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Hubei Vanz Pharm Co.,Ltd

We are both manufacture and trader , have very good quality and competitive price, meanwhile , we have exported to other market 100kg every month. Appearance:white powder Storage:Nomal Package:25kg/drum Application:intermediates Transportation:Nor

high quality Sorafenib intermediates

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $280.0

Type:Manufacturers

inquiry

Jiangsu Huaen Energy Co., Ltd.

White Powder

2-Amino-5-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-Amino-2-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Name 5-Amino-2-chlorobenzotrifluoride CAS 320-51-4 Assay 99% Appearance Yellowish crystal or liquid Capacity 500mt/year Min.package 100gram Standard

5-Amino-2-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine supplier in China

Cas:320-51-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

5-Amino-2-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

Cas:320-51-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-chloro-α,α,α-trifluoro-m-toluidine

Cas:320-51-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Benzenamine,4-chloro-3-(trifluoromethyl)- 320-51-4 ISO Manufacturer

Cas:320-51-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

5-Amino-2-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

5-Amino-2-Chlorobenzotrifluoride

Cas:320-51-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

4-Chloro-3-(trifluoromethyl) aniline

Cas:320-51-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Amino-2-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

High purity CAS 320-51-4 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

High purity CAS 320-51-4 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine in stock

Cas:320-51-4

Min.Order:1 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 320-51-4 with fast shipping

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: 2-Chloro-5-Aminobenzotrifluoride Synonyms: 5-amino-2-chlorobenzotrifluoride CAS:320-51-4 MF: C8H2Cl2F6 Appearance:Colorless transparent liquid, Storage: Preserve in well-closed, light-resistant and airtight containers. Package: 25kgs/dr

2-Chloro-5-Aminobenzotrifluoride

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenamine,4-chloro-3-(trifluoromethyl)- 320-51-4

Cas:320-51-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

5-Amino-2-chlorobenzo trifluoride

Cas:320-51-4

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine CAS:320-51-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine CAS:320-51-4

Cas:320-51-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenamine,4-chloro-3-(trifluoromethyl)-

Cas:320-51-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Benzenamine,4-chloro-3-(trifluoromethyl)-/ LIDE PHARMA- Factory supply / Best price

Cas:320-51-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:320-51-4

Cas:320-51-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to pinkish crystalline powder Storage:R.T Package:25kg/drum Application:used as pharmaceutical and pesticide intermediates Transportation:Express/Sea/Air Port:Any port in China

Factory price ready stock 5-amino-2-chlorobenzotrifluoride

Cas:320-51-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-5-Amino-Benzotrifluoride

Cas:320-51-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-Chloro-alpha,alpha,alpha-trifluoro-M-toluidine

Cas:320-51-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

Cas:320-51-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

regorafenib intermediate 5-amino-2-chlorobenzotrifluoride CAS:320-51-4 We are top supplier of regorafenib intermediates. Application:Regorafenib intermediate Port:shanghai seaport

regorafenib intermediate 5-amino-2-chlorobenzotrifluoride CAS:320-51-4

Cas:320-51-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-AMINO-2-CHLOROBENZOTRIFLUORIDE

Cas:320-51-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloro-3-trifluoromethylaniline

Cas:320-51-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-chloro-3-(trifluoromethyl)nitrobenzene
777-37-7

4-chloro-3-(trifluoromethyl)nitrobenzene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With sodium tetrahydroborate; TPGS-750-M In tetrahydrofuran; water at 20℃; for 1h; Catalytic behavior; Reagent/catalyst;98%
With sodium tetrahydroborate In tetrahydrofuran; water at 20℃; for 2h; Inert atmosphere; Green chemistry; chemoselective reaction;94%
With sodium tetrahydroborate; iron; water at 20℃; for 2h;94%
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With copper dichloride; 1-hexyl-3-methylimidazol-1-ium chloride at 40℃; for 8h; regioselective reaction;94%
1,4-dichloro-2-trifluoromethylbenzene
320-50-3

1,4-dichloro-2-trifluoromethylbenzene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;84%
Multi-step reaction with 2 steps
1: hydrazine hydrate; pyridine / ethyl acetate; dichloromethane / 4 h / 130 °C / Autoclave
2: Raney nickel / methanol / 1 h / Reflux
View Scheme
5-bromo-2-chlorobenzotrifluoride
445-01-2

5-bromo-2-chlorobenzotrifluoride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chlorobenzotrifluoride With magnesium In tetrahydrofuran Inert atmosphere;
Stage #2: With C10H17NO In tetrahydrofuran; toluene at -45℃; for 2h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;
61%
4-chloropicolinamide
99586-65-9

4-chloropicolinamide

4-amino-phenol
123-30-8

4-amino-phenol

A

4-(4-aminophenoxy)-2-pyridinecarboxamide
284462-80-2

4-(4-aminophenoxy)-2-pyridinecarboxamide

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With potassium tert-butylate; sodium chloride In methanol; hexane; ethyl acetate; N,N-dimethyl-formamideA 58%
B n/a
With potassium tert-butylate; sodium chloride In methanol; hexane; ethyl acetate; N,N-dimethyl-formamideA 58%
B n/a
With potassium tert-butylate; sodium chloride In methanol; hexane; ethyl acetate; N,N-dimethyl-formamideA 58%
B n/a
1-(4-bromophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)-5-thioxoimidazolidine-2,4-dione
1198619-79-2

1-(4-bromophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)-5-thioxoimidazolidine-2,4-dione

benzylamine
100-46-9

benzylamine

A

3-benzyl-5-(benzylimino)-1-(4-bromophenyl)imidazolidine-2,4-dione
1198619-80-5

3-benzyl-5-(benzylimino)-1-(4-bromophenyl)imidazolidine-2,4-dione

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
for 1h; Reflux;A 51%
B n/a
cloflucarban
369-77-7

cloflucarban

A

4-chloro-aniline
106-47-8

4-chloro-aniline

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 83℃; for 24h; Irradiation; further reagents, further conditions;
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / HNO3; H2SO4 / 0.5 h / 50 - 60 °C
2: 65 percent / NaSH*9H2O; NaHCO3 / methanol; H2O / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: HNO3, H2SO4
2: H2 / PtO2
View Scheme
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / 1 h / Heating
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic anhydride; nitric acid / 3 h / 10 - 12 °C
2: iron(III) chloride hexahydrate; hydrazine hydrate / ethanol / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / water / 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique
View Scheme
5-bromo-2-chlorobenzotrifluoride
445-01-2

5-bromo-2-chlorobenzotrifluoride

A

C14H7Cl2F6N
1445972-32-6

C14H7Cl2F6N

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 24h; Inert atmosphere; Overall yield = 72 %; Overall yield = 140.9 mg;
regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
In water; acetonitrile at 80℃; for 72h;
regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

C

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 5h;
methanol
67-56-1

methanol

regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide

4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide

C

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 24h;
2-chloro-1-(trifluoromethyl)phenylhydrazine
91626-53-8

2-chloro-1-(trifluoromethyl)phenylhydrazine

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With Raney nickel In methanol for 1h; Time; Reflux;8.6 g
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In ethyl acetate at 80℃; for 1h;99.2%
In ethyl acetate at -5 - 80℃; for 3h; Solvent;95%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)triazene

1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)triazene

Conditions
ConditionsYield
With SHNC In water for 25h; Ambient temperature;99%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

[(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride
351-33-7

[(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; Inert atmosphere;99%
With pyridine In dichloromethane at 0 - 20℃; for 2h;98%
With triethylamine In dichloromethane at 0℃; for 1.5h;84.7%
Stage #1: chloroacetyl chloride; 4-chloro-3-trifluoromethyl-aniline With sodium hydrogencarbonate In diethyl ether; water at 20℃; for 1h; Schotten-Baumann Reaction;
Stage #2: With hydrogenchloride In diethyl ether; water
With triethylamine In dichloromethane at 0℃; for 1.5h;
2-benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid

2-benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

2-benzyl-N-(2,4-dichlorophenyl)-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxamide

2-benzyl-N-(2,4-dichlorophenyl)-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃; for 14h; Product distribution / selectivity; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);99%
tert-Butyl 2,2,2-trichloroacetimidate
98946-18-0

tert-Butyl 2,2,2-trichloroacetimidate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

tert-butyl(4-chloro-3-trifluoromethylphenyl)amine
1631962-34-9

tert-butyl(4-chloro-3-trifluoromethylphenyl)amine

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In nitromethane at 20℃; for 2h; Inert atmosphere;99%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

2-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide

2-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;99%
1-Adamantanecarbonyl chloride
2094-72-6

1-Adamantanecarbonyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N-[4-chloro-3-(trifluoromethyl)phenyl]adamantane-1-carboxamide

N-[4-chloro-3-(trifluoromethyl)phenyl]adamantane-1-carboxamide

Conditions
ConditionsYield
With triethylamine In acetone at 90℃; for 3h; Inert atmosphere;99%
phenyl chloroformate
1885-14-9

phenyl chloroformate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

phenyl (4-chloro-3-(trifluoromethyl)phenyl) carbamate

phenyl (4-chloro-3-(trifluoromethyl)phenyl) carbamate

Conditions
ConditionsYield
With potassium carbonate In water; toluene at 20℃; for 1h; Cooling with ice;99%
sodium isocyanate
917-61-3

sodium isocyanate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-chloro-3-trifluoromethylphenylurea
343247-69-8

4-chloro-3-trifluoromethylphenylurea

Conditions
ConditionsYield
With acetic acid In water at 40 - 50℃; for 2h; Temperature;97.2%
With acetic acid In water at 40 - 45℃; for 1 - 2h; Product distribution / selectivity;
With acetic acid In water at 40 - 45℃; Product distribution / selectivity;
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

p-ethoxycarbonylphenyl isocyanate
30806-83-8

p-ethoxycarbonylphenyl isocyanate

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-ethoxycarbonylphenyl) urea

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-ethoxycarbonylphenyl) urea

Conditions
ConditionsYield
In dichloromethane97%
In dichloromethane97%
In dichloromethane97%
In dichloromethane97%
In dichloromethane at 20℃;97%
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate
145013-05-4

tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N,N′-bis(tert-butoxycarbonyl)-N′′-4-chloro-3-(trifluoromethyl)guanidine
1443231-54-6

N,N′-bis(tert-butoxycarbonyl)-N′′-4-chloro-3-(trifluoromethyl)guanidine

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine In water; toluene at 20℃;97%
With triethylamine; copper dichloride In dichloromethane at 20℃; for 16h;72%
With iodine; triethylamine In toluene at 0℃;65%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

2-chloro-5-methoxyquinoline
160893-07-2

2-chloro-5-methoxyquinoline

N-(4-chloro-3-(trifluoromethyl)phenyl)-5-methoxyquinolin-2-amine

N-(4-chloro-3-(trifluoromethyl)phenyl)-5-methoxyquinolin-2-amine

Conditions
ConditionsYield
In neat (no solvent) at 160℃;97%
In neat (no solvent) at 160℃;
3-Bromobenzenesulfonyl chloride
2905-24-0

3-Bromobenzenesulfonyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

3-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)benzenesulfonamide

3-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With dmap In toluene at 55℃; Sealed tube;97%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 140℃; for 4h; Temperature; Green chemistry;96.8%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

S,S-dimethyl dithiocarbonate
868-84-8

S,S-dimethyl dithiocarbonate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydroxide In tetrahydrofuran at 35℃; for 1.33333h; Green chemistry;96.2%
5,7-dimethylisatin
39603-24-2

5,7-dimethylisatin

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

3-[(Z)-4-Chloro-3-trifluoromethyl-phenylimino]-5,7-dimethyl-1,3-dihydro-indol-2-one

3-[(Z)-4-Chloro-3-trifluoromethyl-phenylimino]-5,7-dimethyl-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
grinding in agate mortar;96%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde
36663-00-0

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde

diethyl (((4-chloro-3-(trifluoromethyl)phenyl)amino)(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)phosphonate

diethyl (((4-chloro-3-(trifluoromethyl)phenyl)amino)(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)phosphonate

Conditions
ConditionsYield
With Porcine Pancreas Lipase In neat (no solvent) at 45℃; Enzymatic reaction;96%
pivaloyl chloride
3282-30-2

pivaloyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide
13691-92-4

N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide

Conditions
ConditionsYield
In triethylamine95%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 4h;60%
In triethylamine
In triethylamine
phenyl chloroformate
1885-14-9

phenyl chloroformate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester
871555-75-8

(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 5 - 20℃; for 2h;95%
In dichloromethane at 20℃; for 1h;94%
With pyridine In dichloromethane at 0 - 20℃;93.8%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-azido-1-chloro-2-(trifluoromethyl)benzene
85862-78-8

4-azido-1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 4-chloro-3-trifluoromethyl-aniline With hydrogenchloride In water; acetonitrile at 20℃; for 0.333333h;
Stage #2: With sodium nitrite In water; acetonitrile at 20℃; for 1h;
Stage #3: With sodium azide In water; acetonitrile at 0 - 20℃; for 1h;
95%
Stage #1: 4-chloro-3-trifluoromethyl-aniline With hydrogenchloride; sodium nitrite In ethyl acetate at 0℃; for 0.5h;
Stage #2: With sodium azide In ethyl acetate at 20℃; for 2h;
62%
With sodium azide; sodium nitrite In acetonitrile at 0 - 5℃; for 1h;
4-amino-phenol
123-30-8

4-amino-phenol

urea
57-13-6

urea

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
1129683-83-5

4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 130 - 135℃; for 3h; Temperature;94.8%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1,3-diphenyl-4-formylpyrazole
21487-45-6

1,3-diphenyl-4-formylpyrazole

[(4-chloro-3-trifluoromethyl-phenylamino)-(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonic acid diethyl ester

[(4-chloro-3-trifluoromethyl-phenylamino)-(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonic acid diethyl ester

Conditions
ConditionsYield
With Porcine Pancreas Lipase In neat (no solvent) at 45℃; Enzymatic reaction;94%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

C17H11ClF3N3O2

C17H11ClF3N3O2

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;93.3%
difluoronitroacetyl chloride
336-94-7

difluoronitroacetyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N-(4-Chloro-3-trifluoromethyl-phenyl)-2,2-difluoro-2-nitro-acetamide
123633-41-0

N-(4-Chloro-3-trifluoromethyl-phenyl)-2,2-difluoro-2-nitro-acetamide

Conditions
ConditionsYield
In diethyl ether at 29.9℃; for 0.5h;93%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

3-Iodobenzoic acid
618-51-9

3-Iodobenzoic acid

N-[4-chloro-3-(trifluoromethyl)phenyl]-3-iodobenzamide

N-[4-chloro-3-(trifluoromethyl)phenyl]-3-iodobenzamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 70℃; for 20h;93%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Allyl chloroformate
2937-50-0

Allyl chloroformate

(4-chloro-3-trifluoromethyl aniline)carboxylic acid allyl ester

(4-chloro-3-trifluoromethyl aniline)carboxylic acid allyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 5℃; for 2h; Reagent/catalyst; Solvent;92.5%
Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-2-oxoacetate
17738-62-4

ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-2-oxoacetate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;92%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; Schlenk technique;87%
With triethylamine In dichloromethane at 20℃;
3-chloro-3-oxopropanoic acid methyl ester
37517-81-0

3-chloro-3-oxopropanoic acid methyl ester

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

methyl 3-((4-chloro-3-(trifluoromethyl)phenyl)amino)-3-oxopropanoate

methyl 3-((4-chloro-3-(trifluoromethyl)phenyl)amino)-3-oxopropanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;92%
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