Sichuan Zhongbang S&T Co.,Ltd. is a complex enterprise specializing in the research, development, manufacturing and trade of fine chemicals, domestic hygiene, pesticide intermediates and pharmaceutical intermediates; the main products includ
DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:115-19-5
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Cas:115-19-5
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Cas:115-19-5
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Cas:115-19-5
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inquiryItems Technical index Product name 2-Methyl-3-butyn-2-ol CAS No 115-19-5 Molecular formula
2-Methyl-3-butyn-2-ol Molecular Formula:C5H8O Assay: 99%min. (GC) Acetone: 1% max Moisture: 1% max Appearance:Colorless or slightly yellow liquid Storage:Store in dry and cool place with good seal Package:165KG/ galvanized iron drum App
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:115-19-5
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:115-19-5
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inquirySuperior quality, moderate price & quick delivery. Appearance:colourless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediat
Product name: 2-Methyl-Butyn-2-ol CAS No.:115-19-5 Molecule Formula:C5H8O Molecule Weight:84.12 Purity: 98.0% Package: 180kg/drum Description:Colorless clear liquid Manufacture Standards:Enterprise Standard TESTING
Cas:115-19-5
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inquiryWe are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)
Cas:115-19-5
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inquiryShanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We specialize in manufacturing high quality of Advanced Intermediates, Sp
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Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Cas:115-19-5
Min.Order:100 Gram
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inquiry1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers408.Safe and fa
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Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
Product Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard
Cas:115-19-5
Min.Order:1 Kilogram
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an
Cas:115-19-5
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
Conditions | Yield |
---|---|
With sodium In methanol at 0 - 5℃; for 1h; Solvent; Reagent/catalyst; Autoclave; Inert atmosphere; Large scale; | 99.2% |
Stage #1: acetylene With sodium amide In ammonia at -50℃; for 0.5h; Stage #2: acetone at -50 - 25℃; | 87.9% |
Stage #1: acetylene With potassium hydroxide monohydrate In dimethyl sulfoxide at 10 - 15℃; for 7h; Stage #2: acetone In dimethyl sulfoxide at 10 - 15℃; for 9h; Temperature; | 82% |
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 25℃; for 12h; | 99% |
acetone
acetylene
A
2-methyl-but-3-yn-2-ol
B
2,5-dihydroxy-2,5-dimethyl-3-hexyne
Conditions | Yield |
---|---|
With potassium hydride In tetrahydrofuran at 30℃; under 759.826 Torr; for 2.25h; | A 7% B 91% |
Stage #1: acetone; acetylene With potassium 2-methylpropan-2-olate In xylene at 28 - 35℃; for 1h; Stage #2: With water Stage #3: With phosphoric acid Product distribution / selectivity; | A 2.3% B 90% |
Stage #1: acetone; acetylene With potassium 2-methylpropan-2-olate In xylene at 10 - 20℃; for 1h; Stage #2: With water Stage #3: With phosphoric acid Product distribution / selectivity; | A 79% B 3% |
Conditions | Yield |
---|---|
Stage #1: acetone; lithium acetylide; 4,4'-di-tert-butylbiphenyl In tetrahydrofuran at 0℃; for 2h; Stage #2: With water In tetrahydrofuran at 20℃; Product distribution / selectivity; | 81% |
Stage #1: acetone; lithium acetylide; naphthalene In tetrahydrofuran at 0℃; for 2h; Stage #2: With water In tetrahydrofuran at 20℃; Product distribution / selectivity; | 56.5% |
2-methyl-propan-1-ol
acetone
acetylene
A
2-methyl-but-3-yn-2-ol
B
2,5-dihydroxy-2,5-dimethyl-3-hexyne
Conditions | Yield |
---|---|
Stage #1: 2-methyl-propan-1-ol With potassium hydride In tetrahydrofuran at 30℃; under 759.826 Torr; for 0.25h; Stage #2: acetone; acetylene In tetrahydrofuran at 30℃; under 759.826 Torr; for 2.25h; | A 74% B 22% |
2-methyl-3-butyn-2-ol 1-ethoxyethyl ether
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With N,4-dimethyl-N-vinylbenzenesulfonamide; picAuCl2(III) In dichloromethane at 20℃; for 0.25h; Inert atmosphere; | 60% |
Conditions | Yield |
---|---|
In tetrahydrofuran Heating; | 47% |
Stage #1: acetone; acetylenemagnesium bromide In tetrahydrofuran at 0 - 20℃; Stage #2: With ammonium chloride In tetrahydrofuran; water | |
In tetrahydrofuran at -10 - 20℃; |
Conditions | Yield |
---|---|
at -20℃; | |
at -20℃; |
diethyl ether
sodium ethanolate
acetone
acetylene
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With ammonia | |
With ammonia |
Conditions | Yield |
---|---|
With diethyl ether nachfolgende Einw. von Aceton; |
Conditions | Yield |
---|---|
Pyrolysis; | |
With silica gel Pyrolysis; | |
With calcium carbide Pyrolysis; |
3-chloro-3-methylbut-1-yne
cyclopenta-1,3-diene
A
2,2-dimethylbicyclo<3.2.1>oct-6-en-3-one
B
3-Chlor-4,4-dimethylbicyclo<3.2.1>octa-2,6-dien
C
4-(1,1-Dimethyl-2-propinyl)-2-cyclopenten-1-ol
D
propargyl alcohol
E
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With potassium hydroxide; silver trifluoroacetate In pentane at 0℃; Mechanism; |
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane In benzene at 95℃; for 2h; Yield given; |
2-Iodobenzoic acid
A
2-(3-Hydroxy-3-methyl-but-1-ynyl)-benzoic acid
B
(Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one
C
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine 1.) DMF, 1 h, 2.) DMF, a) RT, 1 h, b) 30 deg C, 6 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With sodium amide | |
auf aether.Suspensionen von Natriumamid,Natrium oder Natriumaethylat; |
Conditions | Yield |
---|---|
With potassium hydroxide; ethanol |
Conditions | Yield |
---|---|
at -20℃; |
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
With Dimethoxymethane at 0℃; | |
With dibutyl acetal at -3℃; | |
With diethyl acetal; poly ether at -10℃; | |
With xylene; butan-1-ol at -10℃; | |
With dibutyl acetal at -3℃; |
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
tetrafluoroboric acid; silica gel at 20℃; for 2h; | 100% |
indium(III) chloride at 20℃; for 0.5h; | 100% |
With magnesium(II) perchlorate at 20℃; for 0.5h; | 100% |
phenyl isocyanate
2-methyl-but-3-yn-2-ol
O-α,α-dimethylpropargyl N-phenylcarbamate
Conditions | Yield |
---|---|
With MoCl2O2(dmf)2 In dichloromethane at 20℃; for 0.333333h; | 100% |
With triethylamine In tetrahydrofuran at 70℃; for 12h; Inert atmosphere; | 94% |
With dmap; triethylamine In tetrahydrofuran at 20℃; for 90h; | 88% |
ethyl vinyl ether
2-methyl-but-3-yn-2-ol
2-methyl-3-butyn-2-ol 1-ethoxyethyl ether
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 1h; | 100% |
With sulfuric acid for 0.5h; | 77% |
With hydrogenchloride |
triethylsilyl chloride
2-methyl-but-3-yn-2-ol
2-methyl-2-<(triethylsilyl)oxy>-3-butyne
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0℃; for 1h; | 100% |
2-methyl-but-3-yn-2-ol
Phenyl azide
2-(1-phenyl-1H-1,2,3-triazol-4-yl)-2-propanol
Conditions | Yield |
---|---|
With triethylamine In neat (no solvent) at 20℃; for 24h; Huisgen Cycloaddition; Inert atmosphere; Green chemistry; regioselective reaction; | 100% |
With Cu(OAc)2-anchored mesoporous SBA-15 catalyst (CuSBA-15-PTAA) In water at 50℃; for 6h; | 95% |
With C39H44ClCuN2(1+) In neat (no solvent) at 25℃; for 1h; Schlenk technique; Inert atmosphere; | 94% |
2-methyl-but-3-yn-2-ol
3-Chloro-2-methylpropene
2,6-dimethylhept-6-en-3-yn-2-ol
Conditions | Yield |
---|---|
With copper(l) iodide; TEA at 60℃; | 100% |
With copper(l) iodide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; potassium iodide; sodium sulfite In water; benzene at 75 - 80℃; for 6h; | 92% |
With potassium carbonate; copper(l) iodide; tetrabutyl-ammonium chloride In N,N-dimethyl-formamide for 16h; Product distribution; Ambient temperature; variation of catalysts and reaction time; | 88% |
Conditions | Yield |
---|---|
With carbon dioxide; sodium acetate; copper dichloride In methanol at 40℃; under 105008 Torr; for 4h; | 100% |
With copper(l) iodide; ethyl bromoacetate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 20℃; | 99% |
With oxygen; (TBA)4[γ-H2SiW10O36Cu2(μ-1,1-N3)2] In benzonitrile at 99.84℃; under 760.051 Torr; for 2h; | 99% |
Conditions | Yield |
---|---|
bis(acetonitrile)palladium(II) bromide 1) 0 deg C, 0.5-1 h, 2) r.t.; | 100% |
bis(benzonitrile)palladium(II) bromide In 1,2-dimethoxyethane at 0 - 20℃; for 6h; |
Conditions | Yield |
---|---|
With copper(l) iodide; C80H65BrN2O2P4Pd; triethylamine In water for 7h; Reagent/catalyst; Sonogashira Cross-Coupling; Inert atmosphere; Reflux; | 100% |
With copper(l) iodide; diethylamine; triphenylphosphine; palladium diacetate for 36h; Heating; | 98% |
With copper(l) iodide; palladium diacetate; triphenylphosphine; 3-aminopentane for 36h; Inert atmosphere; Reflux; | 98% |
2-Bromo-6-methoxynaphthalene
2-methyl-but-3-yn-2-ol
2-methyl-4-(6-methoxynaphthalen-2-yl)but-3-yn-2-ol
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine for 17h; Heating; | 100% |
With copper(l) iodide; ethanolamine; triphenylphosphine; palladium on activated charcoal In water; acetonitrile at 80℃; for 15h; Sonogashira cross-coupling; | 80% |
With bis-triphenylphosphine-palladium(II) chloride; copper(I) In triethylamine at 90℃; for 20h; | 79% |
With tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; lithium bromide; copper(ll) bromide In tetrahydrofuran at 90℃; for 2h; Substitution; Title compound not separated from byproducts; | |
With copper(l) iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine In N,N-dimethyl-formamide at 70℃; for 12h; Inert atmosphere; Glovebox; |
1-trifluoromethanesulfonyloxy-4-t-butylcyclohexene
2-methyl-but-3-yn-2-ol
2-methyl-4-(4-tert-butylcyclohexenyl)but-3-yn-2-ol
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; triethylamine In N,N-dimethyl-formamide at 75℃; for 5.5h; | 100% |
(1,1-dimethylethyl)(3-iodophenoxy)dimethylsilane
2-methyl-but-3-yn-2-ol
4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine at 75℃; for 16h; | 100% |
2-methyl-but-3-yn-2-ol
para-nitrophenyl bromide
2-methyl-4-(4-nitrophenyl)but-3-yn-2-ol
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran for 12h; Sonogashira Cross-Coupling; Inert atmosphere; Reflux; | 100% |
With copper(l) iodide; triethylamine; triphenylphosphine at 90℃; for 3h; Sonogashira coupling; Inert atmosphere; | 97% |
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran for 12h; Heating; | 96% |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 4h; Sonogashira Cross-Coupling; Inert atmosphere; | 100% |
With copper(l) iodide; triethylamine; triphenylphosphine at 90℃; for 3h; Sonogashira coupling; Inert atmosphere; | 94% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N,N',N'-tetramethylguanidine at 30℃; for 1h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere; Green chemistry; | 94% |
methyl 4-iodobenzoate
2-methyl-but-3-yn-2-ol
methyl 4-(3-hydroxy-3-methylbut-1-ynyl)benzoate
Conditions | Yield |
---|---|
With copper(l) iodide; (Ph3)2PdCl2; triphenylphosphine; triethylamine for 68h; Sonogashira reaction; Heating; | 100% |
With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; Inert atmosphere; | 96.07% |
With copper(l) iodide; triethylamine; polymer-bound Pt(0)-phoshine In water; acetonitrile at 55℃; for 8h; | 95% |
4-bromo-benzaldehyde
2-methyl-but-3-yn-2-ol
4-(3-hydroxy-3-methylbut-1-ynyl)benzaldehyde
Conditions | Yield |
---|---|
With triethylamine; triphenylphosphine; palladium diacetate Substitution; | 100% |
Stage #1: 4-bromo-benzaldehyde; 2-methyl-but-3-yn-2-ol With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In toluene Inert atmosphere; Stage #2: With diisopropylamine In toluene at 20℃; for 24h; Inert atmosphere; | 97% |
With copper(l) iodide; triethylamine; triphenylphosphine; palladium diacetate In benzene at 75 - 80℃; for 0.666667h; | 93% |
Conditions | Yield |
---|---|
With trifluoroacetic acid at 20 - 75℃; Addition; | 100% |
Conditions | Yield |
---|---|
With trifluoroacetic acid at 20 - 48℃; Addition; | 100% |
2-methyl-but-3-yn-2-ol
bis adduct of diethylene glycol divinyl ether and diethylene glycol
Conditions | Yield |
---|---|
With trifluoroacetic acid at 30 - 35℃; for 12h; Addition; | 100% |
2-methyl-but-3-yn-2-ol
8-bromo-3,3-diphenyl-<3H>-naphtho<2,1-b>pyran
8-(3-hydroxy-3-methylbut-1-ynyl)-3,3-diphenyl-3H-naphtho[2,1-b]pyran
Conditions | Yield |
---|---|
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In diethylamine at 20℃; for 14h; | 100% |
With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride at 20℃; for 16h; Sonogashira coupling; | 96% |
dimethyl (4-nitrobenzylidene)malonate
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With copper(l) iodide; n-butyllithium In tetrahydrofuran; hexane at 20℃; for 3h; | 100% |
4-Iodoacetophenone
2-methyl-but-3-yn-2-ol
1-(4-acetylphenyl)-3-methyl-1-butyn-3-ol
Conditions | Yield |
---|---|
With copper(l) iodide; 1-isobutyl-2,2,6,6-tetramethyl-phosphorinane*HBF4; diisopropylamine; bis(benzonitrile)palladium(II) dichloride In 1,4-dioxane at 20℃; for 6h; Sonogashira reaction; | 100% |
With piperidine; copper(l) iodide; polystyrene-N(CH2PPh2)2PdCl2 In 1,4-dioxane at 60℃; for 2h; Sonogashira coupling reaction; | 94% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Inert atmosphere; | 90% |
3-cyanobromobenzene
2-methyl-but-3-yn-2-ol
3-(3-hydroxy-3-methylbut-1-ynyl)benzonitrile
Conditions | Yield |
---|---|
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 60℃; | 100% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 110℃; for 3h; | 90% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 60℃; for 3h; Sonogashira Cross-Coupling; |
2-methyl-but-3-yn-2-ol
4-n-butoxy-2,6-dibromopyridine
4-butoxy-2,6-bis(3-hydroxy-3-methyl-1-butynyl)pyridine
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine at 20℃; for 3.5h; Sonogashira coupling; | 100% |
benzyl bromide
2-methyl-but-3-yn-2-ol
2-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-propanol
Conditions | Yield |
---|---|
With sodium azide In water at 55℃; for 2h; Green chemistry; regioselective reaction; | 100% |
With sodium azide; bis(2-{phenyliminomethyl}pyrrolato)copper(II) In water at 60℃; for 12h; Schlenk technique; regioselective reaction; | 96% |
With sodium azide; sodium L-ascorbate In water at 60℃; for 5h; | 95% |
2-Chloroquinoline
2-methyl-but-3-yn-2-ol
2-methyl-4-(2′-quinolyl)but-3-yn-2-ol
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 80℃; for 3h; Sonogashira Cross-Coupling; Inert atmosphere; | 100% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 80℃; Inert atmosphere; | 100% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine at 40℃; for 0.5h; Sonogashira Cross-Coupling; | 98% |
isobutyraldehyde
2-methyl-but-3-yn-2-ol
(R/S)-2,6-dimethylhept-3-yne-2,5-diol
Conditions | Yield |
---|---|
Stage #1: 2-methyl-but-3-yn-2-ol With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 0.333333h; Inert atmosphere; Stage #2: isobutyraldehyde With cerium(III) chloride In tetrahydrofuran; hexane Reagent/catalyst; | 100% |
Stage #1: 2-methyl-but-3-yn-2-ol With n-butyllithium In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere; Stage #2: isobutyraldehyde With cerium(III) chloride In tetrahydrofuran at 0℃; Inert atmosphere; | 92% |
Stage #1: 2-methyl-but-3-yn-2-ol With n-butyllithium In tetrahydrofuran at -78℃; for 2h; Stage #2: isobutyraldehyde In tetrahydrofuran at -65 - 20℃; Further stages.; | 81% |
Stage #1: 2-methyl-but-3-yn-2-ol With n-butyllithium at -78℃; for 1h; Inert atmosphere; Stage #2: isobutyraldehyde at -78 - 20℃; Inert atmosphere; |
2,6-diiodo-4-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-pyridine
2-methyl-but-3-yn-2-ol
4-(6-(3-hydroxy-3-methyl-but-1-ynyl)-4-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-pyridin-2-yl)-2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In diethylamine at 20℃; for 5h; Sonogashira reaction; | 100% |
4-[ethoxydi(prop-2-enyl)silyl]iodobenzene
2-methyl-but-3-yn-2-ol
Conditions | Yield |
---|---|
With copper(l) iodide; triethylamine; triphenylphosphine; Pd2(PPh3)2Cl2 In tetrahydrofuran at 50℃; for 1.5h; Sonogashira coupling; | 100% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine In tetrahydrofuran at 50℃; Sonogashira coupling; |
4-iodobenzo[b]thiophene-2-carbonitrile
2-methyl-but-3-yn-2-ol
4-(3-hydroxy-3-methylbut-1-ynyl)benzo[b]thiophene-2-carbonitrile
Conditions | Yield |
---|---|
With CuI In triethylamine | 100% |
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