Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:349-76-8
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:349-76-8
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiry3'-(Trifluoromethyl)acetophenone CAS 349-76-8 3-Acetylbenzotrifluoride CAS no 349-76-8 Ethanone,1-[3-(trifluoromethyl)phenyl]- 3'-(Trifluoromethyl)acetophenone CAS 349-76-8 IN Stock CAS 349-76-8 3-Acetylbenzotrifluoride 3'-(Triflu
Cas:349-76-8
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Cas:349-76-8
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:349-76-8
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:349-76-8
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:349-76-8
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:349-76-8
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inquiryChemical name:3'-(Trifluoromethyl)acetophenone CAS No.349-76-8 Synonyms:C9H7F3O Molecular Fomula: Molecular weight:188.15 Appearance:Colorless liquid Assay:99% Appearance: Colorless Transparent Liquid Storage:Store in cool and dry place,
Cas:349-76-8
Min.Order:1 Kilogram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:349-76-8
Min.Order:1 Kilogram
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inquiry3'-(Trifluoromethyl)acetophenone CAS:349-76-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit
Cas:349-76-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:349-76-8
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:349-76-8
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:349-76-8
Min.Order:1 Kilogram
FOB Price: $6.0 / 10.0
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:Yellow liquid Storage:R.T Package:25kg/Barrel Application:Intermediate Transportation:Express/Sea/Air Port:Any port in China
Cas:349-76-8
Min.Order:25 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:349-76-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:349-76-8
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:349-76-8
Min.Order:0
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:349-76-8
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:349-76-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:light yellow liquid Storage:In Room Temperature Package:25kg/drum, or as per your request. Application:For medicine , pesticide intermediates Transportation:as per your request.
Cas:349-76-8
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct Name: 3'-(Trifluoromethyl)acetophenone Synonyms: 3'-(Trifluoromethyl)acetophenone,99%;3-Trifludromethylacetophen;1-[3-(Trifluoromethyl)phenyl]ethan-1-one, 3-Acetylbenzotrifluoride;3'-(TrifluoroMethyl)acetophenone, 97+%;1-[3-
Cas:349-76-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:349-76-8
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:349-76-8
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:349-76-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With oxygen; acetic acid; [Pd{N,N'-di(2,6-di-iPrC6H3)dihydroimidazol-2-yl}(OAc)2(H2O)] In toluene at 60℃; for 12h; | 99% |
With (1,3-diarylimidazol-2-ylidene)-based Pd; oxygen; acetic acid In toluene at 60℃; for 12h; | 99% |
With [(2-(benzoimidazol-2-yl)-6-(3,5-dimethylpyrazol-1-yl)pyridine)RuCl2(PPh3)]; potassium tert-butylate; acetone In methanol at 56℃; under 750.075 Torr; for 0.166667h; Catalytic behavior; Oppenauer Oxidation; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
With oxygen; silver fluoride In N,N-dimethyl-formamide at 50℃; for 3h; Molecular sieve; | 96% |
m-trifluoromethylphenyl iodide
acetic anhydride
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium (0); N-ethyl-N,N-diisopropylamine; lithium chloride In N,N-dimethyl-formamide at 100℃; for 5h; | 94% |
Conditions | Yield |
---|---|
With potassium fluoride; oxygen In N,N-dimethyl-formamide at 50℃; for 18h; Molecular sieve; | 92% |
2-methyl-2-(3-(trifluoromethyl)phenyl)-1,3-dithiolane
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With iodosylbenzene In dichloromethane at 20℃; for 1.41667h; | 85% |
Conditions | Yield |
---|---|
With acetic anhydride In tetrahydrofuran; toluene at -15 - 20℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere; | 81.3% |
3-bromo-1-trifluoromethylbenzene
acetyl chloride
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
Stage #1: 3-bromo-1-trifluoromethylbenzene With trifluoroacetic acid; cobalt(II) bromide; zinc; zinc dibromide In acetonitrile at 20℃; Stage #2: acetyl chloride In acetonitrile at 20℃; | 80% |
Stage #1: 3-bromo-1-trifluoromethylbenzene With cobalt(II) bromide; zinc dibromide In acetonitrile at 20℃; Electrochemical reaction; Stage #2: acetyl chloride With bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 20℃; Negishi coupling reaction; | 76% |
(i) Mg, (ii) CdCl2, (iii) /BRN= 605303/; Multistep reaction; |
(meta-(trifluoromethyl)phenyl)boronic acid
acetonitrile
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With 1,10-Phenanthroline; nickel(II) bromide 2-methoxyethyl ether complex; sodium hydrogencarbonate In water at 100℃; for 5h; Autoclave; | 77% |
1-(3-aminophenyl)ethanone
(trifluoromethyl)trimethylsilane
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
Stage #1: 1-(3-aminophenyl)ethanone With tert.-butylnitrite; toluene-4-sulfonic acid In acetonitrile at 20℃; for 0.5h; Sandmeyer Reaction; Inert atmosphere; Stage #2: (trifluoromethyl)trimethylsilane With copper(I) thiocyanate; caesium carbonate In acetonitrile at 20℃; for 0.202833h; Sandmeyer Reaction; Inert atmosphere; | 74% |
3-bromo-1-trifluoromethylbenzene
acetic anhydride
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
Stage #1: 3-bromo-1-trifluoromethylbenzene With isopropyl magnesium chloride; lithium chloride In tetrahydrofuran at 70℃; under 50.03 Torr; for 3.5h; Inert atmosphere; Stage #2: acetic anhydride at 0 - 40℃; Inert atmosphere; | 73.8% |
(i) Mg, Et2O, (ii) /BRN= 385737/; Multistep reaction; |
Conditions | Yield |
---|---|
With hydrogenchloride In water; N,N-dimethyl-formamide | 73% |
Conditions | Yield |
---|---|
With manganese(II) bromide; water; lithium perchlorate; copper dichloride In acetonitrile at 60℃; for 8h; Wacker-Tsuji Olefin Oxidation; Sealed tube; Inert atmosphere; Electrochemical reaction; regioselective reaction; | 72% |
3-bromo-1-trifluoromethylbenzene
acetic anhydride
A
α,α,α-trifluorotoluene
B
3,3'-bis(trifluoromethyl)biphenyl
C
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With 3-chloroprop-1-ene; cobalt(II) bromide; zinc; trifluoroacetic acid In acetonitrile for 6h; | A 8 % Chromat. B 2 % Chromat. C 71% |
With 3-chloroprop-1-ene; cobalt(II) bromide; zinc; trifluoroacetic acid In acetonitrile for 6h; | A 11 % Chromat. B 1 % Chromat. C 74 % Chromat. |
ethyl 2-cyanoacetate
(meta-(trifluoromethyl)phenyl)boronic acid
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; water; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine at 90℃; for 8h; | 71% |
3-trifluormethylisopropylbenzene
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; oxygen In benzonitrile at 100℃; for 20h; | 65% |
3-<(trimethylsilyl)ethynyl>benzotrifluoride
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With iron(III) sulphate monohydrate; acetic acid at 95℃; for 40h; regioselective reaction; | 65% |
Conditions | Yield |
---|---|
56% | |
Multi-step reaction with 2 steps 1.1: NaNO2; aq. HCl / 0.33 h / -5 - 0 °C 1.2: CuSO4; AcONa*3H2O / aq. HCl / 1.5 h / 0 - 15 °C 2.1: 14.5 g / conc. HCl / 2 h / Heating View Scheme |
(trifluoromethyl)trimethylsilane
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With 1,10-Phenanthroline; oxygen; copper diacetate; cesium fluoride In Isobutyronitrile at 20℃; under 760.051 Torr; for 3h; Chan-Lam-type reaction; Molecular sieve; Inert atmosphere; | 54% |
trifluoromethanesulfonic acid difluoromethyl ether
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
Stage #1: trifluoromethanesulfonic acid difluoromethyl ether With copper(I) thiophene-2-carboxylate; tetrabutylammonium triphenyldifluorosilicate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: (3-acetylphenyl)(mesityl)iodonium trifluoromethanesulfonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Inert atmosphere; | 54% |
(E)-acetaldoxime
copper(II) sulphate hydrate
3-trifluoromethylaniline
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With sodium nitrite In water | 51.5% |
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; copper diacetate In N,N-dimethyl acetamide at 25℃; under 760.051 Torr; for 16h; Inert atmosphere; | 50% |
pentacarbonyl(methoxymethylcarbene)chromium(0)
(meta-(trifluoromethyl)phenyl)boronic acid
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
Stage #1: pentacarbonyl(methoxymethylcarbene)chromium(0); [3-(trifluoromethyl) phenyl] boronic acid With trifuran-2-yl-phosphane; palladium diacetate; diisopropylamine In toluene at 90℃; for 3h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 60℃; for 2h; Inert atmosphere; | 35% |
2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; copper diacetate In ethyl acetate at 20℃; for 20h; Inert atmosphere; | 30% |
methyl magnesium iodide
3-trifluoromethylbenzonitrile
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With diethyl ether anschliessend Behandeln mit wss. HCl; |
3-trifluoromethylbenzonitrile
methylmagnesium bromide
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With diethyl ether anschliessend Behandeln mit wss. HCl; |
Conditions | Yield |
---|---|
With diethyl ether; dimethylcadmium |
1-(1-Methoxy-vinyl)-3-trifluoromethyl-benzene
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With sulfuric acid In water at 25℃; Rate constant; |
1-(1,1-Dimethoxy-ethyl)-3-trifluoromethyl-benzene
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With hydrogen bromide at 25℃; Rate constant; var. conc. of water; | |
With hydrogen bromide; bromine In chlorobenzene at 25℃; Rate constant; |
Conditions | Yield |
---|---|
In benzene Rate constant; Quantum yield; Irradiation; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol at 0 - 20℃; | 100% |
Stage #1: 3'-(trifluoromethyl)acetophenone With C107H90Cl2N10P4Ru2(2+)*2Cl(1-) In isopropyl alcohol at 82℃; for 0.166667h; Inert atmosphere; Stage #2: With potassium isopropoxide In isopropyl alcohol for 2h; Catalytic behavior; Inert atmosphere; | 99% |
With palladium; hydrogen In methanol at 30℃; for 20h; | 99% |
3'-(trifluoromethyl)acetophenone
3-trifluoromethylbenzoylformaldehyde
Conditions | Yield |
---|---|
With water; hydrogen bromide; dimethyl sulfoxide at 20 - 70℃; | 100% |
With selenium(IV) oxide In methanol | |
Multi-step reaction with 2 steps 1: Br2 / acetic acid 2: DMSO View Scheme | |
With iodine; dimethyl sulfoxide at 90℃; | |
With selenium(IV) oxide In 1,4-dioxane; water at 115℃; for 12h; Inert atmosphere; |
3'-(trifluoromethyl)acetophenone
ethylhydrazine carboxylate
ethyl 2-(1-(3-(trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Heating; | 100% |
With toluene-4-sulfonic acid In benzene for 4h; Heating; | 100% |
3'-(trifluoromethyl)acetophenone
1-(3-(trifluoromethyl)phenyl)ethanone oxime
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 95℃; | 100% |
With pyridine; hydroxylamine hydrochloride at 80℃; for 0.25h; | 96% |
With hydroxylamine hydrochloride; sodium hydroxide In ethanol pH=8; Reflux; | 95.5% |
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene | 100% |
3'-(trifluoromethyl)acetophenone
Conditions | Yield |
---|---|
With potassium formate; Cp*IrCl[(S,S)-(C2H5)2CHCH2SO2dpen]; tetrabutylammomium bromide In water at 50℃; for 24h; Inert atmosphere; | 100% |
With formic acid; C24H28ClN2O2PolRuS; triethylamine In dichloromethane at 40℃; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; |
3'-(trifluoromethyl)acetophenone
(R)-1-(3-trifluoromethylphenyl)ethanol
Conditions | Yield |
---|---|
With potassium tert-butylate; hydrogen; RuCl2[(S)-XylHexaPHEMP][(S)-1,1-dianisyl-2-iPr-1,2-Et(NH2)2] In isopropyl alcohol; tert-butyl alcohol at 20℃; under 6205.94 Torr; for 0.683333h; | 99% |
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C45H58NP; potassium tert-butylate; hydrogen In propan-1-ol at 25 - 30℃; under 4560.31 Torr; for 0.166667h; Autoclave; optical yield given as %ee; enantioselective reaction; | 99% |
With [Fe(II)(3-ethyl-3-isocyanopentane)2((5S,8S,14aS,18aS)-5,8-diphenyl-5,6,7,8,13,14,14a,15,16,17,18,18a,19,20-tetradecahydrotribenzo[b,f,l][1,4]diaza[8,11]diphosphacyclotetradecine)](BF4)2; isopropyl alcohol; sodium t-butanolate at 60℃; for 1h; Glovebox; enantioselective reaction; | 99.7% |
Conditions | Yield |
---|---|
With bromine In diethyl ether for 3h; Ambient temperature; | 99% |
With bromine In chloroform for 1.5h; Ambient temperature; | 92.9% |
With aluminum (III) chloride; bromine In diethyl ether at 20℃; for 1.5h; | 92% |
3'-(trifluoromethyl)acetophenone
1-(3-(trifluoromethyl)phenyl)ethan-1-amine
Conditions | Yield |
---|---|
Stage #1: 3'-(trifluoromethyl)acetophenone With aluminium(III) triflate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 1,2-bis-(diphenylphosphino)ethane In dodecane; toluene at -5℃; under 4500.45 Torr; for 0.5h; Autoclave; Stage #2: With hydrogen In dodecane; toluene at 140℃; under 30003 Torr; for 16h; Acidic conditions; chemoselective reaction; | 99% |
With aluminium(III) triflate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; hydrogen; 1,2-bis-(diphenylphosphino)ethane at 140℃; for 16h; Autoclave; | 99% |
With 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate In methanol at 80℃; for 12h; Inert atmosphere; chemoselective reaction; | 82% |
3'-(trifluoromethyl)acetophenone
(S)-1-(3-trifluoromethylphenyl)ethanol
Conditions | Yield |
---|---|
With D-glucose In aq. phosphate buffer at 25℃; for 24h; pH=7.0; stereoselective reaction; | 99% |
With ethanol; Rhodococcus species-1 alcohol dehydrogenase; NAD; bovine serum albumin; yeast alcohol dehydrogenase; yeast aldehyde dehydrogenase at 30℃; for 12h; pH=7.5; aq. phosphate buffer; Enzymatic reaction; optical yield given as %ee; | 98% |
With formic acid; chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll) In N,N-dimethyl-formamide at 50℃; for 27h; Reagent/catalyst; Temperature; Time; Solvent; Inert atmosphere; Industrial scale; enantioselective reaction; | 98% |
trimethylsulfoxonium iodide
3'-(trifluoromethyl)acetophenone
2-methyl-2-(3-trifluoromethylphenyl)-oxirane
Conditions | Yield |
---|---|
With sodium hydride In dimethyl sulfoxide at 20℃; | 99% |
3'-(trifluoromethyl)acetophenone
A
(R)-1-(3-trifluoromethylphenyl)ethanol
B
triethylamine
Conditions | Yield |
---|---|
A 99% B n/a |
isopropyl alcohol
3'-(trifluoromethyl)acetophenone
(R)-1-(3-trifluoromethylphenyl)ethanol
Conditions | Yield |
---|---|
In argon | 98.7% |
Conditions | Yield |
---|---|
Stage #1: dimethyl sulfate With p-propoxybenzyl sulfide at 90℃; for 2h; Stage #2: 3'-(trifluoromethyl)acetophenone With potassium hydroxide In dimethyl sulfoxide at 50℃; for 4h; | 98.6% |
2-Aminobenzyl alcohol
3'-(trifluoromethyl)acetophenone
2-(3-(trifluoromethyl)phenyl)quinoline
Conditions | Yield |
---|---|
With potassium hydroxide; Grubbs catalyst first generation In 1,4-dioxane at 80℃; for 1h; | 98% |
With silver; potassium hydroxide In toluene at 80℃; for 24h; | 81% |
With dimanganese decacarbonyl; sodium hydroxide In toluene at 110℃; for 2h; Friedlaender Quinoline Synthesis; Inert atmosphere; Glovebox; Sealed tube; | 80% |
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; magnesium bromide; (1S,2R,4R,1'R,2'R,1''S,2''R,4''R)-N-{trans-2'-[2''-hydroxy-7'',7''-dimethylbicyclo[2.2.1]hept-1''-ylmethylsulfonamino]cyclohexyl}-2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-ylmethanesulfonamide In toluene at 0℃; for 12h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 98% |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 25℃; Claisen-Schmidt Condensation; | 97.1% |
1-methyl-1H-indole-2,3-dione
3'-(trifluoromethyl)acetophenone
1-methyl-3-hydroxy-3-(2-(3-trifluoromethylphenyl)-2-oxoethyl)indolin-2-one
Conditions | Yield |
---|---|
With piperidine In ethanol at 20℃; for 6h; | 97% |
Conditions | Yield |
---|---|
Stage #1: 3'-(trifluoromethyl)acetophenone With sodium hydroxide In ethanol; water at 20℃; for 0.0833333h; Claisen-Schmidt Condensation; Stage #2: 2,6-dimethoxybenzaldehyde at 20℃; Claisen-Schmidt Condensation; | 97% |
Conditions | Yield |
---|---|
In ethanol at 0 - 20℃; for 72h; Molecular sieve; Inert atmosphere; Sealed tube; | 96% |
methyl magnesium iodide
3'-(trifluoromethyl)acetophenone
α,α-dimethyl-3-(trifluoromethyl)benzenemethanol
Conditions | Yield |
---|---|
95% |
(2-ethylbutyl)magnesium bromide
3'-(trifluoromethyl)acetophenone
(+)-(R)-4-ethyl-2-(3-(trifluoromethyl)phenyl)hexan-2-ol
Conditions | Yield |
---|---|
With copper(I) bromide dimethylsulfide complex; (S,R)-revJosiphos In diethyl ether; tert-butyl methyl ether at -78℃; for 0.25h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 95% |
ethane-1,2-dithiol
3'-(trifluoromethyl)acetophenone
2-methyl-2-(3-(trifluoromethyl)phenyl)-1,3-dithiolane
Conditions | Yield |
---|---|
at 20℃; | 95% |
Conditions | Yield |
---|---|
Stage #1: phenylacetylene With dimethyl zinc(II) In toluene at 20℃; for 0.5h; Stage #2: 3'-(trifluoromethyl)acetophenone In toluene at 20℃; for 24h; | 94% |
Stage #1: phenylacetylene With tetrabutyl-ammonium chloride; potassium hydroxide In tetrahydrofuran at 20℃; for 12h; Inert atmosphere; Molecular sieve; Stage #2: 3'-(trifluoromethyl)acetophenone In tetrahydrofuran at 20℃; for 72h; Inert atmosphere; Molecular sieve; Stage #3: With water; ammonium chloride In tetrahydrofuran Inert atmosphere; Molecular sieve; | 83% |
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate; tin(ll) chloride In water at 20℃; for 24h; | 94% |
4-methoxy-aniline
3'-(trifluoromethyl)acetophenone
4-methoxy-N-(1-(3-(trifluoromethyl)phenyl)ethyl)aniline
Conditions | Yield |
---|---|
With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; C89H110IrN2O6PS; hydrogen In toluene at 35℃; under 3750.38 Torr; for 24h; Molecular sieve; optical yield given as %ee; enantioselective reaction; | 94% |
1-(5-bromo-2-iodophenyl)ethanone
3'-(trifluoromethyl)acetophenone
7-bromo-3-(3-(trifluoromethyl)phenyl)naphthalen-1-ol
Conditions | Yield |
---|---|
With copper(l) iodide; 1,10-Phenanthroline; sodium t-butanolate In toluene at 20℃; for 4.5h; Inert atmosphere; Sealed tube; | 94% |
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