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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 399-95-1 Regorafenib Intermediate 4-Amino-3-fluorophenol Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Profession

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

High Quality 4-Amino-3-fluorophenol 399-95-1 Manufacturer

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemsigma International Co.,Ltd.

1111MicrosoftInternetExplorer402DocumentNotSpecified7.8 磅Normal0

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Amino-3-fluorophenol Manufacturer/High quality/Best price/In stock

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Amino-3-Fluorophenol supplier in China

Cas:399-95-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

4-Amino-3-Fluorophenol[CAS:399-95-1] Name 4-Amino-3-fluorophenol Synonyms 3-Fluoro-4-aminophenol HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corpor

High purity 4-Amino-3-Fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

good quality Appearance:brown powder Storage:cold storage Package:meet the demand of customer Application:diagnostic reagent Transportation:by sea or by air Port:shanghai

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-amino-3-fluorophenol

Cas:399-95-1

Min.Order:1

Negotiable

Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-amino-3-fluorophenol

Cas:399-95-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM--4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-Amino-3-fluorophenol 399-95-1

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 399-95-1 with best quality

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Amino-3-fluorophenol 399-95-1

Cas:399-95-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-Amino-3-fluorophenol CAS:399-95-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

4-Amino-3-fluorophenol CAS:399-95-1

Cas:399-95-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:399-95-1

Cas:399-95-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Amino-3-Fluorophenol

Cas:399-95-1

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU-CHEM - 4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Nanjing Fred Technology Co.,Ltd.

4-Amino-3-fluorophenol is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:Brown to black solid Storage:Room temperature, Keep in Dark Place. Package:According to customer request Appl

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-AMINO-3-FLUOROPHENOL

Cas:399-95-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

4-Amino-3-fluorophenol 399-95-1

Cas:399-95-1

Min.Order:1 Gram

Negotiable

Type:Other

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JINING XINHE CHEMICAL CO., LTD

Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit

4-Amino-3-fluorophenol Insecticide

Cas:399-95-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

MolecularWeight: 127.1163 MolecularFormula: C6H6FNO … Appearance:Gray White Powder or Brown crystal Package:aluminium foil bag Application:pharmaceutical and research Transportation:No Special Requirements Port:Suzhou

4-Amino-3-fluorophenol

Cas:399-95-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-Amino-3-fluorophenol(399-95-1)

Cas:399-95-1

Min.Order:100 Gram

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Type:Other

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Synthetic route

3-fluoro-4-nitrophenol
394-41-2

3-fluoro-4-nitrophenol

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran; ethanol at 20℃; for 4.5h;100%
With iron; acetic acid In ethyl acetate for 3h; Heating / reflux;98%
With hydrogen; palladium 10% on activated carbon In ethyl acetate for 4h;97%
N-(2-fluoro-4-hydroxyphenyl)acetamide
103842-00-8

N-(2-fluoro-4-hydroxyphenyl)acetamide

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
With hydrogenchloride In water at 80℃; Inert atmosphere;88%
aluminium hydride
7784-21-6

aluminium hydride

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
With sulfuric acid In water86%
With sulfuric acid In water86%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
With oxalic acid; aluminium In water at 80 - 85℃; for 1.5h;40.7%
With sulfuric acid at 90℃; (electrochemical reduction);
3-fluoro-4-phenylazo-phenol
326-18-1

3-fluoro-4-phenylazo-phenol

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
With sodium dithionite; water
O-(3-fluorophenyl)hydroxylamine
127682-43-3

O-(3-fluorophenyl)hydroxylamine

A

3-fluorophenol
372-20-3

3-fluorophenol

B

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

C

2-amino-5-fluorophenol
53981-24-1

2-amino-5-fluorophenol

D

2-amino-3-fluorophenol
53981-23-0

2-amino-3-fluorophenol

Conditions
ConditionsYield
With trifluoroacetic acid at 70℃; for 6h; Product distribution; Rate constant; Kinetics; ΔH(excit.), ΔG(excit.), ΔS(excit.);
3-fluorophenol
372-20-3

3-fluorophenol

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: sodium dithionite; water
View Scheme
Multi-step reaction with 2 steps
1: nitric acid / water / 0.5 h / 8 - 10 °C / Cooling with ice
2: sodium sulfide / 0.08 h / Microwave irradiation; Ionic liquid
View Scheme
3-fluoro-4-nitrophenol
394-41-2

3-fluoro-4-nitrophenol

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
In water; acetic acid
2-fluoro-4-hydroxyaniline hydrochloride
18266-53-0

2-fluoro-4-hydroxyaniline hydrochloride

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
With sodium hydroxide In methanol; water
C6H4FN2

C6H4FN2

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(II) sulfate; sulfuric acid; water / 100 °C
2: nitric acid / water / 0.5 h / 8 - 10 °C / Cooling with ice
3: sodium sulfide / 0.08 h / Microwave irradiation; Ionic liquid
View Scheme
meta-fluoroaniline
372-19-0

meta-fluoroaniline

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium nitrite / 1 h / Cooling with ice; Ionic liquid
1.2: 1 h
2.1: copper(II) sulfate; sulfuric acid; water / 100 °C
3.1: nitric acid / water / 0.5 h / 8 - 10 °C / Cooling with ice
4.1: sodium sulfide / 0.08 h / Microwave irradiation; Ionic liquid
View Scheme
2,4-Difluoronitrobenzene
446-35-5

2,4-Difluoronitrobenzene

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate / 5.5 h / 45 °C / Inert atmosphere
2: benzene; aluminum (III) chloride / 11 h / 45 °C
3: nickel(II) nitrate; palladium dichloride; tetrabutoxytitanium; hydrogen / ethanol / 2 h / 45 °C / 1500.15 Torr
View Scheme
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

acetic anhydride
108-24-7

acetic anhydride

N-(2-fluoro-4-hydroxyphenyl)acetamide
103842-00-8

N-(2-fluoro-4-hydroxyphenyl)acetamide

Conditions
ConditionsYield
Stage #1: 4-amino-3-fluorophenol; acetic anhydride With acetic acid at 20℃; for 2h;
Stage #2: With water at 20℃; for 0.5h;
100%
In 1,2-dichloro-ethane at 10 - 20℃; for 2.5h;95.8%
In water66%
In water66%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

3-fluoro-4-(piperazin-1-yl)phenol hydrochloride

3-fluoro-4-(piperazin-1-yl)phenol hydrochloride

Conditions
ConditionsYield
In sulfolane at 150℃; for 16h;98%
4-bromo-pyridine-2-carboxylic acid methyl amide
1209459-88-0

4-bromo-pyridine-2-carboxylic acid methyl amide

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium iodide; sodium hydroxide In water at 30 - 70℃; for 2h; Reagent/catalyst;97.5%
N-(6-methoxybenzo[d]thiazol-2-yl)-1H-imidazole-1-carboxamide
945404-21-7

N-(6-methoxybenzo[d]thiazol-2-yl)-1H-imidazole-1-carboxamide

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

1-(2-fluoro-4-hydroxyphenyl)-3-(6-methoxybenzo[d]thiazol-2-yl)urea

1-(2-fluoro-4-hydroxyphenyl)-3-(6-methoxybenzo[d]thiazol-2-yl)urea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃;97%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Conditions
ConditionsYield
With potassium carbonate In 1,2-dichloro-ethane for 4h; Reflux;96.3%
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2h;
Stage #2: 4-chloro-N-methylpicolinamide In tetrahydrofuran Reagent/catalyst; Solvent; Temperature; Reflux;
94%
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In dimethyl amine at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate In dimethyl amine at 85℃; Time; Inert atmosphere;
92%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

4-((tert-butyldimethylsilyl)oxy)-2-fluoroaniline

4-((tert-butyldimethylsilyl)oxy)-2-fluoroaniline

Conditions
ConditionsYield
With 1H-imidazole In tetrahydrofuran at 20℃; for 12h;95%
C11H7ClN4OS
1353531-00-6

C11H7ClN4OS

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

1-(6-chlorobenzo[d]thiazol-2-yl)-3-(2-fluoro-4-hydroxyphenyl)urea

1-(6-chlorobenzo[d]thiazol-2-yl)-3-(2-fluoro-4-hydroxyphenyl)urea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃;94%
methyl 4-formyl-2-methyl-benzoate
74733-23-6

methyl 4-formyl-2-methyl-benzoate

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-[(2-fluoro-4-hydroxy-phenylamino)-methyl]-2-methyl-benzoic acid methyl ester

4-[(2-fluoro-4-hydroxy-phenylamino)-methyl]-2-methyl-benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: methyl 4-formyl-2-methyl-benzoate; 4-amino-3-fluorophenol With acetic acid at 20℃; for 2h;
Stage #2: With sodium tris(acetoxy)borohydride at 20℃;
Stage #3: With water; sodium hydrogencarbonate In ethyl acetate
93%
1H-indol-2-ylcarboxaldehyde
19005-93-7

1H-indol-2-ylcarboxaldehyde

2-Butynoic acid
590-93-2

2-Butynoic acid

1,1,3,3-tetramethylbutane isonitrile
14542-93-9

1,1,3,3-tetramethylbutane isonitrile

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

N-(1-(1H-indol-2-yl)-2-oxo-2-((2,4,4-trimethylpentan-2-yl)amino)ethyl)-N-(2-fluoro-4-hydroxyphenyl)but-2-ynamide

N-(1-(1H-indol-2-yl)-2-oxo-2-((2,4,4-trimethylpentan-2-yl)amino)ethyl)-N-(2-fluoro-4-hydroxyphenyl)but-2-ynamide

Conditions
ConditionsYield
With sodium sulfate In methanol at 20℃; Ugi Condensation;93%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

benzyl chloroformate
501-53-1

benzyl chloroformate

benzyl (2-fluoro-4-hydroxyphenyl)carbamate
1195781-24-8

benzyl (2-fluoro-4-hydroxyphenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;92%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

2,4-Dimethoxybenzaldehyde
613-45-6

2,4-Dimethoxybenzaldehyde

4-[(2,4-dimethoxybenzyl)amino]-3-fluorophenol

4-[(2,4-dimethoxybenzyl)amino]-3-fluorophenol

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 5h;92%
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 5h;92%
C15H22ClN3O3
1431703-16-0

C15H22ClN3O3

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

C21H27FN4O4

C21H27FN4O4

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl acetamide at 100℃; for 16h;92%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-chloro-2-pyridinecarboxamide hydrochloride

4-chloro-2-pyridinecarboxamide hydrochloride

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Conditions
ConditionsYield
Stage #1: 4-amino-3-fluorophenol With copper(l) iodide at 85℃;
Stage #2: 4-chloro-2-pyridinecarboxamide hydrochloride for 6h; Temperature; Reagent/catalyst;
91.1%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester
911297-02-4

N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With indium(III) chloride at 35℃; for 2h;90%
With indium(III) chloride at 35℃; for 2h; Neat (no solvent);90%
indium(III) chloride at 35℃; for 2h; Neat (no solvent);90%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl N-(2-fluoro-4-hydroxyphenyl)carbamate

phenyl N-(2-fluoro-4-hydroxyphenyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h; Cooling with ice;90%
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

propionic acid anhydride
123-62-6

propionic acid anhydride

C9H10FNO2

C9H10FNO2

Conditions
ConditionsYield
In dichloromethane at 10 - 20℃; for 2.5h;89.8%
4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline
205448-32-4

4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline
479690-10-3

3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline

Conditions
ConditionsYield
Stage #1: 4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline; 4-amino-3-fluorophenol With sodium t-butanolate In ISOPROPYLAMIDE at 95 - 100℃; for 18h; Industry scale;
Stage #2: With aniline; sodium t-butanolate In ISOPROPYLAMIDE at 50 - 100℃; for 18h; Industry scale;
Stage #3: With water In ISOPROPYLAMIDE at 20 - 30℃; Industry scale;
89%
With sodium t-butanolate In N,N-dimethyl acetamide at 95 - 100℃; for 36h;
4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;89%
In dichloromethane for 6h; Reflux;
In dichloromethane at 20℃; for 16h; Inert atmosphere; Schlenk technique;401 mg
carbon monoxide
201230-82-2

carbon monoxide

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

phenylacetylene
536-74-3

phenylacetylene

C15H12FNO2

C15H12FNO2

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; toluene-4-sulfonic acid In tetrahydrofuran; acetonitrile at 120℃; under 23272.3 Torr; for 72h; regioselective reaction;88%
C22H28ClNO3
1097210-75-7

C22H28ClNO3

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

C28H32ClFN2O3
1097211-09-0

C28H32ClFN2O3

Conditions
ConditionsYield
Stage #1: C22H28ClNO3 With methanesulfonyl chloride; triethylamine In 1,2-dichloro-ethane at 0 - 25℃; for 2h;
Stage #2: 4-amino-3-fluorophenol In 1,2-dichloro-ethane at 85℃; for 12h;
87%
2,4-dichloropyridine
26452-80-2

2,4-dichloropyridine

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-(2-chloro-pyridin-4-yloxy)-2-fluorophenylamine
1041861-97-5

4-(2-chloro-pyridin-4-yloxy)-2-fluorophenylamine

Conditions
ConditionsYield
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 0.5h;
Stage #2: 2,4-dichloropyridine In ISOPROPYLAMIDE at 80℃; for 12h;
86%
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 0.5h;
Stage #2: 2,4-dichloropyridine In ISOPROPYLAMIDE at 80℃; for 12h;
86%
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 0.5h;
Stage #2: 2,4-dichloropyridine In N,N-dimethyl acetamide at 80℃; for 12h;
86%
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 0.5h;
Stage #2: 2,4-dichloropyridine In N,N-dimethyl acetamide at 85℃; for 4h;
83%
trifluoromethyl trifluorovinyl ether
1187-93-5

trifluoromethyl trifluorovinyl ether

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

2-fluoro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]-aniline
122267-39-4

2-fluoro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]-aniline

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide; toluene at 0℃; for 3h;85%
1H-indol-2-ylcarboxaldehyde
19005-93-7

1H-indol-2-ylcarboxaldehyde

2-Butynoic acid
590-93-2

2-Butynoic acid

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

N-(2-(tert-butylamino)-1-(1H-indol-2-yl)-2-oxoethyl)-N-(2-fluoro-4-hydroxyphenyl)but-2-ynamide

N-(2-(tert-butylamino)-1-(1H-indol-2-yl)-2-oxoethyl)-N-(2-fluoro-4-hydroxyphenyl)but-2-ynamide

Conditions
ConditionsYield
With sodium sulfate In methanol at 20℃; Ugi Condensation;85%
3-methoxyphenyl bromide
2398-37-0

3-methoxyphenyl bromide

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

4-[(3-methoxyphenyl)amino]-3-fluorophenol
1198117-82-6

4-[(3-methoxyphenyl)amino]-3-fluorophenol

Conditions
ConditionsYield
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ll); sodium t-butanolate In 1,4-dioxane at 110℃; for 3h; Inert atmosphere;84%
4-methyl-1,2,3-thiadiazole-5-yl-formyl isocyanate
1254781-51-5

4-methyl-1,2,3-thiadiazole-5-yl-formyl isocyanate

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

1-(2-fluoro-4-hydroxyphenyl)-3-[(4-methyl-1,2,3-thiadiazol-5-yl)carbonyl]urea
1417340-65-8

1-(2-fluoro-4-hydroxyphenyl)-3-[(4-methyl-1,2,3-thiadiazol-5-yl)carbonyl]urea

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 20℃; for 8h;83%
In 1,2-dichloro-ethane at 20℃; for 8.25h;83%
carbon monoxide
201230-82-2

carbon monoxide

4-amino-3-fluorophenol
399-95-1

4-amino-3-fluorophenol

phenylacetylene
536-74-3

phenylacetylene

C15H12FNO2

C15H12FNO2

Conditions
ConditionsYield
With 5-chloro-2-hydroxybenzoic acid; boric acid; palladium diacetate; 1,2-bis[di(t-butyl)phosphinomethyl]benzene In acetonitrile at 110℃; under 18100.7 Torr; for 48h;83%

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