 24h;
76%
2,4-difluorobenzonitrile
3939-09-1

2,4-difluorobenzonitrile

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 2.5h; Green chemistry;92%
2,4-difluoroethynylbenzene
302912-34-1

2,4-difluoroethynylbenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide at 120℃; under 760.051 Torr; for 48h;92%
2,4-difluoro-3-chlorobenzoic acid
154257-75-7

2,4-difluoro-3-chlorobenzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; zinc for 2h; Heating;91%
2,4-difluorophenyl 2,3,4,5,6-pentafluorobenzenesulfonate

2,4-difluorophenyl 2,3,4,5,6-pentafluorobenzenesulfonate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;90%
formic acid
64-18-6

formic acid

2,4-difluoro-1-iodobenzene
2265-93-2

2,4-difluoro-1-iodobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;87%
2',4'-difluoroacetophenone
364-83-0

2',4'-difluoroacetophenone

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate; acetic acid at 180℃; under 18751.9 Torr; for 1.5h; Reagent/catalyst; Temperature; Green chemistry;85%
With sodium percarbonate; potassium tert-butylate; sphingosylphosphorylcholine; meta-dinitrobenzene In tert-butyl alcohol at 80℃; for 5h;23%
With potassium permanganate Oxidation;
2,4-difluorophenyl trifluoromethanesulfonate

2,4-difluorophenyl trifluoromethanesulfonate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;82%
2,4-dinitrobenzoic acid
610-30-0

2,4-dinitrobenzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With potassium fluoride; cetyltrimethylammonim bromide In N,N-dimethyl-formamide at 120℃; for 7h;72.4%
2,4-difluorotoluene
452-76-6

2,4-difluorotoluene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With potassium permanganate
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

carbon dioxide
124-38-9

carbon dioxide

A

3-bromo-2,6-difluorobenzoic acid
28314-81-0

3-bromo-2,6-difluorobenzoic acid

B

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

C

2,6-difluorobenzoic acid
385-00-2

2,6-difluorobenzoic acid

Conditions
ConditionsYield
With n-butyllithium 1) hexane, Et2O, 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction. Yields of byproduct given;
With n-butyllithium 1) hexane, THF; 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction. Yields of byproduct given;
4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

A

2,3,4,5-tetrafluorobenzoic acid
1201-31-6

2,3,4,5-tetrafluorobenzoic acid

B

3,4-Difluorobenzoic acid
455-86-7

3,4-Difluorobenzoic acid

C

2,4,5-trifluorobenzoic acid
446-17-3

2,4,5-trifluorobenzoic acid

D

2,3,4,-trifluorobenzoic acid
61079-72-9

2,3,4,-trifluorobenzoic acid

E

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

F

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With fluorine In sulfuric acid Product distribution; various substrate to fluorine ratios; also in 98percent HCOOH;
2,4-difluorobenzaldehyde
1550-35-2

2,4-difluorobenzaldehyde

A

2,4-difluorophenol
367-27-1

2,4-difluorophenol

B

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With 4-hydroxyacetophenone monooxygenase from P. fluorescens ACB; oxygen; NADPH In phosphate buffer at 30℃; for 1h; pH=8.0; Enzyme kinetics; Baeyer-Villiger oxidation;
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: BuLi / hexane; tetrahydrofuran / 0.75 h / -75 °C
1.2: 74 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane / 0.75 h / -75 °C
2.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 90 percent / tetrahydrofuran; hexane
3.1: 91 percent / Zn; aq. NaOH / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C
2: 89 percent / sec-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h
3: 98 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 98 percent / sec-BuLi; I2 / tetrahydrofuran; cyclohexane / -75 °C
2: 48 percent / LDA / tetrahydrofuran; hexane / -75 °C
3: 92 percent / BuLi / tetrahydrofuran; hexane / -75 °C
View Scheme
Multi-step reaction with 2 steps
2: KMnO4
View Scheme
1-chloro-2,6-difluorobenzene
38361-37-4

1-chloro-2,6-difluorobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
1.2: 90 percent / tetrahydrofuran; hexane
2.1: 91 percent / Zn; aq. NaOH / 2 h / Heating
View Scheme
1-triethylsilyl-2,6-difluorobenzene
651027-02-0

1-triethylsilyl-2,6-difluorobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / sec-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h
2: 98 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating
View Scheme
2,6-difluoroiodobenzene
13697-89-7

2,6-difluoroiodobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / LDA / tetrahydrofuran; hexane / -75 °C
2: 92 percent / BuLi / tetrahydrofuran; hexane / -75 °C
View Scheme
phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

2,4-difluorobenzoyl chloride
72482-64-5

2,4-difluorobenzoyl chloride

A

benzoic acid hydrazide
613-94-5

benzoic acid hydrazide

B

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
In pyridineA 98 g (79%)
B n/a
C22H18F2O4

C22H18F2O4

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
In ethanol; dichloromethane at 25℃; Kinetics;
2,4-difluorophenol
367-27-1

2,4-difluorophenol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane; water / 16 h / 20 °C / Schlenk technique; Inert atmosphere
View Scheme
2,4-difluorophenylcarbonylmethylenetriphenylphosphine

2,4-difluorophenylcarbonylmethylenetriphenylphosphine

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide In tetrahydrofuran at 50℃; for 18h; Inert atmosphere;
2,4-dinitrotoluene
121-14-2

2,4-dinitrotoluene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Stage #1: 2,4-dinitrotoluene With ammonium chloride In ethanol at 75 - 85℃; for 1.16667h;
Stage #2: With manganese(IV) oxide; tetrabutylammomium bromide; dihydrogen peroxide at 40 - 60℃; for 1h;
Stage #3: With tetrabutylammomium bromide; sodium fluoride In N,N-dimethyl-formamide at 100 - 115℃; for 5.5h;
3,5-dichloro-N-(4-cyanophenyl)-2,4,6-trifluorobenzamide

3,5-dichloro-N-(4-cyanophenyl)-2,4,6-trifluorobenzamide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis
2: hydrogenchloride / 18 h / 80 °C
View Scheme
3,5-dichloro-2,4,6-trifluorobenzoyl chloride

3,5-dichloro-2,4,6-trifluorobenzoyl chloride

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis
3: hydrogenchloride / 18 h / 80 °C
View Scheme
2,4,6-trifluoro-3,5-dichlorobenzoic acid
13656-36-5

2,4,6-trifluoro-3,5-dichlorobenzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 4 h / 70 °C
2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis
4: hydrogenchloride / 18 h / 80 °C
View Scheme
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluorobenzoyl chloride
72482-64-5

2,4-difluorobenzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; Cooling with ice;100%
Stage #1: 2,4-difluoro-benzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h;
Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h;
100%
With thionyl chloride Heating;96%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-5-iodobenzoic acid

2,4-difluoro-5-iodobenzoic acid

Conditions
ConditionsYield
With N-iodo-succinimide; sulfuric acid at 0℃; for 4h;100%
With N-iodo-succinimide; trifluorormethanesulfonic acid at 5 - 50℃; for 1.5h; Product distribution / selectivity;100%
With N-Iodosuccinamide; sulfuric acid at 0 - 5℃; for 5h;94%
(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester
869489-00-9

(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

(2S,4S)-4-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4S)-4-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester; 2,4-difluoro-benzoic acid With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
100%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-5-nitro-benzoic acid
153775-33-8

2,4-difluoro-5-nitro-benzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0 - 20℃; for 16.5h;98%
With sulfuric acid; nitric acid In water at 20 - 50℃; for 3.5h;98%
With sulfuric acid; nitric acid at 0 - 20℃; for 16.5h;98%
3,4,5-Trimethoxyaniline
24313-88-0

3,4,5-Trimethoxyaniline

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-N-(3,4,5-trimethoxyphenyl)benzamide

2,4-difluoro-N-(3,4,5-trimethoxyphenyl)benzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;98%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

methyl 2,4-difluorobenzoate
106614-28-2

methyl 2,4-difluorobenzoate

Conditions
ConditionsYield
With thionyl chloride In methanol97%
Multi-step reaction with 2 steps
1: thionyl chloride; sulfuric acid / 0.2 h / Inert atmosphere; Reflux
2: triethylamine / dichloromethane / 0 °C / Inert atmosphere
View Scheme
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

4-fluorosalicylic acid
345-29-9

4-fluorosalicylic acid

Conditions
ConditionsYield
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 130℃; for 4h;95.1%
With sodium hydroxide In dimethyl sulfoxide at 130℃; for 8h;90%
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 135℃; for 4h;68%
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 135℃; for 6h;67.52%
With sodium hydroxide In 1-methyl-pyrrolidin-2-one at 150℃; for 1h;
benzo[1,3]dioxolo-5-ylamine
14268-66-7

benzo[1,3]dioxolo-5-ylamine

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

N-(benzo[d][1,3]dioxol-5-yl)-2,4-difluorobenzamide

N-(benzo[d][1,3]dioxol-5-yl)-2,4-difluorobenzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;93%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-N-(4-methoxyphenyl)benzamide

2,4-difluoro-N-(4-methoxyphenyl)benzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;93%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

3-fluorophenol
372-20-3

3-fluorophenol

Conditions
ConditionsYield
With water; sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 170 - 175℃; for 15h; Sealed tube;92.8%
3,4-dimethoxyaniline
6315-89-5

3,4-dimethoxyaniline

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

N-(3,4-dimethoxyphenyl)-2,4-difluorobenzamide

N-(3,4-dimethoxyphenyl)-2,4-difluorobenzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;91%
methyl (L)-leucinate hydrochloride
7517-19-3

methyl (L)-leucinate hydrochloride

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

(S)-methyl 2-(2,4-difluorobenzamido)-4-methylpentanoate

(S)-methyl 2-(2,4-difluorobenzamido)-4-methylpentanoate

Conditions
ConditionsYield
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;90%
europium(III) hydroxide

europium(III) hydroxide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

C21H13EuF6O8

C21H13EuF6O8

Conditions
ConditionsYield
In methanol; acetone at 60℃; for 1h;89%
tert-butyl alcohol
75-65-0

tert-butyl alcohol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

tert-butyl 2,4-difluorobenzoate
500353-15-1

tert-butyl 2,4-difluorobenzoate

Conditions
ConditionsYield
With dmap; di-tert-butyl dicarbonate for 48h;86%
With dmap; di-tert-butyl dicarbonate at 20℃; for 24h;84%
With dmap; di-tert-butyl dicarbonate In dichloromethane at 20℃; for 24h;84%
ethanol
64-17-5

ethanol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

ethyl 2,4-di-fluorobenzoate
108928-00-3

ethyl 2,4-di-fluorobenzoate

Conditions
ConditionsYield
With sulfuric acid for 3h; Heating;85%
With hydrogenchloride at 80℃; for 24.25h;76%
Stage #1: ethanol; 2,4-difluoro-benzoic acid With hydrogenchloride for 5.33333h; Heating / reflux;
Stage #2: With sodium hydroxide In diethyl ether; water
With hydrogenchloride
With sulfuric acid Heating;
3,5-dimethylphenyl iodide
22445-41-6

3,5-dimethylphenyl iodide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

3,5-difluoro-3',5'-dimethyl-1,1'-biphenyl
1344681-47-5

3,5-difluoro-3',5'-dimethyl-1,1'-biphenyl

Conditions
ConditionsYield
With palladium diacetate; acetic acid; silver carbonate at 130℃; for 16h; regioselective reaction;85%
5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carbohydrazide

5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carbohydrazide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2-(5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-3-yl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole

2-(5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-3-yl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With trichlorophosphate Reflux;85%
ethyl 3-(dimethylamino)acrylate
924-99-2, 1117-37-9, 114894-59-6

ethyl 3-(dimethylamino)acrylate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

(Z)-ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate

(Z)-ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate

Conditions
ConditionsYield
Stage #1: 2,4-difluoro-benzoic acid With thionyl chloride at 80℃; for 2h;
Stage #2: ethyl 3-(dimethylamino)acrylate With triethylamine In toluene at 90℃; for 12h;
85%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl alcohol
75-65-0

tert-butyl alcohol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

tert-butyl 2,4-difluorobenzoate
500353-15-1

tert-butyl 2,4-difluorobenzoate

Conditions
ConditionsYield
dmap In dichloromethane at 20℃; for 24h;84%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

tert-butyl 2,4-difluorobenzoate
500353-15-1

tert-butyl 2,4-difluorobenzoate

Conditions
ConditionsYield
With dmap In dichloromethane; tert-butyl alcohol at 20℃; for 24h;84%
dmap In tert-butyl alcohol at 40℃; for 18h;81%

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