Products

Refine

Country

Business Type

Certificate

Display

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

High Quality Norfloxacin 70458-96-7 Manufacturer

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Zhengzhou Yuanli Biological Technology Co., Ltd.

Biggest and profoessional manufacturer of Norfloxacin 1. Molecular formula: C16H18FN3O3 2. Molecular weight: 319.33 3. Packing: 25kg/drum 4. Appearance: white to pale yellow crystalline powder 5. Melting range: 220℃ 6. Annual supply: 1000 tons

Biggest manufacturer of Norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Norfloxacin Manufacturer/High quality/Best price/In stock

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Norfloxacin 70458-96-7

Cas:70458-96-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to yellow crystalline powder Complies Identification (a)

High purity 70458-96-7 Norfloxacin

Cas:70458-96-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Norfloxacin manufacturer with low price

Cas:70458-96-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Norfloxacin Cas 70458-96-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:A white to pale yellow crystalline powder Storage:Store in 2-8℃ Package

Factory low price Norfloxacin Cas 70458-96-7 with high quality in USP standard

Cas:70458-96-7

Min.Order:25 Kilogram

FOB Price: $38.0 / 40.0

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Popular goods 99% Norfloxacin hydrochloride/hcl powder CAS:70458-96-7

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $19.0 / 29.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Norfloxacin Lactate

Cas:70458-96-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Norfloxacin Lactate Injection 70458-96-7 GMP Manufacturer

Cas:70458-96-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Norfloxacin

Cas:70458-96-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Norfloxacin

Cas:70458-96-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Name: Norfloxacin The alias:1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylica;Zoroxin; CAS NO:70458-96-7 EINECS NO:274-614-4 Molecular formula:C16H18FN3O3 Molecular weight:319.34 Product Quality 12 years of chemi

Norfloxacin /CAS:70458-96-7/with best price

Cas:70458-96-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Kono Chem Co.,Ltd

CASNumber: 70458-96-7 Name: Norfloxacin MolecularStructure: 230)thi…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:Foil bag or drum Applicat

Norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $400.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Norfloxacin

Cas:70458-96-7

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM -Norfloxacin

Cas:70458-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 70458-96-7 with best quality

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Norfloxacin 4803P MK-0366 Zoroxin China supply high purity

Cas:70458-96-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Norfloxacin Synonyms: Norfloxacine; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid; 2-hydroxypropanoic acid; 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid CAS: 70458-96-7 MF: C16H18FN3O3

Norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1.Good capacity; 2.Safe deliver 3. High quality with best price Appearance:White Powder Storage:Dry and cool place Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Application:For Pharmaceutical Intermediates Transportation:By DHL, TNT

API Manufacturer Norfloxacin Manufacturer 70458-96-7 Anti-infectives

Cas:70458-96-7

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Pharmaceutical Intermediate Norfloxacin HCl Norfloxacin for Broad-Spectrum Antibacterial

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Norfloxacin 70458-96-7

Cas:70458-96-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Norfloxacin Quinolones

Cas:70458-96-7

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Norfloxacin CAS:70458-96-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Norfloxacin CAS:70458-96-7

Cas:70458-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Norfloxacin

Cas:70458-96-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:70458-96-7

Cas:70458-96-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C16H17BF3N3O3
94498-83-6

C16H17BF3N3O3

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide Heating;98%
piperazine
110-85-0

piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With aluminum tri-bromide In ethanol at 65℃; for 5h; Temperature; Solvent; Reagent/catalyst;91.7%
In N,N-dimethyl-formamide at 100 - 130℃; for 2h;82.9%
In ethanol at 120℃; for 0.583333h; Microwave irradiation;80%
at 130 - 140℃; for 5h;66%
In dimethyl sulfoxide at 140℃;
1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid sodium salt

1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid sodium salt

piperazine
110-85-0

piperazine

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With aluminum (III) chloride In i-Amyl alcohol at 140℃; for 8h; Solvent; Temperature;90.9%
piperazine
110-85-0

piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

A

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

B

7-chloro-1-ethyl-1,4-dihydro-4-oxo-6-(1-piperazinyl)quinoline-3-carboxylic acid
75001-78-4

7-chloro-1-ethyl-1,4-dihydro-4-oxo-6-(1-piperazinyl)quinoline-3-carboxylic acid

Conditions
ConditionsYield
In water for 16h; Heating;A 85%
B n/a
In water at 150℃; for 5h;A 50%
B n/a
In dimethylsulfoxide-d6 at 100℃; Rate constant;
In dimethylsulfoxide-d6 at 120 - 130℃;A 80 % Spectr.
B 20 % Spectr.
ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate
74011-47-5

ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In water; acetic acid84%
With sodium hydroxide for 2h; Heating; Yield given;
piperazine
110-85-0

piperazine

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
70032-25-6

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With triethylamine In water for 8h; Reflux;84%
With triethylamine In water for 5h; Substitution; Heating;79%
1-Ethyl-6-fluoro-1,4-dihydro-7-<4-(cyanomethyl)-1-piperazinyl>-4-oxoquinoline-3-carboxylic acid
99726-81-5

1-Ethyl-6-fluoro-1,4-dihydro-7-<4-(cyanomethyl)-1-piperazinyl>-4-oxoquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In chloroform at 50℃; for 10h;83%
piperazine
110-85-0

piperazine

2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester
106648-05-9

2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 125 - 130℃;
Stage #2: piperazine With aluminum (III) chloride In ethanol at 85℃; for 8h; Reagent/catalyst; Temperature; Solvent;
77.3%
1-Ethyl-6-fluoro-1,4-dihydro-7-<4-<(ethoxycarbonyl)methyl>-1-piperazinyl>-4-oxoquinoline-3-carboxylic Acid
118476-20-3

1-Ethyl-6-fluoro-1,4-dihydro-7-<4-<(ethoxycarbonyl)methyl>-1-piperazinyl>-4-oxoquinoline-3-carboxylic Acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In chloroform at 50℃; for 10h;77%
Multi-step reaction with 2 steps
1: 470 mg / m-chloroperbenzoic acid (MCPBA) / CHCl3 / 3 h / 0 °C
2: 239 mg / CHCl3 / 1) r.t., 5 min, 2) 50 deg C, 6 h
View Scheme
piperazine
110-85-0

piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

pyrographite
7440-44-0

pyrographite

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With pyridine; sodium hydroxide In phosphorus pentaoxide; ethanol; water; acetic acid; N,N-dimethyl-formamide70%
piperazine
110-85-0

piperazine

1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester
100505-08-6

1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With triethylamine In water for 10h; Substitution; Heating;69%
7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
127142-90-9

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h;68.9%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2-oxopropyl)-1-piperazinyl]-quinoline-3-carboxylic acid
103175-73-1

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2-oxopropyl)-1-piperazinyl]-quinoline-3-carboxylic acid

A

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

B

1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
70459-04-0

1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In chloroform for 6h; Ambient temperature;A 59%
B 32%
With 3-chloro-benzenecarboperoxoic acid In chloroform for 6h; Mechanism; Product distribution; Ambient temperature; other substrates;A 59%
B 32%
piperazine
110-85-0

piperazine

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
70032-25-6

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

A

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

B

1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
70459-04-0

1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: piperazine; 6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid With triethylamine In N,N-dimethyl-formamide for 10h; Substitution; Heating;
Stage #2: N,N-dimethyl-formamide for 10h; Formylation; Heating;
A 55%
B 32%
1-ethyl-6-fluoro-1,4-dihydro-7-<4-(1-methyl-2-oxopropyl)-1-piperazinyl>-4-oxoquinoline-3-carboxylic acid
103258-03-3

1-ethyl-6-fluoro-1,4-dihydro-7-<4-(1-methyl-2-oxopropyl)-1-piperazinyl>-4-oxoquinoline-3-carboxylic acid

A

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

B

1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
70459-04-0

1-ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In chloroform for 12h; Ambient temperature;A 52%
B 27%
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid 2-hexadecanoyloxy-1-hexadecanoyloxymethyl-ethyl ester
1369320-98-8

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid 2-hexadecanoyloxy-1-hexadecanoyloxymethyl-ethyl ester

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With lipase at 37℃; for 10h; pH=1.2; Kinetics; Solvent; pH-value; Reagent/catalyst; aq. buffer; Enzymatic reaction;32%
N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin
85195-76-2

N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin

A

carbon dioxide
124-38-9

carbon dioxide

B

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C

dimethylglyoxal
431-03-8

dimethylglyoxal

Conditions
ConditionsYield
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life 12 h; in AIJ :half-life 8.5 h); taken for complete hydrolysis in 40 percent mouse blood : 15 min;;
N-(2-oxo-1,3-dioxol-4-yl)methyl NFLX
105439-96-1

N-(2-oxo-1,3-dioxol-4-yl)methyl NFLX

A

carbon dioxide
124-38-9

carbon dioxide

B

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C

2-oxopropanal
78-98-8

2-oxopropanal

Conditions
ConditionsYield
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life 0.7 h; in AIJ :half-life 1.5 h); taken for complete hydrolysis in 40 percent mouse blood : 10 min;;
N-(4-oxo-2-hexen-3-yloxy)carbonyl NFLX
105439-98-3

N-(4-oxo-2-hexen-3-yloxy)carbonyl NFLX

A

3,4-hexanedione
4437-51-8

3,4-hexanedione

B

carbon dioxide
124-38-9

carbon dioxide

C

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life >20 h); taken for complete hydrolysis in 40 percent mouse blood : >200 min;;
N-(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX
86761-10-6

N-(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX

A

4,4-dimethyl-2,3-pentanedione
40898-19-9

4,4-dimethyl-2,3-pentanedione

B

carbon dioxide
124-38-9

carbon dioxide

C

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life 18 h); taken for complete hydrolysis in 40 percent mouse blood : 120 min;;
N-(5-phenyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX
105439-97-2

N-(5-phenyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX

A

carbon dioxide
124-38-9

carbon dioxide

B

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C

1-Phenylpropane-1,2-dione
579-07-7

1-Phenylpropane-1,2-dione

Conditions
ConditionsYield
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life >20 h); taken for complete hydrolysis in 40 percent mouse blood : 150 min;;
N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
105440-03-7

N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

A

4,4-dimethyl-2,3-pentanedione
40898-19-9

4,4-dimethyl-2,3-pentanedione

B

carbon dioxide
124-38-9

carbon dioxide

C

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
In potassium hydroxide for 0.166667h; Ambient temperature; hydrolyses (in AGJ :half-life 18 h; in AIJ :half-life 11 h); taken for complete hydrolysis in 40 percent mouse blood : 20 min;;
1-Ethyl-6-fluoro-4-oxo-7-[4-(2-oxo-propyl)-4-oxy-piperazin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid

1-Ethyl-6-fluoro-4-oxo-7-[4-(2-oxo-propyl)-4-oxy-piperazin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
In chloroform Ambient temperature;
7-(4-Ethoxycarbonylmethyl-4-oxy-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-(4-Ethoxycarbonylmethyl-4-oxy-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
In chloroform 1) r.t., 5 min, 2) 50 deg C, 6 h;239 mg
piperazine
110-85-0

piperazine

C16H14BClFNO7

C16H14BClFNO7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide 1.) DMSO, 110 deg C, 2 h; 2.) reflux, 1 h; Yield given;
C12H8BClF3NO3
94498-82-5

C12H8BClF3NO3

A

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

B

p-methyl-ω-haloacetophenone

p-methyl-ω-haloacetophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C
2: 98 percent / aq. NaOH / Heating
View Scheme
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

A

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

B

p-methyl-ω-haloacetophenone

p-methyl-ω-haloacetophenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / BF3*Et2O / diethyl ether; CH2Cl2 / Heating
2: 98 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C
3: 98 percent / aq. NaOH / Heating
View Scheme
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
4: 90 percent / 2N NaOH / 2 h / Heating
5: 66 percent / 5 h / 130 - 140 °C
View Scheme
1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
70458-94-5

1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / 2N NaOH / 2 h / Heating
2: 66 percent / 5 h / 130 - 140 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / methanol; water / 2 h / Reflux
2: N,N-dimethyl-formamide / 2 h / 100 - 130 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide; water / ethanol / 2.5 h / Reflux
2: dimethyl sulfoxide / 140 °C
View Scheme
N-(4-(2-chloroacetamido)butyl)-2,3-diisopropoxybenzamide
1416579-55-9

N-(4-(2-chloroacetamido)butyl)-2,3-diisopropoxybenzamide

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C35H46FN5O7
1416579-56-0

C35H46FN5O7

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium iodide In N,N-dimethyl-formamide at 20℃; for 36h;100%
formaldehyd
50-00-0

formaldehyd

5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-thiol

5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-thiol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C38H43FN8O4S

C38H43FN8O4S

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 0.1h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube;100%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C16H18FN3O3*C7H12N2

C16H18FN3O3*C7H12N2

Conditions
ConditionsYield
In methanol; water at 20℃; for 2h;100%
C57H55N5O10

C57H55N5O10

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C67H68FN7O10

C67H68FN7O10

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide99%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-Ethyl-6-fluoro-1,4-dihydro-7-<4-<(ethoxycarbonyl)methyl>-1-piperazinyl>-4-oxoquinoline-3-carboxylic Acid
118476-20-3

1-Ethyl-6-fluoro-1,4-dihydro-7-<4-<(ethoxycarbonyl)methyl>-1-piperazinyl>-4-oxoquinoline-3-carboxylic Acid

Conditions
ConditionsYield
Stage #1: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid With sodium ethanolate In ethanol for 0.0666667h; Microwave irradiation;
Stage #2: ethyl bromoacetate for 0.25h; Reagent/catalyst; Time; Microwave irradiation;
98%
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 20℃;74%
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 8h; Ambient temperature;61%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

A

formaldehyd
50-00-0

formaldehyd

B

ammonia
7664-41-7

ammonia

C

6-fluoro-7-amino-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
75001-63-7

6-fluoro-7-amino-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
With potassium permanganate; cetyltrimethylammonim bromide; acetic acid In water; acetonitrile at 24.84℃; Kinetics; Catalytic behavior; Mechanism; Thermodynamic data; Activation energy; Temperature; Concentration; Solvent; UV-irradiation;A n/a
B n/a
C 98%
3-(4-benzyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one

3-(4-benzyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

6-(4-{[4-benzyl-3-(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl)-1-ethyl-5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

6-(4-{[4-benzyl-3-(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl)-1-ethyl-5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
With formaldehyd In dimethyl sulfoxide at 50℃; Microwave irradiation;98%
formaldehyd
50-00-0

formaldehyd

3-(4-benzyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one

3-(4-benzyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

6-(4-{[4-benzyl-3-(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl)-1-ethyl-5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

6-(4-{[4-benzyl-3-(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl)-1-ethyl-5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
In dimethyl sulfoxide at 50℃; for 0.0833333h; Temperature; Microwave irradiation;98%
formaldehyd
50-00-0

formaldehyd

1-ethyl-3-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-methyl-1,8-naphthyridin-4(1H)-one

1-ethyl-3-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-methyl-1,8-naphthyridin-4(1H)-one

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-(4-{[4-ethyl-3-(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl)-5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-(4-{[4-ethyl-3-(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl)-5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: formaldehyd; 1-ethyl-3-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-methyl-1,8-naphthyridin-4(1H)-one; 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid In dimethyl sulfoxide at 20℃; for 0.25h;
Stage #2: With indium(III) chloride In dimethyl sulfoxide for 5h; Temperature;
98%
formaldehyd
50-00-0

formaldehyd

{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,3,4-oxadiazole-2-thiol
1456620-74-8

{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,3,4-oxadiazole-2-thiol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-(4-{[5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-2-thioxo-1,3,4-oxadiazole-3(2H)-yl]methyl}piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-(4-{[5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-2-thioxo-1,3,4-oxadiazole-3(2H)-yl]methyl}piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 0.0833333h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube;98%
2-(chloromethyl)-5-nitro-1H-benzo[d]imidazole
14625-39-9

2-(chloromethyl)-5-nitro-1H-benzo[d]imidazole

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-7-(4-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-7-(4-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 72h;98%
4-chloro-6-[1-(vinylsulfonyl)pyrrolidin-2-yl]benzene-1,3-diol

4-chloro-6-[1-(vinylsulfonyl)pyrrolidin-2-yl]benzene-1,3-diol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C28H32ClFN4O7S

C28H32ClFN4O7S

Conditions
ConditionsYield
With triethylamine In ethanol; water Michael Addition; Reflux;98%
4-(bromomethyl)benzyl alcohol
71831-21-5

4-(bromomethyl)benzyl alcohol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-(4-(4-(hydroxymethyl)benzyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-(4-(4-(hydroxymethyl)benzyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid With potassium carbonate In water; acetonitrile at 20℃; for 0.0833333h;
Stage #2: 4-(bromomethyl)benzyl alcohol In water; acetonitrile at 20℃;
97.1%
acetic anhydride
108-24-7

acetic anhydride

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
74011-56-6

7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Conditions
ConditionsYield
With triethylamine at 90 - 100℃;97%
With acetic acid at 35℃; for 1h;69%
for 5h; Heating;
With acetic acid at 35℃; for 1h;
formaldehyd
50-00-0

formaldehyd

5-{[(3-fluoro-4-thiomorpholin-4-ylphenyl)amino]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

5-{[(3-fluoro-4-thiomorpholin-4-ylphenyl)amino]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-{4-[(3-{[(3-fluoro-4-thiomorpholin-4-ylphenyl)amino]methyl}-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)methyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-{4-[(3-{[(3-fluoro-4-thiomorpholin-4-ylphenyl)amino]methyl}-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)methyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In neat (no solvent) for 0.0833333h; Solvent; Time; Reagent/catalyst; Mannich Aminomethylation; Microwave irradiation; Sealed tube; Green chemistry;97%
formaldehyd
50-00-0

formaldehyd

5-[({3-fluoro-4-[4-(4-fluorophenyl)piperazin-1-yl]phenyl}amino)methyl]-1,3,4-oxadiazole-2(3H)-thione

5-[({3-fluoro-4-[4-(4-fluorophenyl)piperazin-1-yl]phenyl}amino)methyl]-1,3,4-oxadiazole-2(3H)-thione

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-(4-{[5-[({3-fluoro-4-[4-(4-fluorophenyl)piperazin-1-yl]phenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-(4-{[5-[({3-fluoro-4-[4-(4-fluorophenyl)piperazin-1-yl]phenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In neat (no solvent) at 50℃; for 0.333333h; Reagent/catalyst; Solvent; Time; Microwave irradiation; Sealed tube;97%
formaldehyd
50-00-0

formaldehyd

5-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-ethyl-4H-1,2,4-triazole-3-thiol

5-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-ethyl-4H-1,2,4-triazole-3-thiol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-{4-[(3-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-1-yl)methyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-{4-[(3-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-1-yl)methyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
In neat (no solvent) for 0.25h; Solvent; Mannich Aminomethylation; Microwave irradiation; Green chemistry;97%
formaldehyd
50-00-0

formaldehyd

indole-2,3-dione
91-56-5

indole-2,3-dione

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

7-[4-(2,3-dioxo-2,3-dihydro-indol-1-ylmethyl)-piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-[4-(2,3-dioxo-2,3-dihydro-indol-1-ylmethyl)-piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
With acetic acid In water for 2h; Mannich reaction; Heating;96%
3-(bromoacetyl)coumarin oxime
176720-62-0

3-(bromoacetyl)coumarin oxime

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

C27H25FN4O6

C27H25FN4O6

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 22 - 25℃; for 12h;96%
formaldehyd
50-00-0

formaldehyd

5-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-one

5-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-one

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-{4-[(3-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-benzyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl)methyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-{4-[(3-{[4-(4-nitrophenyl)piperazin-1-yl]methyl}-4-benzyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl)methyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
In neat (no solvent) for 0.25h; Solvent; Mannich Aminomethylation; Microwave irradiation; Green chemistry;96%
formaldehyd
50-00-0

formaldehyd

4-(4-fluorophenyl)-5-[(4-phenylpiperazin-1-yl)methyl]-4H-1,2,4-triazol-3-thiol

4-(4-fluorophenyl)-5-[(4-phenylpiperazin-1-yl)methyl]-4H-1,2,4-triazol-3-thiol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-[4-({4-fluorophenyl-3-[(4-phenylpiperazin-1-yl)methyl]-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)piperazin-1-yl]-1,4-dihydroquinolin-3-carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-[4-({4-fluorophenyl-3-[(4-phenylpiperazin-1-yl)methyl]-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)piperazin-1-yl]-1,4-dihydroquinolin-3-carboxylic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.333333h; Mannich Aminomethylation; Microwave irradiation; Sealed tube;96%
formaldehyd
50-00-0

formaldehyd

5-Bromo-1H-indole-2,3-dione
87-48-9

5-Bromo-1H-indole-2,3-dione

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

7-[4-(5-bromo-2,3-dioxo-2,3-dihydro-indol-1-ylmethyl)-piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-[4-(5-bromo-2,3-dioxo-2,3-dihydro-indol-1-ylmethyl)-piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
With acetic acid In water for 2h; Mannich reaction; Heating;95.14%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

7-(4-formylpiperazin-1-yl)-1-ethyl-6-fluoroquinoline-4-one
959774-07-3

7-(4-formylpiperazin-1-yl)-1-ethyl-6-fluoroquinoline-4-one

Conditions
ConditionsYield
With potassium cyanide at 120℃; for 24h;95%
4-bromophenylglyoxal
5195-29-9

4-bromophenylglyoxal

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

7-(4-(2-(4-bromophenyl)-2-oxoethanethioyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-(4-(2-(4-bromophenyl)-2-oxoethanethioyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
With sulfur; sodium sulfide In N,N-dimethyl-formamide at 110℃; for 7h; Willgerodt-Kindler Rearrangement;95%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

N,N,N',N'-tetramethylguanidine
80-70-6

N,N,N',N'-tetramethylguanidine

C16H18FN3O3*C5H13N3

C16H18FN3O3*C5H13N3

Conditions
ConditionsYield
In methanol at 20℃; for 3h;95%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Norfloxacin hydrochloride
68077-27-0

Norfloxacin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 1h;95%
Multi-step reaction with 2 steps
1: sodium hydroxide / tetrahydrofuran / 20 °C
2: hydrogenchloride / ethanol; water / 3 h / Reflux
View Scheme
formaldehyd
50-00-0

formaldehyd

4-ethyl-5-[(4-phenylpiperazin-1-yl)methyl]-4H-1,2,4-triazol-3-thiol

4-ethyl-5-[(4-phenylpiperazin-1-yl)methyl]-4H-1,2,4-triazol-3-thiol

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-[4-({4-ethyl-3-[(4-phenylpiperazin-1-yl)methyl]-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)piperazin-1-yl]-1,4-dihydroquinolin-3-carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-[4-({4-ethyl-3-[(4-phenylpiperazin-1-yl)methyl]-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)piperazin-1-yl]-1,4-dihydroquinolin-3-carboxylic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.333333h; Mannich Aminomethylation; Microwave irradiation; Sealed tube;95%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
127142-90-9

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃;94.2%
With triethylamine In dichloromethane at 20℃; for 2.5h;
With sodium hydroxide In tetrahydrofuran at 20℃;126 mg
4-nitrophenylglyoxal
4974-57-6

4-nitrophenylglyoxal

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

1-ethyl-6-fluoro-7-(4-(2-(4-nitrophenyl)-2-oxoethanethioyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-(4-(2-(4-nitrophenyl)-2-oxoethanethioyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
With sulfur; sodium sulfide In N,N-dimethyl-formamide at 110℃; for 7h; Willgerodt-Kindler Rearrangement;94%
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View