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Hangzhou Huarong Pharm Co., Ltd.

KDMF is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, dev

Abiraterone acetate KDMF

Cas:154229-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Abiraterone acetate

Cas:154229-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,

17-(3-pyridyl)-5,16-androstadien-3beta-acetate

Cas:154229-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Suzhou Lipin chemical Co., Ltd.

high quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:key intermediates Port:SHANGH

154229-18-2 Abiraterone acetate

Cas:154229-18-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality abiraterone acetate? supplier in China

Cas:154229-18-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

1. guaranteed purity; 2. large quantity in stock; 3. largest manufacturer; 4. best service after shipment with email; 5. high quality & competitive price; Appearance:powder Storage:store in cool and dry P

CAS:154229-18-2 Abiraterone acetate with best price

Cas:154229-18-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical

CAS 154229-18-2 Rolapitant

Cas:154229-18-2

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Abiraterone[CAS:154229-19-3] Abiraterone Acetate[CAS:154229-18-2] Diethyl(3-pyridyl)borane[CAS:89878-14-8] 17-Iodoandrosta-5,16-dien-3beta-ol[CAS:32138-69-5] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation o

Supply Abiraterone acetate and intermediate

Cas:154229-18-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Abiraterone acetate

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Abiraterone acetate Manufacturer/High quality/Best price/In stock

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Abiraterone acetate

Cas:154229-18-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

D - glucuronic acid and N - acetyl glucosamine disaccharides unit composed of hyaluronic acid (Hyaluronan), also called uronic acid, hyaluronic acid, basic structure is made up of two disaccharides unit D - glucuronic acid and N - acetyl glucosamin

Abiraterone Acetate

Cas:154229-18-2

Min.Order:1000 Gram

FOB Price: $5000.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Abirateroneacetate The alias:Abiraterone Acotate;Abiraterone Acetate impurity; CAS NO:154229-18-2 Molecular formula:C26H33NO2 Molecular weight:391.55 Product Quality 12 years of chemical raw materials Mature operation of the industry

Abirateroneacetate/CAS:154229-18-2/High quality

Cas:154229-18-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

17-(3-pyridyl)-5,16-androstadien-3beta-acetate

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

17-(3-pyridyl)-5,16-androstadien-3beta-acetate Basic information Product Name: 17-(3-pyridyl)-5,16-androstadien-3beta-acetate Synonyms: 17-(3-pyridyl)-5,16-androstadien-3beta-acetate

154229-18-2

Cas:154229-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can

99% Purity Abiraterone Acetate 154229-18-2 Abironex

Cas:154229-18-2

Min.Order:1 Metric Ton

FOB Price: $5.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 154229-18-2 with best quality

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

17-(3-pyridyl)-5,16-androstadien-3beta-acetate CAS154229-18-2

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Prouduct name: Abiraterone Acotate CAS: 154229-18-2 Appearance: white powder Purity: 99%min Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:drug used in castration-resistant prostate

Abiraterone Acetate

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china

High Quality Abiraterone Acetate CAS:154229-18-2

Cas:154229-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White to white crystalline powder Storage:Store in sealed co

Abiraterone acetate(Cas no:154229-18-2)

Cas:154229-18-2

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed

Abiraterone acetate 99%

Cas:154229-18-2

Min.Order:100 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

PI Chemical Pharmaceutical Intermediate Material High Purity Abiraterone Acetate 154229-18-2

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $400.0 / 600.0

Type:Trading Company

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: Abiraterone acetate CAS: 154229-18-2 MF: C26H33NO2 MW: 391.55 EINECS: 620-314-7 Mol File: 154229-18-2.mol Abiraterone acetate Structure Abiraterone acetate Chemical Properties Melting point 127-130°C Boiling

Abiraterone acetate

Cas:154229-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Abiraterone acetate with CAS:154229-18-2

Cas:154229-18-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 35.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Abiraterone acetate 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exported to many co

Abiraterone acetate

Cas:154229-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)-

Cas:154229-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C28H40O4

C28H40O4

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With hydroxylamine hydrochloride In acetonitrile97%
With hydroxylamine hydrochloride In acetonitrile97%
acetic anhydride
108-24-7

acetic anhydride

abiraterone
154229-19-3

abiraterone

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With dmap In acetone at 20 - 65℃; for 1h;95.3%
With pyridine; dmap; triethylamine at 0 - 20℃; for 5h;95%
With pyridine In acetonitrile Reflux; Large scale;91.6%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-Diethylboranylpyridine
89878-14-8

3-Diethylboranylpyridine

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran at 65℃; for 4h; Reflux;95%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water for 1h; Reflux;95%
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate In tetrahydrofuran; water at 60℃; for 1h;94%
3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

17-iodoandrosta-5,16-dien-3β-ol 3-acetate

17-iodoandrosta-5,16-dien-3β-ol 3-acetate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Stage #1: 3-pyridylboronic acid With [1,1-bis(di-tert-butylphosphino)ferrocene]palladium(II)dichloride; XPhos at 20℃; for 0.75h; Inert atmosphere;
Stage #2: 17-iodoandrosta-5,16-dien-3β-ol 3-acetate With triethylamine at 40℃; for 10h; Reagent/catalyst; Temperature; Inert atmosphere;
95%
C24H31NO*C2HF3O2

C24H31NO*C2HF3O2

acetyl chloride
75-36-5

acetyl chloride

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 5 - 20℃; for 0.5h; Reagent/catalyst;90%
acetyl chloride
75-36-5

acetyl chloride

abiraterone
154229-19-3

abiraterone

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In diethyl ether at 20℃; for 4h;85.1%
With 2-(Dimethylamino)pyridine; triethylamine In diethyl ether; ethanol; hexane; water84%
With triethylamine In ethyl acetate at 5 - 20℃; for 2h;83%
3-Bromopyridine
626-55-1

3-Bromopyridine

prasterone acetate
853-23-6

prasterone acetate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; for 18h;84.7%
petroleum-diethyl ether

petroleum-diethyl ether

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-Diethylboranylpyridine
89878-14-8

3-Diethylboranylpyridine

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran; bis(triphenylphosphine)palladium(II)-chloride84%
abiraterone acetate phosphate

abiraterone acetate phosphate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water for 2h;79.2%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: 3-pyridylboronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
79%
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 80℃; for 1h; Suzuki Coupling; Inert atmosphere;73%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water at -5 - 5℃; Inert atmosphere; Reflux;4.5 g
abiraterone acetate trifluoroacetate

abiraterone acetate trifluoroacetate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium carbonate In dichloromethane; water at 20℃; for 1h; pH=> 10;76.4%
3-Diethylboranylpyridine
89878-14-8

3-Diethylboranylpyridine

17-iodoandrosta-5,16-dien-3β-ol 3-acetate

17-iodoandrosta-5,16-dien-3β-ol 3-acetate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With palladium on activated charcoal; potassium carbonate In ethanol at 60℃; for 3h;76.3%
abiraterone acetate mesylate

abiraterone acetate mesylate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water for 2h;75.2%
17-iodoandrosta-5,16-dien-3β-ol 3-acetate

17-iodoandrosta-5,16-dien-3β-ol 3-acetate

3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
329214-79-1

3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With palladium on activated charcoal; potassium hydrogencarbonate In ethanol at 100℃; for 6h;72.9%
C26H33NO2*C2H2O4

C26H33NO2*C2H2O4

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water68.2%
abiraterone-3-acetate esylate
1609268-14-5

abiraterone-3-acetate esylate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium acetate; pyrographite In methanol for 0.5h;68%
3-Bromopyridine
626-55-1

3-Bromopyridine

3-acetyl-5-dehydroepiandrosterone p-toluenesulfonyl hydrazone
89359-48-8

3-acetyl-5-dehydroepiandrosterone p-toluenesulfonyl hydrazone

A

C47H61NO4

C47H61NO4

B

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); caesium carbonate In 1,4-dioxane at 90℃; for 52h; Concentration; Reagent/catalyst; Temperature; Time;A 42%
B 15%
acetic anhydride
108-24-7

acetic anhydride

abiraterone
154229-19-3

abiraterone

A

abiraterone acetate
154229-18-2

abiraterone acetate

B

3β-Acetoxy-16-(3β-acetoxyandrosta-5,16-dien-17-yl)-17-(3-pyridyl)androsta-5,16-diene
186826-68-6

3β-Acetoxy-16-(3β-acetoxyandrosta-5,16-dien-17-yl)-17-(3-pyridyl)androsta-5,16-diene

Conditions
ConditionsYield
With pyridine for 24h; Ambient temperature; Yield given. Yields of byproduct given;
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

3α-hydroxy-androsten-(5)-one-(17)

3α-hydroxy-androsten-(5)-one-(17)

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / NH2NH2*H2O, aq, NH2NH2*H2SO4 / ethanol / 120 h / Ambient temperature
2: 83 percent / I2, 1,1,3,3-tetramethylguanidine / tetrahydrofuran; diethyl ether / 1 h
3: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C
4: pyridine / 24 h / Ambient temperature
View Scheme
17-iodo-5,16-androstadien-3-ol
32138-69-5

17-iodo-5,16-androstadien-3-ol

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C
2: pyridine / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water / 22 h / 70 - 75 °C
2: dmap / acetonitrile / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; methanol / 28 h / 65 - 70 °C
2: dmap / acetonitrile / 5 h / Reflux
View Scheme
dehydroepiandrosterone-17-hydrazone
63015-10-1

dehydroepiandrosterone-17-hydrazone

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / I2, 1,1,3,3-tetramethylguanidine / tetrahydrofuran; diethyl ether / 1 h
2: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C
3: pyridine / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: iodine / methanol; dichloromethane / 3 h / -10 - 5 °C
2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / methanol; tetrahydrofuran; water / 10 h / 60 - 65 °C
3: pyridine / 24 h / 25 - 35 °C
View Scheme
Multi-step reaction with 3 steps
1: iodine; N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / diethyl ether / 4 h / 20 °C
View Scheme
prasterone acetate
853-23-6

prasterone acetate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 58 percent / 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 12 h
2: 84 percent / bis(triphenylphosphine)palladium(II) chloride, aq. Na2CO3 / tetrahydrofuran / 1 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate / dichloromethane / 4 h / -5 - 5 °C
2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 1 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 4 h / -80 - 0 °C
2.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 20 h / 20 - 70 °C / Reflux
2.2: 2 h / 0 °C
3.1: sodium hydrogencarbonate / water; dichloromethane
View Scheme
prasterone acetate
853-23-6

prasterone acetate

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-Diethylboranylpyridine
89878-14-8

3-Diethylboranylpyridine

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 80℃; for 5h;
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 4 h / 20 - 25 °C
2: 2,6-dimethylpyridine / dichloromethane / 2 h / 20 °C
3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 65 - 67 °C / Reflux
4: sodium hydroxide / water; methanol / 70 - 75 °C
5: triethylamine; dmap / tetrahydrofuran / 24 h / 20 - 25 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 16 h / 20 °C
2.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C / Inert atmosphere
2.2: 17 h / -78 - 20 °C / Inert atmosphere
3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
5.1: pyridine / 6 h / 0 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 16 h / 20 °C
2.1: lithium chloride; zinc(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2.2: 5 h / 0 °C / Inert atmosphere
3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
5.1: pyridine / 6 h / 0 - 20 °C
View Scheme
3-Bromopyridine
626-55-1

3-Bromopyridine

3-acetyl-5-dehydroepiandrosterone p-toluenesulfonyl hydrazone
89359-48-8

3-acetyl-5-dehydroepiandrosterone p-toluenesulfonyl hydrazone

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos for 4h; Inert atmosphere; Reflux;
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Inert atmosphere; Reflux;
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Reflux; Inert atmosphere;
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In 1,4-dioxane at 110℃; for 5h; Concentration; Reagent/catalyst; Temperature; Time; Inert atmosphere;
3β-formyl-oxy-5-androsten-17-one
29163-23-3

3β-formyl-oxy-5-androsten-17-one

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2,6-dimethylpyridine / dichloromethane / 2 h / 20 °C
2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 65 - 67 °C / Reflux
3: sodium hydroxide / water; methanol / 70 - 75 °C
4: triethylamine; dmap / tetrahydrofuran / 24 h / 20 - 25 °C
View Scheme
3β-formyloxyandrosta-5,16-diene-17-yl trifluoromethanesulphonate
1429742-48-2

3β-formyloxyandrosta-5,16-diene-17-yl trifluoromethanesulphonate

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 65 - 67 °C / Reflux
2: sodium hydroxide / water; methanol / 70 - 75 °C
3: triethylamine; dmap / tetrahydrofuran / 24 h / 20 - 25 °C
View Scheme
pyridin-3-ylmagnesium bromide
21970-14-9

pyridin-3-ylmagnesium bromide

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium chloride; zinc(II) chloride
2: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
4: pyridine / 6 h / 0 - 20 °C
View Scheme
(3S)-3-tert-butyldimethylsilyloxyandrost-5-en-17-one
42151-23-5

(3S)-3-tert-butyldimethylsilyloxyandrost-5-en-17-one

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C / Inert atmosphere
1.2: 17 h / -78 - 20 °C / Inert atmosphere
2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
4.1: pyridine / 6 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: lithium chloride; zinc(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 5 h / 0 °C / Inert atmosphere
2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
4.1: pyridine / 6 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 30 °C
2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 6 h / 20 - 65 °C
3: hydrogenchloride / water; methanol / 1 h / 20 - 30 °C
4: dmap / acetone / 1 h / 20 - 65 °C
View Scheme
abiraterone acetate
154229-18-2

abiraterone acetate

abiraterone
154229-19-3

abiraterone

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol; water for 1h;96%
With sodium hydroxide In methanol at 20℃; for 2h; Reagent/catalyst;95.8%
With potassium hydroxide In tetrahydrofuran; methanol at 30℃; for 1h; Inert atmosphere;94%
ethanesulfonic acid
594-45-6

ethanesulfonic acid

abiraterone acetate
154229-18-2

abiraterone acetate

abiraterone-3-acetate esylate
1609268-14-5

abiraterone-3-acetate esylate

Conditions
ConditionsYield
In 2-methyltetrahydrofuran at 1 - 49℃; for 0.5h; Cooling with ice;85%
abiraterone acetate
154229-18-2

abiraterone acetate

abiraterone acetate hydrochloride

abiraterone acetate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; isopropyl alcohol at 20℃; Temperature; Solvent; Reflux;85%
abiraterone acetate
154229-18-2

abiraterone acetate

methyl iodide
74-88-4

methyl iodide

3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-methylpyridin-1-ium iodide

3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-methylpyridin-1-ium iodide

Conditions
ConditionsYield
In acetonitrile at 90℃; for 16h; Inert atmosphere;84.5%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine

5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine

abiraterone acetate
154229-18-2

abiraterone acetate

(3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridin-4-yl)diphenyl(6-(trifluoromethyl)pyridin-3-yl)phosphonium trifluoromethanesulfonate

(3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridin-4-yl)diphenyl(6-(trifluoromethyl)pyridin-3-yl)phosphonium trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: trifluoromethylsulfonic anhydride; 5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine; abiraterone acetate In dichloromethane at -50℃; for 1h; Inert atmosphere;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; for 0.333333 - 0.5h; Inert atmosphere;
69%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

abiraterone acetate
154229-18-2

abiraterone acetate

A

(3S,8R,9S,10R,13S,14S)-17-(4-cyanopyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

(3S,8R,9S,10R,13S,14S)-17-(4-cyanopyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

B

(3S,8R,9S,10R,13S,14S)-17-(6-cyanopyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

(3S,8R,9S,10R,13S,14S)-17-(6-cyanopyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

C

(3S,8R,9S,10R,13S,14S)-17-(2-cyanopyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ylacetate

(3S,8R,9S,10R,13S,14S)-17-(2-cyanopyridin-3-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ylacetate

Conditions
ConditionsYield
Stage #1: abiraterone acetate With trifluoromethylsulfonic anhydride In chloroform at 20℃; for 1h; Inert atmosphere; Sealed tube;
Stage #2: trimethylsilyl cyanide In chloroform at 60℃; for 3h; Inert atmosphere; Sealed tube;
Stage #3: With 4-methyl-morpholine In chloroform at 60℃; for 17h; Inert atmosphere; Sealed tube;
A 67%
B 2%
C 4%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

triphenylphosphine
603-35-0

triphenylphosphine

abiraterone acetate
154229-18-2

abiraterone acetate

C44H47NO2P(1+)*CF3O3S(1-)

C44H47NO2P(1+)*CF3O3S(1-)

Conditions
ConditionsYield
Stage #1: trifluoromethylsulfonic anhydride; abiraterone acetate In dichloromethane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: triphenylphosphine In dichloromethane at -78℃; for 0.5h; Inert atmosphere;
Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; Inert atmosphere; regioselective reaction;
67%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

triphenylphosphine
603-35-0

triphenylphosphine

abiraterone acetate
154229-18-2

abiraterone acetate

(3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridin-4-yl)triphenylphosphonium trifluoromethanesulfonate

(3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridin-4-yl)triphenylphosphonium trifluoromethanesulfonate

Conditions
ConditionsYield
at -78 - 20℃; Alkaline conditions;67%
prasterone acetate
853-23-6

prasterone acetate

abiraterone acetate
154229-18-2

abiraterone acetate

(3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate hydrochloride
877319-47-6

(3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; tert-butyl methyl ether at 20℃; for 1h; Product distribution / selectivity;48%
With hydrogenchloride In diethyl ether; ethyl acetate at 20℃; for 1h; Product distribution / selectivity;30%
With hydrogenchloride In methanol; diethyl ether at 20℃; for 1h; Product distribution / selectivity;
prasterone acetate
853-23-6

prasterone acetate

abiraterone acetate
154229-18-2

abiraterone acetate

abiraterone acetate sulphate
877319-48-7

abiraterone acetate sulphate

Conditions
ConditionsYield
With sulfuric acid In tert-butyl methyl ether; water at 20℃; for 1h; Product distribution / selectivity;48%
With sulfuric acid In water; ethyl acetate at 20℃; for 1h; Product distribution / selectivity;
With sulfuric acid In methanol; water at 20℃; for 1h; Product distribution / selectivity;
methanesulfonic acid
75-75-2

methanesulfonic acid

prasterone acetate
853-23-6

prasterone acetate

abiraterone acetate
154229-18-2

abiraterone acetate

abiraterone acetate mesylate

abiraterone acetate mesylate

Conditions
ConditionsYield
In tert-butyl methyl ether; ethyl acetate Product distribution / selectivity;41%
In tert-butyl methyl ether for 1 - 48h; Product distribution / selectivity;41%
In di-isopropyl ether for 1h; Product distribution / selectivity;37%
2,3-bis(4-methylbenzoic acid)succinic acid
1039646-91-7

2,3-bis(4-methylbenzoic acid)succinic acid

prasterone acetate
853-23-6

prasterone acetate

abiraterone acetate
154229-18-2

abiraterone acetate

C20H18O8*C26H33NO2

C20H18O8*C26H33NO2

Conditions
ConditionsYield
In tert-butyl methyl ether at 20℃; for 1h; Product distribution / selectivity;40%
In ethyl acetate at 20℃; for 1h; Product distribution / selectivity;20%
In methanol at 20℃; for 16h; Product distribution / selectivity;

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