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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryItems Standard Result Appearance White or off-white solid White solid Assay,HPLC 99%min
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/506.html Product Name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to yellow powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermedia
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inquiry4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS No.:327-78-6 Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Molecular Structure Molecular Formula: C8H3ClF3NO
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
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inquiryName: 4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE CAS NO: 327-78-6 Grade:Medical chemicals and exports Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulner
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inquiryProduct Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Synonyms: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate,98%;Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-;4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 98% 5GR;4-chloro-a,a,a-trifl
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:327-78-6
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inquiry4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS:327-78-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Application:Pharmaceutical intermediate Port:Chinese main port
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inquiry4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS:327-78-6 Specification Items Specification Product name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS# 327-78-6
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
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inquiry4-Chloro-3-(trifluoromethyl)phenyl isocyanate is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to off-white solid Storage:Room temperature, Keep in Dark Place. Package:Accordi
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirybis(trichloromethyl) carbonate
4-chloro-3-trifluoromethyl-aniline
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 100% |
In ethyl acetate at 80℃; for 1h; | 99.2% |
In ethyl acetate at -5 - 80℃; for 3h; Solvent; | 95% |
4-chloro-3-trifluoromethyl-aniline
trichloromethyl chloroformate
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In benzene for 12h; Product distribution / selectivity; Reflux; | |
for 12h; Reflux; | |
In benzene for 12h; Reflux; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic anhydride; nitric acid / 3 h / 10 - 12 °C 2: iron(III) chloride hexahydrate; hydrazine hydrate / ethanol / 3 h / Reflux 3: dmap / 1,2-dichloro-ethane / -5 - 5 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid; nitric acid / water / 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique 2: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique View Scheme |
4-chloro-3-trifluoromethyl-aniline
1,1'-carbonyldiimidazole
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane at 50℃; for 16h; |
4-chloro-3-(trifluoromethyl)nitrobenzene
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique View Scheme |
2-aminomethyl-3-(4-fluoro-phenyl)-3H-quinazolin-4-one
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(4-chloro-3-trifluoromethylphenyl)-3-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylmethyl]urea
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 100% |
In chloroform | 98% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
3-aminophenylboronic acid pinacolate
1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea
Conditions | Yield |
---|---|
In dichloromethane | 100% |
In dichloromethane for 0.333333h; |
4-(4-amino-3-(trifluoromethyl)phenoxy)-3-nitropyridin-2-amine
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(4-(2-amino-3-nitropyridin-4-yloxy)-2-(trifluoromethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
Conditions | Yield |
---|---|
at 20℃; for 20h; Inert atmosphere; | 99% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 99% |
In tetrahydrofuran at 20℃; | 49% |
1H-imidazole
4-chloro-3-(trifluoromethyl)phenyl isocyanate
N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
Conditions | Yield |
---|---|
In chloroform at 0 - 20℃; for 2h; | 98% |
7-(4-amino-2-methoxyphenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-3-methoxyphenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 14h; | 98% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 16h; Inert atmosphere; | 98% |
3-bromobenzylamine hydrochloride
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(3-bromo-benzyl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 0 - 20℃; for 3h; | 97.8% |
3-nitrobenzylamine hydrochloride
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(4-chloro-3-trifluoromethyl-phenyl)-3-(3-nitro-benzyl)-urea
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 2h; | 97% |
1,2-benzisothiazolin-3-one
4-chloro-3-(trifluoromethyl)phenyl isocyanate
N-[4-chloro-3-(trifluoromethyl)phenyl]benzisothiazol-3-one-2-amide
Conditions | Yield |
---|---|
In tetrahydrofuran; dichloromethane for 0.5h; Reflux; | 97% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 3h; | 96.5% |
3-(4-pyridinyloxy)benzylamine
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(4-chloro-3-trifluoromethylphenyl)-3-[3-(4-pyridinyloxy)benzyl]urea
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; | 96% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)phenyl isocyanate
sorafenib
Conditions | Yield |
---|---|
With zirconia grinding balls In acetonitrile for 4h; Milling; | 96% |
In ethyl acetate at 20 - 30℃; Large scale; | 94.2% |
In dichloromethane | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
toluene-4-sulfonic acid
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In ethyl acetate at 40 - 71℃; for 0.5h; Stage #2: toluene-4-sulfonic acid In water; ethyl acetate at 71℃; for 0.666667h; Product distribution / selectivity; | 96% |
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In butanone at 20 - 85℃; Stage #2: toluene-4-sulfonic acid In butanone at 20℃; | 88% |
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In tetrahydrofuran at 25 - 64℃; for 0.5h; Stage #2: toluene-4-sulfonic acid In tetrahydrofuran at 64℃; Product distribution / selectivity; | 81.6% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
tert-butyl 4-(3-methoxy-4-(1H-pyrazol-4-yl)benzoyl)-3-phenylpiperazine-1-carboxylate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 96% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
3-methyl-piperazine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 96% |
Conditions | Yield |
---|---|
In Triethylene glycol dimethyl ether at 180℃; for 1h; | 96% |
In Triethylene glycol dimethyl ether at 180℃; for 1h; | 96% |
In Triethylene glycol dimethyl ether at 20 - 180℃; for 1h; Sealed tube; Green chemistry; | 70% |
4-nitro-aniline
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-nitrophenyl)urea
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 24h; | 96% |
In dichloromethane at 20℃; for 48h; | 90% |
In dichloromethane at 20℃; for 24h; | 73% |
In tetrahydrofuran at 20℃; for 2h; |
4-(4-aminophenoxy)-2-pyridine-(N-(methyl-d3))carboxamide
4-chloro-3-(trifluoromethyl)phenyl isocyanate
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea
Conditions | Yield |
---|---|
In dichloromethane; dimethyl sulfoxide at 20℃; for 0.333333h; Inert atmosphere; | 95.4% |
In dichloromethane; dimethyl sulfoxide at 20℃; for 0.333333h; Inert atmosphere; | 95.4% |
In dichloromethane; dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Large scale; | 95.4% |
C18H18N2O2S
4-chloro-3-(trifluoromethyl)phenyl isocyanate
N-[(+/-)-1-phenylethyl]-{6-[3-(4-chloro-3-(trifluoromethyl)phenyl)urea]naphthalen-2-yl}sulfonamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 20℃; for 0.2h; Inert atmosphere; | 95.4% |
methyl 4‐(4‐aminophenoxy)picolinate
4-chloro-3-(trifluoromethyl)phenyl isocyanate
methyl 4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinate
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; Inert atmosphere; | 95% |
In dichloromethane at 0 - 20℃; for 22h; | 85% |
In dichloromethane at 20℃; for 2h; | 76% |
In dichloromethane at 0 - 20℃; | 5.9 g |
4-amino-phenol
4-chloro-3-(trifluoromethyl)phenyl isocyanate
4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 3h; | 95% |
In acetonitrile | 95% |
In dichloromethane at 20℃; for 16h; | 94% |
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
4-chloro-3-(trifluoromethyl)phenyl isocyanate
regorafenib
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 1.5h; | 94.5% |
In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; | 90% |
In dichloromethane for 24h; | 87% |
Conditions | Yield |
---|---|
Multistep reaction.; | 94% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1h; | 94% |
4-(4-amino-3-(methylthio)phenoxy)-3-nitropyridin-2-amine
4-chloro-3-(trifluoromethyl)phenyl isocyanate
1-[4-(2-amino-3-nitropyridin-4-yloxy)-2-(methylthio)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea
Conditions | Yield |
---|---|
at 20℃; for 20h; Inert atmosphere; | 93% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 12h; | 93% |
In tetrahydrofuran at 20℃; | 93% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; | 93% |
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; Cooling with ice; | 93% |
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