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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 755037-03-7 Regorafenib API Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.

Regorafenib

Cas:755037-03-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Regorafenib Manufacturer/High quality/Best price/In stock

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Regorafenib(BAY 73-4506) CAS No.755037-03-7

Cas:755037-03-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10g/100g/1kg/foil bag Application:medicine raw material Transportation

Manufacturer high quality Regorafenib Cas 755037-03-7 with good price

Cas:755037-03-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Regorafenib CAS No.:755037-03-7 Name: BAY 73-4506 Synonyms: Regorafenib; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide Molecular Structure

High purity Regorafenib CAS No.:755037-03-7

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Regorafenib 755037-03-7 GMP Manufacturer

Cas:755037-03-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Regorafenib

Cas:755037-03-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

Regorafenib

Cas:755037-03-7

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hubei DiBo chemical co., LTD

Name:BAY 73-4506; Regorafenib The alias:4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide CAS NO: 755037-03-7 Molecular formula:C21H15ClF4N4O3 Molecular weight:482.82 Product Qualit

Regorafenib/CAS:755037-03-7/Raw material supply

Cas:755037-03-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 755037-03-7 Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 755037-03-7 with best quality

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name: 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide Cas No.: 755037-03-7 Molecular Formula: C21H15ClF4N4O3 Molecular Weight: 482

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

RegorafenibCAS NO.: 755037-03-7

Cas:755037-03-7

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Off-white or light yellow crystalline powder Storage:Store i

Rebeprazole Sodium Pharmaceutical Raw Materials 755037-03-7 Treating Cancer

Cas:755037-03-7

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Anticancer Inhibitor Raw Material Powder CAS 755037-03-7 Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Regorafenib 755037-03-7

Cas:755037-03-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Regorafenib Synonyms: Regorafenib;BAY 73-4506;4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;BAY 73-4506(Regorafenib);4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)

Regorafenib

Cas:755037-03-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Regorafenib

Cas:755037-03-7

Min.Order:1 Gram

FOB Price: $13.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Regorafenib CAS 755037-03-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

Regorafenib CAS 755037-03-7

Cas:755037-03-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

High Purity 99% price quality CAS 755037-03-7 Regorafenib

Cas:755037-03-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R.T Package:25kg/drum Application:Regorafenib is a novel oral multi-target protein kinase inhibitor, which can block tumor cell proliferation, inhibit tumor angiogenesis and regulate tumor microenvironment, and has go

Factory price ready stock Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:off-white crystal powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao

Sell/Synthesis Regorafenib 755037-03-7 BAY-73-4506 hydrate 99.8% off-white crystal powder

Cas:755037-03-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Regorafenib is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to off-white solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:Pharmaceutical f

Regorafenib

Cas:755037-03-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Regorafenib 755037-03-7

Cas:755037-03-7

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Regorafenib

Cas:755037-03-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 140℃; for 4h; Temperature; Green chemistry;96.8%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

S,S-dimethyl dithiocarbonate
868-84-8

S,S-dimethyl dithiocarbonate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydroxide In tetrahydrofuran at 35℃; for 1.33333h; Green chemistry;96.2%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 1.5h;94.5%
In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;90%
In dichloromethane for 24h;87%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Reflux
2.1: 1-methyl-pyrrolidin-2-one / 100 °C
2.2: 4.17 h / 100 °C
2.3: 0.17 h / 80 °C
3.1: toluene; tetrahydrofuran / 4.5 h / 20 °C
3.2: 2.25 h
View Scheme
Multi-step reaction with 3 steps
1.1: cyclohexane / Reflux
2.1: 1-methyl-pyrrolidin-2-one / 100 °C
2.2: 3.67 h / 100 °C
2.3: 0.17 h / 80 °C
3.1: toluene; tetrahydrofuran / 4.5 h / 20 °C
3.2: 2.25 h
View Scheme
Multi-step reaction with 3 steps
1.1: Reflux
2.1: 1-methyl-pyrrolidin-2-one / 100 °C
2.2: 5.5 h / 100 °C
2.3: 0.17 h / 80 °C
3.1: toluene; tetrahydrofuran / 4.5 h / 20 °C
3.2: 2.25 h
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.42 h / 0 °C
1.2: 16 h / 100 °C
2.1: toluene / 72 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 6 h / Reflux
2: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C
View Scheme
C12H16FNO
1338722-52-3

C12H16FNO

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-methyl-pyrrolidin-2-one / 100 °C
1.2: 4.17 h / 100 °C
1.3: 0.17 h / 80 °C
2.1: toluene; tetrahydrofuran / 4.5 h / 20 °C
2.2: 2.25 h
View Scheme
C11H14FNO
1338722-53-4

C11H14FNO

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-methyl-pyrrolidin-2-one / 100 °C
1.2: 5.5 h / 100 °C
1.3: 0.17 h / 80 °C
2.1: toluene; tetrahydrofuran / 4.5 h / 20 °C
2.2: 2.25 h
View Scheme
3-fluoro-4-nitrophenol
394-41-2

3-fluoro-4-nitrophenol

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h
2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.42 h / 0 °C
2.2: 16 h / 100 °C
3.1: toluene / 72 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / diethylene glycol dimethyl ether / 6 h / Reflux
2: hydrogen / methanol / 3 h / 20 °C / 1520.1 Torr / Autoclave
3: tetrahydrofuran / 5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere
2: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1125.11 Torr
3: dichloromethane / 3 h / 0 - 25 °C
View Scheme
2-Picolinic acid
98-98-6

2-Picolinic acid

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium bromide / chlorobenzene / 0.25 h / 50 °C
1.2: 23 h / 85 °C
2.1: water; toluene / 7 h / 20 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 5 h / 100 °C
4.1: sulfuric acid; nitric acid / water / 1.5 h / -10 - 0 °C
5.1: ammonium chloride; iron; hydrogenchloride / water; ethanol / 0.25 h / Reflux
6.1: ethyl acetate / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride / N,N-dimethyl-formamide
2.1: sodium hydroxide / tetrahydrofuran / 3 h / -5 °C
3.1: potassium tert-butylate / dimethyl amine / 2 h / 20 °C / Inert atmosphere
3.2: 85 °C / Inert atmosphere
4.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride; sodium bromide / N,N-dimethyl-formamide / 30 h / 80 °C
2.1: sodium hydroxide / tetrahydrofuran / 3 h / -5 °C
3.1: potassium tert-butylate / dimethyl amine / 2 h / 20 °C / Inert atmosphere
3.2: 85 °C / Inert atmosphere
4.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / 18 h / 70 °C / Inert atmosphere; Schlenk technique
2.1: tetrahydrofuran; methanol; water / 1 h / 0 - 10 °C / Inert atmosphere; Schlenk technique
3.1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique
3.2: 16 h / 110 °C / Inert atmosphere; Schlenk technique
4.1: sulfuric acid; nitric acid / water / 1 h / 0 °C / Inert atmosphere; Schlenk technique
4.2: 1 h / 80 °C / Inert atmosphere; Schlenk technique
5.1: dichloromethane; ethyl acetate / 18 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
4-chloro-2-pyridine carboxylic acid chloride hydrochloride

4-chloro-2-pyridine carboxylic acid chloride hydrochloride

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: water; toluene / 7 h / 20 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 5 h / 100 °C
3.1: sulfuric acid; nitric acid / water / 1.5 h / -10 - 0 °C
4.1: ammonium chloride; iron; hydrogenchloride / water; ethanol / 0.25 h / Reflux
5.1: ethyl acetate / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 3.03 h / Inert atmosphere
2.2: 10 h / 90 °C / Inert atmosphere
3.1: dichloromethane / 24 h
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tetrahydrofuran / 3 h / -5 °C
2.1: potassium tert-butylate / dimethyl amine / 2 h / 20 °C / Inert atmosphere
2.2: 85 °C / Inert atmosphere
3.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: tetrahydrofuran; methanol; water / 1 h / 0 - 10 °C / Inert atmosphere; Schlenk technique
2.1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique
2.2: 16 h / 110 °C / Inert atmosphere; Schlenk technique
3.1: sulfuric acid; nitric acid / water / 1 h / 0 °C / Inert atmosphere; Schlenk technique
3.2: 1 h / 80 °C / Inert atmosphere; Schlenk technique
4.1: dichloromethane; ethyl acetate / 18 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 5 h / 100 °C
2.1: sulfuric acid; nitric acid / water / 1.5 h / -10 - 0 °C
3.1: ammonium chloride; iron; hydrogenchloride / water; ethanol / 0.25 h / Reflux
4.1: ethyl acetate / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 0 - 50 °C
1.2: 100 °C
2.1: sulfuric acid; nitric acid / 1.5 h / -10 - 0 °C
3.1: iron; ammonium chloride; hydrogenchloride / water; ethanol / 1 h / Reflux
4.1: ethyl acetate / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 3.03 h / Inert atmosphere
1.2: 10 h / 90 °C / Inert atmosphere
2.1: dichloromethane / 24 h
View Scheme
4-(3-fluorophenoxy)-N-methylpyridine-2-carboxamide

4-(3-fluorophenoxy)-N-methylpyridine-2-carboxamide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / water / 1.5 h / -10 - 0 °C
2: ammonium chloride; iron; hydrogenchloride / water; ethanol / 0.25 h / Reflux
3: ethyl acetate / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / 1.5 h / -10 - 0 °C
2: iron; ammonium chloride; hydrogenchloride / water; ethanol / 1 h / Reflux
3: ethyl acetate / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid; nitric acid / water / 1 h / 0 °C / Inert atmosphere; Schlenk technique
1.2: 1 h / 80 °C / Inert atmosphere; Schlenk technique
2.1: dichloromethane; ethyl acetate / 18 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
4-(4-nitro-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

4-(4-nitro-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium chloride; iron; hydrogenchloride / water; ethanol / 0.25 h / Reflux
2: ethyl acetate / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: iron; ammonium chloride; hydrogenchloride / water; ethanol / 1 h / Reflux
2: ethyl acetate / 0.5 h / 20 °C
View Scheme
3-fluorophenol
372-20-3

3-fluorophenol

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 0 - 50 °C
1.2: 100 °C
2.1: sulfuric acid; nitric acid / 1.5 h / -10 - 0 °C
3.1: iron; ammonium chloride; hydrogenchloride / water; ethanol / 1 h / Reflux
4.1: ethyl acetate / 0.5 h / 20 °C
View Scheme
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalic acid; aluminium / water / 1.5 h / 80 - 85 °C
2: potassium tert-butylate / N,N-dimethyl acetamide / 1.5 h / 0 - 90 °C
3: tetrahydrofuran / 12 h / 30 °C
View Scheme
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 15.5 h / 0 - 20 °C / Inert atmosphere
2.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 3.03 h / Inert atmosphere
3.2: 10 h / 90 °C / Inert atmosphere
4.1: dichloromethane / 24 h
View Scheme
[1,3]-dioxolan-2-one
96-49-1

[1,3]-dioxolan-2-one

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With cetyltrimethylammonium hydroxide In dichloromethane at 35℃; for 1.33333h;21.99 g
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

4-chloro-3-(trifluoromethyl)benzoic acid
1737-36-6

4-chloro-3-(trifluoromethyl)benzoic acid

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Stage #1: 4-chloro-3-(trifluoromethyl)benzoic acid With pyridine; diphenylphosphoranyl azide In 1,4-dioxane at 0℃; for 1.5h; Reflux;
Stage #2: 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide In 1,4-dioxane for 1h; Reflux;
methyl 4-chloropyridine-2-carboxylate hydrochloride

methyl 4-chloropyridine-2-carboxylate hydrochloride

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanol / tetrahydrofuran
2.1: potassium tert-butylate / dimethyl amine / 2 h / 20 °C / Inert atmosphere
2.2: 85 °C / Inert atmosphere
3.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
N-(2-fluoro-4-hydroxyphenyl)acetamide
103842-00-8

N-(2-fluoro-4-hydroxyphenyl)acetamide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water / 80 °C / Inert atmosphere
2.1: potassium tert-butylate / dimethyl amine / 2 h / 20 °C / Inert atmosphere
2.2: 85 °C / Inert atmosphere
3.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / dimethyl amine / 2 h / 20 °C / Inert atmosphere
1.2: 85 °C / Inert atmosphere
2.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 6 h / Reflux
2: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C
View Scheme
3-chloro-N-methyl-benzamide
18370-10-0

3-chloro-N-methyl-benzamide

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h;
C7H4FN3O2

C7H4FN3O2

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene; N,N-dimethyl-formamide / 90 °C / Inert atmosphere
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h
2.2: 6 h / 80 °C
View Scheme
2-fluoro-4-hydroxybenzoic acid
65145-13-3

2-fluoro-4-hydroxybenzoic acid

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.08 h / 0 °C / Inert atmosphere
2.1: sodium azide; dmap / toluene; N,N-dimethyl-formamide / Inert atmosphere
3.1: toluene; N,N-dimethyl-formamide / 90 °C / Inert atmosphere
4.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h
4.2: 6 h / 80 °C
View Scheme
C19H14FO4P

C19H14FO4P

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium azide; dmap / toluene; N,N-dimethyl-formamide / Inert atmosphere
2.1: toluene; N,N-dimethyl-formamide / 90 °C / Inert atmosphere
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h
3.2: 6 h / 80 °C
View Scheme
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Stage #1: 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea With potassium tert-butylate In N,N-dimethyl-formamide for 2h;
Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate at 80℃; for 6h;
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / water / 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique
4: dichloromethane; ethyl acetate / 18 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
4-chloro-3-(trifluoromethyl)nitrobenzene
777-37-7

4-chloro-3-(trifluoromethyl)nitrobenzene

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique
3: dichloromethane; ethyl acetate / 18 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride
348-91-4

N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide; acetonitrile at 15 - 30℃; for 1h; Large scale;24.17 kg
4-chloro-3-(trifluoromethyl)-N-(triphenylphosphanylidene)anilinium bromide

4-chloro-3-(trifluoromethyl)-N-(triphenylphosphanylidene)anilinium bromide

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.17 h
1.2: 0.33 h / 20 °C
2.1: toluene
View Scheme
regorafenib
755037-03-7

regorafenib

cis-dichlorobis(dimethylsulfoxide)platinum(II)
75992-73-3, 25794-47-2, 30729-25-0, 15274-33-6, 22840-91-1, 14568-13-9

cis-dichlorobis(dimethylsulfoxide)platinum(II)

Pt(regorafenib)(DMSO)Cl2

Pt(regorafenib)(DMSO)Cl2

Conditions
ConditionsYield
In methanol; water at 55℃; for 36h; Temperature; Solvent; Autoclave;95%
In methanol; acetone at 65℃; for 24h;
regorafenib
755037-03-7

regorafenib

maleic acid
110-16-7

maleic acid

C21H15ClF4N4O3*C4H4O4

C21H15ClF4N4O3*C4H4O4

Conditions
ConditionsYield
In methanol; n-heptane at 20℃; for 4h; Solvent;90.7%
heptanedioic acid
111-16-0

heptanedioic acid

regorafenib
755037-03-7

regorafenib

C21H15ClF4N4O3*C7H12O4

C21H15ClF4N4O3*C7H12O4

Conditions
ConditionsYield
In dichloromethane at 20℃; for 12h; Solvent;89.4%
regorafenib
755037-03-7

regorafenib

malonic acid
141-82-2

malonic acid

C21H15ClF4N4O3*C3H4O4

C21H15ClF4N4O3*C3H4O4

Conditions
ConditionsYield
In dichloromethane at 20℃; for 12h; Solvent;84.5%
regorafenib
755037-03-7

regorafenib

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride
835621-07-3

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; 1,3-dioxane79%
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane79%
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane79%
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane79%
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane79%
regorafenib
755037-03-7

regorafenib

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate
835621-09-5

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate

Conditions
ConditionsYield
With benzenesulfonic acid In ethanol69%
regorafenib
755037-03-7

regorafenib

benzenesulfonic acid
98-11-3

benzenesulfonic acid

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate
835621-09-5

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide phenylsulfonate

Conditions
ConditionsYield
In ethanol Heating;69%
In ethanol Heating;69%
In ethanol Heating / reflux;69%
In ethanol Heating;69%
regorafenib
755037-03-7

regorafenib

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide mesylate
835621-08-4

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide mesylate

Conditions
ConditionsYield
With methanesulfonic acid In ethanol
regorafenib
755037-03-7

regorafenib

methanesulfonic acid
75-75-2

methanesulfonic acid

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide mesylate
835621-08-4

4-{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide mesylate

Conditions
ConditionsYield
In ethanol
In ethanol
In ethanol
In ethanol
regorafenib
755037-03-7

regorafenib

4-[4({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
1019206-88-2

4-[4({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate

Conditions
ConditionsYield
With water In acetone Product distribution / selectivity;
With water In acetonitrile at 25℃; for 168h; Product distribution / selectivity;
With water In ethanol at -20℃; Product distribution / selectivity;
regorafenib
755037-03-7

regorafenib

2-hydroxyethanesulfonic acid
107-36-8

2-hydroxyethanesulfonic acid

regorafenib isethionate salt

regorafenib isethionate salt

Conditions
ConditionsYield
In water; ethyl acetate at 40℃; for 2h; Solvent; Temperature;
regorafenib
755037-03-7

regorafenib

ethanesulfonic acid
594-45-6

ethanesulfonic acid

regorafenib ethanesulfonic acid salt

regorafenib ethanesulfonic acid salt

Conditions
ConditionsYield
In water; ethyl acetate at 50℃; for 2h; Solvent; Temperature;
regorafenib
755037-03-7

regorafenib

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

regorafenib p-toluenesulfonate salt

regorafenib p-toluenesulfonate salt

Conditions
ConditionsYield
In propan-1-ol at 50℃; for 4h; Solvent; Temperature;
regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
In water; acetonitrile at 80℃; for 72h;
regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

C

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 5h;
regorafenib
755037-03-7

regorafenib

A

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

B

C21H15ClF4N4O4

C21H15ClF4N4O4

Conditions
ConditionsYield
With dihydrogen peroxide In water at 20℃; for 144h;

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