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GL Biochem (Shanghai) Ltd.

GL Biochem (Shanghai) Ltd. founded in 1998, has become an internationally recognized biochemical manufacturing company that specializes in producing/synthesizing and providing peptide reagents, custom peptides and antibodies. GL Biochem is based in

Fmoc-Asn(Trt)-OH, Fmoc-N-trityl-L-asparagine, MFCD00077049

Cas:132388-59-1

Min.Order:1 Gram

FOB Price: $21.0 / 28.0

Type:Manufacturers

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Chengdu Baishixing Science and Technology Industry Co., Ltd.

Fmoc-Asn(Trt)

Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Fmoc-N-trityl-L-asparagine Manufacturer/High quality/Best price/In stock

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Fmoc-Asn(Trt)-Oh supplier in China

Cas:132388-59-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Fmoc-N-trityl-L-Asparagine CAS:132388-59-1

Cas:132388-59-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product description: Product name Fmoc-N-trityl-L-asparagine CAS number 132388-59-1 Assay ≥99% Appearance White powder Capacity 100mt/year Application Pharmaceutical interme

Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:100 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

Fmoc-L-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,

Fmoc-N-trityl-L-Asparagine

Cas:132388-59-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

132388-59-1 Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nα-9-Fluorenylmethoxycarbonyl-Nτ-trityl-L-asparagine

Cas:132388-59-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Fmoc-N-trityl-L-asparagine CAS NO: 132388-59-1 Grade:Medical scientific research and export Molecular formula:C38H32N2O5 Molecular weight:596.67 Product Quality 12 years of chemical raw materials Mature operation of the industry Syste

Fmoc-N-trityl-L-asparagine/ CAS:132388-59-1/Fmoc-N-trityl-L-asparagine raw material/ high-quality

Cas:132388-59-1

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Leader Biochemical Group

About Product Technical Details

China Largest factory Manufacturer Supply High Quality Fmoc-Asn(Trt)-OH/N-ALPHA-FMOC-N-GAMMA-TRITYL-L-ASPARAGINE CAS 132388-59-1

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Fmoc-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 132388-59-1 with best quality

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell High Qality CAS 132388-59-1 Fmoc-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Fmoc-N-trityl-L-asparagine CAS132388-59-1

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Fmoc-Asn(Trt)-OH CAS No. 132388-59-1 Synonyms Fmoc-L-Asparagine(Trt)-OH Purity 98.0% min Molecular Formula C38H32N2O5 Molecular Weight 595.7 Appearance: whit

Fmoc-N-trityl-L-Asparagine

Cas:132388-59-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

132388-59-1 Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Fmoc-N-trityl-L-asparagine 132388-59-1

Cas:132388-59-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Fmoc-N-trityl-L-asparagineCAS:132388-59-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

Fmoc-N-trityl-L-asparagineCAS:132388-59-1

Cas:132388-59-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Fmoc-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:1 Gram

FOB Price: $2388.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Fmoc-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

FMOC-N-TRITYL-L-ASPARAGINE

Cas:132388-59-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Fmoc-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Fmoc-N-trityl-L-asparagine

Cas:132388-59-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Fmoc-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity FMOC-Asn(Trt)-OH

Cas:132388-59-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(S)-2-Amino-N-trityl-succinamic acid
132388-58-0

(S)-2-Amino-N-trityl-succinamic acid

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Fmoc-Asn(TrT)-F

Fmoc-Asn(TrT)-F

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Conditions
ConditionsYield
With water In N,N-dimethyl-formamide for 24h; Product distribution; Ambient temperature; effect of water content on stability of various Fmoc-amino acid fluorides;
triphenylmethyl alcohol
76-84-6

triphenylmethyl alcohol

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / acetic anhydride, conc.H2SO4 / acetic acid / 1.25 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic anhydride, conc.H2SO4 / acetic acid / 1 h / 50 °C
2: H2 / Pd-C
View Scheme
N-benzyloxycarbonyl-N'-trityl-L-asparagine
132388-57-9

N-benzyloxycarbonyl-N'-trityl-L-asparagine

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / Pd-C
View Scheme
triphenylmethyl alcohol
76-84-6

triphenylmethyl alcohol

Fmoc-Asn-OH
71989-16-7

Fmoc-Asn-OH

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Conditions
ConditionsYield
With sulfuric acid; acetic anhydride In tetrahydrofuran; methanol; di-isopropyl ether; water; acetic acid; ethyl acetate
aqueous potassium bisulfate

aqueous potassium bisulfate

H-Asn(Trt)-OH.0.5 H2 O

H-Asn(Trt)-OH.0.5 H2 O

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; di-isopropyl ether; water; ethyl acetate
Fmoc-Asn(Trt)-OBt

Fmoc-Asn(Trt)-OBt

A

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

B

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

Conditions
ConditionsYield
With water for 6h; Kinetics;
C119H188N12O14S
1258442-46-4

C119H188N12O14S

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

C157H218N14O18S
1258442-38-4

C157H218N14O18S

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
(4-(hydroxymethyl)phenyl)diphenylphosphine oxide
5068-20-2

(4-(hydroxymethyl)phenyl)diphenylphosphine oxide

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

C57H47N2O6P

C57H47N2O6P

Conditions
ConditionsYield
Stage #1: (4-(hydroxymethyl)phenyl)diphenylphosphine oxide; L-Asn(Trt) With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h;
Stage #2: With dmap In dichloromethane at 20℃; for 2h;
99%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

methyl iodide
74-88-4

methyl iodide

methyl (S)-2-((9H-fluoren-9-yl)methoxycarbonylamino)-4-oxo-4-(tritylamino)butanoate

methyl (S)-2-((9H-fluoren-9-yl)methoxycarbonylamino)-4-oxo-4-(tritylamino)butanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 1h;99%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

D-Asn(Trt)-OBn

D-Asn(Trt)-OBn

Fmoc-L-Asn(Trt)-D-Asn(Trt)-OBn

Fmoc-L-Asn(Trt)-D-Asn(Trt)-OBn

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃;98%
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride98%
Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

Fmoc-(tBu)Asp-OH
71989-14-5

Fmoc-(tBu)Asp-OH

Fmoc-Lys(tert-butoxycarbonyl)
71989-26-9

Fmoc-Lys(tert-butoxycarbonyl)

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Fmoc-(S)-2-aminohexanoic acid
77284-32-3

Fmoc-(S)-2-aminohexanoic acid

N-(9-fluorenylmethoxycarbonyl)-D-valine
84624-17-9

N-(9-fluorenylmethoxycarbonyl)-D-valine

C58H82N8O12

C58H82N8O12

Conditions
ConditionsYield
Stage #1: Fmoc-(tBu)Asp-OH With O-(1H-6-chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.833333h; 2-chlorotrityl resin; Automated synthesizer;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.0833333h; 2-chlorotrityl resin; Automated synthesizer;
Stage #3: Fmoc-Pro-OH; Fmoc-Lys(tert-butoxycarbonyl); L-Asn(Trt); Fmoc-(S)-2-aminohexanoic acid; N-(9-fluorenylmethoxycarbonyl)-D-valine Further stages;
97%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

tert-butyl 4-aminobutanoate hydrochloride

tert-butyl 4-aminobutanoate hydrochloride

Fmoc-Asn(Trt)-GABA-OtBu

Fmoc-Asn(Trt)-GABA-OtBu

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In dichloromethane Inert atmosphere;97%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

tert-butylamine
75-64-9

tert-butylamine

Fmoc-Asn(Trt)-NHtBu
1370293-55-2

Fmoc-Asn(Trt)-NHtBu

Conditions
ConditionsYield
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -18℃; for 2h;96%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

4-methoxycarbonyl aniline
619-45-4

4-methoxycarbonyl aniline

methyl (S)-4-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-4-(tritylamino)butanamido)benzoate

methyl (S)-4-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-4-(tritylamino)butanamido)benzoate

Conditions
ConditionsYield
With triethylamine; trichlorophosphate In dichloromethane at 0℃; for 2h;96%
With triethylamine; trichlorophosphate In dichloromethane at 0℃; for 2h; Inert atmosphere;13.97 g
HCl*H-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-OKb, Kb=2,4-didocosyloxybenzyl

HCl*H-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-OKb, Kb=2,4-didocosyloxybenzyl

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

HCl*H-Asn(Trt)-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-Okb, Kb=2,4-didocosyloxybenzyl

HCl*H-Asn(Trt)-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-Okb, Kb=2,4-didocosyloxybenzyl

Conditions
ConditionsYield
Stage #1: HCl*H-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-OKb, Kb=2,4-didocosyloxybenzyl; L-Asn(Trt) With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: With piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; N,N-dimethyl-formamide pH=Ca. 6;
95.4%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(S)-Nα-(Fluoren-9-ylmethoxycarbonyl)-Nγ-tritylasparagine tert-butyldimethylsilyl ester
313944-83-1

(S)-Nα-(Fluoren-9-ylmethoxycarbonyl)-Nγ-tritylasparagine tert-butyldimethylsilyl ester

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1.41667h; Esterification;95%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

C20H18NO4Pol

C20H18NO4Pol

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid
146549-21-5

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid

N-(tert-butoxycarbonyl)-D-allylglycine
170899-08-8

N-(tert-butoxycarbonyl)-D-allylglycine

(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid
170642-28-1

(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid

2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester
936116-88-0

2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

Conditions
ConditionsYield
Stage #1: C20H18NO4Pol With piperidine In 1-methyl-pyrrolidin-2-one not specified;
Stage #2: L-Asn(Trt) With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one not specified;
Stage #3: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid; N-(tert-butoxycarbonyl)-D-allylglycine; (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid Further stages;
95%
L-Asn(Trt)
132388-59-1

L-Asn(Trt)

(S)-2-Amino-N-trityl-succinamic acid
132388-58-0

(S)-2-Amino-N-trityl-succinamic acid

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 50℃; for 12h;95%
4-aminobenzenemethanol
623-04-1

4-aminobenzenemethanol

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

9H-fluorene-9-ylmethyl[(2S)-1-{[4-(hydroxymethyl)phenyl]amino}-1,4-dioxo-4-(tritylamino)butane-2-yl]carbamate

9H-fluorene-9-ylmethyl[(2S)-1-{[4-(hydroxymethyl)phenyl]amino}-1,4-dioxo-4-(tritylamino)butane-2-yl]carbamate

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In tetrahydrofuran at 20℃;93%
Stage #1: L-Asn(Trt) With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h;
Stage #2: 4-aminobenzenemethanol With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 3h;
90%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h;
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In tetrahydrofuran at 20℃;19.2 g
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

Fmoc-(tBu)Asp-OH
71989-14-5

Fmoc-(tBu)Asp-OH

Fmoc-Ile-OH
71989-23-6

Fmoc-Ile-OH

Fmoc-Lys(tert-butoxycarbonyl)
71989-26-9

Fmoc-Lys(tert-butoxycarbonyl)

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

C55H76N8O12

C55H76N8O12

Conditions
ConditionsYield
Stage #1: Fmoc-(tBu)Asp-OH With O-(1H-6-chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.833333h; 2-chlorotrityl resin; Automated synthesizer;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.0833333h; 2-chlorotrityl resin; Automated synthesizer;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Pro-OH; Fmoc-Ile-OH; Fmoc-Lys(tert-butoxycarbonyl); L-Asn(Trt) Further stages;
93%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

C42H38N4O9

C42H38N4O9

Fmoc-(tBu)Asp-OH
71989-14-5

Fmoc-(tBu)Asp-OH

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

C51H69N17O16

C51H69N17O16

Conditions
ConditionsYield
Stage #1: Fmoc-(tBu)Asp-OH With N-ethyl-N,N-diisopropylamine In dichloromethane for 4h; Inert atmosphere;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.35h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; C42H38N4O9; L-Asn(Trt); Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;
92%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

HCl*H-Glu(OtBu)-OKb, Kb=2,4-didocosyloxybenzyl

HCl*H-Glu(OtBu)-OKb, Kb=2,4-didocosyloxybenzyl

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

Fmoc-(tBu)Asp-OH
71989-14-5

Fmoc-(tBu)Asp-OH

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

HCl*H-Gly-Asn(Trt)-Gly-Asp(OtBu)-Phe-Glu(OtBu)-OKb, Kb=2,4-didocosyloxybenzyl

HCl*H-Gly-Asn(Trt)-Gly-Asp(OtBu)-Phe-Glu(OtBu)-OKb, Kb=2,4-didocosyloxybenzyl

Conditions
ConditionsYield
Stage #1: HCl*H-Glu(OtBu)-OKb, Kb=2,4-didocosyloxybenzyl; N-Fmoc L-Phe With N-ethyl-N,N-diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: With piperidine; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-(tBu)Asp-OH; L-Asn(Trt) Further stages;
90.8%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Fmoc-Ser(tBu)-OH
71989-33-8

Fmoc-Ser(tBu)-OH

Fmoc-Glu(OtBu)-OH
71989-18-9

Fmoc-Glu(OtBu)-OH

acetic anhydride
108-24-7

acetic anhydride

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

Ac-S(tBu)E(OtBu)VN(trt)-OH
1447762-81-3

Ac-S(tBu)E(OtBu)VN(trt)-OH

Conditions
ConditionsYield
Stage #1: L-Asn(Trt) With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3.25h;
Stage #2: With piperidine In N,N-dimethyl-formamide
Stage #3: Fmoc-Val-OH; Fmoc-Ser(tBu)-OH; Fmoc-Glu(OtBu)-OH; acetic anhydride Further stages;
90%
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(dimethylamino)hexanoic acid

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(dimethylamino)hexanoic acid

Fmoc-O-methyl-L-serine
159610-93-2

Fmoc-O-methyl-L-serine

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

L-Asn(Trt)
132388-59-1

L-Asn(Trt)

N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine
77128-72-4

N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine

HO-Phe-Tyr(Me)-Ser(Me)-Asn(Trt)-Lys(Me)2-NH2

HO-Phe-Tyr(Me)-Ser(Me)-Asn(Trt)-Lys(Me)2-NH2

Conditions
ConditionsYield
Stage #1: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(dimethylamino)hexanoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane for 4h;
Stage #2: With piperidine In N,N-dimethyl-formamide; isopropyl alcohol
Stage #3: Fmoc-O-methyl-L-serine; N-Fmoc L-Phe; L-Asn(Trt); N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine Further stages;
90%

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