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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3'-(Trifluoromethyl)acetophenone Manufacturer/High quality/Best price/In stock

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Trifluoromethylacetophenone supplier in China

Cas:349-76-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3'-(trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 349-76-8 Ethanone,1-[3-(trifluoromethyl)phenyl]-

Cas:349-76-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3'-(Trifluoromethyl)Acetophenone

Cas:349-76-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

3'-(Trifluoromethyl)acetophenone CAS 349-76-8 3-Acetylbenzotrifluoride CAS no 349-76-8 Ethanone,1-[3-(trifluoromethyl)phenyl]- 3'-(Trifluoromethyl)acetophenone CAS 349-76-8 IN Stock CAS 349-76-8 3-Acetylbenzotrifluoride 3'-(Triflu

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Factory supply 3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 349-76-8 with fast shipping

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical name:3'-(Trifluoromethyl)acetophenone CAS No.349-76-8 Synonyms:C9H7F3O Molecular Fomula: Molecular weight:188.15 Appearance:Colorless liquid Assay:99% Appearance: Colorless Transparent Liquid Storage:Store in cool and dry place,

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanone,1-[3-(trifluoromethyl)phenyl]- 349-76-8

Cas:349-76-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3'-(Trifluoromethyl)acetophenone CAS:349-76-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

3'-(Trifluoromethyl)acetophenone CAS:349-76-8

Cas:349-76-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanone,1-[3-(trifluoromethyl)phenyl]-

Cas:349-76-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:349-76-8

Cas:349-76-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

3′-(Trifluoromethyl)acetophenone cas:349-76-8

Cas:349-76-8

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

3′-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Trifluoromethylacetophenone

Cas:349-76-8

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Yellow liquid Storage:R.T Package:25kg/Barrel Application:Intermediate Transportation:Express/Sea/Air Port:Any port in China

Factory Supply 3'-(Trifluoromethyl)acetophenone cas 349-76-8

Cas:349-76-8

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:light yellow liquid Storage:In Room Temperature Package:25kg/drum, or as per your request. Application:For medicine , pesticide intermediates Transportation:as per your request.

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: 3'-(Trifluoromethyl)acetophenone Synonyms: 3'-(Trifluoromethyl)acetophenone,99%;3-Trifludromethylacetophen;1-[3-(Trifluoromethyl)phenyl]ethan-1-one, 3-Acetylbenzotrifluoride;3'-(TrifluoroMethyl)acetophenone, 97+%;1-[3-

3'-(Trifluoromethyl)acetophenone 349-76-8 C9H7F3O

Cas:349-76-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3'-(Trifluoromethyl)acetophenone

Cas:349-76-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-(3-trifluoromethylphenyl)ethanol
454-91-1

1-(3-trifluoromethylphenyl)ethanol

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With oxygen; acetic acid; [Pd{N,N'-di(2,6-di-iPrC6H3)dihydroimidazol-2-yl}(OAc)2(H2O)] In toluene at 60℃; for 12h;99%
With (1,3-diarylimidazol-2-ylidene)-based Pd; oxygen; acetic acid In toluene at 60℃; for 12h;99%
With [(2-(benzoimidazol-2-yl)-6-(3,5-dimethylpyrazol-1-yl)pyridine)RuCl2(PPh3)]; potassium tert-butylate; acetone In methanol at 56℃; under 750.075 Torr; for 0.166667h; Catalytic behavior; Oppenauer Oxidation; Inert atmosphere;96%
(phenanthroline)CuIII(CF3)3

(phenanthroline)CuIII(CF3)3

3-acetylphenylboronic acid

3-acetylphenylboronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With oxygen; silver fluoride In N,N-dimethyl-formamide at 50℃; for 3h; Molecular sieve;96%
m-trifluoromethylphenyl iodide
401-81-0

m-trifluoromethylphenyl iodide

acetic anhydride
108-24-7

acetic anhydride

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium (0); N-ethyl-N,N-diisopropylamine; lithium chloride In N,N-dimethyl-formamide at 100℃; for 5h;94%
(bipyridine)CuIII(CF3)3

(bipyridine)CuIII(CF3)3

3-acetylphenylboronic acid

3-acetylphenylboronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With potassium fluoride; oxygen In N,N-dimethyl-formamide at 50℃; for 18h; Molecular sieve;92%
2-methyl-2-(3-(trifluoromethyl)phenyl)-1,3-dithiolane
139214-45-2

2-methyl-2-(3-(trifluoromethyl)phenyl)-1,3-dithiolane

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With iodosylbenzene In dichloromethane at 20℃; for 1.41667h;85%
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

ethylmagnesium bromide

ethylmagnesium bromide

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With acetic anhydride In tetrahydrofuran; toluene at -15 - 20℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;81.3%
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

acetyl chloride
75-36-5

acetyl chloride

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
Stage #1: 3-bromo-1-trifluoromethylbenzene With trifluoroacetic acid; cobalt(II) bromide; zinc; zinc dibromide In acetonitrile at 20℃;
Stage #2: acetyl chloride In acetonitrile at 20℃;
80%
Stage #1: 3-bromo-1-trifluoromethylbenzene With cobalt(II) bromide; zinc dibromide In acetonitrile at 20℃; Electrochemical reaction;
Stage #2: acetyl chloride With bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 20℃; Negishi coupling reaction;
76%
(i) Mg, (ii) CdCl2, (iii) /BRN= 605303/; Multistep reaction;
(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

acetonitrile
75-05-8

acetonitrile

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With 1,10-Phenanthroline; nickel(II) bromide 2-methoxyethyl ether complex; sodium hydrogencarbonate In water at 100℃; for 5h; Autoclave;77%
1-(3-aminophenyl)ethanone
99-03-6

1-(3-aminophenyl)ethanone

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
Stage #1: 1-(3-aminophenyl)ethanone With tert.-butylnitrite; toluene-4-sulfonic acid In acetonitrile at 20℃; for 0.5h; Sandmeyer Reaction; Inert atmosphere;
Stage #2: (trifluoromethyl)trimethylsilane With copper(I) thiocyanate; caesium carbonate In acetonitrile at 20℃; for 0.202833h; Sandmeyer Reaction; Inert atmosphere;
74%
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

acetic anhydride
108-24-7

acetic anhydride

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
Stage #1: 3-bromo-1-trifluoromethylbenzene With isopropyl magnesium chloride; lithium chloride In tetrahydrofuran at 70℃; under 50.03 Torr; for 3.5h; Inert atmosphere;
Stage #2: acetic anhydride at 0 - 40℃; Inert atmosphere;
73.8%
(i) Mg, Et2O, (ii) /BRN= 385737/; Multistep reaction;
3-trifluoromethyl-1-butoxystyrene

3-trifluoromethyl-1-butoxystyrene

3,3,3-trifluoro-1-phenylpropan-1-one
709-21-7

3,3,3-trifluoro-1-phenylpropan-1-one

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With hydrogenchloride In water; N,N-dimethyl-formamide73%
3-(trifluoromethyl)styrene
402-24-4

3-(trifluoromethyl)styrene

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With manganese(II) bromide; water; lithium perchlorate; copper dichloride In acetonitrile at 60℃; for 8h; Wacker-Tsuji Olefin Oxidation; Sealed tube; Inert atmosphere; Electrochemical reaction; regioselective reaction;72%
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

acetic anhydride
108-24-7

acetic anhydride

A

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

B

3,3'-bis(trifluoromethyl)biphenyl
580-82-5

3,3'-bis(trifluoromethyl)biphenyl

C

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With 3-chloroprop-1-ene; cobalt(II) bromide; zinc; trifluoroacetic acid In acetonitrile for 6h;A 8 % Chromat.
B 2 % Chromat.
C 71%
With 3-chloroprop-1-ene; cobalt(II) bromide; zinc; trifluoroacetic acid In acetonitrile for 6h;A 11 % Chromat.
B 1 % Chromat.
C 74 % Chromat.
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; water; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine at 90℃; for 8h;71%
3-trifluormethylisopropylbenzene
49623-20-3

3-trifluormethylisopropylbenzene

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen In benzonitrile at 100℃; for 20h;65%
3-<(trimethylsilyl)ethynyl>benzotrifluoride
40230-93-1

3-<(trimethylsilyl)ethynyl>benzotrifluoride

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With iron(III) sulphate monohydrate; acetic acid at 95℃; for 40h; regioselective reaction;65%
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
56%
Multi-step reaction with 2 steps
1.1: NaNO2; aq. HCl / 0.33 h / -5 - 0 °C
1.2: CuSO4; AcONa*3H2O / aq. HCl / 1.5 h / 0 - 15 °C
2.1: 14.5 g / conc. HCl / 2 h / Heating
View Scheme
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

3-acetylphenylboronic acid

3-acetylphenylboronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; copper diacetate; cesium fluoride In Isobutyronitrile at 20℃; under 760.051 Torr; for 3h; Chan-Lam-type reaction; Molecular sieve; Inert atmosphere;54%
trifluoromethanesulfonic acid difluoromethyl ether
1885-46-7

trifluoromethanesulfonic acid difluoromethyl ether

(3-acetylphenyl)(mesityl)iodonium trifluoromethanesulfonate

(3-acetylphenyl)(mesityl)iodonium trifluoromethanesulfonate

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
Stage #1: trifluoromethanesulfonic acid difluoromethyl ether With copper(I) thiophene-2-carboxylate; tetrabutylammonium triphenyldifluorosilicate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: (3-acetylphenyl)(mesityl)iodonium trifluoromethanesulfonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Inert atmosphere;
54%
(E)-acetaldoxime
5780-37-0

(E)-acetaldoxime

copper(II) sulphate hydrate
155146-37-5

copper(II) sulphate hydrate

3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With sodium nitrite In water51.5%
Umemoto's reagent
129946-88-9

Umemoto's reagent

3-acetylphenylboronic acid

3-acetylphenylboronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; copper diacetate In N,N-dimethyl acetamide at 25℃; under 760.051 Torr; for 16h; Inert atmosphere;50%
pentacarbonyl(methoxymethylcarbene)chromium(0)
20540-69-6

pentacarbonyl(methoxymethylcarbene)chromium(0)

(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
Stage #1: pentacarbonyl(methoxymethylcarbene)chromium(0); [3-(trifluoromethyl) phenyl] boronic acid With trifuran-2-yl-phosphane; palladium diacetate; diisopropylamine In toluene at 90℃; for 3h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 60℃; for 2h; Inert atmosphere;
35%
2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate
1214756-50-9

2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate

3-acetylphenylboronic acid

3-acetylphenylboronic acid

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; copper diacetate In ethyl acetate at 20℃; for 20h; Inert atmosphere;30%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With diethyl ether anschliessend Behandeln mit wss. HCl;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

methylmagnesium bromide
75-16-1

methylmagnesium bromide

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With diethyl ether anschliessend Behandeln mit wss. HCl;
3-(Trifluoromethyl)benzoyl chloride
2251-65-2

3-(Trifluoromethyl)benzoyl chloride

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With diethyl ether; dimethylcadmium
1-(1-Methoxy-vinyl)-3-trifluoromethyl-benzene
89726-06-7

1-(1-Methoxy-vinyl)-3-trifluoromethyl-benzene

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With sulfuric acid In water at 25℃; Rate constant;
1-(1,1-Dimethoxy-ethyl)-3-trifluoromethyl-benzene
73589-85-2

1-(1,1-Dimethoxy-ethyl)-3-trifluoromethyl-benzene

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
With hydrogen bromide at 25℃; Rate constant; var. conc. of water;
With hydrogen bromide; bromine In chlorobenzene at 25℃; Rate constant;
1-(3-trifluoromethylphenyl)pentan-1-one
1705-17-5

1-(3-trifluoromethylphenyl)pentan-1-one

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

Conditions
ConditionsYield
In benzene Rate constant; Quantum yield; Irradiation;
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-(3-trifluoromethylphenyl)ethanol
454-91-1

1-(3-trifluoromethylphenyl)ethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 0 - 20℃;100%
Stage #1: 3'-(trifluoromethyl)acetophenone With C107H90Cl2N10P4Ru2(2+)*2Cl(1-) In isopropyl alcohol at 82℃; for 0.166667h; Inert atmosphere;
Stage #2: With potassium isopropoxide In isopropyl alcohol for 2h; Catalytic behavior; Inert atmosphere;
99%
With palladium; hydrogen In methanol at 30℃; for 20h;99%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

3-trifluoromethylbenzoylformaldehyde
38923-38-5

3-trifluoromethylbenzoylformaldehyde

Conditions
ConditionsYield
With water; hydrogen bromide; dimethyl sulfoxide at 20 - 70℃;100%
With selenium(IV) oxide In methanol
Multi-step reaction with 2 steps
1: Br2 / acetic acid
2: DMSO
View Scheme
With iodine; dimethyl sulfoxide at 90℃;
With selenium(IV) oxide In 1,4-dioxane; water at 115℃; for 12h; Inert atmosphere;
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

ethylhydrazine carboxylate
4114-31-2

ethylhydrazine carboxylate

ethyl 2-(1-(3-(trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylate
170650-69-8

ethyl 2-(1-(3-(trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene Heating;100%
With toluene-4-sulfonic acid In benzene for 4h; Heating;100%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-(3-(trifluoromethyl)phenyl)ethanone oxime
99705-50-7

1-(3-(trifluoromethyl)phenyl)ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 95℃;100%
With pyridine; hydroxylamine hydrochloride at 80℃; for 0.25h;96%
With hydroxylamine hydrochloride; sodium hydroxide In ethanol pH=8; Reflux;95.5%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-(1-(3-(trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylic acid ethyl ester

2-(1-(3-(trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylic acid ethyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene100%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-(3'-trifluoromethylphenyl)ethanol

1-(3'-trifluoromethylphenyl)ethanol

Conditions
ConditionsYield
With potassium formate; Cp*IrCl[(S,S)-(C2H5)2CHCH2SO2dpen]; tetrabutylammomium bromide In water at 50℃; for 24h; Inert atmosphere;100%
With formic acid; C24H28ClN2O2PolRuS; triethylamine In dichloromethane at 40℃; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

(R)-1-(3-trifluoromethylphenyl)ethanol
454-91-1, 68120-40-1, 96789-80-9, 127852-24-8

(R)-1-(3-trifluoromethylphenyl)ethanol

Conditions
ConditionsYield
With potassium tert-butylate; hydrogen; RuCl2[(S)-XylHexaPHEMP][(S)-1,1-dianisyl-2-iPr-1,2-Et(NH2)2] In isopropyl alcohol; tert-butyl alcohol at 20℃; under 6205.94 Torr; for 0.683333h;99%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C45H58NP; potassium tert-butylate; hydrogen In propan-1-ol at 25 - 30℃; under 4560.31 Torr; for 0.166667h; Autoclave; optical yield given as %ee; enantioselective reaction;99%
With [Fe(II)(3-ethyl-3-isocyanopentane)2((5S,8S,14aS,18aS)-5,8-diphenyl-5,6,7,8,13,14,14a,15,16,17,18,18a,19,20-tetradecahydrotribenzo[b,f,l][1,4]diaza[8,11]diphosphacyclotetradecine)](BF4)2; isopropyl alcohol; sodium t-butanolate at 60℃; for 1h; Glovebox; enantioselective reaction;99.7%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone
2003-10-3

2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone

Conditions
ConditionsYield
With bromine In diethyl ether for 3h; Ambient temperature;99%
With bromine In chloroform for 1.5h; Ambient temperature;92.9%
With aluminum (III) chloride; bromine In diethyl ether at 20℃; for 1.5h;92%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-(3-(trifluoromethyl)phenyl)ethan-1-amine
59382-36-4

1-(3-(trifluoromethyl)phenyl)ethan-1-amine

Conditions
ConditionsYield
Stage #1: 3'-(trifluoromethyl)acetophenone With aluminium(III) triflate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 1,2-bis-(diphenylphosphino)ethane In dodecane; toluene at -5℃; under 4500.45 Torr; for 0.5h; Autoclave;
Stage #2: With hydrogen In dodecane; toluene at 140℃; under 30003 Torr; for 16h; Acidic conditions; chemoselective reaction;
99%
With aluminium(III) triflate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; hydrogen; 1,2-bis-(diphenylphosphino)ethane at 140℃; for 16h; Autoclave;99%
With 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate In methanol at 80℃; for 12h; Inert atmosphere; chemoselective reaction;82%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

(S)-1-(3-trifluoromethylphenyl)ethanol
454-91-1, 68120-40-1, 127852-24-8, 96789-80-9

(S)-1-(3-trifluoromethylphenyl)ethanol

Conditions
ConditionsYield
With D-glucose In aq. phosphate buffer at 25℃; for 24h; pH=7.0; stereoselective reaction;99%
With ethanol; Rhodococcus species-1 alcohol dehydrogenase; NAD; bovine serum albumin; yeast alcohol dehydrogenase; yeast aldehyde dehydrogenase at 30℃; for 12h; pH=7.5; aq. phosphate buffer; Enzymatic reaction; optical yield given as %ee;98%
With formic acid; chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll) In N,N-dimethyl-formamide at 50℃; for 27h; Reagent/catalyst; Temperature; Time; Solvent; Inert atmosphere; Industrial scale; enantioselective reaction;98%
trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-methyl-2-(3-trifluoromethylphenyl)-oxirane
850402-27-6

2-methyl-2-(3-trifluoromethylphenyl)-oxirane

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide at 20℃;99%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

A

(R)-1-(3-trifluoromethylphenyl)ethanol
454-91-1, 68120-40-1, 96789-80-9, 127852-24-8

(R)-1-(3-trifluoromethylphenyl)ethanol

B

triethylamine
121-44-8

triethylamine

Conditions
ConditionsYield
A 99%
B n/a
[RuCl2(p-cymene)]2and

[RuCl2(p-cymene)]2and

potassium hydroxide 2-propanol

potassium hydroxide 2-propanol

isopropyl alcohol
67-63-0

isopropyl alcohol

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

(R)-1-(3-trifluoromethylphenyl)ethanol
454-91-1, 68120-40-1, 96789-80-9, 127852-24-8

(R)-1-(3-trifluoromethylphenyl)ethanol

Conditions
ConditionsYield
In argon98.7%
dimethyl sulfate
77-78-1

dimethyl sulfate

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-(3'-trifluoromethylphenyl)butylene oxide

2-(3'-trifluoromethylphenyl)butylene oxide

Conditions
ConditionsYield
Stage #1: dimethyl sulfate With p-propoxybenzyl sulfide at 90℃; for 2h;
Stage #2: 3'-(trifluoromethyl)acetophenone With potassium hydroxide In dimethyl sulfoxide at 50℃; for 4h;
98.6%
2-Aminobenzyl alcohol
5344-90-1

2-Aminobenzyl alcohol

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-(3-(trifluoromethyl)phenyl)quinoline
396-84-9

2-(3-(trifluoromethyl)phenyl)quinoline

Conditions
ConditionsYield
With potassium hydroxide; Grubbs catalyst first generation In 1,4-dioxane at 80℃; for 1h;98%
With silver; potassium hydroxide In toluene at 80℃; for 24h;81%
With dimanganese decacarbonyl; sodium hydroxide In toluene at 110℃; for 2h; Friedlaender Quinoline Synthesis; Inert atmosphere; Glovebox; Sealed tube;80%
AlPh3*THF

AlPh3*THF

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

C15H13F3O

C15H13F3O

Conditions
ConditionsYield
With titanium(IV) isopropylate; magnesium bromide; (1S,2R,4R,1'R,2'R,1''S,2''R,4''R)-N-{trans-2'-[2''-hydroxy-7'',7''-dimethylbicyclo[2.2.1]hept-1''-ylmethylsulfonamino]cyclohexyl}-2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-ylmethanesulfonamide In toluene at 0℃; for 12h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;98%
meta-hydroxybenzaldehyde
100-83-4

meta-hydroxybenzaldehyde

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-(3-trifluoromethylphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one

1-(3-trifluoromethylphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 25℃; Claisen-Schmidt Condensation;97.1%
1-methyl-1H-indole-2,3-dione
2058-74-4

1-methyl-1H-indole-2,3-dione

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-methyl-3-hydroxy-3-(2-(3-trifluoromethylphenyl)-2-oxoethyl)indolin-2-one
1623807-35-1

1-methyl-3-hydroxy-3-(2-(3-trifluoromethylphenyl)-2-oxoethyl)indolin-2-one

Conditions
ConditionsYield
With piperidine In ethanol at 20℃; for 6h;97%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2,6-dimethoxybenzaldehyde
3392-97-0

2,6-dimethoxybenzaldehyde

(E)-1-(3-(trifluoromethyl)phenyl)-3-(2,6-dimethoxyphenyl)prop-2-en-1-one

(E)-1-(3-(trifluoromethyl)phenyl)-3-(2,6-dimethoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
Stage #1: 3'-(trifluoromethyl)acetophenone With sodium hydroxide In ethanol; water at 20℃; for 0.0833333h; Claisen-Schmidt Condensation;
Stage #2: 2,6-dimethoxybenzaldehyde at 20℃; Claisen-Schmidt Condensation;
97%
3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

methylamine
74-89-5

methylamine

C10H10F3N

C10H10F3N

Conditions
ConditionsYield
In ethanol at 0 - 20℃; for 72h; Molecular sieve; Inert atmosphere; Sealed tube;96%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

α,α-dimethyl-3-(trifluoromethyl)benzenemethanol
618-11-1

α,α-dimethyl-3-(trifluoromethyl)benzenemethanol

Conditions
ConditionsYield
95%
(2-ethylbutyl)magnesium bromide
68506-84-3

(2-ethylbutyl)magnesium bromide

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

(+)-(R)-4-ethyl-2-(3-(trifluoromethyl)phenyl)hexan-2-ol
1379663-90-7

(+)-(R)-4-ethyl-2-(3-(trifluoromethyl)phenyl)hexan-2-ol

Conditions
ConditionsYield
With copper(I) bromide dimethylsulfide complex; (S,R)-revJosiphos In diethyl ether; tert-butyl methyl ether at -78℃; for 0.25h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;95%
ethane-1,2-dithiol
540-63-6

ethane-1,2-dithiol

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-methyl-2-(3-(trifluoromethyl)phenyl)-1,3-dithiolane
139214-45-2

2-methyl-2-(3-(trifluoromethyl)phenyl)-1,3-dithiolane

Conditions
ConditionsYield
at 20℃;95%
phenylacetylene
536-74-3

phenylacetylene

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

2-(3-trifluoromethylphenyl)-4-phenyl-3-butyn-2-ol

2-(3-trifluoromethylphenyl)-4-phenyl-3-butyn-2-ol

Conditions
ConditionsYield
Stage #1: phenylacetylene With dimethyl zinc(II) In toluene at 20℃; for 0.5h;
Stage #2: 3'-(trifluoromethyl)acetophenone In toluene at 20℃; for 24h;
94%
Stage #1: phenylacetylene With tetrabutyl-ammonium chloride; potassium hydroxide In tetrahydrofuran at 20℃; for 12h; Inert atmosphere; Molecular sieve;
Stage #2: 3'-(trifluoromethyl)acetophenone In tetrahydrofuran at 20℃; for 72h; Inert atmosphere; Molecular sieve;
Stage #3: With water; ammonium chloride In tetrahydrofuran Inert atmosphere; Molecular sieve;
83%
allyl bromide
106-95-6

allyl bromide

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

1-m-trifluoromethylphenyl-1-methylbut-3-en-1-ol

1-m-trifluoromethylphenyl-1-methylbut-3-en-1-ol

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate; tin(ll) chloride In water at 20℃; for 24h;94%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

4-methoxy-N-(1-(3-(trifluoromethyl)phenyl)ethyl)aniline
1155868-84-0

4-methoxy-N-(1-(3-(trifluoromethyl)phenyl)ethyl)aniline

Conditions
ConditionsYield
With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; C89H110IrN2O6PS; hydrogen In toluene at 35℃; under 3750.38 Torr; for 24h; Molecular sieve; optical yield given as %ee; enantioselective reaction;94%
1-(5-bromo-2-iodophenyl)ethanone
1261648-81-0

1-(5-bromo-2-iodophenyl)ethanone

3'-(trifluoromethyl)acetophenone
349-76-8

3'-(trifluoromethyl)acetophenone

7-bromo-3-(3-(trifluoromethyl)phenyl)naphthalen-1-ol
1610538-73-2

7-bromo-3-(3-(trifluoromethyl)phenyl)naphthalen-1-ol

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; sodium t-butanolate In toluene at 20℃; for 4.5h; Inert atmosphere; Sealed tube;94%
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