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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Chloro-5-methoxypyrimidine Manufacturer/High quality/Best price/In stock

Cas:22536-65-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloro-5-Methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

2-Chloro-5-methoxypyrimidine manufacturer with low price

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:White or

2-Chloro-5-MethoxypyriMidine

Cas:22536-65-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Fair price CAS 22536-65-8 with fast shipping

Cas:22536-65-8

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry plac

2-Chloro-5-methoxypyrimidine CAS No.22536-65-8

Cas:22536-65-8

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pyrimidine,2-chloro-5-methoxy- 22536-65-8

Cas:22536-65-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Gram

FOB Price: $68.0 / 75.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-Chloro-5-methoxypyrimidine CAS:22536-65-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

2-Chloro-5-methoxypyrimidine CAS:22536-65-8

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pyrimidine,2-chloro-5-methoxy-

Cas:22536-65-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:22536-65-8

Cas:22536-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-5-Methoxypyrimidine

Cas:22536-65-8

Min.Order:0

Negotiable

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Chloro-5-Methoxypyrimidine

Cas:22536-65-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 22536-65-8 2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Chloro-5-methoxypyrimidine Basic information Product Name: 2-Chloro-5-methoxypyrimidine Synonyms: Pyrimidine, 2-chloro-5-methoxy- (8CI,9CI);2-Chloro-5-methoxypyrimidine;PyriMidine,2-chloro-5-Methoxy-;2-Chloro-5-MethoxypyriMidine 97%;2-Chloro

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

22536-65-8 CAS NO.22536-65-8

Cas:22536-65-8

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Nanjing Fred Technology Co.,Ltd.

Taizhou FredChem Co. Ltd. is a high-tech enterprise located in China Medical City specializing in R&D, manufacturing, sales of new APIS, pharmaceutical intermediates and fine chemicals. All of our company is committed to provide high quality ch

2-CHLORO-5-METHOXYPYRIMIDINE

Cas:22536-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-chloro-5-methoxy-pyrimidine

Cas:22536-65-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

2-chloro-5-methoxypyrimidine

Cas:22536-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Chloro-5-methoxypyrimidine cas no. 22536-65-8 98%

Cas:22536-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2,4-dichloro-5-methoxypyrimidine
19646-07-2

2,4-dichloro-5-methoxypyrimidine

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

Conditions
ConditionsYield
With water; zinc In ethanol for 4h; Reflux;58%
With zinc In ethanol; water for 4h; Reflux;58%
With acetic acid; zinc In ethanol Reflux; Large scale;50 g
5-Methoxypyrimidine-2,4(1H,3H)-dione
6623-81-0

5-Methoxypyrimidine-2,4(1H,3H)-dione

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / Reflux
2: zinc; water / ethanol / 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / Reflux
2: zinc / ethanol; water / 4 h / Reflux
View Scheme
2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2‐hydrazinyl‐5‐methoxypyrimidine
34712-29-3

2‐hydrazinyl‐5‐methoxypyrimidine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 60℃; for 24h;96%
2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-chloropyrimidine-5-ol
4983-28-2

2-chloropyrimidine-5-ol

Conditions
ConditionsYield
With hydrogen bromide; DL-methionine In acetic acid for 5h; Reflux;91%
Stage #1: 2-chloro-5-methoxy-pyrimidine With boron tribromide In dichloromethane at 20℃;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
62%
With boron tribromide In dichloromethane at 20℃; for 20h;61%
1-Methylpyrrolidine
120-94-5

1-Methylpyrrolidine

phthalimide
136918-14-4

phthalimide

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

C18H20N4O3

C18H20N4O3

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 160℃; for 12h;85%
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate
375853-82-0, 286961-14-6

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

tert-butyl 4-(5-methoxypyrimidin-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
1440954-81-3

tert-butyl 4-(5-methoxypyrimidin-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane at 140℃; for 0.25h; Microwave irradiation;83%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane at 140℃; for 0.25h; Microwave irradiation;83%
piperazine
110-85-0

piperazine

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

5-methoxy-2-(1-piperazinyl)pyrimidine
59215-39-3

5-methoxy-2-(1-piperazinyl)pyrimidine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; caesium carbonate In 1,4-dioxane at 100℃; for 0.666667h;78%
In isopropyl alcohol at 140℃; for 1h; Microwave irradiation;32%
(R)-3-((tert-butoxycarbonyl)amino)-4-(5-(4-hydroxyphenyl)-2H-tetrazol-2-yl)butyric acid tert-butyl ester

(R)-3-((tert-butoxycarbonyl)amino)-4-(5-(4-hydroxyphenyl)-2H-tetrazol-2-yl)butyric acid tert-butyl ester

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(5-(4-((5-methoxypyrimidin-2-yl)oxy)phenyl)-2H-tetrazol-2-yl)butanoate

tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(5-(4-((5-methoxypyrimidin-2-yl)oxy)phenyl)-2H-tetrazol-2-yl)butanoate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 90℃; for 3h;72%
1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

potassium phtalimide
1074-82-4

potassium phtalimide

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(2-(4-(5-methoxypyrimidin-2-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

2-(2-(4-(5-methoxypyrimidin-2-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 24h; Inert atmosphere;71%
4-methyl-2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

4-methyl-2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

4-methyl-2,6-bis(5-methoxypyrimidin-2-yl)aniline

4-methyl-2,6-bis(5-methoxypyrimidin-2-yl)aniline

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In water; acetonitrile at 100℃; for 16h; Inert atmosphere; Sealed tube;71%
N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamic acid 1,1-dimethylethyl ester
1095708-32-9

N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamic acid 1,1-dimethylethyl ester

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

4-(5-methoxypyrimidin-2-yl)pyridin-2-amine

4-(5-methoxypyrimidin-2-yl)pyridin-2-amine

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 140℃; for 0.833333h; Inert atmosphere; Microwave irradiation;70%
2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

allylmagnesium bromide
1730-25-2

allylmagnesium bromide

C8H9ClN2O

C8H9ClN2O

Conditions
ConditionsYield
Stage #1: 2-chloro-5-methoxy-pyrimidine; allylmagnesium bromide In tetrahydrofuran at 0 - 20℃; for 0.25h;
Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 0℃;
69%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

methyl 5-methoxypyrimidine-2-carboxylate
1415800-40-6

methyl 5-methoxypyrimidine-2-carboxylate

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine In N,N-dimethyl-formamide at 120℃; under 22502.3 Torr;57%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine In acetonitrile at 20 - 100℃; Inert atmosphere;52%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In acetonitrile at 100℃; for 18h; Autoclave;52%
2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

5-methoxypyrimidin-2-amine
13418-77-4

5-methoxypyrimidin-2-amine

Conditions
ConditionsYield
With ammonia In water at 150℃; for 3h; Irradiation;55%
With ammonium hydroxide at 100℃; for 18h; Sealed tube;45%
2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-bromo-5-hydroxypyrimidine

2-bromo-5-hydroxypyrimidine

Conditions
ConditionsYield
With boron tribromide In dichloromethane at -78 - 20℃;54%
2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
1609393-90-9

2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-methoxy-3-(5-methoxypyrimidin-2-yl)aniline

2-methoxy-3-(5-methoxypyrimidin-2-yl)aniline

Conditions
ConditionsYield
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 105℃; for 20h; Suzuki Coupling; Sealed tube; Inert atmosphere;54%
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide
150725-87-4

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

4-tert-butyl-N-{5-(3-methoxy-phenoxy)-6-[2-(5-methoxy-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide

4-tert-butyl-N-{5-(3-methoxy-phenoxy)-6-[2-(5-methoxy-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl acetamide at 20℃; for 48h;52%
ciprofloxacin
85721-33-1

ciprofloxacin

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

C22H22FN5O4

C22H22FN5O4

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 23h;51.4%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

C21H22FN5O4

C21H22FN5O4

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 24h;50.3%
(-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline
1354495-70-7

(-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

(-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol
1354494-79-3

(-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Conditions
ConditionsYield
Stage #1: (-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline; 2-chloro-5-methoxy-pyrimidine In 1,4-dioxane at 80℃; for 26.6h;
Stage #2: With hydrogenchloride In 1,4-dioxane; water at 50℃; for 8h;
Stage #3: With sodium hydrogencarbonate In 1,4-dioxane; water
45%
4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazole

4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazole

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-5-methoxypyrimidine

2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-5-methoxypyrimidine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 160℃; for 1h; Microwave irradiation;45%
With caesium carbonate In acetonitrile at 160℃; for 1.5h; Microwave irradiation;45%
4-benzyl-3-ethoxy-5-methyl-1H-pyrazole
1116655-96-9

4-benzyl-3-ethoxy-5-methyl-1H-pyrazole

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methoxypyrimidine

2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methoxypyrimidine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 160℃; for 1h; Microwave irradiation;44%
4-((4-bromo-2-fluorophenoxy)methyl)piperidine hydrochloride

4-((4-bromo-2-fluorophenoxy)methyl)piperidine hydrochloride

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(4-((4-bromo-2-fluorophenoxy)methyl)piperidin-1-yl)-5-methoxypyrimidine

2-(4-((4-bromo-2-fluorophenoxy)methyl)piperidin-1-yl)-5-methoxypyrimidine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 140℃; for 17h; Microwave irradiation;42%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 140℃; for 17h; Microwave irradiation;42%
sodium salt of ethyl cyanoacetate

sodium salt of ethyl cyanoacetate

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

ethyl 5-methoxypyrimidyl-2-cyanoacetate
65364-67-2

ethyl 5-methoxypyrimidyl-2-cyanoacetate

Conditions
ConditionsYield
at 90℃; for 1h;40%
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(4-chloro-phenyl)-5-methoxy-pyrimidine
1078166-55-8

2-(4-chloro-phenyl)-5-methoxy-pyrimidine

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 100℃; for 0.833333h; Suzuki Coupling;39.6%
clinafloxacin
105956-97-6

clinafloxacin

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

C22H21ClFN5O4

C22H21ClFN5O4

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 25h;36.3%
2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline
214360-73-3

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

4-(5-methoxypyrimidin-2-yl)aniline

4-(5-methoxypyrimidin-2-yl)aniline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 80℃; for 12h; Inert atmosphere;36%
bis(tri-n-butyltin)
813-19-4

bis(tri-n-butyltin)

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(tributylstannyl)-5-methoxypyrimidine
727388-71-8

2-(tributylstannyl)-5-methoxypyrimidine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In toluene Inert atmosphere; Reflux;35.8%
With tetrakis(triphenylphosphine) palladium(0) In toluene for 15h; Inert atmosphere; Reflux;
1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride
1104442-13-8

1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

4-(1-(5-methoxypyrimidin-2-yl)piperidin-4-yloxy)-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one
1104448-30-7

4-(1-(5-methoxypyrimidin-2-yl)piperidin-4-yloxy)-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In water; N,N-dimethyl-formamide at 100℃; for 0.166667h; Microwave irradiation; Inert atmosphere;35%
1-butyn-4-ol
927-74-2

1-butyn-4-ol

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(but-3-ynyloxy)-5-methoxypyrimidine

2-(but-3-ynyloxy)-5-methoxypyrimidine

Conditions
ConditionsYield
Stage #1: 3-Butyn-1-ol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2-chloro-5-methoxy-pyrimidine In tetrahydrofuran at 20℃; for 17h; Inert atmosphere;
32%
4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidine

4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidine

2-chloro-5-methoxy-pyrimidine
22536-65-8

2-chloro-5-methoxy-pyrimidine

2-(4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-5-methoxypyrimidine

2-(4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-5-methoxypyrimidine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile Reflux;31%
With N-ethyl-N,N-diisopropylamine In acetonitrile Reflux;31%

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