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Jiangsu Huaen Energy Co., Ltd.

Talent Advantages: The Company features strong technical strength, possesses an efficient and cohesive management team, and enthusiastic and creative talents. The whole team has excellent execution ability, faces the market competition with firm be

O-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Chlorobenzotrifluoride Manufacturer/High quality/Best price/In stock

Cas:88-16-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chlorobenzotrifluoride supplier in China

Cas:88-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-chlorobenzotrifluoride

Cas:88-16-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: 4-Chlorobenzotrifluoride Synonyms: 1-(Trifluoromethyl)-4-chlorobenzene;1-chloro-4-(trifluoromethyl)-benzen;1-chloro-4-(trimethyl)benzene;alpha,alpha,alpha-trifluoro-4-chlorotoluene;Benzene,1-chloro-4-(trifluoromethyl)-;para-chloro-al

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:88-16-4

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo

BEST PRICE/2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

O-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:Clear colourless to light yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Interme

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

2-Chlorobenzotrifluoride Chemical Properties Melting point -7.4 °C Boiling point 152 °C(lit.) density 1.379 g/mL at 25 °C(l

88-16-4 2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

CAS:88-16-4 EINECS:201-805-1 MW:180.55 MF:C7H4ClF3 Melting point:-7.4 °C Boiling point:152 °C(lit.) Appearance:colorless liquid Package:200kg/Steel drum Transportation:by sea Port:Shanghai

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-Chlorobenzoytifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

Capability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti

2-Chlorobenzoytifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

1-Chloro-2-(trifluoroMethyl)benzene

Cas:88-16-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

Product Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard

factory supply CAS 88-16-4 with competitive price

Cas:88-16-4

Min.Order:1 Kilogram

FOB Price: $112.0

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

88-16-4 2-Chlorobenzotrifluoride Application:88-16-4 2-Chlorobenzotrifluoride

88-16-4 2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an

O-Chlorobenzotrifluoride manufacture

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

88-16-4 2-ChlorobenzotrifluorideAppearance:powder Storage:room tempurature Package:As required Application:medical Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL/FCL for la

88-16-4 2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-Chlorobenzotrifluoride 88-16-4

Cas:88-16-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

2-Chlorobenzotrifluoride

Cas:88-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Amadis Chemical offer CAS#88-16-4;CAT#A842487

Cas:88-16-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-iodochlorobenzene
615-41-8

2-iodochlorobenzene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide at 60 - 70℃; for 6h;84%
1,1'-dichloro-2,2'-difluoroethene
79-35-6

1,1'-dichloro-2,2'-difluoroethene

o-trifluoromethylphenyl bromide
392-83-6

o-trifluoromethylphenyl bromide

A

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

B

1-(2,2-dichloro-1-fluoroethenyl)-2-(trifluoromethyl)benzene
88444-77-3

1-(2,2-dichloro-1-fluoroethenyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With n-butyllithium In diethyl ether for 1h; Heating;A 3%
B 77%
1-Chloro-2-(ethylsulfanyl-difluoro-methyl)-benzene
160911-81-9

1-Chloro-2-(ethylsulfanyl-difluoro-methyl)-benzene

A

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

B

1-Chloro-2-(chloro-difluoro-methyl)-benzene
115345-92-1

1-Chloro-2-(chloro-difluoro-methyl)-benzene

Conditions
ConditionsYield
With bromine trifluoride In trichlorofluoromethane at 0℃;A 70%
B 5%
With bromine trifluoride; trichlorofluoromethane at 0℃;A 70%
B 5%
2-Chloro-dithiobenzoic acid ethyl ester
160911-76-2

2-Chloro-dithiobenzoic acid ethyl ester

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With bromine trifluoride In trichlorofluoromethane at 0℃; for 0.0333333h;70%
Multi-step reaction with 2 steps
1: BrF3 / CCl3F / 0 °C
2: 70 percent / BrF3, CFCl3 / 0 °C
View Scheme
2-iodochlorobenzene
615-41-8

2-iodochlorobenzene

sodium 2,2,2-trifluoroacetate
2923-18-4

sodium 2,2,2-trifluoroacetate

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium fluoride; potassium phosphate In water; N,N-dimethyl-formamide at 20℃; for 48h; Irradiation; Inert atmosphere;63%
With 1-methyl-pyrrolidin-2-one; copper(l) iodide at 160℃; for 4h;87 % Chromat.
With copper; silver(l) oxide In N,N-dimethyl-formamide at 130℃; for 15h; Inert atmosphere;70 %Spectr.
2-bromo-1-chlorobenzene
694-80-4

2-bromo-1-chlorobenzene

sodium 2,2,2-trifluoroacetate
2923-18-4

sodium 2,2,2-trifluoroacetate

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium fluoride; potassium phosphate In water; N,N-dimethyl-formamide at 20℃; for 48h; Irradiation; Inert atmosphere;39%
morpholine
110-91-8

morpholine

2,4-dichloro-benzotrifluoride
320-60-5

2,4-dichloro-benzotrifluoride

A

4-(3-chloro-4-trifluoromethylphenyl)morpholine

4-(3-chloro-4-trifluoromethylphenyl)morpholine

B

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

C

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With Adipic acid; N'-phenyloxalyl bishydrazide; copper diacetate; sodium acetate; cetyltrimethylammonim bromide; 2,5-hexanedione; potassium hydroxide In water at 110℃; for 3h; Inert atmosphere;A 5%
B n/a
C n/a
2-chlorobenzotrichloride
2136-89-2

2-chlorobenzotrichloride

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With hydrogen fluoride; antimonypentachloride
With antimony(III) fluoride
With hydrogen fluoride at 50℃; under 7500.75 Torr; for 1h; Autoclave;
With antimony (V)-fluoride chloride; phosphorus pentachloride; hydrogen fluoride
With hydrogen fluoride at 82℃; under 1500.15 - 13501.4 Torr; for 0.5h; Pressure; Temperature;
2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl;
2,3,5-trichlorotrifluoromethylbenzene
61841-46-1

2,3,5-trichlorotrifluoromethylbenzene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With Dichloromethylsilane at 240℃; (electron irradiation);
para-dichlorobenzene
106-46-7

para-dichlorobenzene

A

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

B

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

C

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

D

1,2,4-Trichlorobenzene
120-82-1

1,2,4-Trichlorobenzene

Conditions
ConditionsYield
With α,α,α-trifluorotoluene; chlorine; iron(III) chloride In tetrachloromethane Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
With α,α,α-trifluorotoluene; chlorine; iron(III) chloride In tetrachloromethane Product distribution; Rate constant;
α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

A

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

B

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

C

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With chlorine; iron(III) chloride at 80℃; Product distribution;A n/a
B 40.0 % Chromat.
C 3.9 % Chromat.
α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

A

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

B

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

C

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

D

1,2,4-Trichlorobenzene
120-82-1

1,2,4-Trichlorobenzene

Conditions
ConditionsYield
With para-dichlorobenzene; chlorine; iron(III) chloride In tetrachloromethane Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
With para-dichlorobenzene; chlorine; iron(III) chloride In tetrachloromethane Product distribution; Rate constant;
iodotrifluoromethane
2314-97-8

iodotrifluoromethane

chlorobenzene
108-90-7

chlorobenzene

A

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

B

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

C

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
at 190℃; for 48h; Title compound not separated from byproducts;A 23 % Chromat.
B 25 % Chromat.
C 52 % Chromat.
bis(trifluoroacetyl)peroxide
383-73-3

bis(trifluoroacetyl)peroxide

chlorobenzene
108-90-7

chlorobenzene

A

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

B

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

C

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
In 1,1,2-Trichloro-1,2,2-trifluoroethane at 70℃; Yield given. Yields of byproduct given;
o-trifluoromethyl-α,α-dichlorotoluene
707-72-2

o-trifluoromethyl-α,α-dichlorotoluene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With chlorine Irradiation;
bis(trifluoromethyl)tellurium
55642-42-7

bis(trifluoromethyl)tellurium

chlorobenzene
108-90-7

chlorobenzene

A

trifluoromethan
75-46-7

trifluoromethan

B

bis(trifluoromethyl) ditelluride
1718-20-3

bis(trifluoromethyl) ditelluride

C

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

D

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

E

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

F

tellur

tellur

Conditions
ConditionsYield
for 168h; Product distribution; Irradiation;
bis(trifluoromethyl)tellurium
55642-42-7

bis(trifluoromethyl)tellurium

chlorobenzene
108-90-7

chlorobenzene

A

trifluoromethan
75-46-7

trifluoromethan

B

bis(trifluoromethyl) ditelluride
1718-20-3

bis(trifluoromethyl) ditelluride

C

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

D

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

E

3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

F

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

G

tellur

tellur

Conditions
ConditionsYield
at 168℃; for 120h; Product distribution;
2-chloro-thiobenzoic acid S-ethyl ester
32357-19-0

2-chloro-thiobenzoic acid S-ethyl ester

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 6H4P(S)S>2
2: BrF3 / CCl3F / 0 °C
3: 70 percent / BrF3, CFCl3 / 0 °C
View Scheme
ortho-chlorobenzoic acid
118-91-2

ortho-chlorobenzoic acid

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1) SO2Cl
2: 6H4P(S)S>2
3: BrF3 / CCl3F / 0 °C
4: 70 percent / BrF3, CFCl3 / 0 °C
View Scheme
2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 160 - 190 °C / Einleiten von Chlor
2: SbF3
View Scheme
2-nitrobenzotrifluoride
384-22-5

2-nitrobenzotrifluoride

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl
View Scheme
N-acetyl-3-trifluoromethylbenzenamine
351-36-0

N-acetyl-3-trifluoromethylbenzenamine

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / und Erwaermen des Reaktionsprodukts mit aethanol.Natronlauge
2: ethanol; concentrated H2SO4 / 0 - 10 °C / Erwaermen der Reaktionsloesung mit Kupferbronze
3: palladium / Hydrogenation
4: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl
View Scheme
4-nitro-3-(trifluoromethyl)benzeneamine
393-11-3

4-nitro-3-(trifluoromethyl)benzeneamine

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol; concentrated H2SO4 / 0 - 10 °C / Erwaermen der Reaktionsloesung mit Kupferbronze
2: palladium / Hydrogenation
3: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl
View Scheme
o-dichloromethyltrichloromethylbenzene
2741-57-3

o-dichloromethyltrichloromethylbenzene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HF
2: Cl2 / Irradiation
View Scheme
2-chlorobenzotrichloride
2136-89-2

2-chlorobenzotrichloride

A

C7H4Cl3F
1258790-97-4

C7H4Cl3F

B

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

C

1-Chloro-2-(chloro-difluoro-methyl)-benzene
115345-92-1

1-Chloro-2-(chloro-difluoro-methyl)-benzene

Conditions
ConditionsYield
With hydrogen fluoride; antimonypentachloride at 50℃; under 7500.75 Torr; for 1h; Autoclave;
2-chlorobenzotrichloride
2136-89-2

2-chlorobenzotrichloride

A

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

B

1-Chloro-2-(chloro-difluoro-methyl)-benzene
115345-92-1

1-Chloro-2-(chloro-difluoro-methyl)-benzene

Conditions
ConditionsYield
With hydrogen fluoride at 50℃; under 7500.75 Torr; for 1h; Autoclave;
2-iodochlorobenzene
615-41-8

2-iodochlorobenzene

(1,10-phenanthroline)(trifluoromethyl)copper (I)

(1,10-phenanthroline)(trifluoromethyl)copper (I)

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;89 %Spectr.
Acetanilid
103-84-4

Acetanilid

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: palladium diacetate; copper diacetate; Trimethylacetic acid / 1,2-dichloro-ethane / 24 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry
2.1: thionyl chloride / methanol / 1.5 h / 75 °C
3.1: sodium nitrite; hydrogenchloride / water / 0 - 5 °C
3.2: 3 h / 0 - 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 1 h / 120 °C / Sealed tube; Inert atmosphere
2.1: copper diacetate; Trimethylacetic acid / 1,2-dichloro-ethane / 12 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube
3.1: thionyl chloride / methanol / 1.5 h / 75 °C
4.1: sodium nitrite; hydrogenchloride / water / 0 - 5 °C
4.2: 3 h / 0 - 60 °C
View Scheme
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

phenylacetylene
536-74-3

phenylacetylene

1-(phenylethynyl)-2-(trifluoromethyl)benzene
147344-86-3

1-(phenylethynyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In ethanol; water at 90℃; for 5h; Sonogashira Cross-Coupling; Green chemistry;100%
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane In N,N-dimethyl-formamide at 140℃; for 20h; Sonogashira cross-coupling;92%
methoxybenzene
100-66-3

methoxybenzene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

(4-methoxyphenyl)-(2-chlorophenyl)-dichloromethane

(4-methoxyphenyl)-(2-chlorophenyl)-dichloromethane

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 3h;100%
1H-imidazole
288-32-4

1H-imidazole

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

1-(2-trifluoromethylphenyl)-imidazole

1-(2-trifluoromethylphenyl)-imidazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 7h;97%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

4-chloro-3-(trifluoromethyl)nitrobenzene
777-37-7

4-chloro-3-(trifluoromethyl)nitrobenzene

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 25℃;96.13%
With sulfuric acid; nitric acid at 20 - 45℃; for 4h;91.3%
With sulfuric acid; nitric acid at 45℃; for 4h;91.3%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

benzene
71-43-2

benzene

1-chloro-2-(dichloro(phenyl)methyl)benzene
3509-85-1

1-chloro-2-(dichloro(phenyl)methyl)benzene

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h;96%
1-(4-fluorophenyl)propan-1-one
456-03-1

1-(4-fluorophenyl)propan-1-one

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

C16H12F4O

C16H12F4O

Conditions
ConditionsYield
With C41H50ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; Reagent/catalyst; Inert atmosphere;96%
styrene
292638-84-7

styrene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

C15H11F3
928030-90-4

C15H11F3

Conditions
ConditionsYield
With potassium carbonate In ethanol; water at 90℃; for 15h; Heck Reaction; Green chemistry;95%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

L-prolinamide
7531-52-4

L-prolinamide

(S)-N'-((2-trifluoromethyl)phenyl)prolinylamide
403478-68-2

(S)-N'-((2-trifluoromethyl)phenyl)prolinylamide

Conditions
ConditionsYield
With 4-diphenylphosphino-13-dicyclohexylphosphino-[2.2]paracyclophane; water; palladium diacetate; caesium carbonate In 1,4-dioxane at 125℃; for 24h; Buchwald-Hartwig coupling;94%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

ethyl acrylate
140-88-5

ethyl acrylate

ethyl 2-trifluoromethylcinnamate
50620-98-9

ethyl 2-trifluoromethylcinnamate

Conditions
ConditionsYield
With potassium carbonate In ethanol; water; N,N-dimethyl-formamide at 100℃; for 5h; Heck Reaction; Green chemistry;94%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

chlorobenzene
108-90-7

chlorobenzene

dichloro-(2-chloro-phenyl)-(4-chloro-phenyl)-methane

dichloro-(2-chloro-phenyl)-(4-chloro-phenyl)-methane

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h;92%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

2-(methylthio)-1-(trifluoromethyl)benzene
322-58-7

2-(methylthio)-1-(trifluoromethyl)benzene

Conditions
ConditionsYield
With N,N-dimethyl-formamide at 40 - 50℃; for 20h;92%
bromobenzene
108-86-1

bromobenzene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

2-chloro-4'-bromo-diphenyldichloromethane

2-chloro-4'-bromo-diphenyldichloromethane

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h;91%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

phenylboronic acid
98-80-6

phenylboronic acid

2-trifluoromethyl-biphenyl
362-59-4

2-trifluoromethyl-biphenyl

Conditions
ConditionsYield
With potassium carbonate; 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole; palladium diacetate In toluene at 100℃; Suzuki coupling;91%
With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydroxide In 1-methyl-pyrrolidin-2-one; dichloromethane; water at 130℃; for 12h; Suzuki coupling;78%
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); Tedicyp In xylene at 130℃; for 20h; Suzuki reaction;100 % Chromat.
magnesium
7439-95-4

magnesium

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

2-trifluoromethylphenylmagnesium chloride
3796-19-8

2-trifluoromethylphenylmagnesium chloride

Conditions
ConditionsYield
With ethyl bromide; tert-butylmagnesium chloride In tetrahydrofuran at 35 - 50℃; for 3h; Product distribution / selectivity;91%
5,5-dimethyl-1,3,2-dioxaborinane
668987-38-0

5,5-dimethyl-1,3,2-dioxaborinane

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

5,5-dimethyl-2-(2-(trifluoromethyl)phenyl)-1,3,2-dioxaborinane
95753-22-3

5,5-dimethyl-2-(2-(trifluoromethyl)phenyl)-1,3,2-dioxaborinane

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); triethylamine; zinc In toluene at 100℃; for 4h; Inert atmosphere;91%
With 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); triethylamine In toluene at 23 - 100℃; Inert atmosphere;52%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

o-trifluoromethylbenzenethiol
13333-97-6

o-trifluoromethylbenzenethiol

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 110℃; for 20h; Inert atmosphere;91%
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 90℃; for 20h; Reagent/catalyst; Inert atmosphere;91%
naphthalene
91-20-3

naphthalene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

1-[Dichloro-(2-chloro-phenyl)-methyl]-naphthalene

1-[Dichloro-(2-chloro-phenyl)-methyl]-naphthalene

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h;90%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

2',4-dichloro-3-(trifluoromethyl)benzophenone
1313994-80-7

2',4-dichloro-3-(trifluoromethyl)benzophenone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid Inert atmosphere; neat (no solvent);90%
bis(1,5-cyclooctadiene)nickel (0)
1295-35-8

bis(1,5-cyclooctadiene)nickel (0)

N,N,N,N,-tetramethylethylenediamine
110-18-9

N,N,N,N,-tetramethylethylenediamine

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

(TMEDA)Ni(Cl)(o-CF3Ph)

(TMEDA)Ni(Cl)(o-CF3Ph)

Conditions
ConditionsYield
at 20℃; for 72h; Glovebox; Inert atmosphere;90%
styrene
292638-84-7

styrene

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

2-styryl-α,α,α-trifluorotoluene
191867-92-2

2-styryl-α,α,α-trifluorotoluene

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium acetate; C84H60N12O8Pd4 at 140℃; for 6h; Heck Reaction; Inert atmosphere; Schlenk technique;89%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-[2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1073339-21-5

2-[2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In tetrahydrofuran at 100℃; for 12h; Inert atmosphere;88%
With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; Sealed tube;88%
tri(allyl)phenylsilane
2633-57-0

tri(allyl)phenylsilane

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

2-trifluoromethyl-biphenyl
362-59-4

2-trifluoromethyl-biphenyl

Conditions
ConditionsYield
Stage #1: triallyl(phenyl)silane With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 1h;
Stage #2: 1-chloro-2-(trifluoromethyl)benzene With XPhos; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran; water at 80℃; for 3h;
86%
Stage #1: triallyl(phenyl)silane With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 1h;
Stage #2: 1-chloro-2-(trifluoromethyl)benzene With XPhos; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran; water at 80℃; for 3h;
86%
furan
110-00-9

furan

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

1,4-epoxy-1,4-dihydro-5-(trifluoromethyl)-naphthalene
853017-48-8

1,4-epoxy-1,4-dihydro-5-(trifluoromethyl)-naphthalene

Conditions
ConditionsYield
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: furan In tetrahydrofuran; hexane at 25℃;
86%
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; hexane at -75℃; for 1h;
Stage #2: furan In tetrahydrofuran; hexane at 25℃;
76%
pyrrolidine
123-75-1

pyrrolidine

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

1-(2-trifluoromethyl-phenyl)pyrrolidine
893086-73-2

1-(2-trifluoromethyl-phenyl)pyrrolidine

Conditions
ConditionsYield
With polymethylhydrosiloxane; sodium t-butanolate; bis(acetylacetonate)nickel(II) In 1,2-dimethoxyethane; toluene at 130℃; for 18h;85%
acetic anhydride
108-24-7

acetic anhydride

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

1-(2-(trifluoromethyl)phenyl)ethan-1-one
17408-14-9

1-(2-(trifluoromethyl)phenyl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With ethyl bromide; ethylmagnesium bromide; magnesium; lithium chloride In tetrahydrofuran at 45 - 50℃; for 4h; Inert atmosphere;
Stage #2: acetic anhydride In tetrahydrofuran at 20 - 30℃; for 2h; Reagent/catalyst; Inert atmosphere; Further stages;
82.7%
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With ethylmagnesium bromide; magnesium; lithium chloride In tetrahydrofuran; ethyl bromide at 45 - 50℃; for 5h; Inert atmosphere;
Stage #2: acetic anhydride In tetrahydrofuran; ethyl bromide; toluene at 20 - 30℃; for 2h; Inert atmosphere;
72.4%
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

1-chloro-2-(tribromomethyl)benzene

1-chloro-2-(tribromomethyl)benzene

Conditions
ConditionsYield
With aluminum tri-bromide; trimethylsilyl bromide at 80℃; Inert atmosphere;82%
With carbon disulfide; aluminum tri-bromide
phenyl trimethylsiloxane
2996-92-1

phenyl trimethylsiloxane

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

2-trifluoromethyl-biphenyl
362-59-4

2-trifluoromethyl-biphenyl

Conditions
ConditionsYield
With tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate at 80℃; for 3h; Hiyama coupling; Inert atmosphere; Neat (no solvent);82%
4-(trimethylsilyl)morpholine
13368-42-8

4-(trimethylsilyl)morpholine

1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

4-(3-(trifluoromethyl)-2-(trimethylsilyl)phenyl)morpholine

4-(3-(trifluoromethyl)-2-(trimethylsilyl)phenyl)morpholine

Conditions
ConditionsYield
With lithium di-1-admantylamide In diethyl ether; cyclohexane at 50℃; for 28h; Inert atmosphere;81%
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