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inquiryBiggest and profoessional manufacturer of Norfloxacin 1. Molecular formula: C16H18FN3O3 2. Molecular weight: 319.33 3. Packing: 25kg/drum 4. Appearance: white to pale yellow crystalline powder 5. Melting range: 220℃ 6. Annual supply: 1000 tons
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inquiryItems Standard Result Appearance White to yellow crystalline powder Complies Identification (a)
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inquiryUnique advantages for Norfloxacin Cas 70458-96-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:A white to pale yellow crystalline powder Storage:Store in 2-8℃ Package
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inquiryName: Norfloxacin The alias:1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylica;Zoroxin; CAS NO:70458-96-7 EINECS NO:274-614-4 Molecular formula:C16H18FN3O3 Molecular weight:319.34 Product Quality 12 years of chemi
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inquiryCASNumber: 70458-96-7 Name: Norfloxacin MolecularStructure: 230)thi…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:Foil bag or drum Applicat
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inquiryName: Norfloxacin Synonyms: Norfloxacine; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid; 2-hydroxypropanoic acid; 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid CAS: 70458-96-7 MF: C16H18FN3O3
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Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
C16H17BF3N3O3
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide Heating; | 98% |
piperazine
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With aluminum tri-bromide In ethanol at 65℃; for 5h; Temperature; Solvent; Reagent/catalyst; | 91.7% |
In N,N-dimethyl-formamide at 100 - 130℃; for 2h; | 82.9% |
In ethanol at 120℃; for 0.583333h; Microwave irradiation; | 80% |
at 130 - 140℃; for 5h; | 66% |
In dimethyl sulfoxide at 140℃; |
piperazine
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With aluminum (III) chloride In i-Amyl alcohol at 140℃; for 8h; Solvent; Temperature; | 90.9% |
piperazine
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
A
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
B
7-chloro-1-ethyl-1,4-dihydro-4-oxo-6-(1-piperazinyl)quinoline-3-carboxylic acid
Conditions | Yield |
---|---|
In water for 16h; Heating; | A 85% B n/a |
In water at 150℃; for 5h; | A 50% B n/a |
In dimethylsulfoxide-d6 at 100℃; Rate constant; | |
In dimethylsulfoxide-d6 at 120 - 130℃; | A 80 % Spectr. B 20 % Spectr. |
ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetic acid | 84% |
With sodium hydroxide for 2h; Heating; Yield given; |
piperazine
6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In water for 8h; Reflux; | 84% |
With triethylamine In water for 5h; Substitution; Heating; | 79% |
1-Ethyl-6-fluoro-1,4-dihydro-7-<4-(cyanomethyl)-1-piperazinyl>-4-oxoquinoline-3-carboxylic acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In chloroform at 50℃; for 10h; | 83% |
piperazine
2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 125 - 130℃; Stage #2: piperazine With aluminum (III) chloride In ethanol at 85℃; for 8h; Reagent/catalyst; Temperature; Solvent; | 77.3% |
1-Ethyl-6-fluoro-1,4-dihydro-7-<4-<(ethoxycarbonyl)methyl>-1-piperazinyl>-4-oxoquinoline-3-carboxylic Acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In chloroform at 50℃; for 10h; | 77% |
Multi-step reaction with 2 steps 1: 470 mg / m-chloroperbenzoic acid (MCPBA) / CHCl3 / 3 h / 0 °C 2: 239 mg / CHCl3 / 1) r.t., 5 min, 2) 50 deg C, 6 h View Scheme |
piperazine
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
pyrographite
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With pyridine; sodium hydroxide In phosphorus pentaoxide; ethanol; water; acetic acid; N,N-dimethyl-formamide | 70% |
piperazine
1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In water for 10h; Substitution; Heating; | 69% |
7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h; | 68.9% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2-oxopropyl)-1-piperazinyl]-quinoline-3-carboxylic acid
A
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
B
1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In chloroform for 6h; Ambient temperature; | A 59% B 32% |
With 3-chloro-benzenecarboperoxoic acid In chloroform for 6h; Mechanism; Product distribution; Ambient temperature; other substrates; | A 59% B 32% |
piperazine
6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
N,N-dimethyl-formamide
A
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
B
1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: piperazine; 6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid With triethylamine In N,N-dimethyl-formamide for 10h; Substitution; Heating; Stage #2: N,N-dimethyl-formamide for 10h; Formylation; Heating; | A 55% B 32% |
1-ethyl-6-fluoro-1,4-dihydro-7-<4-(1-methyl-2-oxopropyl)-1-piperazinyl>-4-oxoquinoline-3-carboxylic acid
A
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
B
1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In chloroform for 12h; Ambient temperature; | A 52% B 27% |
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid 2-hexadecanoyloxy-1-hexadecanoyloxymethyl-ethyl ester
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With lipase at 37℃; for 10h; pH=1.2; Kinetics; Solvent; pH-value; Reagent/catalyst; aq. buffer; Enzymatic reaction; | 32% |
N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin
A
carbon dioxide
B
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
C
dimethylglyoxal
Conditions | Yield |
---|---|
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life 12 h; in AIJ :half-life 8.5 h); taken for complete hydrolysis in 40 percent mouse blood : 15 min;; |
N-(2-oxo-1,3-dioxol-4-yl)methyl NFLX
A
carbon dioxide
B
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
C
2-oxopropanal
Conditions | Yield |
---|---|
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life 0.7 h; in AIJ :half-life 1.5 h); taken for complete hydrolysis in 40 percent mouse blood : 10 min;; |
N-(4-oxo-2-hexen-3-yloxy)carbonyl NFLX
A
3,4-hexanedione
B
carbon dioxide
C
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life >20 h); taken for complete hydrolysis in 40 percent mouse blood : >200 min;; |
N-(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX
A
4,4-dimethyl-2,3-pentanedione
B
carbon dioxide
C
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life 18 h); taken for complete hydrolysis in 40 percent mouse blood : 120 min;; |
N-(5-phenyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX
A
carbon dioxide
B
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
C
1-Phenylpropane-1,2-dione
Conditions | Yield |
---|---|
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life >20 h); taken for complete hydrolysis in 40 percent mouse blood : 150 min;; |
N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
A
4,4-dimethyl-2,3-pentanedione
B
carbon dioxide
C
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life 18 h; in AIJ :half-life 11 h); taken for complete hydrolysis in 40 percent mouse blood : 20 min;; |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In chloroform Ambient temperature; |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In chloroform 1) r.t., 5 min, 2) 50 deg C, 6 h; | 239 mg |
piperazine
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide 1.) DMSO, 110 deg C, 2 h; 2.) reflux, 1 h; Yield given; |
C12H8BClF3NO3
A
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 98 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C 2: 98 percent / aq. NaOH / Heating View Scheme |
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
A
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / BF3*Et2O / diethyl ether; CH2Cl2 / Heating 2: 98 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C 3: 98 percent / aq. NaOH / Heating View Scheme |
3-chloro-4-fluorophenylamine
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 100 percent / 2 h / 120 - 130 °C 2: diphenyl ether / 1 h / Heating 3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 4: 90 percent / 2N NaOH / 2 h / Heating 5: 66 percent / 5 h / 130 - 140 °C View Scheme |
1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / 2N NaOH / 2 h / Heating 2: 66 percent / 5 h / 130 - 140 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / methanol; water / 2 h / Reflux 2: N,N-dimethyl-formamide / 2 h / 100 - 130 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide; water / ethanol / 2.5 h / Reflux 2: dimethyl sulfoxide / 140 °C View Scheme |
N-(4-(2-chloroacetamido)butyl)-2,3-diisopropoxybenzamide
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
C35H46FN5O7
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; potassium iodide In N,N-dimethyl-formamide at 20℃; for 36h; | 100% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; for 0.1h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 100% |
DBN
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 2h; | 100% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide | 99% |
ethyl bromoacetate
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-7-<4-<(ethoxycarbonyl)methyl>-1-piperazinyl>-4-oxoquinoline-3-carboxylic Acid
Conditions | Yield |
---|---|
Stage #1: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid With sodium ethanolate In ethanol for 0.0666667h; Microwave irradiation; Stage #2: ethyl bromoacetate for 0.25h; Reagent/catalyst; Time; Microwave irradiation; | 98% |
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; | 74% |
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 8h; Ambient temperature; | 61% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
A
formaldehyd
B
ammonia
C
6-fluoro-7-amino-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With potassium permanganate; cetyltrimethylammonim bromide; acetic acid In water; acetonitrile at 24.84℃; Kinetics; Catalytic behavior; Mechanism; Thermodynamic data; Activation energy; Temperature; Concentration; Solvent; UV-irradiation; | A n/a B n/a C 98% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With formaldehyd In dimethyl sulfoxide at 50℃; Microwave irradiation; | 98% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 50℃; for 0.0833333h; Temperature; Microwave irradiation; | 98% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Stage #1: formaldehyd; 1-ethyl-3-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-methyl-1,8-naphthyridin-4(1H)-one; 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid In dimethyl sulfoxide at 20℃; for 0.25h; Stage #2: With indium(III) chloride In dimethyl sulfoxide for 5h; Temperature; | 98% |
formaldehyd
{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,3,4-oxadiazole-2-thiol
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; for 0.0833333h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 98% |
2-(chloromethyl)-5-nitro-1H-benzo[d]imidazole
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 72h; | 98% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In ethanol; water Michael Addition; Reflux; | 98% |
4-(bromomethyl)benzyl alcohol
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid With potassium carbonate In water; acetonitrile at 20℃; for 0.0833333h; Stage #2: 4-(bromomethyl)benzyl alcohol In water; acetonitrile at 20℃; | 97.1% |
acetic anhydride
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine at 90 - 100℃; | 97% |
With acetic acid at 35℃; for 1h; | 69% |
for 5h; Heating; | |
With acetic acid at 35℃; for 1h; |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In neat (no solvent) for 0.0833333h; Solvent; Time; Reagent/catalyst; Mannich Aminomethylation; Microwave irradiation; Sealed tube; Green chemistry; | 97% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In neat (no solvent) at 50℃; for 0.333333h; Reagent/catalyst; Solvent; Time; Microwave irradiation; Sealed tube; | 97% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In neat (no solvent) for 0.25h; Solvent; Mannich Aminomethylation; Microwave irradiation; Green chemistry; | 97% |
formaldehyd
indole-2,3-dione
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With acetic acid In water for 2h; Mannich reaction; Heating; | 96% |
3-(bromoacetyl)coumarin oxime
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 22 - 25℃; for 12h; | 96% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In neat (no solvent) for 0.25h; Solvent; Mannich Aminomethylation; Microwave irradiation; Green chemistry; | 96% |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 0.333333h; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 96% |
formaldehyd
5-Bromo-1H-indole-2,3-dione
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With acetic acid In water for 2h; Mannich reaction; Heating; | 95.14% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
N,N-dimethyl-formamide
7-(4-formylpiperazin-1-yl)-1-ethyl-6-fluoroquinoline-4-one
Conditions | Yield |
---|---|
With potassium cyanide at 120℃; for 24h; | 95% |
4-bromophenylglyoxal
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With sulfur; sodium sulfide In N,N-dimethyl-formamide at 110℃; for 7h; Willgerodt-Kindler Rearrangement; | 95% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
N,N,N',N'-tetramethylguanidine
Conditions | Yield |
---|---|
In methanol at 20℃; for 3h; | 95% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Norfloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 1h; | 95% |
Multi-step reaction with 2 steps 1: sodium hydroxide / tetrahydrofuran / 20 °C 2: hydrogenchloride / ethanol; water / 3 h / Reflux View Scheme |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 0.333333h; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 95% |
di-tert-butyl dicarbonate
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 20℃; | 94.2% |
With triethylamine In dichloromethane at 20℃; for 2.5h; | |
With sodium hydroxide In tetrahydrofuran at 20℃; | 126 mg |
4-nitrophenylglyoxal
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With sulfur; sodium sulfide In N,N-dimethyl-formamide at 110℃; for 7h; Willgerodt-Kindler Rearrangement; | 94% |
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