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inquiryProduct Name: 4-Chlorobenzotrifluoride Synonyms: 1-(Trifluoromethyl)-4-chlorobenzene;1-chloro-4-(trifluoromethyl)-benzen;1-chloro-4-(trimethyl)benzene;alpha,alpha,alpha-trifluoro-4-chlorotoluene;Benzene,1-chloro-4-(trifluoromethyl)-;para-chloro-al
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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2-Chlorobenzotrifluoride Chemical Properties Melting point -7.4 °C Boiling point 152 °C(lit.) density 1.379 g/mL at 25 °C(l
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inquiryCAS:88-16-4 EINECS:201-805-1 MW:180.55 MF:C7H4ClF3 Melting point:-7.4 °C Boiling point:152 °C(lit.) Appearance:colorless liquid Package:200kg/Steel drum Transportation:by sea Port:Shanghai
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SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryCapability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti
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Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
Product Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard
Cas:88-16-4
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
88-16-4 2-Chlorobenzotrifluoride Application:88-16-4 2-Chlorobenzotrifluoride
Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
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inquiryConditions | Yield |
---|---|
In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide at 60 - 70℃; for 6h; | 84% |
1,1'-dichloro-2,2'-difluoroethene
o-trifluoromethylphenyl bromide
A
1-chloro-2-(trifluoromethyl)benzene
B
1-(2,2-dichloro-1-fluoroethenyl)-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With n-butyllithium In diethyl ether for 1h; Heating; | A 3% B 77% |
1-Chloro-2-(ethylsulfanyl-difluoro-methyl)-benzene
A
1-chloro-2-(trifluoromethyl)benzene
B
1-Chloro-2-(chloro-difluoro-methyl)-benzene
Conditions | Yield |
---|---|
With bromine trifluoride In trichlorofluoromethane at 0℃; | A 70% B 5% |
With bromine trifluoride; trichlorofluoromethane at 0℃; | A 70% B 5% |
2-Chloro-dithiobenzoic acid ethyl ester
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With bromine trifluoride In trichlorofluoromethane at 0℃; for 0.0333333h; | 70% |
Multi-step reaction with 2 steps 1: BrF3 / CCl3F / 0 °C 2: 70 percent / BrF3, CFCl3 / 0 °C View Scheme |
2-iodochlorobenzene
sodium 2,2,2-trifluoroacetate
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With potassium fluoride; potassium phosphate In water; N,N-dimethyl-formamide at 20℃; for 48h; Irradiation; Inert atmosphere; | 63% |
With 1-methyl-pyrrolidin-2-one; copper(l) iodide at 160℃; for 4h; | 87 % Chromat. |
With copper; silver(l) oxide In N,N-dimethyl-formamide at 130℃; for 15h; Inert atmosphere; | 70 %Spectr. |
2-bromo-1-chlorobenzene
sodium 2,2,2-trifluoroacetate
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With potassium fluoride; potassium phosphate In water; N,N-dimethyl-formamide at 20℃; for 48h; Irradiation; Inert atmosphere; | 39% |
morpholine
2,4-dichloro-benzotrifluoride
B
4-chlorobenzotrifluoride
C
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With Adipic acid; N'-phenyloxalyl bishydrazide; copper diacetate; sodium acetate; cetyltrimethylammonim bromide; 2,5-hexanedione; potassium hydroxide In water at 110℃; for 3h; Inert atmosphere; | A 5% B n/a C n/a |
Conditions | Yield |
---|---|
With hydrogen fluoride; antimonypentachloride | |
With antimony(III) fluoride | |
With hydrogen fluoride at 50℃; under 7500.75 Torr; for 1h; Autoclave; | |
With antimony (V)-fluoride chloride; phosphorus pentachloride; hydrogen fluoride | |
With hydrogen fluoride at 82℃; under 1500.15 - 13501.4 Torr; for 0.5h; Pressure; Temperature; |
Conditions | Yield |
---|---|
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl; |
2,3,5-trichlorotrifluoromethylbenzene
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With Dichloromethylsilane at 240℃; (electron irradiation); |
para-dichlorobenzene
A
4-chlorobenzotrifluoride
B
3-chlorotrifluoromethylbenzene
C
1-chloro-2-(trifluoromethyl)benzene
D
1,2,4-Trichlorobenzene
Conditions | Yield |
---|---|
With α,α,α-trifluorotoluene; chlorine; iron(III) chloride In tetrachloromethane Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; | |
With α,α,α-trifluorotoluene; chlorine; iron(III) chloride In tetrachloromethane Product distribution; Rate constant; |
α,α,α-trifluorotoluene
A
4-chlorobenzotrifluoride
B
3-chlorotrifluoromethylbenzene
C
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With chlorine; iron(III) chloride at 80℃; Product distribution; | A n/a B 40.0 % Chromat. C 3.9 % Chromat. |
α,α,α-trifluorotoluene
A
4-chlorobenzotrifluoride
B
3-chlorotrifluoromethylbenzene
C
1-chloro-2-(trifluoromethyl)benzene
D
1,2,4-Trichlorobenzene
Conditions | Yield |
---|---|
With para-dichlorobenzene; chlorine; iron(III) chloride In tetrachloromethane Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; | |
With para-dichlorobenzene; chlorine; iron(III) chloride In tetrachloromethane Product distribution; Rate constant; |
iodotrifluoromethane
chlorobenzene
A
4-chlorobenzotrifluoride
B
3-chlorotrifluoromethylbenzene
C
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
at 190℃; for 48h; Title compound not separated from byproducts; | A 23 % Chromat. B 25 % Chromat. C 52 % Chromat. |
bis(trifluoroacetyl)peroxide
chlorobenzene
A
4-chlorobenzotrifluoride
B
3-chlorotrifluoromethylbenzene
C
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
In 1,1,2-Trichloro-1,2,2-trifluoroethane at 70℃; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With chlorine Irradiation; |
bis(trifluoromethyl)tellurium
chlorobenzene
A
trifluoromethan
B
bis(trifluoromethyl) ditelluride
C
4-chlorobenzotrifluoride
D
3-chlorotrifluoromethylbenzene
E
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
for 168h; Product distribution; Irradiation; |
bis(trifluoromethyl)tellurium
chlorobenzene
A
trifluoromethan
B
bis(trifluoromethyl) ditelluride
C
α,α,α-trifluorotoluene
D
4-chlorobenzotrifluoride
E
3-chlorotrifluoromethylbenzene
F
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
at 168℃; for 120h; Product distribution; |
2-chloro-thiobenzoic acid S-ethyl ester
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 6H4P(S)S>2 2: BrF3 / CCl3F / 0 °C 3: 70 percent / BrF3, CFCl3 / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1) SO2Cl 2: 6H4P(S)S>2 3: BrF3 / CCl3F / 0 °C 4: 70 percent / BrF3, CFCl3 / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 160 - 190 °C / Einleiten von Chlor 2: SbF3 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium / Hydrogenation 2: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid; nitric acid / und Erwaermen des Reaktionsprodukts mit aethanol.Natronlauge 2: ethanol; concentrated H2SO4 / 0 - 10 °C / Erwaermen der Reaktionsloesung mit Kupferbronze 3: palladium / Hydrogenation 4: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol; concentrated H2SO4 / 0 - 10 °C / Erwaermen der Reaktionsloesung mit Kupferbronze 2: palladium / Hydrogenation 3: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HF 2: Cl2 / Irradiation View Scheme |
2-chlorobenzotrichloride
A
C7H4Cl3F
B
1-chloro-2-(trifluoromethyl)benzene
C
1-Chloro-2-(chloro-difluoro-methyl)-benzene
Conditions | Yield |
---|---|
With hydrogen fluoride; antimonypentachloride at 50℃; under 7500.75 Torr; for 1h; Autoclave; |
2-chlorobenzotrichloride
A
1-chloro-2-(trifluoromethyl)benzene
B
1-Chloro-2-(chloro-difluoro-methyl)-benzene
Conditions | Yield |
---|---|
With hydrogen fluoride at 50℃; under 7500.75 Torr; for 1h; Autoclave; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere; | 89 %Spectr. |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: palladium diacetate; copper diacetate; Trimethylacetic acid / 1,2-dichloro-ethane / 24 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry 2.1: thionyl chloride / methanol / 1.5 h / 75 °C 3.1: sodium nitrite; hydrogenchloride / water / 0 - 5 °C 3.2: 3 h / 0 - 60 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: toluene / 1 h / 120 °C / Sealed tube; Inert atmosphere 2.1: copper diacetate; Trimethylacetic acid / 1,2-dichloro-ethane / 12 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube 3.1: thionyl chloride / methanol / 1.5 h / 75 °C 4.1: sodium nitrite; hydrogenchloride / water / 0 - 5 °C 4.2: 3 h / 0 - 60 °C View Scheme |
1-chloro-2-(trifluoromethyl)benzene
phenylacetylene
1-(phenylethynyl)-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate In ethanol; water at 90℃; for 5h; Sonogashira Cross-Coupling; Green chemistry; | 100% |
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane In N,N-dimethyl-formamide at 140℃; for 20h; Sonogashira cross-coupling; | 92% |
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 3h; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 7h; | 97% |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid at 25℃; | 96.13% |
With sulfuric acid; nitric acid at 20 - 45℃; for 4h; | 91.3% |
With sulfuric acid; nitric acid at 45℃; for 4h; | 91.3% |
1-chloro-2-(trifluoromethyl)benzene
benzene
1-chloro-2-(dichloro(phenyl)methyl)benzene
Conditions | Yield |
---|---|
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h; | 96% |
Conditions | Yield |
---|---|
With C41H50ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; Reagent/catalyst; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water at 90℃; for 15h; Heck Reaction; Green chemistry; | 95% |
1-chloro-2-(trifluoromethyl)benzene
L-prolinamide
(S)-N'-((2-trifluoromethyl)phenyl)prolinylamide
Conditions | Yield |
---|---|
With 4-diphenylphosphino-13-dicyclohexylphosphino-[2.2]paracyclophane; water; palladium diacetate; caesium carbonate In 1,4-dioxane at 125℃; for 24h; Buchwald-Hartwig coupling; | 94% |
1-chloro-2-(trifluoromethyl)benzene
ethyl acrylate
ethyl 2-trifluoromethylcinnamate
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water; N,N-dimethyl-formamide at 100℃; for 5h; Heck Reaction; Green chemistry; | 94% |
Conditions | Yield |
---|---|
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h; | 92% |
1-chloro-2-(trifluoromethyl)benzene
sodium thiomethoxide
2-(methylthio)-1-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide at 40 - 50℃; for 20h; | 92% |
Conditions | Yield |
---|---|
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h; | 91% |
1-chloro-2-(trifluoromethyl)benzene
phenylboronic acid
2-trifluoromethyl-biphenyl
Conditions | Yield |
---|---|
With potassium carbonate; 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole; palladium diacetate In toluene at 100℃; Suzuki coupling; | 91% |
With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydroxide In 1-methyl-pyrrolidin-2-one; dichloromethane; water at 130℃; for 12h; Suzuki coupling; | 78% |
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); Tedicyp In xylene at 130℃; for 20h; Suzuki reaction; | 100 % Chromat. |
magnesium
1-chloro-2-(trifluoromethyl)benzene
2-trifluoromethylphenylmagnesium chloride
Conditions | Yield |
---|---|
With ethyl bromide; tert-butylmagnesium chloride In tetrahydrofuran at 35 - 50℃; for 3h; Product distribution / selectivity; | 91% |
5,5-dimethyl-1,3,2-dioxaborinane
1-chloro-2-(trifluoromethyl)benzene
5,5-dimethyl-2-(2-(trifluoromethyl)phenyl)-1,3,2-dioxaborinane
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); triethylamine; zinc In toluene at 100℃; for 4h; Inert atmosphere; | 91% |
With 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); triethylamine In toluene at 23 - 100℃; Inert atmosphere; | 52% |
1-chloro-2-(trifluoromethyl)benzene
o-trifluoromethylbenzenethiol
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 110℃; for 20h; Inert atmosphere; | 91% |
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 90℃; for 20h; Reagent/catalyst; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 3h; | 90% |
1-chloro-2-(trifluoromethyl)benzene
2',4-dichloro-3-(trifluoromethyl)benzophenone
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid Inert atmosphere; neat (no solvent); | 90% |
bis(1,5-cyclooctadiene)nickel (0)
N,N,N,N,-tetramethylethylenediamine
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
at 20℃; for 72h; Glovebox; Inert atmosphere; | 90% |
styrene
1-chloro-2-(trifluoromethyl)benzene
2-styryl-α,α,α-trifluorotoluene
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium acetate; C84H60N12O8Pd4 at 140℃; for 6h; Heck Reaction; Inert atmosphere; Schlenk technique; | 89% |
1-chloro-2-(trifluoromethyl)benzene
bis(pinacol)diborane
2-[2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; | 88% |
With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; Sealed tube; | 88% |
tri(allyl)phenylsilane
1-chloro-2-(trifluoromethyl)benzene
2-trifluoromethyl-biphenyl
Conditions | Yield |
---|---|
Stage #1: triallyl(phenyl)silane With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 1h; Stage #2: 1-chloro-2-(trifluoromethyl)benzene With XPhos; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran; water at 80℃; for 3h; | 86% |
Stage #1: triallyl(phenyl)silane With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 1h; Stage #2: 1-chloro-2-(trifluoromethyl)benzene With XPhos; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran; water at 80℃; for 3h; | 86% |
furan
1-chloro-2-(trifluoromethyl)benzene
1,4-epoxy-1,4-dihydro-5-(trifluoromethyl)-naphthalene
Conditions | Yield |
---|---|
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: furan In tetrahydrofuran; hexane at 25℃; | 86% |
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; hexane at -75℃; for 1h; Stage #2: furan In tetrahydrofuran; hexane at 25℃; | 76% |
pyrrolidine
1-chloro-2-(trifluoromethyl)benzene
1-(2-trifluoromethyl-phenyl)pyrrolidine
Conditions | Yield |
---|---|
With polymethylhydrosiloxane; sodium t-butanolate; bis(acetylacetonate)nickel(II) In 1,2-dimethoxyethane; toluene at 130℃; for 18h; | 85% |
acetic anhydride
1-chloro-2-(trifluoromethyl)benzene
1-(2-(trifluoromethyl)phenyl)ethan-1-one
Conditions | Yield |
---|---|
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With ethyl bromide; ethylmagnesium bromide; magnesium; lithium chloride In tetrahydrofuran at 45 - 50℃; for 4h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran at 20 - 30℃; for 2h; Reagent/catalyst; Inert atmosphere; Further stages; | 82.7% |
Stage #1: 1-chloro-2-(trifluoromethyl)benzene With ethylmagnesium bromide; magnesium; lithium chloride In tetrahydrofuran; ethyl bromide at 45 - 50℃; for 5h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran; ethyl bromide; toluene at 20 - 30℃; for 2h; Inert atmosphere; | 72.4% |
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With aluminum tri-bromide; trimethylsilyl bromide at 80℃; Inert atmosphere; | 82% |
With carbon disulfide; aluminum tri-bromide |
phenyl trimethylsiloxane
1-chloro-2-(trifluoromethyl)benzene
2-trifluoromethyl-biphenyl
Conditions | Yield |
---|---|
With tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate at 80℃; for 3h; Hiyama coupling; Inert atmosphere; Neat (no solvent); | 82% |
4-(trimethylsilyl)morpholine
1-chloro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With lithium di-1-admantylamide In diethyl ether; cyclohexane at 50℃; for 28h; Inert atmosphere; | 81% |
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