img _fcksaAppearance:Off-white crystal Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemic
Cas:1477-50-5
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Cas:1477-50-5
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inquiryOur company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceuti
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Min.Order:1 Gram
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inquiryTIANFUCHEM--1477-50-5--Indole-2-carboxylic acid in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business re
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inquiryProduct Description Product website: http://www.finerchem.com Product Name Indole-2-carboxylic acid CAS No. 1477-50-5
Cas:1477-50-5
Min.Order:1 Gram
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryName: 2-Indolecarboxylic acid CAS:1477-50-5 MF: C9H7NO2 Appearance: white crystalline powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:perindopril intermediate Transportation:By sea or by air Port:Qingdao P
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Cas:1477-50-5
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
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inquiryIndole-2-carboxylic acid CAS:1477-50-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:1477-50-5
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Cas:1477-50-5
Min.Order:1000 Kilogram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:1477-50-5
Min.Order:10 Gram
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:Yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture.Organic Chemistry Transportation
Cas:1477-50-5
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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Min.Order:1 Kilogram
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inquirymoderate price & quick delivery Appearance:Off-white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:? ;Reactant for total synthesis of (±)-d
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
Conditions | Yield |
---|---|
With potassium hydroxide In water at 120℃; for 0.5h; | 99.9% |
With sodium hydroxide In ethanol; water at 70℃; for 2h; | 97% |
With sodium hydroxide at 200℃; for 0.0166667h; Irradiation; microwave; | 94% |
1-(phenylsulfonyl)-1H-indole-2-carboxylic acid
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium t-butanolate In 1,4-dioxane at 80℃; for 3h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With sodium dithionite In 1,4-dioxane; water for 3h; Reflux; | 96% |
With sodium hydroxide; sodium dithionite |
indolin-2-yl carboxylic acid
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In decane at 150℃; for 36h; Inert atmosphere; Schlenk technique; | 96% |
With carbon dioxide; DBN; Eosin Y In dimethyl sulfoxide at 25 - 30℃; for 48h; Irradiation; | 91% |
With 4-tert-Butylcatechol; oxygen In water at 20℃; for 20h; Green chemistry; | 80% |
With perylene diimide covalent immobilized to SiO2 nanospheres; air In N,N-dimethyl acetamide at 20℃; UV-irradiation; | 67% |
With oxygen at 80℃; under 760.051 Torr; for 6h; Catalytic behavior; Green chemistry; chemoselective reaction; |
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With methanol; potassium carbonate; copper(I) bromide In N,N-dimethyl-formamide at 20 - 120℃; Reagent/catalyst; Temperature; Solvent; | 95% |
(Z)-2-phenyl-4-(2-chlorobenzylidene)-(4H)-1,3-oxazol-5-one
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With methanol; copper; sodium carbonate In toluene at 20 - 120℃; | 90% |
Conditions | Yield |
---|---|
With potassium phosphate; bis(N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)palladium(0) In 1,4-dioxane at 100℃; for 10h; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1H-indole With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -20℃; for 0.5h; | 85% |
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol; dimethyl sulfoxide at 100℃; for 11h; regioselective reaction; | 84% |
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate In N,N-dimethyl-formamide at 105℃; | 82% |
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate In N,N-dimethyl-formamide at 105℃; Inert atmosphere; regioselective reaction; | 82% |
1H-indol-2-ylcarboxaldehyde
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With oxygen; acetic anhydride; CoCl2 In 1,2-dichloro-ethane at 25℃; | 77% |
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In water at 70℃; under 3000.3 Torr; for 8h; Temperature; Pressure; | 70% |
Multi-step reaction with 2 steps 1: platinum; acetic acid / Hydrogenation 2: aqueous NaOH View Scheme | |
With hydrogen at 50 - 60℃; under 9750.98 - 10501.1 Torr; Autoclave; |
Conditions | Yield |
---|---|
Stage #1: 2-iodo-1H-indole With n-butyllithium In tetrahydrofuran Stage #2: carbon dioxide In tetrahydrofuran | 61% |
Conditions | Yield |
---|---|
Stage #1: 2-carbethoxyindole With potassium hydroxide In water; acetone at 20℃; for 0.5h; Stage #2: 1-Bromopentane In water; acetone at 20℃; for 8h; | A 30% B 60% |
6H,13H-pyrazino<1,2-a:4,5-a'>diindole-6,13-dione
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran at 20℃; for 2h; | 57% |
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With ammonium hydroxide; hydrogen In methanol pH=7.5; | 56% |
Conditions | Yield |
---|---|
With sodium acetate In water at 255℃; for 0.333333h; Product distribution; Irradiation; microwave; various equivalents and molarity of NaOAc; effect of temp., and time; | A 45% B 55% |
(tert-Butoxycarbonylmethylene)triphenylphosphorane
2-nitro-benzaldehyde
A
indole
B
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With 1,2-dichloro-benzene; triphenylphosphine for 15h; Reflux; | A 29% B 27% |
Conditions | Yield |
---|---|
With sodium at 230 - 250℃; im Kohlendioxyd-Strom; zuletzt bei 300grad; |
Conditions | Yield |
---|---|
With potassium hydroxide beim Schmelzen; |
1-acetyl-2-methylindole
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide beim Schmelzen; |
Conditions | Yield |
---|---|
With potassium hydroxide beim Schmelzen; |
1-hydroxy-1H-indole-2-carboxylic acid
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With acetic acid; zinc | |
With sodium amalgam |
1-acetyl-3-hydroxy-indoline-2-carboxylic acid ethyl ester
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide |
ethyl 2-(3-N,N-diethylaminomethylindole)carboxylate
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With barium dihydroxide |
Conditions | Yield |
---|---|
With acetic acid; zinc | |
With ammonia; iron(II) sulfate |
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
beim Erhitzen ueber den Schmelzpunkt; | |
With sulfuric acid | |
With hydrogenchloride | |
beim Erhitzen ueber den Schmelzpunkt; |
benzaldehyde
A
Indole-2-carboxylic acid
B
1-(2-hydroxy-2-phenylethyl)pyridinium bromide
Conditions | Yield |
---|---|
With sodium hydroxide |
(E)-3-Ureido-but-2-enoic acid ethyl ester
ethyl pyruvate phenylhydrazone
A
Indole-2-carboxylic acid
B
2-carbethoxyindole
Conditions | Yield |
---|---|
at 195℃; α-form; |
Conditions | Yield |
---|---|
at 240 - 280℃; bei der Kalischmelze;neben anderen Produkten; |
diazomethane
Indole-2-carboxylic acid
indole-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In diethyl ether | 100% |
With acetic acid In diethyl ether at -20℃; | 100% |
In diethyl ether at 0℃; | 97% |
With diethyl ether |
Conditions | Yield |
---|---|
With hydrogenchloride for 24h; Heating; | 100% |
Stage #1: methanol; Indole-2-carboxylic acid With sulfuric acid for 12h; Heating / reflux; Stage #2: In methanol; water pH=7; | 100% |
With sulfuric acid for 24h; Reflux; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride for 24h; Heating / reflux; | 100% |
With thionyl chloride In methanol at 0℃; Reflux; | 99% |
With thionyl chloride for 2.25h; Cooling with ice; Reflux; | 99% |
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In tetrahydrofuran for 4h; Ambient temperature; | 100% |
Indole-2-carboxylic acid
4-[(tert-butoxy)carbonyl]-1-[(4-methoxyphenyl)methyl]-6-(phenylmethyl)piperazin-2-one
Conditions | Yield |
---|---|
Stage #1: 4-[(tert-butoxy)carbonyl]-1-[(4-methoxyphenyl)methyl]-6-(phenylmethyl)piperazin-2-one With hydrogenchloride In ethyl acetate deprotection; Stage #2: Indole-2-carboxylic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine Acylation; | 100% |
Conditions | Yield |
---|---|
Stage #1: Indole-2-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.166667h; Stage #2: 3-Phenyl-2-propyn-1-ol With dmap In dichloromethane at 0℃; for 2h; | 100% |
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: Indole-2-carboxylic acid With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.25h; Stage #2: methyl 4-(1-(N-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxamido)cyclopropyl)benzoate dihydrochloride In N,N-dimethyl-formamide for 1h; | 100% |
Indole-2-carboxylic acid
methyl iodide
methyl 1-methyl-1H-indole-2-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere; | 99% |
Stage #1: Indole-2-carboxylic acid With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Metallation; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 5h; Alkylation; | 72.4% |
In N-methyl-acetamide | 1.70 g (72.4%) |
Conditions | Yield |
---|---|
With Bromotrichloromethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine In tetrahydrofuran; dichloromethane at 60℃; for 6h; Inert atmosphere; | 99% |
Stage #1: Indole-2-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 0.5h; Stage #2: benzylamine In tetrahydrofuran at 20℃; for 24h; | 95% |
With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) In N,N-dimethyl-formamide at 20℃; | 74% |
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 25℃; for 4h; | 70% |
Conditions | Yield |
---|---|
With copper(I) oxide; potassium phosphate In 1-methyl-pyrrolidin-2-one at 160℃; for 12h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique; | 99% |
tert-butyl (3S)-3-(methylamino)pyrrolidine-1-carboxylate
Indole-2-carboxylic acid
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 12h; | 99% |
Indole-2-carboxylic acid
N,O-dimethylhydroxylamine*hydrochloride
N-methoxy-N-methyl-1H-indole-2-carboxamide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h; | 98.3% |
Stage #1: Indole-2-carboxylic acid; N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane for 0.0833333h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 3h; | 96% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 4h; | 87% |
Indole-2-carboxylic acid
Indole-2-carbonyl chloride
Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 40℃; for 1.5h; | 98% |
With thionyl chloride In diethyl ether at 20℃; for 12h; | 96% |
With thionyl chloride In dichloromethane at 70℃; for 2h; | 95% |
Indole-2-carboxylic acid
ethyl β-alaninate hydrochloride
3-[(1H-indole-2-carbonyl)amino]propionic acid ethyl ester
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 24h; | 98% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 24h; Condensation; | 95% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h; Inert atmosphere; | 90% |
Indole-2-carboxylic acid
N-methyl-1-naphthalenemethylamine hydrochloride
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 4.5h; Condensation; | 98% |
Indole-2-carboxylic acid
4-Aminobutanol
N-(4-hydroxybutyl)-1H-indole-2-carboxamide
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 98% |
Stage #1: Indole-2-carboxylic acid With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Stage #2: 4-Aminobutanol In dichloromethane at 20℃; | 93% |
Stage #1: Indole-2-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere; Stage #2: 4-Aminobutanol In dichloromethane at 20℃; for 16h; Inert atmosphere; | 93% |
Indole-2-carboxylic acid
3-amino-propionic acid ethyl ester
3-[(1H-indole-2-carbonyl)amino]propionic acid ethyl ester
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane | 98% |
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide at 20℃; |
Conditions | Yield |
---|---|
With thionyl chloride In toluene | 98% |
Indole-2-carboxylic acid
N-[(4-methoxyphenyl)methyl]prop-2-yn-1-amine
N-(4-methoxybenzyl)-N-propargyl-1H-indole-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: Indole-2-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Reflux; Stage #2: N-(4-methoxybenzyl)prop-2-yn-1-amine With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 98% |
Indole-2-carboxylic acid
N-(4-methylbenzyl)prop-2-yn-1-amine
N-(4-methylbenzyl)-N-propargyl-1H-indole-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: Indole-2-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Reflux; Stage #2: N-(4-methylbenzyl)prop-2-yn-1-amine With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 98% |
Indole-2-carboxylic acid
2,2-dimethoxyethylamine
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 25℃; for 2h; | 98% |
With 1,1'-carbonyldiimidazole In 1,4-dioxane at 70℃; for 3h; |
Indole-2-carboxylic acid
3,3-dichloro-2,3-dihydro-1H-indol-2-one
Conditions | Yield |
---|---|
With 1,3-dichloro-5,5-dimethylhydantoin In ethyl acetate at 20℃; | 98% |
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C 2: 1,3-dichloro-5,5-dimethylhydantoin / ethyl acetate / 20 °C View Scheme |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 18h; | 98% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 24h; | 98% |
Indole-2-carboxylic acid
para-nitrophenyl bromide
1-(4-nitrophenyl)-1H-indole-2-carboxylic acid
Conditions | Yield |
---|---|
With quebrachitol; copper; caesium carbonate In water; dimethyl sulfoxide at 100℃; Ullmann Condensation; Inert atmosphere; Green chemistry; | 98% |
With copper; caesium carbonate; methyl-alpha-D-glucopyranoside In water; dimethyl sulfoxide at 100℃; Sealed tube; Green chemistry; | 91% |
Conditions | Yield |
---|---|
With quebrachitol; copper; caesium carbonate In water; dimethyl sulfoxide at 100℃; Ullmann Condensation; Inert atmosphere; Green chemistry; | 98% |
Conditions | Yield |
---|---|
With oxygen; Rose Bengal lactone In water; N,N-dimethyl-formamide for 48h; Inert atmosphere; Irradiation; | 98% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 18h; | 98% |
Indole-2-carboxylic acid
(E)-methyl 2-((methylamino)methyl)-3-phenylacrylate
Conditions | Yield |
---|---|
Stage #1: Indole-2-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 20℃; for 0.416667h; Michael Addition; Inert atmosphere; Schlenk technique; Stage #2: (E)-methyl-2-((methylamino)methyl)-3-phenylacrylate With triethylamine In dimethyl sulfoxide at 20℃; for 3h; Michael Addition; Inert atmosphere; Schlenk technique; | 98% |
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