We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni
Cas:364782-34-3
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCinacalcet Hydrochloride Cas no. 364782-34-3 Cinacalcet Hydrochloride Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manu
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine raw material Transportatio
Cas:364782-34-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryCinacalcet hydrochloride CAS No.:364782-34-3 Name: Cinacalcet hydrochloride Synonyms: N-(
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:364782-34-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:364782-34-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $200.0 / 300.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:364782-34-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:364782-34-3
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:364782-34-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $7.0 / 10.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:364782-34-3
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:364782-34-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAbout us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $300.0 / 320.0
Type:Trading Company
inquiryBeluga chemical professional supply High quality Cinacalcet hydrochloride CAS 364782-34-3 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Mad
Cas:364782-34-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:364782-34-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:364782-34-3
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:364782-34-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryPrice, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo
Cas:364782-34-3
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:364782-34-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detaile
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryProduct Name: Cinacalcet hydrochloride Synonyms: (R)-Cinacalcet Hydrochloride;Cinacalcet(AMG-073) Hydrochloride;AMG-073 HCl;Cinacalcet hydrochloride N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride;Cinacalce
Cas:364782-34-3
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Fandachem Co.,Ltd is China-based top1 exporter and supplier of Cinacalcet hydrochloride 99.9%min,Best Sale, CAS No.: 364782-34-3,please contact for price of Cinacalcet hydrochloride 99.9%min,Best Sale, CAS No.: 364782-34-3 and also you c
Cas:364782-34-3
Min.Order:1 Kilogram
FOB Price: $342.0 / 375.0
Type:Other
inquiry(R)-N-(1-(naphthalen-1-yl)ethyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)formamide
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water for 12h; Reflux; | 100% |
(R)-1-(1-Naphthyl)ethylamine
methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester With potassium carbonate; potassium iodide; 1-(n-butyl)-3-methylimidazolium triflate In acetonitrile for 6h; Reflux; Stage #2: With hydrogenchloride at 50 - 55℃; for 1h; Reagent/catalyst; | 98.25% |
Stage #1: (R)-1-(1-Naphthyl)ethylamine; methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester With potassium carbonate In toluene for 16h; Reflux; Stage #2: With hydrogenchloride In water; toluene at 70℃; Reagent/catalyst; Solvent; Temperature; Time; | 85% |
(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide With sodium tetrahydroborate; iodine In tetrahydrofuran at 0 - 75℃; for 6.5h; Stage #2: With hydrogenchloride In hexane; water for 1h; | 96.22% |
Stage #1: (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide With sodium tetrahydroborate; boron trifluoride In tetrahydrofuran; diethylene glycol dimethyl ether at 45 - 60℃; Stage #2: With hydrogenchloride In toluene Further stages.; | 95% |
Stage #1: (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide With dodecacarbonyl-triangulo-triruthenium; 1,1,3,3-tetramethyldisilazane In toluene at 50℃; for 18h; Stage #2: With hydrogenchloride In 1,4-dioxane at 50℃; | 93% |
cinacalcet
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In n-heptane; ethyl acetate at 20℃; | 95% |
With hydrogenchloride In acetonitrile at 25 - 55℃; for 0.2h; | 93.1% |
With hydrogenchloride In n-heptane; water; toluene at 25 - 30℃; pH=1 - 2; Product distribution / selectivity; | 92.55% |
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-α-methyl-N-[3-[3-trifluoromethylphenyl]propyl]-1-naphthalenemethanamine phosphate With sodium hydroxide In water; ethyl acetate at 20℃; for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In ethyl acetate at 20 - 25℃; | 94% |
vinyl acetate
1-(1-naphthyl)ethanol
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: vinyl acetate; 1-(1-naphthyl)ethanol at 30℃; for 12h; Enzymatic reaction; Stage #2: 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 25℃; Stage #3: With hydrogenchloride In water Solvent; | 93.3% |
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: cinacalcet L-tartrate With sodium carbonate In water at 15 - 20℃; Inert atmosphere; Stage #2: With hydrogenchloride In water; acetonitrile at 15 - 20℃; for 0.5h; | 92.54% |
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine hydrochloride
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogen; palladium dichloride In methanol; ethyl acetate at 20℃; under 750.075 Torr; for 0.5h; Product distribution / selectivity; | 92.5% |
(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In water; ethyl acetate at 25 - 30℃; Large scale; | 91% |
With palladium 10% on activated carbon; hydrogen; potassium carbonate In methanol at 20 - 25℃; under 1500.15 - 2250.23 Torr; for 3h; pH=4.1; | 71% |
With hydrogen; Raney nickel In methanol; ethyl acetate at 20℃; Product distribution / selectivity; Inert atmosphere; | 69.6% |
With hydrogen; palladium(II) hydroxide In methanol at 5 - 10℃; under 1103.36 Torr; for 3h; Product distribution / selectivity; Autoclave; | |
Multi-step reaction with 2 steps 1.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C / Inert atmosphere 1.2: 1 h / 20 °C / Inert atmosphere 2.1: hydrogenchloride; hydrogen / 2-5percent w/w palladium on carbon / water; methanol / 20 - 30 °C / Inert atmosphere View Scheme |
2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In tert-butyl methyl ether; water at 20℃; | 91% |
Sodium 1-hydroxy-3-(3-trifluoromethylphenyl)propane-1-sulfonate
(R)-<1-(1-Naphthyl)ethyl>ammonium chloride
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: Sodium 1-hydroxy-3-(3-trifluoromethylphenyl)propane-1-sulfonate; (R)-<1-(1-Naphthyl)ethyl>ammonium chloride With triethylamine-borane In methanol at 20℃; for 16h; Stage #2: With hydrogenchloride In water at 0℃; for 13h; Reagent/catalyst; | 91% |
(R)-(1-(naphthalen-1-yl)-ethyl)-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-amine hydrochloride
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogen; 5%-palladium/activated carbon In water; isopropyl alcohol at 20℃; for 3h; | 90% |
With hydrogen; 5%-palladium/activated carbon In isopropyl alcohol at 20℃; under 760.051 Torr; for 3h; | 90% |
(R)-1-(1-Naphthyl)ethylamine
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-(3-(trifluoromethyl)phenyl)propyl trifluoromethanesulfonate With potassium hydroxide In toluene for 16h; Reflux; Stage #2: With hydrogenchloride In water; toluene Temperature; | 89% |
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In tert-butyl methyl ether; water at 20℃; | 84% |
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; 2-5percent w/w palladium on carbon In methanol; water at 20 - 30℃; Inert atmosphere; | 83.8% |
1-(3-bromopropyl)-3- (trifluoromethyl)benzene
(R)-1-(1-Naphthyl)ethylamine
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene; (R)-1-(1-Naphthyl)ethylamine With potassium carbonate In toluene for 7h; Reflux; Stage #2: With hydrogenchloride In water; toluene at 50℃; | 83% |
Stage #1: (R)-1-(1-Naphthyl)ethylamine With benzaldehyde at 25 - 30℃; Forster reaction; Stage #2: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene In 1-methyl-pyrrolidin-2-one at 125 - 130℃; Forster reaction; Further stages; | 58% |
(R)-1-(1-Naphthyl)ethylamine
3-[3-(trifluoromethyl)phenyl]propan-1-ol
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propan-1-ol With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In toluene at 110℃; for 6h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; hexane; ethyl acetate; toluene Reagent/catalyst; Time; | 83% |
(R)-3-chloro-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-3-chloro-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride With sodium hydrogencarbonate In water; toluene at 15 - 20℃; pH=8 - 9; Inert atmosphere; Stage #2: With hydrogen; 5% Pd(II)/C(eggshell) In methanol; toluene at 20℃; under 750.075 Torr; Product distribution / selectivity; | 82.6% |
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at 20℃; | 80.8% |
(R)-1-(1-Naphthyl)ethylamine
3-[3-(trifluoromethyl)phenyl]propanal
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propanal With sodium tetrahydroborate; boric acid at 20℃; for 14.5h; Stage #2: With hydrogenchloride In hexane; water at 20℃; for 3.5h; pH=1 - 3; | 80% |
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propanal In tetrahydrofuran at -50 - -45℃; for 2.5h; Stage #2: With titanium(IV) isopropylate In tetrahydrofuran Product distribution / selectivity; |
N-[1-(R)-(-)-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane acetate
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With sodium chloride In 2-methylpropyl acetate; water at 20℃; Product distribution / selectivity; | 79.7% |
With hydrogenchloride In 2-methylpropyl acetate; water at 5 - 10℃; for 0.5h; Product distribution / selectivity; | 72.7% |
With hydrogenchloride In dichloromethane; water for 0.25h; Product distribution / selectivity; |
(R)-1-(1-Naphthyl)ethylamine
3-(3-trifluoromethylphenyl)propanoic acid
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-(3-trifluoromethylphenyl)propanoic acid With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; phenylsilane; 1,2-bis-(diphenylphosphino)ethane In dibutyl ether at 120℃; for 18h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether at -20℃; Schlenk technique; Inert atmosphere; | 74% |
(R)-1-(1-Naphthyl)ethylamine
1-(3-chloropropyl)-3-(trifluoromethyl)benzene
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 1-(3-chloropropyl)-3-(trifluoromethyl)benzene With potassium carbonate In toluene for 15h; Reflux; Stage #2: With hydrogenchloride In water; toluene for 60h; | 73% |
methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester
(R)-<1-(1-Naphthyl)ethyl>ammonium chloride
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In water; toluene for 24h; Inert atmosphere; Reflux; | 71.8% |
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate With hydrogen; 2.5% wt Pd/C In methanol Inert atmosphere; Stage #2: With hydrogenchloride In methanol; water at 25 - 30℃; for 1h; Product distribution / selectivity; Inert atmosphere; | 63.9% |
(R)-N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino]-N-[1-(1-naphthyl)ethylamine]
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino]-N-[1-(1-naphthyl)ethylamine] With 5%-palladium/activated carbon; hydrogen In ethanol at 20℃; under 2250.23 Torr; Stage #2: With hydrogenchloride In ethanol; isopropyl alcohol | 60% |
1'-naphthacetophenone
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1'-naphthacetophenone; 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate In toluene at 40℃; for 48h; Molecular sieve; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene at 0 - 5℃; Reagent/catalyst; | 56.7% |
1-(3-bromopropyl)-3- (trifluoromethyl)benzene
(R)-1-(1-Naphthyl)ethylamine
benzaldehyde
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; benzaldehyde at 25 - 30℃; Stage #2: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene In 1-methyl-pyrrolidin-2-one at 130 - 140℃; for 12h; Stage #3: With hydrogenchloride; water In 1-methyl-pyrrolidin-2-one; toluene pH=0.5 - 2; | 52.1% |
(E)-N-((R)-1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-acrylamide
cinacalcet hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-N-(1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-(E)-acrylamide With dimethylsulfide borane complex In tetrahydrofuran at 0 - 65℃; for 4h; Stage #2: With methanol at 0℃; for 0.5h; Stage #3: With hydrogenchloride; water at 0 - 90℃; for 4h; Product distribution / selectivity; |
cinacalcet hydrochloride
cinacalcet
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water | 96% |
With water; sodium carbonate In di-isopropyl ether at 25℃; for 2.25h; pH=9.5; |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 100℃; for 12h; Inert atmosphere; | 82% |
cinacalcet hydrochloride
1-(3-bromopropyl)-3- (trifluoromethyl)benzene
(R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 110 - 111℃; for 48h; | 69.03% |
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