CAS No.138890-62-7,Brinzolamide Suppliers

Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Brinzolamide

Cas:138890-62-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Brinzolamide Manufacturer/High quality/Best price/In stock

Cas:138890-62-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Brinzolamide

Cas:138890-62-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Brinzolamide Cas 138890-62-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to yellow crystalline powder Storage:Cool dry place Package

Factory good price Brinzolamide Cas 138890-62-7 with high quality and good service

Cas:138890-62-7

Min.Order:10 Gram

FOB Price: $15.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Brinzolamide[CAS:138890-62-7] Name Brinzolamide Synonyms (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Molecular Structure

Brinzolamide

Cas:138890-62-7

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

BrinzolaMide

Cas:138890-62-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Brinzolamide

Cas:138890-62-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Brinzolamide 138890-62-7 GMP Manufacturer

Cas:138890-62-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Brinzolamide

Cas:138890-62-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

High purity CAS 138890-62-7 Brinzolamide in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Fluorene,Ca

High purity CAS 138890-62-7 Brinzolamide in stock

Cas:138890-62-7

Min.Order:1 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Brinzolamide

Cas:138890-62-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 138890-62-7 with best quality

Cas:138890-62-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Brinzolamide/ LIDE PHARMA- Factory supply / Best price

Cas:138890-62-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name ethambutol dihydrochloride Synonyms 2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride;(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride;(2S,2

Brinzolamide

Cas:138890-62-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Brinzolamide 138890-62-7

Cas:138890-62-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Brinzolamide 99%

Cas:138890-62-7

Min.Order:1 Kilogram

FOB Price: $32.0 / 41.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

BrinzolamideCAS: 138890-62-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

BrinzolamideCAS: 138890-62-7

Cas:138890-62-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Brinzolamide

Cas:138890-62-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Brinzolamide CAS NO.138890-62-7

Cas:138890-62-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Brinzolamide manufacturer with low price

Cas:138890-62-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Factory supply Ophthalmic Drugs 99% Brinzolamide , CAS no 138890-62-7 for Antiglaucoma at best price on hot selling!!

Cas:138890-62-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Brinzolamide CAS: 138890-62-7 Specification Items Specification Result Assay 98%-102% 99.58% Appearance White to yellow crystalline po

Factory supply Brinzolamide

Cas:138890-62-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Brinzolamide

Cas:138890-62-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Brinzolamide Synonyms: H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-;Brinzolamide(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-s

Brinzolamide free sample available best quality

Cas:138890-62-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Brinzolamide

Cas:138890-62-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

Azopt Brinzolamid Eye Drops Wholesales CAS 138890-62-7

Cas:138890-62-7

Min.Order:1 Gram

FOB Price: $100.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.，Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Brinzolamide

Cas:138890-62-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Brinzolamide 138890-62-7

Cas:138890-62-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

brinzolamide

Cas:138890-62-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Brinzolamide

Cas:138890-62-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

: C21H29N3O8S4

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With sodium thiomethoxide In methanol at 0 - 25℃; for 12h; Reagent/catalyst;	83%

: C21H29N5O9S4

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With sodium tetradecyl mercaptan In methanol at 0 - 25℃; Reagent/catalyst;	81%

: C11H18N2O8S4

: 75-04-7
ethylamine

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
In tetrahydrofuran; water at 0 - 30℃;	66.3%

: (R)-3,4-dihydro-4-ethylamino-6-chloro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide hydrochloride

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Stage #1: (R)-3,4-dihydro-4-ethylamino-6-chloro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide hydrochloride With sodium hydrogencarbonate Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 1h;	63%

: C20H26N2O9S4

: 75-04-7
ethylamine

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
In water at 11 - 20℃; for 15h; enantioselective reaction;	61%
Stage #1: C20H26N2O9S4; ethylamine In water at 10 - 12℃; for 15h; Stage #2: With hydrogenchloride In water at 20℃; for 1h; Temperature;	2.4 g

: 165117-54-4
(R)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

: 75-04-7
ethylamine

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Stage #1: (R)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide With zinc(II) tosylate; triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 80℃; for 8h; Stage #2: ethylamine In tetrahydrofuran at 0 - 20℃; for 36h; Product distribution / selectivity;	49%
Stage #1: (R)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide With zinc(II) tosylate; triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 80℃; Stage #2: ethylamine In tetrahydrofuran at 0 - 20℃;

: 154127-42-1
(S)-3,4-dihydro-4-hydroxy-2(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide

: 75-04-7
ethylamine

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Stage #1: (S)-3,4-dihydro-4-hydroxy-2(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide With toluene-4-sulfonic acid; triethylamine In tetrahydrofuran at 0 - 20℃; for 18h; Stage #2: ethylamine In tetrahydrofuran at 0 - 20℃; for 36h;
Stage #1: (S)-3,4-dihydro-4-hydroxy-2(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide With triethylamine; p-toluenesulfonyl chloride In tetrahydrofuran at 0 - 20℃; for 18h; Stage #2: ethylamine In tetrahydrofuran at 0 - 20℃;

: C12H19N2O5S3(1-)*Li(1+)

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With sodium acetate; hydroxylamine-O-sulfonic acid In hexane at 0 - 20℃; Product distribution / selectivity;

: 1029324-92-2
(R)-3,4-dihydro-4-(N-ethylamino)-2-(3-methoxy)propyl-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Stage #1: (R)-3,4-dihydro-4-(N-ethylamino)-2-(3-methoxy)propyl-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide With n-butyllithium In tetrahydrofuran; hexane at -60℃; for 8.75h; Inert atmosphere; Stage #2: With sulfur dioxide In tetrahydrofuran; hexane at -65 - 20℃; Stage #3: With sodium acetate trihydrate; hydroxylamine-O-sulfonic acid In ethyl acetate at 0 - 20℃;

: brinzolamide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With chiral-prep-HPLC (Chiralpak IA0.46x15 cm, 5 umChiral-A (IA)002IA00CD-LF007) Resolution of racemate;

: 160982-13-8
(S)-3,4-dihydro-6-chloro-4-hydroxy-2-(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 0 - 20 °C 2.1: water; tetrahydrofuran / 0 - 20 °C 2.2: pH 1 - 3 3.1: sodium hydrogencarbonate 3.2: 1 h / -40 °C View Scheme
Multi-step reaction with 4 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 1.2: 20 °C / pH 4 1.3: 15 h / 0 - 25 °C 2.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 3.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 4.1: water / 15 h / 11 - 20 °C View Scheme

: C17H20ClNO6S3

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: water; tetrahydrofuran / 0 - 20 °C 1.2: pH 1 - 3 2.1: sodium hydrogencarbonate 2.2: 1 h / -40 °C View Scheme

: 1448780-04-8
(R)-(+)-4-ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide maleate

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With triethylamine In water at 25 - 30℃; for 2h; pH=7 - 8.5;	45 g

: 150937-43-2
Brinzolamide hydrochloride

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With triethylamine In water at 25 - 30℃; for 2h; pH=7 - 8.5;	500 g

: C13H20N2O7S3

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 2: water / 15 h / 11 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere 2: sodium thiomethoxide / methanol / 12 h / 0 - 25 °C View Scheme

: 3-acetyl-5-chloro-2-thiophenesulfenamide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C 2.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale 3.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere 3.2: 2 h / 0 - 22 °C 4.1: potassium carbonate / dimethyl sulfoxide 5.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 5.2: 20 °C / pH 4 5.3: 15 h / 0 - 25 °C 6.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 7.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 8.1: water / 15 h / 11 - 20 °C View Scheme

Yield

Multi-step reaction with 8 steps
1.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C
2.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale
3.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere
3.2: 2 h / 0 - 22 °C
4.1: potassium carbonate / dimethyl sulfoxide
5.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere
5.2: 20 °C / pH 4
5.3: 15 h / 0 - 25 °C
6.1: acetonitrile / 19 h / 30 - 85 °C / Reflux
7.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere
8.1: water / 15 h / 11 - 20 °C
View Scheme

: 3-acetyl-5-chloro-2-thiophenesulfonamide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale 2.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere 2.2: 2 h / 0 - 22 °C 3.1: potassium carbonate / dimethyl sulfoxide 4.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 4.2: 20 °C / pH 4 4.3: 15 h / 0 - 25 °C 5.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 6.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 7.1: water / 15 h / 11 - 20 °C View Scheme

Yield

Multi-step reaction with 7 steps
1.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale
2.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere
2.2: 2 h / 0 - 22 °C
3.1: potassium carbonate / dimethyl sulfoxide
4.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere
4.2: 20 °C / pH 4
4.3: 15 h / 0 - 25 °C
5.1: acetonitrile / 19 h / 30 - 85 °C / Reflux
6.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere
7.1: water / 15 h / 11 - 20 °C
View Scheme

: 3-(2-Bromoacetyl)-5-chloro-thiophene-2-sulfonamide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere 1.2: 2 h / 0 - 22 °C 2.1: potassium carbonate / dimethyl sulfoxide 3.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 3.2: 20 °C / pH 4 3.3: 15 h / 0 - 25 °C 4.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 5.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 6.1: water / 15 h / 11 - 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere
1.2: 2 h / 0 - 22 °C
2.1: potassium carbonate / dimethyl sulfoxide
3.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere
3.2: 20 °C / pH 4
3.3: 15 h / 0 - 25 °C
4.1: acetonitrile / 19 h / 30 - 85 °C / Reflux
5.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere
6.1: water / 15 h / 11 - 20 °C
View Scheme

: 36157-40-1
3-acetyl-2,5-dichlorothiophene

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 11 steps 1.1: thiourea / ethanol; water / 2 h / Reflux; Large scale 1.2: 3 h / Reflux; Large scale 2.1: chlorine / toluene / 0.42 h / 8 °C / Cooling with ice 3.1: ammonia / 1 h / 5 - 15 °C 4.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C 5.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale 6.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere 6.2: 2 h / 0 - 22 °C 7.1: potassium carbonate / dimethyl sulfoxide 8.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 8.2: 20 °C / pH 4 8.3: 15 h / 0 - 25 °C 9.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 10.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 11.1: water / 15 h / 11 - 20 °C View Scheme

Yield

Multi-step reaction with 11 steps
1.1: thiourea / ethanol; water / 2 h / Reflux; Large scale
1.2: 3 h / Reflux; Large scale
2.1: chlorine / toluene / 0.42 h / 8 °C / Cooling with ice
3.1: ammonia / 1 h / 5 - 15 °C
4.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C
5.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale
6.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere
6.2: 2 h / 0 - 22 °C
7.1: potassium carbonate / dimethyl sulfoxide
8.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere
8.2: 20 °C / pH 4
8.3: 15 h / 0 - 25 °C
9.1: acetonitrile / 19 h / 30 - 85 °C / Reflux
10.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere
11.1: water / 15 h / 11 - 20 °C
View Scheme

: (S)-3,4-dihydro-6-chloro-4-hydroxy-4H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium carbonate / dimethyl sulfoxide 2.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 2.2: 20 °C / pH 4 2.3: 15 h / 0 - 25 °C 3.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 4.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 5.1: water / 15 h / 11 - 20 °C View Scheme

: 160982-09-2
3-Acetyl-2-(phenylmethyl)thio-5-chlorothiophene

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: chlorine / toluene / 0.42 h / 8 °C / Cooling with ice 2.1: ammonia / 1 h / 5 - 15 °C 3.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C 4.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale 5.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere 5.2: 2 h / 0 - 22 °C 6.1: potassium carbonate / dimethyl sulfoxide 7.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 7.2: 20 °C / pH 4 7.3: 15 h / 0 - 25 °C 8.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 9.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 10.1: water / 15 h / 11 - 20 °C View Scheme

Yield

Multi-step reaction with 10 steps
1.1: chlorine / toluene / 0.42 h / 8 °C / Cooling with ice
2.1: ammonia / 1 h / 5 - 15 °C
3.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C
4.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale
5.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere
5.2: 2 h / 0 - 22 °C
6.1: potassium carbonate / dimethyl sulfoxide
7.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere
7.2: 20 °C / pH 4
7.3: 15 h / 0 - 25 °C
8.1: acetonitrile / 19 h / 30 - 85 °C / Reflux
9.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere
10.1: water / 15 h / 11 - 20 °C
View Scheme

: 154127-42-1
(S)-3,4-dihydro-4-hydroxy-2(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetonitrile / 19 h / 30 - 85 °C / Reflux 2: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 3: water / 15 h / 11 - 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / acetonitrile / 5 h / 78 °C 2.1: triethylamine / tetrahydrofuran / 3 h / -10 - -4 °C 3.1: water / 15 h / 10 - 12 °C 3.2: 1 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: acetonitrile / 1 h / 5 - 15 °C / Inert atmosphere 2: triphenylphosphine; di-isopropyl azodicarboxylate / ethyl acetate / 15 h / 0 - 20 °C / Inert atmosphere 3: sodium tetradecyl mercaptan / methanol / 0 - 25 °C View Scheme
Multi-step reaction with 3 steps 1: acetonitrile / 1 h / 5 - 15 °C / Inert atmosphere 2: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere 3: sodium thiomethoxide / methanol / 12 h / 0 - 25 °C View Scheme

: 3-acetyl-5-chloro-2-thiophenesulfenyl chloride

: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: ammonia / 1 h / 5 - 15 °C 2.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C 3.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale 4.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere 4.2: 2 h / 0 - 22 °C 5.1: potassium carbonate / dimethyl sulfoxide 6.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere 6.2: 20 °C / pH 4 6.3: 15 h / 0 - 25 °C 7.1: acetonitrile / 19 h / 30 - 85 °C / Reflux 8.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere 9.1: water / 15 h / 11 - 20 °C View Scheme

Yield

Multi-step reaction with 9 steps
1.1: ammonia / 1 h / 5 - 15 °C
2.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water / 19 h / 15 - 35 °C
3.1: pyridinium hydrobromide perbromide; sulfuric acid / ethyl acetate / 1.5 h / 1 - 5 °C / Large scale
4.1: B-chlorodiisopinocampheylborane / tert-butyl methyl ether / 3.5 h / -40 - -32 °C / Inert atmosphere
4.2: 2 h / 0 - 22 °C
5.1: potassium carbonate / dimethyl sulfoxide
6.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -70 - -66 °C / Inert atmosphere
6.2: 20 °C / pH 4
6.3: 15 h / 0 - 25 °C
7.1: acetonitrile / 19 h / 30 - 85 °C / Reflux
8.1: triethylamine / tetrahydrofuran / 2 h / -10 - -2 °C / Inert atmosphere
9.1: water / 15 h / 11 - 20 °C
View Scheme

: brinzolamide

A: (S)-brinzolamide

B: 138890-62-7
brinzolamide

Conditions

Conditions	Yield
With AmyCoat [tris(3,5-dimethylphenylcarbamate)amylose] (150 x 46 mm id) chiral column In hexane; isopropyl alcohol at 25℃; Reagent/catalyst; Resolution of racemate;

: 125941-75-5
(S)-2-[(1,1-dimethylethyl)diphenylsilyl]oxypropanoic acid

: 138890-62-7
brinzolamide

: (2S)-2-[(tert-butyldiphenylsilyl)oxy]-N-{[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}propanamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	76%

: (S)-2-(tert-butyldiphenylsilanyloxy)propionic acid (S)-1-((S)-1-carboxyethoxycarbonyl)ethyl ester

: 138890-62-7
brinzolamide

: (2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl (2S)-2-[(tert-butyldiphenylsilyl)oxy]propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	76%

: (2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoic acid

: 138890-62-7
brinzolamide

: (2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-c][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl (2S)-2-(acetyloxy)propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	75%

: (2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-[(tert butyldiphenylsilyl)oxy]propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoic acid

: 138890-62-7
brinzolamide

: C64H87N3O29S3Si

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	74%

: (S)-2-(tert-butyldiphenylsilanyloxy)propionic acid (S)-1-{(S)-1-[(S)-1-((S)-1-carboxyethoxycarbonyl)ethoxycarbonyl]ethoxycarbonyl}ethyl ester

: 138890-62-7
brinzolamide

: C43H59N3O15S3Si

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	68.6%

: 138890-62-7
brinzolamide

: 186377-56-0
(R)-4-(ethylamino)-2-(3-hydroxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide1,1-dioxide

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -78 - 25℃; for 24.1667h; Inert atmosphere;	66%
Stage #1: brinzolamide With boron tribromide In dichloromethane at -78 - 20℃; for 24.16h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide	66%

: (S)-2-(tert-butyl-diphenyl-silanyloxy)-propionic acid (S)-1-carboxy-ethyl ester

: 138890-62-7
brinzolamide

: (1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethyl (2S)-2-[(tert-butyldiphenylsilyl)oxy]propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	65%

: (S)-2-(tert-butyl-diphenyl-silanyloxy)-propionic acid (S)-1-[(S)-1-((S)-1-carboxy-ethoxycarbonyl)-ethoxycarbonyl]-ethyl ester

: 138890-62-7
brinzolamide

: (2S)-1-{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl (2S)-2-[(tert-butyldiphenylsilyl)oxy]propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	65%

: succinic acid (S)-1-{(S)-1-[(S)-1-((S)-1-carboxyethoxycarbonyl)ethoxycarbonyl]ethoxycarbonyl}ethyl ester 3-[1-[4-(2-diethylaminoethylcarbamoyl)-3,5-dimethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl ester

: 138890-62-7
brinzolamide

: (3Z)-3-[(4-{[2-(diethylamino)ethyl]carbamoyl}-3,5-dimethyl-1H-pyrrol-2yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl (2S)-1-{[(2S)-1-{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl butanedioate

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere;	46%

: (2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-[(tert butyldiphenylsilyl)oxy]propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoic acid

: 138890-62-7
brinzolamide

: C58H79N3O25S3Si

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	44.3%

: (2S)‐2‐{[(2S)‐2‐(acetyloxy)propanoyl]oxy}propanoic acid

: 138890-62-7
brinzolamide

: (S)-2-acetoxypropionic acid (S)-2-[4-ethylamino-2-(3-methoxypropyl)-1,1-dioxo-1,2,3,4-tetrahydro-1λ*6*-thieno[3,2-e][1,2]thiazine-6-sulfonylamino]-1-methyl-2-oxoethyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	37%

: octadecanoic acid (S)-1-[(S)-1-((S)-1-{(S)-1-[(S)-1-((S)-1-carboxy-ethoxycarbonyl)ethoxycarbonyl]ethoxycarbonyl}ethoxycarbonyl)ethoxycarbonyl]ethyl ester

: 138890-62-7
brinzolamide

: (2S)-1-{[(2S)-1-{[(2S)-1-{[(2S)-1{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl octadecanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	35%

: (S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionyloxy)propionyloxy]-propionic acid

: 138890-62-7
brinzolamide

: (2S)-1-{[(2S)-1-{[(2S)-1-{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl (2S)-2-(acetyloxy)propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	32%

: octadecanoic acid (S)-1-{(S)-1-[(S)-1-((S)-1-carboxyethoxycarbonyl)ethoxy carbonyl]ethoxycarbonyl}ethyl ester

: 138890-62-7
brinzolamide

: octadecanoic acid (S)-1-[(S)-1-((S)-1-{(S)-2-[4-ethylamino-2-(3-methoxypropyl)-1,1-dioxo-1,2,3,4-tetrahydro-1λ*6*-thieno[3,2-e][1,2]thiazine-6-sulfonylamino]-1-methyl-2-oxo-ethoxycarbonyl}ethoxycarbonyl)ethoxycarbonyl]ethyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	27.3%

: (S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionic acid

: 138890-62-7
brinzolamide

: (2S)-1-{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-c][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl (2S)-2-(acetyloxy)propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	27%

: (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionyloxy)propionic acid

: 138890-62-7
brinzolamide

: (2S)-1-{[(2S)-1-{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-c][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl(acetyloxy) propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	26%

: (2S)-2-{[(2S)-2-{[(2S)-2-[(4-{[(3Z)-3-[(4-{[2-(diethylamino)ethyl]carbamoyl}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl]oxy}-4-oxobutanoyl)oxy]propanoyl]oxy}propanoyl]oxy}propanoic acid

: 138890-62-7
brinzolamide

: (3Z)-3-[(4-{[2-(diethylamino)ethyl]carbamoyl}-3,5-dimethyl-1H-pyrrol-2yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl (2S)-1-{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl butanedioate

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere;	26%

: octadecanoic acid (S)-1-((S)-1-{(S)-1-[(S)-1-((S)-1-{(S)-1-[(S)-1-((S)-1-carboxyethoxycarbonyl)ethoxycarbonyl]ethoxycarbonyl}ethoxycarbonyl)ethoxycarbonyl]ethoxycarbonyl}ethoxycarbonyl)ethyl ester

: 138890-62-7
brinzolamide

: (2S)-1-{[(2S)-1-{[(2S)-1-{[(2S)-1{[(2S)-1-{[(2S)-1{[(2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-c][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl]oxy}-1-oxopropan-2-yl octadecanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	25%

: (S)-2-tert-butoxypropionic acid (S)-1-((S)-1-carboxyethoxycarbonyl)ethyl ester

: 138890-62-7
brinzolamide

: (2S)-1-[(1S)-1-({[(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1λ6-thieno[3,2-e][1,2]thiazin-6-yl]sulfonyl}carbamoyl)ethoxy]-1-oxopropan-2-yl (2S)-2-(tert-butoxy)propanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	24%

: C54H84O26

: 138890-62-7
brinzolamide

: C66H103N3O30S3

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h;	19.4%

: C60H92O30

: 138890-62-7
brinzolamide

: C72H111N3O34S3

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;	8%

Related products

138-89-6

Benzenamine,N,N-dimethyl-4-nitroso-

13889-95-7

Carbonochloridothioicacid, S-(1,1-dimethylethyl) ester

13889-96-8

Carbonochloridothioicacid, S-octyl ester

13889-98-0

Ethanone,1-(1-piperazinyl)-

13889-99-1

Carbonodithioic acid,S,S-bis(2-aminoethyl) ester, dihydrochloride (9CI)

138900-55-7

Boronic acid,B-[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]-

138907-70-7

Ethyl 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylate

138907-73-0

ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

138914-13-3

Pentane,3-nitro-, ion(1-)

13891-62-8

Acetic acid, 2-bromo-,2-bromoethyl ester

Raw Materials

Hot Products

125995-13-3

(4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate

98-96-4

Pyrazinamide

7631-95-0

Molybdate(MoO42-), sodium (1:2), (T-4)-

72830-09-2

2-Chloromethyl-3,4-dimethoxypyridinium chloride

446-86-6

Azathioprine

108-86-1

Bromobenzene

320-67-2

5-Azacytidine

91-16-7

1,2-Dimethoxybenzene

104987-11-3

Tacrolimus

141-53-7

Sodium formate

8001-54-5

Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

9003-39-8

Povidone

10161-34-9

Trenbolone acetate

402957-28-2

Telaprevir

68-19-9

Cyanocobalamin

Products

Refine

Country

Business Type

Certificate

Display

Chemvon Biotechnology Co. Ltd.

Dayang Chem (Hangzhou) Co.,Ltd.

Hebei yanxi chemical co.,LTD.

Wuhan Fortuna Chemical Co.,Ltd

Hangzhou Think Chemical Co. Ltd

Henan Allgreen Chemical Co.,Ltd

Ality Chemical Corporation

Xi'an Xszo Chem Co., Ltd.

Chemwill Asia Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Hebei Nengqian Chemical Import and Export Co., LTD

Zhuozhou Wenxi import and Export Co., Ltd

LIDE PHARMACEUTICALS LIMITED

Henan Sinotech Import&Export Corporation

Shanghai Upbio Tech Co.,Ltd

Baoji Guokang Healthchem co.,ltd

Qingdao Beluga Import and Export Co., LTD

Shandong Hanjiang Chemical Co., Ltd.

Changchun Artel lmport and Export trade company

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Wuhan Wonda Pharm Limited

Lonwin Chemical Group Limited

Henan Wentao Chemical Product Co., Ltd.

Wuhan Zenuo Biological Medicine Technology Co Ltd

Triumph International Development Limilted

Hebei Mojin Biotechnology Co.,Ltd

Wuhan Han Sheng New Material Technology Co.，Ltd

Taizhou Crene Biotechnology co.ltd

Hangzhou Keyingchem Co.,Ltd

Afine Chemicals Limited

Synthetic route

Related products

Raw Materials

Hot Products