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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Benzo-12-crown 4-ether

Cas:14174-08-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply Benzo-12-crown-4 CAS 14174-08-4 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/

Manufacturer supply Benzo-12-crown-4 CAS 14174-08-4 with attractive price

Cas:14174-08-4

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% BENZO-12-CROWN-4 14174-08-4 Producer

Cas:14174-08-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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SICHUAN ZHONGBANG NEW MATERIAL CO., LTD

SICHUAN ZHONGBANG NEW MATERIAL CO., LTD is a complex enterprise specializing in the research, development, manufacturing and trade of fine chemicals, domestic hygiene, pesticide intermediates and pharmaceutical intermediates; we now are the larges

98%BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 14174-08-4 with best price

Cas:14174-08-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro- 14174-08-4

Cas:14174-08-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

BENZO-12-CROWN-4 CAS:14174-08-4

Cas:14174-08-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

14174-08-4 BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: BENZO-12-CROWN-4 Synonyms: BENZO-12-CROWN-4;BENZO-12-CROWN 4-ETHER;2,3-BENZO-1,4,7,10-TETRAOXADODEC-2-ENE;6,7,9,10,12,13-HEXAHYDROBENZO[1,4,7,10]TETRAOXOCYCLODODECIN;4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-1;BENZO-1

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Benzo-12-crown-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Manufacturers

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Greenutra Resource Inc

BENZO-12-CROWN-4Appearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Benzo-12-crown 4-Ether

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Benzo-12-crown 4-etherAppearance:detailed in specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:An important raw material and intermediate used in Organic Synthesis, Pharmaceuticals Transportation:Sea/air/c

Benzo-12-crown 4-ether

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

Benzo-12-crown-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

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BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

2,3-Benzo-1,4,7,10-tetraoxadodec-2-ene

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Other

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

2,3-Benzo-1,4,7,10-Tetraoxadodec-2-Ene

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Other

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

14174-08-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Benzo-12-crown-4 14174-08-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

home-produced Application:medicine

BENZO-12-CROWN-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Benzo-12-crown-4 14174-08-4

Cas:14174-08-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

o-hydroxyphenyl 3,6-dioxa-8-bromooctyl ether
77963-44-1

o-hydroxyphenyl 3,6-dioxa-8-bromooctyl ether

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 25℃;94%
With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 25℃; Rate constant;94.0 % Spectr.
benzene-1,2-diol
120-80-9

benzene-1,2-diol

triethylene glycol di-(p-toluenesulfonate)
19249-03-7

triethylene glycol di-(p-toluenesulfonate)

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
Stage #1: benzene-1,2-diol With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 50 - 60℃; for 0.5h;
Stage #2: triethylene glycol di-(p-toluenesulfonate) In water; toluene for 6h; Reflux;
52%
Stage #1: benzene-1,2-diol With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Large scale;
Stage #2: triethylene glycol di-(p-toluenesulfonate) In N,N-dimethyl-formamide at 85 - 90℃; Large scale;
28%
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene for 16h; Heating;18%
With lithium hydroxide; sodium hydroxide 1.) THF; Yield given. Multistep reaction;
benzene-1,2-diol
120-80-9

benzene-1,2-diol

1,2-bis(2-chloroethoxy)ethane
112-26-5

1,2-bis(2-chloroethoxy)ethane

A

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

B

dibenzo-24-crown ether
14174-09-5

dibenzo-24-crown ether

Conditions
ConditionsYield
With lithium hydroxide In water; butan-1-ol for 28h; modified Pedersen procedure; Heating;A 26%
B 27%
With lithium hydroxide In water; butan-1-ol at 100℃; for 30h;A 10%
B 7.8%
With sodium hydroxide In water; tert-butyl alcohol for 30h; Heating; Title compound not separated from byproducts;
benzene-1,2-diol
120-80-9

benzene-1,2-diol

1,2-bis(2-chloroethoxy)ethane
112-26-5

1,2-bis(2-chloroethoxy)ethane

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
With lithium hydroxide monohydrate In water; butan-1-ol at 95℃; Inert atmosphere;14.4%
With sodium hydroxide; lithium perchlorate 1.) DMSO, 60 deg C, 15 min, 2.) 110 deg C, 22 h; Yield given. Multistep reaction;
With sodium hydroxide; lithium perchlorate 1) room temperature, 15 min; 2) 110 deg C, 24 h, DMSO; Yield given. Multistep reaction;
Stage #1: benzene-1,2-diol With lithium bromide monohydrate; lithium hydroxide monohydrate In water; butan-1-ol at 20 - 110℃; for 0.1h; Inert atmosphere;
Stage #2: 1,2-bis(2-chloroethoxy)ethane In water; butan-1-ol at 110℃; for 5h; Inert atmosphere;
2,2'-(1,2-phenylenedioxy)diethanol
10234-40-9

2,2'-(1,2-phenylenedioxy)diethanol

1,2-bis-tosyloxyethane
6315-52-2

1,2-bis-tosyloxyethane

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene for 16h; Heating;13%
2,2'-<1,2-Phenylenbis(oxy)-2,1-ethandiyloxy>bisethanol
99700-26-2

2,2'-<1,2-Phenylenbis(oxy)-2,1-ethandiyloxy>bisethanol

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride In toluene at 70 - 75℃; for 13h;7%
bis(o-phenylene)glycol ditosylate
54535-06-7

bis(o-phenylene)glycol ditosylate

ethylene glycol
107-21-1

ethylene glycol

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene for 16h; Heating;5%
2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-phenol anion
87494-76-6

2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-phenol anion

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
sodium cation In water; dimethyl sulfoxide for 25h;
C12H16O4*CNS(1-)*K(1+)

C12H16O4*CNS(1-)*K(1+)

A

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

B

potassium thioacyanate
333-20-0

potassium thioacyanate

Conditions
ConditionsYield
In acetonitrile at 24.9℃; Equilibrium constant;
C12H16O4*CNS(1-)*Na(1+)

C12H16O4*CNS(1-)*Na(1+)

A

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

B

sodium thiocyanide
540-72-7

sodium thiocyanide

Conditions
ConditionsYield
In acetonitrile at 24.9℃; Equilibrium constant;
C12H16O4*CNS(1-)*Li(1+)

C12H16O4*CNS(1-)*Li(1+)

A

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

B

lithium thiocyanate
556-65-0

lithium thiocyanate

Conditions
ConditionsYield
In acetonitrile at 24.9℃; Equilibrium constant;
C12H16O4*2CNS(1-)*Ca(2+)

C12H16O4*2CNS(1-)*Ca(2+)

A

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

B

calcium thiocyanate
2092-16-2

calcium thiocyanate

Conditions
ConditionsYield
In acetonitrile at 24.9℃; Equilibrium constant;
C12H16O4*CHNS*H3N

C12H16O4*CHNS*H3N

A

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

B

ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

Conditions
ConditionsYield
In acetonitrile at 24.9℃; Equilibrium constant;
benzene-1,2-diol
120-80-9

benzene-1,2-diol

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 52 percent / K2CO3 / dimethylformamide / 10 h / 95 - 100 °C
2: 85 percent / aq. NaOH / 3.5 h / 30 - 95 °C
3: 7 percent / aq. NaOH; (nC4H9)4NI; p-TsCl / toluene / 13 h / 70 - 75 °C
View Scheme
2-[2-(2-hydroxyethoxy)ethoxy]phenol
111875-70-8

2-[2-(2-hydroxyethoxy)ethoxy]phenol

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / aq. NaOH / 3.5 h / 30 - 95 °C
2: 7 percent / aq. NaOH; (nC4H9)4NI; p-TsCl / toluene / 13 h / 70 - 75 °C
View Scheme
1,2-bis-(2-bromo-ethoxy)-ethane
31255-10-4

1,2-bis-(2-bromo-ethoxy)-ethane

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 16 percent / KOH
2: 94.0 percent Spectr. / Me4NOH / dimethylsulfoxide; H2O / 25 °C
View Scheme
2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PBr3, pyridine
2: 16 percent / KOH
3: 94.0 percent Spectr. / Me4NOH / dimethylsulfoxide; H2O / 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide / tetrahydrofuran / 7 h / 20 °C
2.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 0.5 h / 50 - 60 °C
2.2: 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; tetrahydrofuran / 2 h / 5 °C / Large scale
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Large scale
2.2: 85 - 90 °C / Large scale
View Scheme
((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate
55400-73-2

((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate

benzene-1,2-diol
120-80-9

benzene-1,2-diol

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Conditions
ConditionsYield
Stage #1: benzene-1,2-diol With caesium carbonate In acetonitrile for 3h; Reflux; Inert atmosphere;
Stage #2: ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate In acetonitrile Inert atmosphere; Reflux;
tantalum(V) oxide

tantalum(V) oxide

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

hydrogen fluoride
7664-39-3

hydrogen fluoride

water
7732-18-5

water

[(benzo-12-crown-4)2*H3O][TaF6]

[(benzo-12-crown-4)2*H3O][TaF6]

Conditions
ConditionsYield
In methanol; hydrogen fluoride aq. HF; Ta2O5 dissolved in 45% aq. HF; 2 equiv. CH3OH soln. of crown ether added; stored at 20-25°C in exsiccator for a low evapn. of solvent over several days; elem. anal.;95%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

tantalum pentafluoride
7783-71-3

tantalum pentafluoride

hydrogen fluoride
7664-39-3

hydrogen fluoride

water
7732-18-5

water

[(benzo-12-crown-4)2*H3O][TaF6]

[(benzo-12-crown-4)2*H3O][TaF6]

Conditions
ConditionsYield
In hydrogen fluoride aq. HF; TaF5 in aq. 45% HF added to soln. of crown ether; stored at 20-25°C in exsiccator for a low evapn. of solvent over several days;95%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

5-nitroisatin
611-09-6

5-nitroisatin

C32H34N2O11
1366625-22-0

C32H34N2O11

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In chloroform at 25℃; regioselective reaction;95%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

tert-butyl alcohol
75-65-0

tert-butyl alcohol

12-(tert-butyl)-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine
98987-34-9

12-(tert-butyl)-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine

Conditions
ConditionsYield
With sulfuric acid In chloroform Product distribution; Heating; different solvents, other crown ethers;94%
With sulfuric acid In chloroform Heating;94%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

3-(p-tolyl)-1,2,4-triazin-5(2H)-one
36993-93-8

3-(p-tolyl)-1,2,4-triazin-5(2H)-one

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-p-tolyl-1-trifluoroacetyl-1,6-dihydro-4H-[1,2,4]triazin-5-one
420118-14-5

6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-p-tolyl-1-trifluoroacetyl-1,6-dihydro-4H-[1,2,4]triazin-5-one

Conditions
ConditionsYield
In trifluoroacetic acid at 20℃; for 3h;94%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

2-nitro-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxabenzocyclododecene
78554-67-3

2-nitro-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxabenzocyclododecene

Conditions
ConditionsYield
With nitric acid In chloroform; acetic acid at 20℃; for 6h;93%
With nitric acid In acetonitrile for 0.5h; Heating;92%
With nitric acid; acetic acid In chloroform at 20℃; for 24h; Cooling with ice;75%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Na[Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

Na[Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

[Na(benzo-12-crown-4)2][Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

[Na(benzo-12-crown-4)2][Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

Conditions
ConditionsYield
In diethyl ether at 23℃; for 1h;91%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

diethyl ether
60-29-7

diethyl ether

[(Et2O)Na(OC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]2

[(Et2O)Na(OC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]2

[(benzo-12-crown-4)2Na]{Na[(OC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]2}

[(benzo-12-crown-4)2Na]{Na[(OC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]2}

Conditions
ConditionsYield
Stage #1: benzo-12-crown-4; [(Et2O)Na(OC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]2 at 23℃; for 0.0833333h;
Stage #2: diethyl ether for 0.5h;
84%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

Na[Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

Na[Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

[(benzo-12-crown-4)2Na][(XylNC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

[(benzo-12-crown-4)2Na][(XylNC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]

Conditions
ConditionsYield
Stage #1: benzo-12-crown-4; 2,6-dimethylphenyl isonitrile; Na[Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)] In diethyl ether at 23℃; for 0.0833333h;
Stage #2: for 0.25h; Further stages;
82%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

chloroacetyl chloride
79-04-9

chloroacetyl chloride

C14H17ClO5

C14H17ClO5

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 2h;79%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

12-bromo-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]-tetraoxacyclododecine
118409-81-7

12-bromo-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]-tetraoxacyclododecine

Conditions
ConditionsYield
With dioxane dibromide In tetrahydrofuran for 0.166667h;78%
With bromine In 1,4-dioxane Bromination;
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

3-phenyl-1,2,4-triazin-5-one
54673-30-2

3-phenyl-1,2,4-triazin-5-one

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

4-(5-Oxo-1-trifluoroacetyl-3-phenyl-1,2,5,6-tetrahydro-1,2,4-triazin-6-yl)benzo-12-crown-4

4-(5-Oxo-1-trifluoroacetyl-3-phenyl-1,2,5,6-tetrahydro-1,2,4-triazin-6-yl)benzo-12-crown-4

Conditions
ConditionsYield
at 20℃; for 1h; Substitution; Acylation;77%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

3-phenyl-1,2,4-triazin-5-one
54673-30-2

3-phenyl-1,2,4-triazin-5-one

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

6-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-phenyl-1-(2,2,2-trifluoro-acetyl)-1,6-dihydro-4H-[1,2,4]triazin-5-one

6-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-phenyl-1-(2,2,2-trifluoro-acetyl)-1,6-dihydro-4H-[1,2,4]triazin-5-one

Conditions
ConditionsYield
In trifluoroacetic acid at 20℃; for 3h;77%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

indan-1,2,3-trione hydrate
485-47-2

indan-1,2,3-trione hydrate

C33H34O10
1366625-24-2

C33H34O10

Conditions
ConditionsYield
With sulfuric acid In chloroform at 25℃; regioselective reaction;77%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

acetic anhydride
108-24-7

acetic anhydride

1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone
107996-83-8

1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone

Conditions
ConditionsYield
With PPA In acetic acid at 60℃;76%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

C36H42O12

C36H42O12

Conditions
ConditionsYield
With iron(III) chloride; dipotassium peroxodisulfate at 10 - 15℃; for 2h;75.6%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecene-2-sulfonyl chloride
126867-37-6

6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecene-2-sulfonyl chloride

Conditions
ConditionsYield
With chlorosulfonic acid In chloroform for 6h; Ambient temperature;75%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

1,3,4,6-bis(2-oxapropylene)tetrahydro-3a,6a-diphenylimidazo<4,5-d>imidazole-2,5(1H,3H)-dione
111380-75-7

1,3,4,6-bis(2-oxapropylene)tetrahydro-3a,6a-diphenylimidazo<4,5-d>imidazole-2,5(1H,3H)-dione

28b,28c-diphenyl-2,3,5,6,8,9,12,14,17,18,20,21,23,24,27,28b,28c,29-octadecahydro-1,4,7,10,16,19,22,25-octaoxa-12a,13a,27a,28a-tetraazacyclododeca[1',2':4,5]benzo[1,2-f]cyclododeca[1'',2'':4',5']benzo[1',2':5,6]azuleno[2,1,8-ija]azulene-13,28-dione
1380508-63-3

28b,28c-diphenyl-2,3,5,6,8,9,12,14,17,18,20,21,23,24,27,28b,28c,29-octadecahydro-1,4,7,10,16,19,22,25-octaoxa-12a,13a,27a,28a-tetraazacyclododeca[1',2':4,5]benzo[1,2-f]cyclododeca[1'',2'':4',5']benzo[1',2':5,6]azuleno[2,1,8-ija]azulene-13,28-dione

Conditions
ConditionsYield
With polyphosphoric acid at 80 - 85℃; for 0.5h;75%
With polyphosphoric acid at 80℃;
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

Bromoacetaldehyde diethyl acetal
2032-35-1

Bromoacetaldehyde diethyl acetal

C26H32O8

C26H32O8

Conditions
ConditionsYield
Stage #1: benzo-12-crown-4; Bromoacetaldehyde diethyl acetal With sulfuric acid; acetic acid at 0 - 20℃;
Stage #2: In pentan-1-ol for 6h; Reflux;
71%
Stage #1: benzo-12-crown-4; Bromoacetaldehyde diethyl acetal With sulfuric acid; acetic acid
Stage #2: In pentan-1-ol Heating;
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

1-acetyl-3-p-tolyl-1,6-dihydro-4H-[1,2,4]triazin-5-one

1-acetyl-3-p-tolyl-1,6-dihydro-4H-[1,2,4]triazin-5-one

1-acetyl-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-p-tolyl-1,6-dihydro-4H-[1,2,4]triazin-5-one
420118-24-7

1-acetyl-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-p-tolyl-1,6-dihydro-4H-[1,2,4]triazin-5-one

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 3h;69%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

hexamethylenetetramine
100-97-0

hexamethylenetetramine

2,3-(4-formylbenzo)-1,4,7,10-tetraoxa-2-cyclododecene
84993-16-8

2,3-(4-formylbenzo)-1,4,7,10-tetraoxa-2-cyclododecene

Conditions
ConditionsYield
With trifluoroacetic acid at 90 - 95℃; for 24h;68%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

3-ethylsulfanyl-4H-[1,2,4]triazin-5-one
89179-74-8

3-ethylsulfanyl-4H-[1,2,4]triazin-5-one

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

3-Ethylsulfanyl-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-1-(2,2,2-trifluoro-acetyl)-1,6-dihydro-4H-[1,2,4]triazin-5-one

3-Ethylsulfanyl-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-1-(2,2,2-trifluoro-acetyl)-1,6-dihydro-4H-[1,2,4]triazin-5-one

Conditions
ConditionsYield
In trifluoroacetic acid at 20℃; for 6h;65%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

acetic acid
64-19-7

acetic acid

A

1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone
107996-83-8

1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone

B

2,3-(4,5-diacetyl)benzo-12-crown-4 ether

2,3-(4,5-diacetyl)benzo-12-crown-4 ether

Conditions
ConditionsYield
With polyphosporic acid at 80℃; for 0.666667h;A 64%
B n/a
With PPA at 80℃; for 1.25h;A n/a
B 62%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

propionic acid
802294-64-0

propionic acid

A

1-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-propan-1-one

1-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-propan-1-one

B

1-(3-Propionyl-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-propan-1-one

1-(3-Propionyl-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-propan-1-one

Conditions
ConditionsYield
With PPA at 80℃;A n/a
B 64%
With PPA at 80℃;
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

3-(4-Chlorophenyl)-2H-1,2,4-triazin-5-one

3-(4-Chlorophenyl)-2H-1,2,4-triazin-5-one

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

3-(4-Chloro-phenyl)-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-1-(2,2,2-trifluoro-acetyl)-1,6-dihydro-4H-[1,2,4]triazin-5-one

3-(4-Chloro-phenyl)-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-1-(2,2,2-trifluoro-acetyl)-1,6-dihydro-4H-[1,2,4]triazin-5-one

Conditions
ConditionsYield
In trifluoroacetic acid at 20℃; for 6h;64%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

(4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene
17454-42-1, 125279-92-7, 125356-38-9

(4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene

Conditions
ConditionsYield
With hydrogen; (PAA)6RhCl In water; isopropyl alcohol under 760 Torr;60%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

1-adamanthanol
768-95-6

1-adamanthanol

2-Adamantan-1-yl-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecene

2-Adamantan-1-yl-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecene

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In 1,4-dioxane Heating;59%
benzo-12-crown-4
14174-08-4

benzo-12-crown-4

butyric acid
107-92-6

butyric acid

A

1-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-butan-1-one

1-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-butan-1-one

B

1-(3-Butyryl-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-butan-1-one

1-(3-Butyryl-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-butan-1-one

Conditions
ConditionsYield
With PPA at 80℃;A 57%
B n/a
With PPA at 80℃; for 0.666667h;
sulfur
10544-50-0

sulfur

benzo-12-crown-4
14174-08-4

benzo-12-crown-4

sodium amalgam

sodium amalgam

(K[Mo(13)C(N(CH3(C(2)H3)2C)(C6H3(CH3)2))3])2

(K[Mo(13)C(N(CH3(C(2)H3)2C)(C6H3(CH3)2))3])2

Na(1+)*2(C4H4(C2O)(C2H4O)3)*[Mo(13)CS(N(CH3(C(2)H3)2C)(C6H3(CH3)2))3](1-)=[Na(C24H32O8)][Mo(13)CS(N(C4H3(2)H6)(C8H9))3]

Na(1+)*2(C4H4(C2O)(C2H4O)3)*[Mo(13)CS(N(CH3(C(2)H3)2C)(C6H3(CH3)2))3](1-)=[Na(C24H32O8)][Mo(13)CS(N(C4H3(2)H6)(C8H9))3]

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether; benzene stirring of (KMo(13)C(N(C(CD3)2CH3)(C6H3Me2))3)2 in C6H6/ether at -35°C, addn. of S8; stirring for 2 h; filtration, drying, transferring to vial with Na/Hg in THF, filtration after 2 h, drying, dissolving in soln. of benzo-12-crown-4 (2 equiv.); in 1:1 benzene/ether; pptn., recrystn. from 3:2 pentane/THF; elem. anal.;56%

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