KDMF is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, dev
Cas:154229-18-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryChemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k
Cas:154229-18-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,
Cas:154229-18-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryhigh quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:key intermediates Port:SHANGH
Cas:154229-18-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:154229-18-2
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiry1. guaranteed purity; 2. large quantity in stock; 3. largest manufacturer; 4. best service after shipment with email; 5. high quality & competitive price; Appearance:powder Storage:store in cool and dry P
Cas:154229-18-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:154229-18-2
Min.Order:1 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryAbiraterone[CAS:154229-19-3] Abiraterone Acetate[CAS:154229-18-2] Diethyl(3-pyridyl)borane[CAS:89878-14-8] 17-Iodoandrosta-5,16-dien-3beta-ol[CAS:32138-69-5] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation o
Cas:154229-18-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:154229-18-2
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:154229-18-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:154229-18-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryD - glucuronic acid and N - acetyl glucosamine disaccharides unit composed of hyaluronic acid (Hyaluronan), also called uronic acid, hyaluronic acid, basic structure is made up of two disaccharides unit D - glucuronic acid and N - acetyl glucosamin
Cas:154229-18-2
Min.Order:1000 Gram
FOB Price: $5000.0
Type:Trading Company
inquiryName:Abirateroneacetate The alias:Abiraterone Acotate;Abiraterone Acetate impurity; CAS NO:154229-18-2 Molecular formula:C26H33NO2 Molecular weight:391.55 Product Quality 12 years of chemical raw materials Mature operation of the industry
Cas:154229-18-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiry17-(3-pyridyl)-5,16-androstadien-3beta-acetate Basic information Product Name: 17-(3-pyridyl)-5,16-androstadien-3beta-acetate Synonyms: 17-(3-pyridyl)-5,16-androstadien-3beta-acetate
Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can
Cas:154229-18-2
Min.Order:1 Metric Ton
FOB Price: $5.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiryProuduct name: Abiraterone Acotate CAS: 154229-18-2 Appearance: white powder Purity: 99%min Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:drug used in castration-resistant prostate
Appearance:White powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:154229-18-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White to white crystalline powder Storage:Store in sealed co
Cas:154229-18-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed
Cas:154229-18-2
Min.Order:100 Gram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $400.0 / 600.0
Type:Trading Company
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:154229-18-2
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryProduct Name: Abiraterone acetate CAS: 154229-18-2 MF: C26H33NO2 MW: 391.55 EINECS: 620-314-7 Mol File: 154229-18-2.mol Abiraterone acetate Structure Abiraterone acetate Chemical Properties Melting point 127-130°C Boiling
Cas:154229-18-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:154229-18-2
Min.Order:1 Kilogram
FOB Price: $20.0 / 35.0
Type:Trading Company
inquiryBeluga chemical professional supply Abiraterone acetate 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exported to many co
Cas:154229-18-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:154229-18-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryabiraterone acetate
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride In acetonitrile | 97% |
With hydroxylamine hydrochloride In acetonitrile | 97% |
Conditions | Yield |
---|---|
With dmap In acetone at 20 - 65℃; for 1h; | 95.3% |
With pyridine; dmap; triethylamine at 0 - 20℃; for 5h; | 95% |
With pyridine In acetonitrile Reflux; Large scale; | 91.6% |
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
3-Diethylboranylpyridine
abiraterone acetate
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran at 65℃; for 4h; Reflux; | 95% |
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water for 1h; Reflux; | 95% |
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate In tetrahydrofuran; water at 60℃; for 1h; | 94% |
3-pyridylboronic acid
abiraterone acetate
Conditions | Yield |
---|---|
Stage #1: 3-pyridylboronic acid With [1,1-bis(di-tert-butylphosphino)ferrocene]palladium(II)dichloride; XPhos at 20℃; for 0.75h; Inert atmosphere; Stage #2: 17-iodoandrosta-5,16-dien-3β-ol 3-acetate With triethylamine at 40℃; for 10h; Reagent/catalyst; Temperature; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 5 - 20℃; for 0.5h; Reagent/catalyst; | 90% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In diethyl ether at 20℃; for 4h; | 85.1% |
With 2-(Dimethylamino)pyridine; triethylamine In diethyl ether; ethanol; hexane; water | 84% |
With triethylamine In ethyl acetate at 5 - 20℃; for 2h; | 83% |
Conditions | Yield |
---|---|
In diethyl ether at 0 - 20℃; for 18h; | 84.7% |
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
3-Diethylboranylpyridine
abiraterone acetate
Conditions | Yield |
---|---|
With sodium carbonate In tetrahydrofuran; bis(triphenylphosphine)palladium(II)-chloride | 84% |
abiraterone acetate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water for 2h; | 79.2% |
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
3-pyridylboronic acid
abiraterone acetate
Conditions | Yield |
---|---|
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry; Stage #2: 3-pyridylboronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry; | 79% |
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 80℃; for 1h; Suzuki Coupling; Inert atmosphere; | 73% |
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water at -5 - 5℃; Inert atmosphere; Reflux; | 4.5 g |
abiraterone acetate
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water at 20℃; for 1h; pH=> 10; | 76.4% |
3-Diethylboranylpyridine
abiraterone acetate
Conditions | Yield |
---|---|
With palladium on activated charcoal; potassium carbonate In ethanol at 60℃; for 3h; | 76.3% |
abiraterone acetate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water for 2h; | 75.2% |
3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
abiraterone acetate
Conditions | Yield |
---|---|
With palladium on activated charcoal; potassium hydrogencarbonate In ethanol at 100℃; for 6h; | 72.9% |
abiraterone acetate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water | 68.2% |
abiraterone-3-acetate esylate
abiraterone acetate
Conditions | Yield |
---|---|
With sodium acetate; pyrographite In methanol for 0.5h; | 68% |
3-Bromopyridine
3-acetyl-5-dehydroepiandrosterone p-toluenesulfonyl hydrazone
B
abiraterone acetate
Conditions | Yield |
---|---|
With dichloro bis(acetonitrile) palladium(II); caesium carbonate In 1,4-dioxane at 90℃; for 52h; Concentration; Reagent/catalyst; Temperature; Time; | A 42% B 15% |
acetic anhydride
abiraterone
A
abiraterone acetate
B
3β-Acetoxy-16-(3β-acetoxyandrosta-5,16-dien-17-yl)-17-(3-pyridyl)androsta-5,16-diene
Conditions | Yield |
---|---|
With pyridine for 24h; Ambient temperature; Yield given. Yields of byproduct given; |
dehydroepiandrosterone
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / NH2NH2*H2O, aq, NH2NH2*H2SO4 / ethanol / 120 h / Ambient temperature 2: 83 percent / I2, 1,1,3,3-tetramethylguanidine / tetrahydrofuran; diethyl ether / 1 h 3: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C 4: pyridine / 24 h / Ambient temperature View Scheme |
17-iodo-5,16-androstadien-3-ol
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C 2: pyridine / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water / 22 h / 70 - 75 °C 2: dmap / acetonitrile / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; methanol / 28 h / 65 - 70 °C 2: dmap / acetonitrile / 5 h / Reflux View Scheme |
dehydroepiandrosterone-17-hydrazone
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 83 percent / I2, 1,1,3,3-tetramethylguanidine / tetrahydrofuran; diethyl ether / 1 h 2: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C 3: pyridine / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: iodine / methanol; dichloromethane / 3 h / -10 - 5 °C 2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / methanol; tetrahydrofuran; water / 10 h / 60 - 65 °C 3: pyridine / 24 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 3 steps 1: iodine; N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / diethyl ether / 4 h / 20 °C View Scheme |
prasterone acetate
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 58 percent / 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 12 h 2: 84 percent / bis(triphenylphosphine)palladium(II) chloride, aq. Na2CO3 / tetrahydrofuran / 1 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate / dichloromethane / 4 h / -5 - 5 °C 2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 1 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 4 h / -80 - 0 °C 2.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 20 h / 20 - 70 °C / Reflux 2.2: 2 h / 0 °C 3.1: sodium hydrogencarbonate / water; dichloromethane View Scheme |
prasterone acetate
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
3-Diethylboranylpyridine
abiraterone acetate
Conditions | Yield |
---|---|
With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 80℃; for 5h; |
dehydroepiandrosterone
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 4 h / 20 - 25 °C 2: 2,6-dimethylpyridine / dichloromethane / 2 h / 20 °C 3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 65 - 67 °C / Reflux 4: sodium hydroxide / water; methanol / 70 - 75 °C 5: triethylamine; dmap / tetrahydrofuran / 24 h / 20 - 25 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 1H-imidazole / dichloromethane / 16 h / 20 °C 2.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C / Inert atmosphere 2.2: 17 h / -78 - 20 °C / Inert atmosphere 3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C 5.1: pyridine / 6 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 1H-imidazole / dichloromethane / 16 h / 20 °C 2.1: lithium chloride; zinc(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 2.2: 5 h / 0 °C / Inert atmosphere 3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C 5.1: pyridine / 6 h / 0 - 20 °C View Scheme |
3-Bromopyridine
3-acetyl-5-dehydroepiandrosterone p-toluenesulfonyl hydrazone
abiraterone acetate
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos for 4h; Inert atmosphere; Reflux; | |
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Inert atmosphere; Reflux; | |
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Reflux; Inert atmosphere; | |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In 1,4-dioxane at 110℃; for 5h; Concentration; Reagent/catalyst; Temperature; Time; Inert atmosphere; |
3β-formyl-oxy-5-androsten-17-one
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2,6-dimethylpyridine / dichloromethane / 2 h / 20 °C 2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 65 - 67 °C / Reflux 3: sodium hydroxide / water; methanol / 70 - 75 °C 4: triethylamine; dmap / tetrahydrofuran / 24 h / 20 - 25 °C View Scheme |
3β-formyloxyandrosta-5,16-diene-17-yl trifluoromethanesulphonate
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 65 - 67 °C / Reflux 2: sodium hydroxide / water; methanol / 70 - 75 °C 3: triethylamine; dmap / tetrahydrofuran / 24 h / 20 - 25 °C View Scheme |
pyridin-3-ylmagnesium bromide
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium chloride; zinc(II) chloride 2: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C 4: pyridine / 6 h / 0 - 20 °C View Scheme |
(3S)-3-tert-butyldimethylsilyloxyandrost-5-en-17-one
abiraterone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C / Inert atmosphere 1.2: 17 h / -78 - 20 °C / Inert atmosphere 2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C 4.1: pyridine / 6 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium chloride; zinc(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 1.2: 5 h / 0 °C / Inert atmosphere 2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C 4.1: pyridine / 6 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 30 °C 2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 6 h / 20 - 65 °C 3: hydrogenchloride / water; methanol / 1 h / 20 - 30 °C 4: dmap / acetone / 1 h / 20 - 65 °C View Scheme |
abiraterone acetate
abiraterone
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran; methanol; water for 1h; | 96% |
With sodium hydroxide In methanol at 20℃; for 2h; Reagent/catalyst; | 95.8% |
With potassium hydroxide In tetrahydrofuran; methanol at 30℃; for 1h; Inert atmosphere; | 94% |
ethanesulfonic acid
abiraterone acetate
abiraterone-3-acetate esylate
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 1 - 49℃; for 0.5h; Cooling with ice; | 85% |
abiraterone acetate
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane; isopropyl alcohol at 20℃; Temperature; Solvent; Reflux; | 85% |
abiraterone acetate
methyl iodide
Conditions | Yield |
---|---|
In acetonitrile at 90℃; for 16h; Inert atmosphere; | 84.5% |
trifluoromethylsulfonic anhydride
abiraterone acetate
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; 5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine; abiraterone acetate In dichloromethane at -50℃; for 1h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; for 0.333333 - 0.5h; Inert atmosphere; | 69% |
Conditions | Yield |
---|---|
Stage #1: abiraterone acetate With trifluoromethylsulfonic anhydride In chloroform at 20℃; for 1h; Inert atmosphere; Sealed tube; Stage #2: trimethylsilyl cyanide In chloroform at 60℃; for 3h; Inert atmosphere; Sealed tube; Stage #3: With 4-methyl-morpholine In chloroform at 60℃; for 17h; Inert atmosphere; Sealed tube; | A 67% B 2% C 4% |
trifluoromethylsulfonic anhydride
triphenylphosphine
abiraterone acetate
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; abiraterone acetate In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #2: triphenylphosphine In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; Inert atmosphere; regioselective reaction; | 67% |
trifluoromethylsulfonic anhydride
triphenylphosphine
abiraterone acetate
Conditions | Yield |
---|---|
at -78 - 20℃; Alkaline conditions; | 67% |
prasterone acetate
abiraterone acetate
(3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; tert-butyl methyl ether at 20℃; for 1h; Product distribution / selectivity; | 48% |
With hydrogenchloride In diethyl ether; ethyl acetate at 20℃; for 1h; Product distribution / selectivity; | 30% |
With hydrogenchloride In methanol; diethyl ether at 20℃; for 1h; Product distribution / selectivity; |
prasterone acetate
abiraterone acetate
abiraterone acetate sulphate
Conditions | Yield |
---|---|
With sulfuric acid In tert-butyl methyl ether; water at 20℃; for 1h; Product distribution / selectivity; | 48% |
With sulfuric acid In water; ethyl acetate at 20℃; for 1h; Product distribution / selectivity; | |
With sulfuric acid In methanol; water at 20℃; for 1h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In tert-butyl methyl ether; ethyl acetate Product distribution / selectivity; | 41% |
In tert-butyl methyl ether for 1 - 48h; Product distribution / selectivity; | 41% |
In di-isopropyl ether for 1h; Product distribution / selectivity; | 37% |
2,3-bis(4-methylbenzoic acid)succinic acid
prasterone acetate
abiraterone acetate
Conditions | Yield |
---|---|
In tert-butyl methyl ether at 20℃; for 1h; Product distribution / selectivity; | 40% |
In ethyl acetate at 20℃; for 1h; Product distribution / selectivity; | 20% |
In methanol at 20℃; for 16h; Product distribution / selectivity; |
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