Product Detail Minimum Order Qty. 10 Gram
Cas:13745-86-3
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day
Cas:13745-86-3
Min.Order:1 Kilogram
FOB Price: $4.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:13745-86-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:13745-86-3
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:13745-86-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:13745-86-3
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:13745-86-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry11-Chloro-dibenzo[b,f][1,4]thiazepine CAS:13745-86-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qua
Cas:13745-86-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:13745-86-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists
Cas:13745-86-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:13745-86-3
Min.Order:1 Gram
FOB Price: $649.19
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:13745-86-3
Min.Order:100 Gram
Negotiable
Type:Other
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:13745-86-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:13745-86-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:Pale-Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:A metabolite o
Cas:13745-86-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryProduct Name: 11-Chloro-dibenzo[b,f][1,4]thiazepine CAS: 13745-86-3 MF: C13H8ClNS MW: 245.73 EINECS: Mol File: 13745-86-3.mol 11-Chloro-dibenzo[b,f][1,4]thiazepine Structure 11-Chloro-dibenzo[b,f][1,4]thiazepine Chemical Properti
Cas:13745-86-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:13745-86-3
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:13745-86-3
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:13745-86-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:13745-86-3
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:13745-86-3
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:13745-86-3
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiry1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:13745-86-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
dibenzo[b,f][1,4]thiazepin-11-one
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With trichlorophosphate In toluene at 100℃; for 12h; Inert atmosphere; | 99% |
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux; | 97% |
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux; | 97% |
2-((2-aminophenyl)thio)benzoic acid
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With trichlorophosphate for 5 - 6h; Product distribution / selectivity; Heating / reflux; | |
With triethylamine; trichlorophosphate In toluene for 5 - 6h; Product distribution / selectivity; Heating / reflux; | |
With trichlorophosphate In toluene for 5 - 6h; Product distribution / selectivity; Heating / reflux; |
dibenzo[b,f][1,4]thiazepin-11-one
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With phosphorus pentachloride; nitrogen In dichloromethane | |
With phosphorus pentachloride; nitrogen In dichloromethane; toluene |
phenyl [2-(phenylsulphanyl)phenyl]carbamate
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: polyphosphoric acid / Heating 2: N,N-dimethyl-aniline; trichlorophosphate / 105 °C View Scheme | |
Multi-step reaction with 2 steps 1: PPA / 100 °C 2: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme | |
Multi-step reaction with 2 steps 1: polyphosphoric acid / 8 h / 100 - 105 °C 2: N,N-dimethyl-aniline; trichlorophosphate / toluene View Scheme | |
Multi-step reaction with 2 steps 1: methanesulfonic acid; phosphorus pentoxide / 2.5 h / 80 - 110 °C 2: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C View Scheme |
2-nitrophenyl phenyl sulfide
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen / methanol / 4137.29 Torr 2: sodium carbonate 3: polyphosphoric acid / Heating 4: N,N-dimethyl-aniline; trichlorophosphate / 105 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogen / methanol / 4137.29 Torr 2: sodium carbonate / tetrahydrofuran; water 3: PPA / 100 °C 4: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme | |
Multi-step reaction with 4 steps 1: iron; ammonium chloride / water 2: sodium carbonate / toluene 3: polyphosphoric acid / 8 h / 100 - 105 °C 4: N,N-dimethyl-aniline; trichlorophosphate / toluene View Scheme |
2-phenylsulfanyl-aniline
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium carbonate 2: polyphosphoric acid / Heating 3: N,N-dimethyl-aniline; trichlorophosphate / 105 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium carbonate / tetrahydrofuran; water 2: PPA / 100 °C 3: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme | |
Multi-step reaction with 3 steps 1: sodium carbonate / toluene 2: polyphosphoric acid / 8 h / 100 - 105 °C 3: N,N-dimethyl-aniline; trichlorophosphate / toluene View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene / 0.08 h / 4 °C 1.2: 1.5 h / 4 °C 2.1: methanesulfonic acid; phosphorus pentoxide / 2.5 h / 80 - 110 °C 3.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C View Scheme |
thiophenol
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C 5: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme | |
Multi-step reaction with 5 steps 1: copper; sodium hydroxide / tetralin / 6 h / 130 °C 2: sulfuric acid / toluene / 1 h / 0 - 80 °C 3: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 4: toluene-4-sulfonic acid / toluene / Reflux 5: trichlorophosphate / 4 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide / methanol 2: iron; ammonium chloride / water 3: sodium carbonate / toluene 4: polyphosphoric acid / 8 h / 100 - 105 °C 5: N,N-dimethyl-aniline; trichlorophosphate / toluene View Scheme |
2-Chloronitrobenzene
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C 5: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide / methanol 2: iron; ammonium chloride / water 3: sodium carbonate / toluene 4: polyphosphoric acid / 8 h / 100 - 105 °C 5: N,N-dimethyl-aniline; trichlorophosphate / toluene View Scheme |
Thiosalicylic acid
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium hydroxide / water; isopropyl alcohol 2: ethyl acetate 3: triethylamine; benzotriazol-1-ol / dichloromethane 4: trichlorophosphate View Scheme | |
Multi-step reaction with 4 steps 1: potassium hydroxide / water; isopropyl alcohol / 20 °C 2: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 12 h / 20 °C 4: trichlorophosphate / 2 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: potassium hydroxide / isopropyl alcohol; water / 20 °C 2: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C 4: trichlorophosphate / 2 h / Reflux View Scheme |
ortho-nitrofluorobenzene
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium hydroxide / water; isopropyl alcohol 2: ethyl acetate 3: triethylamine; benzotriazol-1-ol / dichloromethane 4: trichlorophosphate View Scheme | |
Multi-step reaction with 4 steps 1: potassium hydroxide / water; isopropyl alcohol / 20 °C 2: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 12 h / 20 °C 4: trichlorophosphate / 2 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: potassium hydroxide / isopropyl alcohol; water / 20 °C 2: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C 4: trichlorophosphate / 2 h / Reflux View Scheme |
2‑(2‑nitrophenylsulfanyl)benzoic acid
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethyl acetate 2: triethylamine; benzotriazol-1-ol / dichloromethane 3: trichlorophosphate View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 12 h / 20 °C 3: trichlorophosphate / 2 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C 3: trichlorophosphate / 2 h / Reflux View Scheme |
2-(phenylthio)benzoic acid
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / toluene / 1 h / 0 - 80 °C 2: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 3: toluene-4-sulfonic acid / toluene / Reflux 4: trichlorophosphate / 4 h / Reflux View Scheme |
thio-xanthene-9-one
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 2: toluene-4-sulfonic acid / toluene / Reflux 3: trichlorophosphate / 4 h / Reflux View Scheme |
9H-thioxanthen-9-one oxime
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 4 h / Reflux View Scheme |
ortho-chlorobenzoic acid
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: copper; sodium hydroxide / tetralin / 6 h / 130 °C 2: sulfuric acid / toluene / 1 h / 0 - 80 °C 3: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 4: toluene-4-sulfonic acid / toluene / Reflux 5: trichlorophosphate / 4 h / Reflux View Scheme |
2-amino-benzenethiol
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate; iron; copper / N,N-dimethyl-formamide / 3 h / 120 °C 2.1: toluene / 0.08 h / 4 °C 2.2: 1.5 h / 4 °C 3.1: methanesulfonic acid; phosphorus pentoxide / 2.5 h / 80 - 110 °C 4.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C View Scheme |
iodobenzene
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate; iron; copper / N,N-dimethyl-formamide / 3 h / 120 °C 2.1: toluene / 0.08 h / 4 °C 2.2: 1.5 h / 4 °C 3.1: methanesulfonic acid; phosphorus pentoxide / 2.5 h / 80 - 110 °C 4.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C View Scheme |
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With trichlorophosphate at 70℃; for 3h; |
1-[2-(2-hydroxyethoxy)ethyl]piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
In toluene at 105 - 107℃; | 99% |
In toluene at 110 - 120℃; for 8h; Product distribution / selectivity; | 98% |
In toluene Reflux; | 92% |
11-chloro-dibenzo[b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; 4-phenyl-N-methylpyridinium iodide; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc In dimethyl sulfoxide at 80℃; for 8h; Reagent/catalyst; Inert atmosphere; | 99% |
4-ethylpiperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-[4-ethyl-1-piperazinyl]dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium carbonate In toluene for 5h; | 96% |
11-chloro-dibenzo[b,f][1,4]thiazepine
butyl magnesium bromide
Conditions | Yield |
---|---|
iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether at -78 - 20℃; for 0.0833333h; Product distribution / selectivity; | 93% |
iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20℃; for 0.0833333h; Product distribution / selectivity; | 93% |
pyrrolidine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-(pyrrolidin-1-yl)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With triethylamine In toluene at 100℃; for 6h; | 92% |
1H-imidazole
11-chloro-dibenzo[b,f][1,4]thiazepine
11-(imidazol-1-yl)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With triethylamine In toluene at 100℃; for 7h; | 92% |
11-chloro-dibenzo[b,f][1,4]thiazepine
4-Aminoacetophenone
Conditions | Yield |
---|---|
With pyridine for 4h; Heating; | 91% |
11-chloro-dibenzo[b,f][1,4]thiazepine
cyclohexylmagnesiumchloride
Conditions | Yield |
---|---|
iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether at -78 - 20℃; for 0.0833333h; Product distribution / selectivity; | 89% |
iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20℃; for 0.0833333h; Product distribution / selectivity; | 89% |
11-chloro-dibenzo[b,f][1,4]thiazepine
1,2,4-Triazole
11-(1,2,4-triazol-1-yl)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With triethylamine In toluene at 100℃; for 6h; | 89% |
piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; toluene | 88% |
With hydrogenchloride In ethanol; toluene | 88% |
With hydrogenchloride In ethanol; toluene | 88% |
piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-[4-(2-hydroxyethyl)-1-piperazinyl]dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In 5,5-dimethyl-1,3-cyclohexadiene at 105 - 115℃; for 5h; Reagent/catalyst; | 88% |
In toluene for 4h; Heating; |
piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol; toluene | 88% |
2-methylimidazole
11-chloro-dibenzo[b,f][1,4]thiazepine
11-(2-methylimidazol-1-yl)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With triethylamine In toluene at 100℃; for 8h; | 88% |
piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With IPA-HCl In toluene | 87% |
In toluene | |
In dimethyl sulfoxide; toluene at 25 - 30℃; for 3h; Product distribution / selectivity; Industry scale; Inert atmosphere; |
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether at -78 - 20℃; for 0.0833333h; Product distribution / selectivity; | 86% |
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20℃; for 0.0833333h; Product distribution / selectivity; | 86% |
Conditions | Yield |
---|---|
With triethylamine In toluene at 60 - 65℃; for 8h; | 83% |
4-methyl-1H-imidazole
11-chloro-dibenzo[b,f][1,4]thiazepine
11-(4-methylimidazol-1-yl)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With triethylamine In toluene at 100℃; for 8h; | 80% |
11-chloro-dibenzo[b,f][1,4]thiazepine
Cyclopropylamine
Conditions | Yield |
---|---|
Stage #1: 11-chloro-dibenzo[b,f][1,4]thiazepine; Cyclopropylamine With triethylamine In water; toluene at 60 - 70℃; for 6h; Stage #2: With hydrogenchloride In hexane | 79% |
piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
In o-xylene at 20 - 142℃; for 40h; Heating / reflux; | 78% |
11-chloro-dibenzo[b,f][1,4]thiazepine
benzylamine
11-(benzylamino)dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With triethylamine at 60 - 65℃; for 4h; | 76% |
11-chloro-dibenzo[b,f][1,4]thiazepine
(R)-2-benzylpiperazine
Conditions | Yield |
---|---|
In toluene for 19h; Heating / reflux; | 74% |
11-chloro-dibenzo[b,f][1,4]thiazepine
1-t-Butoxycarbonylpiperazine
(E)-tert-butyl 4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
In o-xylene at 130℃; for 7h; | 62% |
1-(2-hydroxyethyl)piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
O-Dealkyl Quetiapine
Conditions | Yield |
---|---|
In xylene at 170℃; for 12 - 18h; | 53% |
In xylene Heating; | |
In 1-methyl-pyrrolidin-2-one; toluene for 6 - 8h; Heating / reflux; |
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
Stage #1: 7-(benzyloxy)-12-(10,11-difluoro-7,12-dihydrobenzo[e]naphtho[1,2-b]thiepin-7-yl)-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione With potassium carbonate In dimethyl sulfoxide at 20℃; for 0.25h; Inert atmosphere; Stage #2: 11-chloro-dibenzo[b,f][1,4]thiazepine In dimethyl sulfoxide at 80℃; for 0.5h; Inert atmosphere; | 46% |
1-[2-(2-hydroxyethoxy)ethyl]piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; 11-chloro-dibenzo[b,f][1,4]thiazepine With triethylamine In toluene at 95℃; for 60h; Stage #2: (2E)-but-2-enedioic acid In ethanol at 25℃; for 0.5h; Product distribution / selectivity; | 40% |
Conditions | Yield |
---|---|
Stage #1: α-picoline With n-butyllithium In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #2: 11-chloro-dibenzo[b,f][1,4]thiazepine In tetrahydrofuran at -78 - 20℃; for 12h; Inert atmosphere; | 28% |
piperidine
11-chloro-dibenzo[b,f][1,4]thiazepine
11-piperidin-1-yl-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
In xylene for 5h; Heating; |
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