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inquiryManufacturer supply Benzo-12-crown-4 CAS 14174-08-4 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquirySICHUAN ZHONGBANG NEW MATERIAL CO., LTD is a complex enterprise specializing in the research, development, manufacturing and trade of fine chemicals, domestic hygiene, pesticide intermediates and pharmaceutical intermediates; we now are the larges
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o
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inquiryProduct Name: BENZO-12-CROWN-4 Synonyms: BENZO-12-CROWN-4;BENZO-12-CROWN 4-ETHER;2,3-BENZO-1,4,7,10-TETRAOXADODEC-2-ENE;6,7,9,10,12,13-HEXAHYDROBENZO[1,4,7,10]TETRAOXOCYCLODODECIN;4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-1;BENZO-1
We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
BENZO-12-CROWN-4Appearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air
Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
Benzo-12-crown 4-etherAppearance:detailed in specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:An important raw material and intermediate used in Organic Synthesis, Pharmaceuticals Transportation:Sea/air/c
We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a
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inquiry1,4,7,10-Benzotetraoxacyclododecin,2,3,5,6,8,9-hexahydro-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
Cas:14174-08-4
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inquiry1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
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inquiryo-hydroxyphenyl 3,6-dioxa-8-bromooctyl ether
benzo-12-crown-4
Conditions | Yield |
---|---|
With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 25℃; | 94% |
With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 25℃; Rate constant; | 94.0 % Spectr. |
benzene-1,2-diol
triethylene glycol di-(p-toluenesulfonate)
benzo-12-crown-4
Conditions | Yield |
---|---|
Stage #1: benzene-1,2-diol With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 50 - 60℃; for 0.5h; Stage #2: triethylene glycol di-(p-toluenesulfonate) In water; toluene for 6h; Reflux; | 52% |
Stage #1: benzene-1,2-diol With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Large scale; Stage #2: triethylene glycol di-(p-toluenesulfonate) In N,N-dimethyl-formamide at 85 - 90℃; Large scale; | 28% |
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene for 16h; Heating; | 18% |
With lithium hydroxide; sodium hydroxide 1.) THF; Yield given. Multistep reaction; |
benzene-1,2-diol
1,2-bis(2-chloroethoxy)ethane
A
benzo-12-crown-4
B
dibenzo-24-crown ether
Conditions | Yield |
---|---|
With lithium hydroxide In water; butan-1-ol for 28h; modified Pedersen procedure; Heating; | A 26% B 27% |
With lithium hydroxide In water; butan-1-ol at 100℃; for 30h; | A 10% B 7.8% |
With sodium hydroxide In water; tert-butyl alcohol for 30h; Heating; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate In water; butan-1-ol at 95℃; Inert atmosphere; | 14.4% |
With sodium hydroxide; lithium perchlorate 1.) DMSO, 60 deg C, 15 min, 2.) 110 deg C, 22 h; Yield given. Multistep reaction; | |
With sodium hydroxide; lithium perchlorate 1) room temperature, 15 min; 2) 110 deg C, 24 h, DMSO; Yield given. Multistep reaction; | |
Stage #1: benzene-1,2-diol With lithium bromide monohydrate; lithium hydroxide monohydrate In water; butan-1-ol at 20 - 110℃; for 0.1h; Inert atmosphere; Stage #2: 1,2-bis(2-chloroethoxy)ethane In water; butan-1-ol at 110℃; for 5h; Inert atmosphere; |
2,2'-(1,2-phenylenedioxy)diethanol
1,2-bis-tosyloxyethane
benzo-12-crown-4
Conditions | Yield |
---|---|
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene for 16h; Heating; | 13% |
2,2'-<1,2-Phenylenbis(oxy)-2,1-ethandiyloxy>bisethanol
benzo-12-crown-4
Conditions | Yield |
---|---|
With sodium hydroxide; tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride In toluene at 70 - 75℃; for 13h; | 7% |
Conditions | Yield |
---|---|
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene for 16h; Heating; | 5% |
2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-phenol anion
benzo-12-crown-4
Conditions | Yield |
---|---|
sodium cation In water; dimethyl sulfoxide for 25h; |
Conditions | Yield |
---|---|
In acetonitrile at 24.9℃; Equilibrium constant; |
Conditions | Yield |
---|---|
In acetonitrile at 24.9℃; Equilibrium constant; |
Conditions | Yield |
---|---|
In acetonitrile at 24.9℃; Equilibrium constant; |
Conditions | Yield |
---|---|
In acetonitrile at 24.9℃; Equilibrium constant; |
Conditions | Yield |
---|---|
In acetonitrile at 24.9℃; Equilibrium constant; |
benzene-1,2-diol
benzo-12-crown-4
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 52 percent / K2CO3 / dimethylformamide / 10 h / 95 - 100 °C 2: 85 percent / aq. NaOH / 3.5 h / 30 - 95 °C 3: 7 percent / aq. NaOH; (nC4H9)4NI; p-TsCl / toluene / 13 h / 70 - 75 °C View Scheme |
2-[2-(2-hydroxyethoxy)ethoxy]phenol
benzo-12-crown-4
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / aq. NaOH / 3.5 h / 30 - 95 °C 2: 7 percent / aq. NaOH; (nC4H9)4NI; p-TsCl / toluene / 13 h / 70 - 75 °C View Scheme |
1,2-bis-(2-bromo-ethoxy)-ethane
benzo-12-crown-4
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 16 percent / KOH 2: 94.0 percent Spectr. / Me4NOH / dimethylsulfoxide; H2O / 25 °C View Scheme |
2,2'-[1,2-ethanediylbis(oxy)]bisethanol
benzo-12-crown-4
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: PBr3, pyridine 2: 16 percent / KOH 3: 94.0 percent Spectr. / Me4NOH / dimethylsulfoxide; H2O / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium hydroxide / tetrahydrofuran / 7 h / 20 °C 2.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 0.5 h / 50 - 60 °C 2.2: 6 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water; tetrahydrofuran / 2 h / 5 °C / Large scale 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Large scale 2.2: 85 - 90 °C / Large scale View Scheme |
((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate
benzene-1,2-diol
benzo-12-crown-4
Conditions | Yield |
---|---|
Stage #1: benzene-1,2-diol With caesium carbonate In acetonitrile for 3h; Reflux; Inert atmosphere; Stage #2: ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate In acetonitrile Inert atmosphere; Reflux; |
Conditions | Yield |
---|---|
In methanol; hydrogen fluoride aq. HF; Ta2O5 dissolved in 45% aq. HF; 2 equiv. CH3OH soln. of crown ether added; stored at 20-25°C in exsiccator for a low evapn. of solvent over several days; elem. anal.; | 95% |
benzo-12-crown-4
tantalum pentafluoride
hydrogen fluoride
water
Conditions | Yield |
---|---|
In hydrogen fluoride aq. HF; TaF5 in aq. 45% HF added to soln. of crown ether; stored at 20-25°C in exsiccator for a low evapn. of solvent over several days; | 95% |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In chloroform at 25℃; regioselective reaction; | 95% |
benzo-12-crown-4
tert-butyl alcohol
12-(tert-butyl)-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine
Conditions | Yield |
---|---|
With sulfuric acid In chloroform Product distribution; Heating; different solvents, other crown ethers; | 94% |
With sulfuric acid In chloroform Heating; | 94% |
benzo-12-crown-4
3-(p-tolyl)-1,2,4-triazin-5(2H)-one
trifluoroacetic anhydride
6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-p-tolyl-1-trifluoroacetyl-1,6-dihydro-4H-[1,2,4]triazin-5-one
Conditions | Yield |
---|---|
In trifluoroacetic acid at 20℃; for 3h; | 94% |
benzo-12-crown-4
2-nitro-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxabenzocyclododecene
Conditions | Yield |
---|---|
With nitric acid In chloroform; acetic acid at 20℃; for 6h; | 93% |
With nitric acid In acetonitrile for 0.5h; Heating; | 92% |
With nitric acid; acetic acid In chloroform at 20℃; for 24h; Cooling with ice; | 75% |
benzo-12-crown-4
Conditions | Yield |
---|---|
In diethyl ether at 23℃; for 1h; | 91% |
benzo-12-crown-4
diethyl ether
Conditions | Yield |
---|---|
Stage #1: benzo-12-crown-4; [(Et2O)Na(OC)Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)]2 at 23℃; for 0.0833333h; Stage #2: diethyl ether for 0.5h; | 84% |
benzo-12-crown-4
2,6-dimethylphenyl isonitrile
Conditions | Yield |
---|---|
Stage #1: benzo-12-crown-4; 2,6-dimethylphenyl isonitrile; Na[Re(η5-Cp)(N,N′-bis(2,6-diisopropylphenyl)-3,5-dimethyl-β-diketiminate)] In diethyl ether at 23℃; for 0.0833333h; Stage #2: for 0.25h; Further stages; | 82% |
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 2h; | 79% |
benzo-12-crown-4
12-bromo-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]-tetraoxacyclododecine
Conditions | Yield |
---|---|
With dioxane dibromide In tetrahydrofuran for 0.166667h; | 78% |
With bromine In 1,4-dioxane Bromination; |
benzo-12-crown-4
3-phenyl-1,2,4-triazin-5-one
trifluoroacetic anhydride
Conditions | Yield |
---|---|
at 20℃; for 1h; Substitution; Acylation; | 77% |
benzo-12-crown-4
3-phenyl-1,2,4-triazin-5-one
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In trifluoroacetic acid at 20℃; for 3h; | 77% |
Conditions | Yield |
---|---|
With sulfuric acid In chloroform at 25℃; regioselective reaction; | 77% |
benzo-12-crown-4
acetic anhydride
1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone
Conditions | Yield |
---|---|
With PPA In acetic acid at 60℃; | 76% |
benzo-12-crown-4
Conditions | Yield |
---|---|
With iron(III) chloride; dipotassium peroxodisulfate at 10 - 15℃; for 2h; | 75.6% |
benzo-12-crown-4
6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecene-2-sulfonyl chloride
Conditions | Yield |
---|---|
With chlorosulfonic acid In chloroform for 6h; Ambient temperature; | 75% |
benzo-12-crown-4
1,3,4,6-bis(2-oxapropylene)tetrahydro-3a,6a-diphenylimidazo<4,5-d>imidazole-2,5(1H,3H)-dione
28b,28c-diphenyl-2,3,5,6,8,9,12,14,17,18,20,21,23,24,27,28b,28c,29-octadecahydro-1,4,7,10,16,19,22,25-octaoxa-12a,13a,27a,28a-tetraazacyclododeca[1',2':4,5]benzo[1,2-f]cyclododeca[1'',2'':4',5']benzo[1',2':5,6]azuleno[2,1,8-ija]azulene-13,28-dione
Conditions | Yield |
---|---|
With polyphosphoric acid at 80 - 85℃; for 0.5h; | 75% |
With polyphosphoric acid at 80℃; |
Conditions | Yield |
---|---|
Stage #1: benzo-12-crown-4; Bromoacetaldehyde diethyl acetal With sulfuric acid; acetic acid at 0 - 20℃; Stage #2: In pentan-1-ol for 6h; Reflux; | 71% |
Stage #1: benzo-12-crown-4; Bromoacetaldehyde diethyl acetal With sulfuric acid; acetic acid Stage #2: In pentan-1-ol Heating; |
benzo-12-crown-4
1-acetyl-6-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-3-p-tolyl-1,6-dihydro-4H-[1,2,4]triazin-5-one
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 3h; | 69% |
benzo-12-crown-4
hexamethylenetetramine
2,3-(4-formylbenzo)-1,4,7,10-tetraoxa-2-cyclododecene
Conditions | Yield |
---|---|
With trifluoroacetic acid at 90 - 95℃; for 24h; | 68% |
benzo-12-crown-4
3-ethylsulfanyl-4H-[1,2,4]triazin-5-one
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In trifluoroacetic acid at 20℃; for 6h; | 65% |
benzo-12-crown-4
acetic acid
A
1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone
Conditions | Yield |
---|---|
With polyphosporic acid at 80℃; for 0.666667h; | A 64% B n/a |
With PPA at 80℃; for 1.25h; | A n/a B 62% |
benzo-12-crown-4
propionic acid
Conditions | Yield |
---|---|
With PPA at 80℃; | A n/a B 64% |
With PPA at 80℃; |
benzo-12-crown-4
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In trifluoroacetic acid at 20℃; for 6h; | 64% |
benzo-12-crown-4
(4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene
Conditions | Yield |
---|---|
With hydrogen; (PAA)6RhCl In water; isopropyl alcohol under 760 Torr; | 60% |
benzo-12-crown-4
1-adamanthanol
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In 1,4-dioxane Heating; | 59% |
benzo-12-crown-4
butyric acid
Conditions | Yield |
---|---|
With PPA at 80℃; | A 57% B n/a |
With PPA at 80℃; for 0.666667h; |
sulfur
benzo-12-crown-4
Conditions | Yield |
---|---|
In tetrahydrofuran; diethyl ether; benzene stirring of (KMo(13)C(N(C(CD3)2CH3)(C6H3Me2))3)2 in C6H6/ether at -35°C, addn. of S8; stirring for 2 h; filtration, drying, transferring to vial with Na/Hg in THF, filtration after 2 h, drying, dissolving in soln. of benzo-12-crown-4 (2 equiv.); in 1:1 benzene/ether; pptn., recrystn. from 3:2 pentane/THF; elem. anal.; | 56% |
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