Product Name

  • Name

    Cinacalcet hydrochloride

  • EINECS 620-490-5
  • CAS No. 364782-34-3
  • Article Data60
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 175-177 °C
  • Formula C22H22F3N.HCl
  • Boiling Point 440.9 °C at 760 mmHg
  • Molecular Weight 393.88
  • Flash Point 220.5 °C
  • Transport Information
  • Appearance Off-white to tan solid
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 364782-34-3 (Cinacalcet hydrochloride)
  • Hazard Symbols
  • Synonyms Mimpara;Regpara;Sensipar;1-Naphthalenemethanamine,a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-,hydrochloride, (aR)-(9CI);
  • PSA 12.03000
  • LogP 7.33490

Synthetic route

(R)-N-(1-(naphthalen-1-yl)ethyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)formamide
1601479-86-0

(R)-N-(1-(naphthalen-1-yl)ethyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)formamide

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water for 12h; Reflux;100%
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester
21172-43-0

methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester With potassium carbonate; potassium iodide; 1-(n-butyl)-3-methylimidazolium triflate In acetonitrile for 6h; Reflux;
Stage #2: With hydrogenchloride at 50 - 55℃; for 1h; Reagent/catalyst;		98.25%
Stage #1: (R)-1-(1-Naphthyl)ethylamine; methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester With potassium carbonate In toluene for 16h; Reflux;
Stage #2: With hydrogenchloride In water; toluene at 70℃; Reagent/catalyst; Solvent; Temperature; Time;		85%
(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide
1005450-55-4

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide With sodium tetrahydroborate; iodine In tetrahydrofuran at 0 - 75℃; for 6.5h;
Stage #2: With hydrogenchloride In hexane; water for 1h;		96.22%
Stage #1: (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide With sodium tetrahydroborate; boron trifluoride In tetrahydrofuran; diethylene glycol dimethyl ether at 45 - 60℃;
Stage #2: With hydrogenchloride In toluene Further stages.;		95%
Stage #1: (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide With dodecacarbonyl-triangulo-triruthenium; 1,1,3,3-tetramethyldisilazane In toluene at 50℃; for 18h;
Stage #2: With hydrogenchloride In 1,4-dioxane at 50℃;		93%
cinacalcet
226256-56-0

cinacalcet

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In n-heptane; ethyl acetate at 20℃;95%
With hydrogenchloride In acetonitrile at 25 - 55℃; for 0.2h;93.1%
With hydrogenchloride In n-heptane; water; toluene at 25 - 30℃; pH=1 - 2; Product distribution / selectivity;92.55%
(R)-α-methyl-N-[3-[3-trifluoromethylphenyl]propyl]-1-naphthalenemethanamine phosphate

(R)-α-methyl-N-[3-[3-trifluoromethylphenyl]propyl]-1-naphthalenemethanamine phosphate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-α-methyl-N-[3-[3-trifluoromethylphenyl]propyl]-1-naphthalenemethanamine phosphate With sodium hydroxide In water; ethyl acetate at 20℃; for 1h; Inert atmosphere;
Stage #2: With hydrogenchloride In ethyl acetate at 20 - 25℃;		94%
vinyl acetate
108-05-4

vinyl acetate

1-(1-naphthyl)ethanol
57605-95-5

1-(1-naphthyl)ethanol

3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
104774-87-0

3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: vinyl acetate; 1-(1-naphthyl)ethanol at 30℃; for 12h; Enzymatic reaction;
Stage #2: 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 25℃;
Stage #3: With hydrogenchloride In water Solvent;		93.3%
...Expand
cinacalcet L-tartrate

cinacalcet L-tartrate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: cinacalcet L-tartrate With sodium carbonate In water at 15 - 20℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water; acetonitrile at 15 - 20℃; for 0.5h;		92.54%
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine hydrochloride
1240705-66-1

N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine hydrochloride

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogen; palladium dichloride In methanol; ethyl acetate at 20℃; under 750.075 Torr; for 0.5h; Product distribution / selectivity;92.5%
(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride
1207533-91-2

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In water; ethyl acetate at 25 - 30℃; Large scale;91%
With palladium 10% on activated carbon; hydrogen; potassium carbonate In methanol at 20 - 25℃; under 1500.15 - 2250.23 Torr; for 3h; pH=4.1;71%
With hydrogen; Raney nickel In methanol; ethyl acetate at 20℃; Product distribution / selectivity; Inert atmosphere;69.6%
With hydrogen; palladium(II) hydroxide In methanol at 5 - 10℃; under 1103.36 Torr; for 3h; Product distribution / selectivity; Autoclave;
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C / Inert atmosphere
1.2: 1 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; hydrogen / 2-5percent w/w palladium on carbon / water; methanol / 20 - 30 °C / Inert atmosphere
View Scheme
2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide
1410044-63-1

2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether; water at 20℃;91%
Sodium 1-hydroxy-3-(3-trifluoromethylphenyl)propane-1-sulfonate
1015421-30-3

Sodium 1-hydroxy-3-(3-trifluoromethylphenyl)propane-1-sulfonate

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride
82572-04-1

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: Sodium 1-hydroxy-3-(3-trifluoromethylphenyl)propane-1-sulfonate; (R)-<1-(1-Naphthyl)ethyl>ammonium chloride With triethylamine-borane In methanol at 20℃; for 16h;
Stage #2: With hydrogenchloride In water at 0℃; for 13h; Reagent/catalyst;		91%
(R)-(1-(naphthalen-1-yl)-ethyl)-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-amine hydrochloride
1093944-40-1

(R)-(1-(naphthalen-1-yl)-ethyl)-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-amine hydrochloride

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In water; isopropyl alcohol at 20℃; for 3h;90%
With hydrogen; 5%-palladium/activated carbon In isopropyl alcohol at 20℃; under 760.051 Torr; for 3h;90%
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-(3-(trifluoromethyl)phenyl)propyl trifluoromethanesulfonate

3-(3-(trifluoromethyl)phenyl)propyl trifluoromethanesulfonate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-(3-(trifluoromethyl)phenyl)propyl trifluoromethanesulfonate With potassium hydroxide In toluene for 16h; Reflux;
Stage #2: With hydrogenchloride In water; toluene Temperature;		89%
N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-tritylamine

N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-tritylamine

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether; water at 20℃;84%
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine fumarate

N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine fumarate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; 2-5percent w/w palladium on carbon In methanol; water at 20 - 30℃; Inert atmosphere;83.8%
1-(3-bromopropyl)-3- (trifluoromethyl)benzene
129254-76-8

1-(3-bromopropyl)-3- (trifluoromethyl)benzene

(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene; (R)-1-(1-Naphthyl)ethylamine With potassium carbonate In toluene for 7h; Reflux;
Stage #2: With hydrogenchloride In water; toluene at 50℃;		83%
Stage #1: (R)-1-(1-Naphthyl)ethylamine With benzaldehyde at 25 - 30℃; Forster reaction;
Stage #2: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene In 1-methyl-pyrrolidin-2-one at 125 - 130℃; Forster reaction; Further stages;		58%
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-[3-(trifluoromethyl)phenyl]propan-1-ol
78573-45-2

3-[3-(trifluoromethyl)phenyl]propan-1-ol

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propan-1-ol With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In toluene at 110℃; for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether; hexane; ethyl acetate; toluene Reagent/catalyst; Time;		83%
(R)-3-chloro-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
1273259-52-1

(R)-3-chloro-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-3-chloro-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride With sodium hydrogencarbonate In water; toluene at 15 - 20℃; pH=8 - 9; Inert atmosphere;
Stage #2: With hydrogen; 5% Pd(II)/C(eggshell) In methanol; toluene at 20℃; under 750.075 Torr; Product distribution / selectivity;		82.6%
N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine bisulfate

N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine bisulfate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 20℃;80.8%
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-[3-(trifluoromethyl)phenyl]propanal
21172-41-8

3-[3-(trifluoromethyl)phenyl]propanal

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propanal With sodium tetrahydroborate; boric acid at 20℃; for 14.5h;
Stage #2: With hydrogenchloride In hexane; water at 20℃; for 3.5h; pH=1 - 3;		80%
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propanal In tetrahydrofuran at -50 - -45℃; for 2.5h;
Stage #2: With titanium(IV) isopropylate In tetrahydrofuran Product distribution / selectivity;
N-[1-(R)-(-)-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane acetate
1025064-29-2

N-[1-(R)-(-)-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane acetate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With sodium chloride In 2-methylpropyl acetate; water at 20℃; Product distribution / selectivity;79.7%
With hydrogenchloride In 2-methylpropyl acetate; water at 5 - 10℃; for 0.5h; Product distribution / selectivity;72.7%
With hydrogenchloride In dichloromethane; water for 0.25h; Product distribution / selectivity;
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-(3-trifluoromethylphenyl)propanoic acid With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; phenylsilane; 1,2-bis-(diphenylphosphino)ethane In dibutyl ether at 120℃; for 18h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether at -20℃; Schlenk technique; Inert atmosphere;		74%
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

1-(3-chloropropyl)-3-(trifluoromethyl)benzene
82258-76-2

1-(3-chloropropyl)-3-(trifluoromethyl)benzene

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 1-(3-chloropropyl)-3-(trifluoromethyl)benzene With potassium carbonate In toluene for 15h; Reflux;
Stage #2: With hydrogenchloride In water; toluene for 60h;		73%
methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester
21172-43-0

methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride
82572-04-1

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In water; toluene for 24h; Inert atmosphere; Reflux;71.8%
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate

N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate With hydrogen; 2.5% wt Pd/C In methanol Inert atmosphere;
Stage #2: With hydrogenchloride In methanol; water at 25 - 30℃; for 1h; Product distribution / selectivity; Inert atmosphere;		63.9%
(R)-N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino]-N-[1-(1-naphthyl)ethylamine]
1201910-95-3

(R)-N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino]-N-[1-(1-naphthyl)ethylamine]

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino]-N-[1-(1-naphthyl)ethylamine] With 5%-palladium/activated carbon; hydrogen In ethanol at 20℃; under 2250.23 Torr;
Stage #2: With hydrogenchloride In ethanol; isopropyl alcohol		60%
1'-naphthacetophenone
941-98-0

1'-naphthacetophenone

3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
104774-87-0

3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: 1'-naphthacetophenone; 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate In toluene at 40℃; for 48h; Molecular sieve; Inert atmosphere;
Stage #2: With hydrogenchloride In water; toluene at 0 - 5℃; Reagent/catalyst;		56.7%
1-(3-bromopropyl)-3- (trifluoromethyl)benzene
129254-76-8

1-(3-bromopropyl)-3- (trifluoromethyl)benzene

(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

benzaldehyde
100-52-7

benzaldehyde

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; benzaldehyde at 25 - 30℃;
Stage #2: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene In 1-methyl-pyrrolidin-2-one at 130 - 140℃; for 12h;
Stage #3: With hydrogenchloride; water In 1-methyl-pyrrolidin-2-one; toluene pH=0.5 - 2;		52.1%
...Expand
(E)-N-((R)-1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-acrylamide
1095393-66-0

(E)-N-((R)-1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-acrylamide

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-N-(1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-(E)-acrylamide With dimethylsulfide borane complex In tetrahydrofuran at 0 - 65℃; for 4h;
Stage #2: With methanol at 0℃; for 0.5h;
Stage #3: With hydrogenchloride; water at 0 - 90℃; for 4h; Product distribution / selectivity;
cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

cinacalcet
226256-56-0

cinacalcet

Conditions
ConditionsYield
With sodium carbonate In dichloromethane; water96%
With water; sodium carbonate In di-isopropyl ether at 25℃; for 2.25h; pH=9.5;
cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

benzyl bromide
100-39-0

benzyl bromide

C29H28F3N

C29H28F3N

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 100℃; for 12h; Inert atmosphere;82%
cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

1-(3-bromopropyl)-3- (trifluoromethyl)benzene
129254-76-8

1-(3-bromopropyl)-3- (trifluoromethyl)benzene

(R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine
1271930-15-4

(R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine

Conditions
ConditionsYield
With potassium carbonate In toluene at 110 - 111℃; for 48h;69.03%

Cinacalcet hydrochloride Chemical Properties

Molecular Structure of Cinacalcet hydrochloride (CAS NO.364782-34-3):

IUPAC Name: N-[(1R)-1-Naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride 
Molecular Formula: C22H22F3N.HCl
Molecular Weight: 393.88
H-Bond Donor: 2
H-Bond Acceptor: 4 
Flash Point: 220.5 °C
Enthalpy of Vaporization: 69.81 kJ/mol
Boiling Point: 440.9 °C at 760 mmHg
Vapour Pressure: 5.67E-08 mmHg at 25 °C
Melting Point: 175-177 °C
Appearance: Off-White to Tan Solid
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals 
SMILES: FC(F)(F)c1cccc(c1)CCCN[C@@H](c3c2ccccc2ccc3)C.Cl 
InChI: InChI=1/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
InChIKey: QANQWUQOEJZMLL-PKLMIRHRBW
Classification Code: Treatment of hyperparathyroidism and related disorders, such as hypercalcemia [reduction of PTH secretion through modulation of calcium ion receptors on parathyroid cells] 

Cinacalcet hydrochloride Uses

 Cinacalcet hydrochloride (CAS NO.364782-34-3) is used for clinical trial in secondary hyperparathyroidism.

Cinacalcet hydrochloride Specification

 Cinacalcet hydrochloride (CAS NO.364782-34-3), its Synonyms are 1-Naphthalenemethanamine, alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-, (alphaR)-, hydrochloride ; AMG 073 HCl ; AMG073 HCl ; Cinacalcet HCl ; Mimpara ; N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride ; Regpara ; Sensipar .

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