Specifications CAS No.: 65-19-0 Other Names: Horny Goat Weed Extract MF: C21H27ClN2O3
1.Quick details: [Name of Product]Yohimbe P.E. [Latin Name]Corynante Yohimbe L. [Plant Origin and Distribution] Yohimbine, is a plant produced in West Africa, which is extract from the bark of a proposed alkaloid, is an evergreen plant come from
Cas:146-48-5
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryYohimbine Extract Product Name: yohimbe extract Plant original: Pausinystalia Yohimbe Specifications: 8~98% Yohimbine HCl by HPLC Molecular Formula: C21H27ClN2O Molecular Mass: 390.904 CAS No: 65-19-0 Quality
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $18.0
Type:Trading Company
inquiryDayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:146-48-5
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
Cas:146-48-5
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryHebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ
Best service,high quality and cheap price. Appearance:White crystalline powder Storage: in cool dry container Package:25kg/drum,1kg/bag Application:Mainly used in medicine, health food, tobacco, cosmetics raw materials or auxiliary materials, etc T
We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $14.7 / 19.7
Type:Manufacturers
inquiry17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester Basic information Product Name: 17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester Synonyms:
Cas:146-48-5
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:146-48-5
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can
Cas:146-48-5
Min.Order:1 Metric Ton
FOB Price: $5.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry plac
Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:146-48-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:146-48-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:146-48-5
Min.Order:1 Kilogram
FOB Price: $10.0 / 100.0
Type:Trading Company
inquiryYohimbine CAS: 146-48-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s
Cas:146-48-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:146-48-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester CAS: 146-48-5 Specification tests specifications results assay 95.5% to 99.0% 99.0% appearance
Cas:146-48-5
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryPRODUCT DETAILS Yohimbine Basic information Overview Information Effectiveness Side Effects Product Name: Yohimbine Synonyms: yohimbine;YOHIMBINE, C-;17alpha-Hyd
Cas:146-48-5
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:146-48-5
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:146-48-5
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryChengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:146-48-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry(1R,2S,4aR,13bS,14aS)-methyl-2-hydroxy-1,2,4a,5,7,8,13,13b,14,14a-decahydroindolo[2',3':3,4]pyrido-[1,2-b]isoquinoline-1-carboxylate
Yohimbine
Conditions | Yield |
---|---|
With 10% Pd/C; hydrogen In ethyl acetate for 14h; | 100% |
With palladium 10% on activated carbon; hydrogen In ethyl acetate under 760.051 Torr; for 15h; | 100% |
Conditions | Yield |
---|---|
With L-Selectride In tetrahydrofuran at -78℃; for 0.5h; | 86% |
With sodium tetrahydroborate In isopropyl alcohol Product distribution; Reduction; |
Yohimbine
Conditions | Yield |
---|---|
With acetic acid at 160℃; for 0.0166667h; Reagent/catalyst; Temperature; Microwave irradiation; stereospecific reaction; | 74% |
Yohimbine
Conditions | Yield |
---|---|
With acetic acid at 160℃; for 0.0833333h; Microwave irradiation; stereospecific reaction; | 62% |
Yohimbine
Conditions | Yield |
---|---|
With acetic acid at 160℃; for 0.0166667h; Microwave irradiation; stereospecific reaction; | 59% |
4-cyano-3,17-dihydroxy-3,4-seco-yohimbane-16-carboxylic acid methyl ester
Yohimbine
Conditions | Yield |
---|---|
With acetic acid at 160℃; for 0.0166667h; Time; Microwave irradiation; stereospecific reaction; | 50% |
Yohimbine
Conditions | Yield |
---|---|
With acetic acid at 160℃; for 0.0166667h; Microwave irradiation; stereospecific reaction; | 32% |
Yohimbine
Conditions | Yield |
---|---|
With acetic acid at 160℃; for 0.0833333h; Microwave irradiation; stereospecific reaction; | 17% |
Yohimbine
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate |
Yohimbine
Conditions | Yield |
---|---|
With acetic acid; zinc |
Conditions | Yield |
---|---|
With hydrogenchloride; methanol |
Conditions | Yield |
---|---|
With potassium hydroxide Behandeln des Reaktionsprodukts mit methanol.HCl; |
3α-15α-20β-17α-hydroxylyohimbine-16α-carboxylic acid methyl ester
Yohimbine
Conditions | Yield |
---|---|
With N-Ac-Leu |
(+)-3,14-didehydroyohimbine
dibenzoyl peroxide
A
14α-benzoyloxypseudoyohimbine
B
14β-benzoyloxyyohimbine
C
Yohimbine
Conditions | Yield |
---|---|
With sodium tetrahydroborate Yield given. Multistep reaction. Yields of byproduct given; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In methanol at 10 - 15℃; | A 47 mg B 25 mg |
(1R,2S,4aR,8aR,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
A
(+)-3,14-didehydroyohimbine
B
17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester
C
17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester
D
Yohimbine
Conditions | Yield |
---|---|
With sodium methylate In methanol for 0.666667h; Heating; Further byproducts given. Title compound not separated from byproducts; | A 16 % Spectr. B 27 % Spectr. C 22 % Spectr. D 18 % Spectr. |
(1R,2S,4aR,8aR,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
B
(+)-3,14-didehydroyohimbine
C
17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester
D
17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester
E
Yohimbine
Conditions | Yield |
---|---|
With sodium methylate In methanol for 0.666667h; Product distribution; Equilibrium constant; Mechanism; Heating; solvolysis by KOH, MeOH, NaOMe; | A 17 % Spectr. B 16 % Spectr. C 27 % Spectr. D 22 % Spectr. E 18 % Spectr. |
Yohimbine
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid Behandeln des Reaktionsprodukts mit Diazomethan in Methanol und Aether; |
water
hydrogen bromide
acetic acid
pseudoyohimbine
Yohimbine
Conditions | Yield |
---|---|
Behandeln des Reaktionsprodukts mit Diazomethan in Methanol und Aether; |
Conditions | Yield |
---|---|
Behandeln des Reaktionsprodukts mit methanol.HCl; |
Conditions | Yield |
---|---|
With acetic acid for 96h; Isomerization; epimerisation; Heating; | |
With acetic acid for 48h; Heating; |
Conditions | Yield |
---|---|
In methanol | 1.8 mg |
secologanin
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: pyridine / 12 h 2: TFA / tetrahydrofuran / 1 h / Heating 3: NaOMe / methanol / 12 h 4: 70 percent / β-glucosidase / H2O / 96 h / 37 °C / pH 7.0 5: 85 percent / NaCNBH3 / methanol / 48 h 6: 75 percent / aq. HCl / acetone / 2 h / Heating 7: 100 percent / H2 / Pd/C / methanol 8: DMSO; Ac2O / 16 h 9: NaBH4 / propan-2-ol / 20 h 10: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 9 steps 1.1: pyridine / 12 h 2.1: TFA / 1 h / 13 °C / Heating 3.1: NaOMe / methanol / 12 h 4.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 5.1: methanol 5.2: 85 percent / NaCNBH3 / methanol 6.1: 75 percent / HCl (10 percent) / 2 h / Heating 7.1: hydrogen / PtO2 / ethanol / 24 h 8.1: DMSO; Ac2O 9.1: NaBH4 / propan-2-ol View Scheme | |
Multi-step reaction with 10 steps 1.1: pyridine / 12 h 2.1: TFA / 1 h / 13 °C / Heating 3.1: NaOMe / methanol / 12 h 4.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 5.1: methanol 5.2: 85 percent / NaCNBH3 / methanol 6.1: 75 percent / HCl (10 percent) / 2 h / Heating 7.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 8.1: DMSO; Ac2O / 16 h 9.1: NaBH4 / propan-2-ol / 20 h 10.1: AcOH / 96 h / Heating View Scheme | |
Multi-step reaction with 10 steps 1.1: pyridine / 12 h 2.1: TFA / 1 h / 13 °C / Heating 3.1: NaOMe / methanol / 12 h 4.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 5.1: methanol 5.2: 85 percent / NaCNBH3 / methanol 6.1: 75 percent / HCl (10 percent) / 2 h / Heating 7.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 8.1: AcOH / 96 h / Heating 9.1: DMSO; Ac2O 10.1: NaBH4 / propan-2-ol View Scheme |
O,O,O,O-tetraacetylsecologaninn
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: TFA / tetrahydrofuran / 1 h / Heating 2: NaOMe / methanol / 12 h 3: 70 percent / β-glucosidase / H2O / 96 h / 37 °C / pH 7.0 4: 85 percent / NaCNBH3 / methanol / 48 h 5: 75 percent / aq. HCl / acetone / 2 h / Heating 6: 100 percent / H2 / Pd/C / methanol 7: DMSO; Ac2O / 16 h 8: NaBH4 / propan-2-ol / 20 h 9: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 8 steps 1.1: TFA / 1 h / 13 °C / Heating 2.1: NaOMe / methanol / 12 h 3.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 4.1: methanol 4.2: 85 percent / NaCNBH3 / methanol 5.1: 75 percent / HCl (10 percent) / 2 h / Heating 6.1: hydrogen / PtO2 / ethanol / 24 h 7.1: DMSO; Ac2O 8.1: NaBH4 / propan-2-ol View Scheme | |
Multi-step reaction with 9 steps 1.1: TFA / 1 h / 13 °C / Heating 2.1: NaOMe / methanol / 12 h 3.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 4.1: methanol 4.2: 85 percent / NaCNBH3 / methanol 5.1: 75 percent / HCl (10 percent) / 2 h / Heating 6.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 7.1: DMSO; Ac2O / 16 h 8.1: NaBH4 / propan-2-ol / 20 h 9.1: AcOH / 96 h / Heating View Scheme | |
Multi-step reaction with 9 steps 1.1: TFA / 1 h / 13 °C / Heating 2.1: NaOMe / methanol / 12 h 3.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 4.1: methanol 4.2: 85 percent / NaCNBH3 / methanol 5.1: 75 percent / HCl (10 percent) / 2 h / Heating 6.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 7.1: AcOH / 96 h / Heating 8.1: DMSO; Ac2O 9.1: NaBH4 / propan-2-ol View Scheme |
Methyl (2S,3R,4S)-4-(1,3-Dioxolan-2-ylmethyl)-2-(β-D-glucopyranosyloxy)-3,4-dihydro-3-vinyl-2H-pyran-5-carboxylate
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 70 percent / β-glucosidase / H2O / 96 h / 37 °C / pH 7.0 2: 85 percent / NaCNBH3 / methanol / 48 h 3: 75 percent / aq. HCl / acetone / 2 h / Heating 4: 100 percent / H2 / Pd/C / methanol 5: DMSO; Ac2O / 16 h 6: NaBH4 / propan-2-ol / 20 h 7: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 2.1: methanol 2.2: 85 percent / NaCNBH3 / methanol 3.1: 75 percent / HCl (10 percent) / 2 h / Heating 4.1: hydrogen / PtO2 / ethanol / 24 h 5.1: DMSO; Ac2O 6.1: NaBH4 / propan-2-ol View Scheme | |
Multi-step reaction with 7 steps 1.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 2.1: methanol 2.2: 85 percent / NaCNBH3 / methanol 3.1: 75 percent / HCl (10 percent) / 2 h / Heating 4.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 5.1: DMSO; Ac2O / 16 h 6.1: NaBH4 / propan-2-ol / 20 h 7.1: AcOH / 96 h / Heating View Scheme | |
Multi-step reaction with 7 steps 1.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 2.1: methanol 2.2: 85 percent / NaCNBH3 / methanol 3.1: 75 percent / HCl (10 percent) / 2 h / Heating 4.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 5.1: AcOH / 96 h / Heating 6.1: DMSO; Ac2O 7.1: NaBH4 / propan-2-ol View Scheme |
Methyl (2S,3R,4S)-4-(1,3-Dioxolan-2-ylmethyl)-3,4-dihydro-2-(2,3,4,6-tetraacetyl-β-D-glucopyranosyloxy)-3-vinyl-2H-pyran-5-carboxylate
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: NaOMe / methanol / 12 h 2: 70 percent / β-glucosidase / H2O / 96 h / 37 °C / pH 7.0 3: 85 percent / NaCNBH3 / methanol / 48 h 4: 75 percent / aq. HCl / acetone / 2 h / Heating 5: 100 percent / H2 / Pd/C / methanol 6: DMSO; Ac2O / 16 h 7: NaBH4 / propan-2-ol / 20 h 8: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 7 steps 1.1: NaOMe / methanol / 12 h 2.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 3.1: methanol 3.2: 85 percent / NaCNBH3 / methanol 4.1: 75 percent / HCl (10 percent) / 2 h / Heating 5.1: hydrogen / PtO2 / ethanol / 24 h 6.1: DMSO; Ac2O 7.1: NaBH4 / propan-2-ol View Scheme | |
Multi-step reaction with 8 steps 1.1: NaOMe / methanol / 12 h 2.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 3.1: methanol 3.2: 85 percent / NaCNBH3 / methanol 4.1: 75 percent / HCl (10 percent) / 2 h / Heating 5.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 6.1: DMSO; Ac2O / 16 h 7.1: NaBH4 / propan-2-ol / 20 h 8.1: AcOH / 96 h / Heating View Scheme | |
Multi-step reaction with 8 steps 1.1: NaOMe / methanol / 12 h 2.1: 70 percent / β-glucosidase / 96 h / 37 °C / pH 7.0 3.1: methanol 3.2: 85 percent / NaCNBH3 / methanol 4.1: 75 percent / HCl (10 percent) / 2 h / Heating 5.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 6.1: AcOH / 96 h / Heating 7.1: DMSO; Ac2O 8.1: NaBH4 / propan-2-ol View Scheme |
17-oxo-yohimbane-16-carboxylic acid methyl ester
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaBH4 / propan-2-ol / 20 h 2: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: NaBH4 / propan-2-ol / 20 h 2: AcOH / 96 h / Heating View Scheme |
(1R,2R,6R)-2-[1,3]Dioxolan-2-ylmethyl-3-formyl-6-hydroxy-cyclohex-3-enecarboxylic acid methyl ester
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 85 percent / NaCNBH3 / methanol / 48 h 2: 75 percent / aq. HCl / acetone / 2 h / Heating 3: 100 percent / H2 / Pd/C / methanol 4: DMSO; Ac2O / 16 h 5: NaBH4 / propan-2-ol / 20 h 6: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: methanol 1.2: 85 percent / NaCNBH3 / methanol 2.1: 75 percent / HCl (10 percent) / 2 h / Heating 3.1: hydrogen / PtO2 / ethanol / 24 h 4.1: DMSO; Ac2O 5.1: NaBH4 / propan-2-ol View Scheme | |
Multi-step reaction with 6 steps 1.1: methanol 1.2: 85 percent / NaCNBH3 / methanol 2.1: 75 percent / HCl (10 percent) / 2 h / Heating 3.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 4.1: DMSO; Ac2O / 16 h 5.1: NaBH4 / propan-2-ol / 20 h 6.1: AcOH / 96 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1.1: methanol 1.2: 85 percent / NaCNBH3 / methanol 2.1: 75 percent / HCl (10 percent) / 2 h / Heating 3.1: 100 percent / hydrogen / Pd/C / methanol / 12 h 4.1: AcOH / 96 h / Heating 5.1: DMSO; Ac2O 6.1: NaBH4 / propan-2-ol View Scheme |
(-)-3-iso-19,20-dehydro-β-yohimbine
Yohimbine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / H2 / Pd/C / methanol 2: DMSO; Ac2O / 16 h 3: NaBH4 / propan-2-ol / 20 h 4: glacial acetic acid / 48 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / PtO2 / ethanol / 24 h 2: DMSO; Ac2O 3: NaBH4 / propan-2-ol View Scheme | |
Multi-step reaction with 4 steps 1: 100 percent / hydrogen / Pd/C / methanol / 12 h 2: DMSO; Ac2O / 16 h 3: NaBH4 / propan-2-ol / 20 h 4: AcOH / 96 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 100 percent / hydrogen / Pd/C / methanol / 12 h 2: AcOH / 96 h / Heating 3: DMSO; Ac2O 4: NaBH4 / propan-2-ol View Scheme |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride | 94% |
Yohimbine
Conditions | Yield |
---|---|
With sodium amide for 5 - 6h; Heating / reflux; | 90% |
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride 2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide View Scheme |
Yohimbine
Conditions | Yield |
---|---|
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; deuterium In tetrahydrofuran at 55℃; under 750.075 Torr; for 22h; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With sodium cyanoborohydride In trifluoroacetic acid | A 89% B 9% |
With sodium cyanoborohydride In trifluoroacetic acid at 20℃; for 3h; | A 79% B 18% |
With sodium tetrahydroborate; trifluoroacetic acid | A 68% B 1% |
Conditions | Yield |
---|---|
With mercury(II) diacetate at 60℃; | 85% |
Conditions | Yield |
---|---|
With ammonium chloride; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 40℃; for 3h; | 83% |
With ammonium chloride; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 40℃; for 3h; | 83% |
Conditions | Yield |
---|---|
With ammonium chloride; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20 - 40℃; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With phosphoric acid; dicyclohexyl-carbodiimide In dimethyl sulfoxide | 81% |
Conditions | Yield |
---|---|
Stage #1: allyl methyl carbonate With tris(dibenzylideneacetone)dipalladium (0); trifuran-2-yl-phosphane In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: Yohimbine In dichloromethane at 20℃; Inert atmosphere; diastereoselective reaction; | 79% |
dicobalt octacarbonyl
Yohimbine
Conditions | Yield |
---|---|
Stage #1: dicobalt octacarbonyl; 6CO*2Co*C12H21BrF2Si In dichloromethane; toluene at 20℃; for 3h; Inert atmosphere; Stage #2: Yohimbine With silver trifluoromethanesulfonate; triethylamine In dichloromethane; toluene for 0.5h; Inert atmosphere; chemoselective reaction; | 74% |
Yohimbine
Conditions | Yield |
---|---|
With dihydrogen peroxide In methanol at 60℃; for 6h; | 70% |
Conditions | Yield |
---|---|
In dichloromethane for 0.25h; Ambient temperature; | 67% |
Yohimbine
A
(1R,2S,4aR,8aS,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
B
(1R,2S,4aR,8aR,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With tert-butylhypochlorite; triethylamine In dichloromethane | A 67% B 28% |
With tert-butylhypochlorite In tetrachloromethane; dichloromethane at -17℃; for 0.5h; | A 55% B 32% |
Yohimbine
Conditions | Yield |
---|---|
With mercury(II) diacetate; edetate disodium In acetic acid for 1.5h; Heating; | 66% |
With mercury(II) diacetate; edetate disodium In acetic acid for 1.5h; Heating; Yield given; |
bromocyane
Yohimbine
A
4-cyano-3,17-dihydroxy-3,4-seco-yohimbane-16-carboxylic acid methyl ester
B
4-cyano-3,17-dihydroxy-3,4-seco-yohimbane-16-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran; dichloromethane; water at 20℃; for 23h; Inert atmosphere; | A n/a B 63% |
With water In tetrahydrofuran; dichloromethane at 20℃; for 23h; Inert atmosphere; Overall yield = 63 %; Overall yield = 208 mg; | A n/a B n/a |
Conditions | Yield |
---|---|
In dichloromethane; N,N-dimethyl-formamide at 100℃; for 0.000763889h; Microwave irradiation; Sealed tube; | 56% |
In dichloromethane; N,N-dimethyl-formamide at 100℃; for 0.0458333h; Microwave irradiation; Inert atmosphere; | 56% |
Conditions | Yield |
---|---|
In dichloromethane; chloroform at 20℃; for 6.5h; Inert atmosphere; | 55% |
In dichloromethane; chloroform at 20℃; for 6.5h; Inert atmosphere; | 36% |
Conditions | Yield |
---|---|
With silver(l) oxide at 20℃; for 8h; stereoselective reaction; | A 55% B 20% |
bromocyane
ethanol
Yohimbine
B
4-cyano-3-ethoxy-17-hydroxy-3,4-seco-yohimbane-16-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In dichloromethane; chloroform at 20℃; for 6.5h; Inert atmosphere; | A n/a B 47% |
In dichloromethane; chloroform at 20℃; for 6.5h; Inert atmosphere; Overall yield = 47 %; Overall yield = 171 mg; | A n/a B n/a |
Conditions | Yield |
---|---|
In dichloromethane; chloroform at 20℃; for 6.5h; Inert atmosphere; | A 39% B 9% |
Yohimbine
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; | 37% |
Conditions | Yield |
---|---|
In dichloromethane; chloroform at 20℃; for 6.5h; Inert atmosphere; | A 37% B 8% |
In dichloromethane; chloroform for 4h; Reflux; Inert atmosphere; | A 37% B 8% |
Conditions | Yield |
---|---|
With bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 40℃; for 3h; | 35% |
Conditions | Yield |
---|---|
With formic acid; silver(l) oxide In acetonitrile at 40℃; for 12h; stereoselective reaction; | 35% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View