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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-hydroxypivalic acid

Cas:4835-90-9

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Hydroxypivalic acid

Cas:4835-90-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

1.best quality 2.low price 3-Hydroxypivalic acid from Henan Tianfu Chemical: Henan Tianfu Chemical Co.,LTD was built in 2009 with an ISO certificate in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we had e

3-Hydroxypivalic acid -2,2-dimethyl-propanoic acid

Cas:4835-90-9

Min.Order:1 Kilogram

FOB Price: $60.0 / 150.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 4835-90-9 with best price

Cas:4835-90-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Propanoic acid,3-hydroxy-2,2-dimethyl-

Cas:4835-90-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:1 Kilogram

FOB Price: $76.0 / 85.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-Hydroxypivalic acid CAS:4835-90-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

3-Hydroxypivalic acid CAS:4835-90-9

Cas:4835-90-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanoic acid,3-hydroxy-2,2-dimethyl-

Cas:4835-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Propanoic acid,3-hydroxy-2,2-dimethyl-

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Hydroxypivalic Acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Top supplier 3-Hydroxypivalic acid 4835-90-9 in China

Cas:4835-90-9

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used to make other chemic

Propanoic acid,3-hydroxy-2,2-dimethyl-

Cas:4835-90-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 2,2-Dimethyl-3-Hydroxypropionic Acid CAS No.:4835-90-9 Molecule Formula: C5H10O3 Molecule Weight:118.13 Purity: 99.0% Package: 25kg/drum Description:Colorless transparent liquid Manufacture Standards:Enterprise Standard

Lower Price 2,2-Dimethyl-3-Hydroxypropionic Acid

Cas:4835-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Hydroxypivalic acid Synonyms: THYODIGLYCOL;THIODIETHYLENE GLYCOL;3-hydroxy-2,2-dimethyl-propanoicaci;Propanoic acid, 3-hydroxy-2,2-dimethyl-;HYDROXYPIVALIC ACID;BETA-THIODIGLYCOL;3-HYDROXY-2,2-DIMETHYLPROPANOIC ACID;3-Hydroxypiv

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4835-90-9 CAS NO.4835-90-9

Cas:4835-90-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Hydroxypivalic acid cas no. 4835-90-9 98%

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Hydroxypivalic Acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hefei TNJ chemical industry co.,ltd

Name: 2,2-Dimethyl-3-hydroxypropionic acid CAS: 4835-90-9 Molecular Formula: C5H10O3 Molecular Weight: 118.131 Application:Fine chemical

2,2-Dimethyl-3-hydroxypropionic acid CAS 4835-90-9

Cas:4835-90-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 2,2-Dimethyl-3-hydroxypropionic Acid 500g

Cas:4835-90-9

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Hydroxypivalic Acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-Hydroxypivalic Acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-Hydroxy-2,2-dimethylpropanoic acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

3-Hydroxypivalic acid

Cas:4835-90-9

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

2,2-dimethyl-3-hydroxypropionaldehyde
597-31-9

2,2-dimethyl-3-hydroxypropionaldehyde

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Stage #1: 2,2-dimethyl-3-hydroxypropionaldehyde With sodium hydroxide at 85 - 95℃; for 2h;
Stage #2: With ammonium hydroxide; H1044 at 60℃; for 8h; pH=7 - 9;
91%
With phosphotungstic acid; dihydrogen peroxide In water at 55℃; for 2h; Temperature; Reagent/catalyst; Time;85%
With sodium hydroxide; oxygen; palladium/alumina at 39.85℃; under 760 Torr; Kinetics; Further Variations:; Temperatures;
Multi-step reaction with 2 steps
1: water; aluminium amalgam
2: potassium permanganate
View Scheme
N-[3-acetoxy-2,2-dimethylpropanoyl]-S-methyl-S-2-pyridylsulfoximine
1384980-61-3

N-[3-acetoxy-2,2-dimethylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

A

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

B

imino(methyl)(pyridin-2-yl)-λ6-sulfanone
76456-06-9

imino(methyl)(pyridin-2-yl)-λ6-sulfanone

Conditions
ConditionsYield
With hydrogenchloride; water at 50℃; for 3h;A 88%
B 87%
Methyl 2,2-dimethyl-3-hydroxypropionate
14002-80-3

Methyl 2,2-dimethyl-3-hydroxypropionate

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With water; lithium hydroxide In tetrahydrofuran; methanol at 0 - 20℃; for 1.5h;73%
With lithium hydroxide In tetrahydrofuran; methanol; water at 20℃; for 1.3h;
With lithium hydroxide In tetrahydrofuran; methanol; water at 0 - 20℃;
2,2-dimethyl-3-oxo-3-(pyrrolidin-1-yl)propyl acetate

2,2-dimethyl-3-oxo-3-(pyrrolidin-1-yl)propyl acetate

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With hydrogenchloride; water for 12h; Inert atmosphere; Schlenk technique; Reflux;56%
formaldehyd
50-00-0

formaldehyd

L-valine
72-18-4

L-valine

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Stage #1: formaldehyd; L-valine With ketopantoate hydroxymethyltransferase; nickel dichloride at 20℃; for 24h; pH=7.5; Enzymatic reaction;
Stage #2: With dihydrogen peroxide pH=7.5;
Stage #3: With catalase from bovine liver In aq. phosphate buffer pH=7; Enzymatic reaction;
51%
carbon monoxide
201230-82-2

carbon monoxide

3-hydroxy-2-methyl-1-propene
513-42-8

3-hydroxy-2-methyl-1-propene

A

dihydro-4-methyl-2(3H)-furanone
64190-48-3, 65284-00-6, 70470-05-2, 1679-49-8

dihydro-4-methyl-2(3H)-furanone

B

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Stage #1: carbon monoxide; 3-hydroxy-2-methyl-1-propene With dicarbonylacetylacetonato rhodium (I); 2-isopropoxy-1-methyl-3-phenyl-2,3-dihydro-1H-benzo[d][1,3]azaphosphole; hydrogen; toluene-4-sulfonic acid In benzene at 45℃; under 20686.5 Torr; for 12h;
Stage #2: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In water; tert-butyl alcohol at 20℃; regioselective reaction;
A n/a
B 49%
2,2-dimethyl-3-hydroxypropionaldehyde
597-31-9

2,2-dimethyl-3-hydroxypropionaldehyde

A

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

B

2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

Conditions
ConditionsYield
With potassium carbonate
With potassium carbonate
3-hydroxy-2,2-dimethylpropionitrile
19295-57-9

3-hydroxy-2,2-dimethylpropionitrile

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With hydrogenchloride
3-acetoxy-2,2-dimethyl-propionitrile
41296-71-3

3-acetoxy-2,2-dimethyl-propionitrile

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Verseifung;
2,2-dimethyl-3-pivaloyloxy-propionic acid
854648-82-1

2,2-dimethyl-3-pivaloyloxy-propionic acid

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Hydrolysis;
2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With potassium permanganate
With sodium hydroxide; potassium permanganate
With potassium permanganate
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid
3: sodium hydroxide / methanol
View Scheme
4-chloro-3,3-dimethylbutane-2-one
13104-53-5

4-chloro-3,3-dimethylbutane-2-one

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2-Carboxyl-2,2-dimethyl ethyl radical
26299-74-1

2-Carboxyl-2,2-dimethyl ethyl radical

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With hydroxide In water at 20 - 24℃; Rate constant; at various pH;
2,2-dimethyl-3-hydroxypropionaldehyde
597-31-9

2,2-dimethyl-3-hydroxypropionaldehyde

KMnO4

KMnO4

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Trimethylacetic acid
75-98-9

Trimethylacetic acid

A

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

B

2,2,5,5-tetramethylhexanedioic acid
4916-85-2

2,2,5,5-tetramethylhexanedioic acid

C

3-hydroperoxy-2,2-dimethyl-propionic acid

3-hydroperoxy-2,2-dimethyl-propionic acid

Conditions
ConditionsYield
das Natrium-Salz reagiert;beim Leiten durch eine Methan-Sauerstoff-Flamme;
3-bromo-2,2-dimethylpropionic acid ethyl ester
2843-18-7

3-bromo-2,2-dimethylpropionic acid ethyl ester

alkali

alkali

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

3-hydroxy-2,2-dimethylpropionitrile
19295-57-9

3-hydroxy-2,2-dimethylpropionitrile

hydrochloric acid <15 percent >

hydrochloric acid <15 percent >

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

(hydroxy-lin-pentakis-pivaloyloxy)-pivalic acid
24342-15-2

(hydroxy-lin-pentakis-pivaloyloxy)-pivalic acid

KOH-solution

KOH-solution

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

polyoxymethylene

polyoxymethylene

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With zinc; benzene Verseifen des entstehenden Aethylesters mit Kalilauge;
2,2-dimethyl-3-hydroxy-propyl 2,2-dimethyl-3-hydroxypropionate
1115-20-4

2,2-dimethyl-3-hydroxy-propyl 2,2-dimethyl-3-hydroxypropionate

KOH-solution

KOH-solution

A

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

B

2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

3-hydroxy-2,2-dimethylpropionaldoxime
36559-87-2

3-hydroxy-2,2-dimethylpropionaldoxime

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Destillation
2: hydrochloric acid
View Scheme
Trimethylacetic acid
75-98-9

Trimethylacetic acid

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine / 150 °C
2: Hydrolysis
View Scheme
3-chloropivalic acid
13511-38-1

3-chloropivalic acid

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With sodium hydroxide In water
methanol
67-56-1

methanol

2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

A

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

B

Methyl 2,2-dimethyl-3-hydroxypropionate
14002-80-3

Methyl 2,2-dimethyl-3-hydroxypropionate

Conditions
ConditionsYield
With 1% Pd/TiO2; oxygen; sodium hydroxide at 80℃; under 2250.23 Torr; for 24h;
With 1 wt% Au/TiO2; oxygen; sodium hydroxide at 80℃; under 2250.23 Torr; Solvent;
methanol
67-56-1

methanol

2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

A

2,2-dimethyl-3-hydroxypropionaldehyde
597-31-9

2,2-dimethyl-3-hydroxypropionaldehyde

B

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

C

Methyl 2,2-dimethyl-3-hydroxypropionate
14002-80-3

Methyl 2,2-dimethyl-3-hydroxypropionate

Conditions
ConditionsYield
With 1% Au-Pd/TiO2; oxygen; sodium hydroxide at 80℃; under 2250.23 Torr; for 4h;
(3-hydroxy-2,2-dimethyl-propyl)acetate
117756-41-9

(3-hydroxy-2,2-dimethyl-propyl)acetate

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: sodium hydroxide / methanol
View Scheme
3-acetoxy-2,2-dimethylpropionic acid
2843-16-5

3-acetoxy-2,2-dimethylpropionic acid

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol
5-hydroxypentanal
4221-03-8

5-hydroxypentanal

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With aluminum oxide; bismuth(III) oxide; sodium hydroxide In water at 70℃; for 2h; Temperature;
N’-(2,2-dimethylpropylidene)-N,N-diethyl-ethylendiamine

N’-(2,2-dimethylpropylidene)-N,N-diethyl-ethylendiamine

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; oxygen In acetone at -5℃; for 20h; Glovebox;8 mg
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanoic acid
528602-18-8

3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanoic acid

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane100%
With 1H-imidazole In tetrahydrofuran
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

benzyl bromide
100-39-0

benzyl bromide

benzyl 2,2-dimethyl-3-hydroxypropanoic acid
17701-61-0

benzyl 2,2-dimethyl-3-hydroxypropanoic acid

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 16h;100%
Stage #1: 3-Hydroxy-2,2-dimethylpropanoic acid With caesium carbonate In methanol; water
Stage #2: benzyl bromide In N,N-dimethyl-formamide for 7h; Further stages.;
5.64 g
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 5h;
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

1-Chloroethyl ethyl carbonate
50893-36-2

1-Chloroethyl ethyl carbonate

rac-1-ethoxycarbonyloxy-ethyl 3-hydroxy-2,2-dimethylpropanoate
1131569-68-0

rac-1-ethoxycarbonyloxy-ethyl 3-hydroxy-2,2-dimethylpropanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 70℃;100%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

4-bromodeacetyl colchicine

4-bromodeacetyl colchicine

4-bromo-N-(3-hydroxy-2,2-dimethylpropionyl)deacetyl colchicine

4-bromo-N-(3-hydroxy-2,2-dimethylpropionyl)deacetyl colchicine

Conditions
ConditionsYield
Stage #1: 3-Hydroxy-2,2-dimethylpropanoic acid With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 4-bromodeacetyl colchicine In N,N-dimethyl-formamide at 20℃;
100%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

5,5-dimethyl-2-(2-phenylethyl)-1,3-dioxan-4-one
250356-02-6

5,5-dimethyl-2-(2-phenylethyl)-1,3-dioxan-4-one

Conditions
ConditionsYield
Stage #1: 3-Hydroxy-2,2-dimethylpropanoic acid With 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane for 12h;
Stage #2: 3-phenyl-propionaldehyde With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -78℃; for 2h; Further stages.;
99%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

acetyl chloride
75-36-5

acetyl chloride

3-acetoxy-2,2-dimethylpropionic acid
2843-16-5

3-acetoxy-2,2-dimethylpropionic acid

Conditions
ConditionsYield
Heating;97%
at 0 - 20℃; for 16h; Inert atmosphere;96%
With pyridine at 0 - 20℃; for 3h;95%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2-benzyl-3-(dimethylamino)-2-methyl-2H-azirine
114234-21-8

2-benzyl-3-(dimethylamino)-2-methyl-2H-azirine

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N,N-dimethylcarbamoyl)-2-phenylethyl]propanamide
266338-67-4

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N,N-dimethylcarbamoyl)-2-phenylethyl]propanamide

Conditions
ConditionsYield
In acetonitrile at 20℃; for 30h; Addition;97%
In tetrahydrofuran at 20℃; for 24h;88%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

O-benzylethanolamine
38336-04-8

O-benzylethanolamine

N-(2-(benzyloxy)ethyl)-3-hydroxy-2,2-dimethylpropanamide
1093206-04-2

N-(2-(benzyloxy)ethyl)-3-hydroxy-2,2-dimethylpropanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;97%
With benzotriazol-1-ol In dichloromethane97%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-propionic acid
162635-08-7

2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-propionic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 3h;95%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

(R)-1-methylpyrrolidin-3-ylamine

(R)-1-methylpyrrolidin-3-ylamine

(R)-3-hydroxy-2,2-dimethyl-N-(1-methylpyrrolidin-3-yl)propanamide

(R)-3-hydroxy-2,2-dimethyl-N-(1-methylpyrrolidin-3-yl)propanamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;94%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine
75755-40-7

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide
339315-16-1

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

Conditions
ConditionsYield
In acetonitrile at 20℃; for 17h;93%
In tetrahydrofuran at 20℃; for 24h;93%
2,3,4-tri-O-acetyl-L-rhamnopyranosyl ortho-hexynylbenzoate
1230076-22-8

2,3,4-tri-O-acetyl-L-rhamnopyranosyl ortho-hexynylbenzoate

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

C17H26O10
1221152-39-1

C17H26O10

Conditions
ConditionsYield
With trifluoromethanesulfonyloxy(triphenylphosphine)gold(I); boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; Molecular sieve; Inert atmosphere; chemoselective reaction;92%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

7-methoxyspiro[chroman-2,4'-piperidin]-4-one hydrochloric acid
1031416-37-1

7-methoxyspiro[chroman-2,4'-piperidin]-4-one hydrochloric acid

1'-(3-hydroxy-2,2-dimethylpropanoyl)-7-methoxyspiro[chroman-2,4'-piperidin]-4-one

1'-(3-hydroxy-2,2-dimethylpropanoyl)-7-methoxyspiro[chroman-2,4'-piperidin]-4-one

Conditions
ConditionsYield
Stage #1: 3-Hydroxy-2,2-dimethylpropanoic acid With HATU In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: 7-methoxyspiro[chroman-2,4'-piperidin]-4-one hydrochloric acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;
92%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2-((4-(trifluoromethyl)phenyl)amino)benzohydrazide

2-((4-(trifluoromethyl)phenyl)amino)benzohydrazide

N’-(3-hydroxy-2,2-dimethylpropanoyl)-2-((4-(trifluoromethyl)phenyl)amino)benzohydrazide

N’-(3-hydroxy-2,2-dimethylpropanoyl)-2-((4-(trifluoromethyl)phenyl)amino)benzohydrazide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 12h; Temperature; Reagent/catalyst; Solvent;89.6%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

L-phenylalanine tert-butyl ester hydrochloride
15100-75-1

L-phenylalanine tert-butyl ester hydrochloride

tert-butyl (S)-2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-3-phenylpropanoate
877609-88-6

tert-butyl (S)-2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-3-phenylpropanoate

Conditions
ConditionsYield
With triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 20℃;89%
chloroform
67-66-3

chloroform

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

[N,N'-dimethyl-N,N'-bis(2-oxido-5-bromobenzyl)ethylenediamine]titanium(IV) diisopropoxide

[N,N'-dimethyl-N,N'-bis(2-oxido-5-bromobenzyl)ethylenediamine]titanium(IV) diisopropoxide

[N,N'-dimethyl-N,N'-bis(2-oxido-5-bromobenzyl)ethylenediamine](2,2-dimethyl-3-oxidopropanoato)titanium(IV)

[N,N'-dimethyl-N,N'-bis(2-oxido-5-bromobenzyl)ethylenediamine](2,2-dimethyl-3-oxidopropanoato)titanium(IV)

[N,N'-dimethyl-N,N'-bis(2-oxido-5-bromobenzyl)ethylenediamine](2,2-dimethyl-3-oxidopropanoato)titanium(IV) - hydroxypivalic acid - chloroform (2/1/1)

[N,N'-dimethyl-N,N'-bis(2-oxido-5-bromobenzyl)ethylenediamine](2,2-dimethyl-3-oxidopropanoato)titanium(IV) - hydroxypivalic acid - chloroform (2/1/1)

Conditions
ConditionsYield
In chloroform a soln. of ligand added dropwise to a soln. of Ti complex, stirred for 15 min; evapd. (vac.), suspended in hexanes, filtered, vac.-dried overnight; elem. anal.;A 89%
B n/a
aminomalonic acid diethyl ester
6829-40-9

aminomalonic acid diethyl ester

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

diethyl-N-(β-hydroxypivaloyl)-aminomalonate
88143-81-1

diethyl-N-(β-hydroxypivaloyl)-aminomalonate

Conditions
ConditionsYield
With 1-cyclohexyl-3-(2-morpholino-ethyl)-carbodiimide; benzotriazol-1-ol; triethylamine In dichloromethane for 20h;88%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

allyl bromide
106-95-6

allyl bromide

2-propenyl 2,2-dimethyl-3-hydroxypropanoate
919106-36-8

2-propenyl 2,2-dimethyl-3-hydroxypropanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 18h;88%
aminomalonic acid diethyl ester
6829-40-9

aminomalonic acid diethyl ester

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

A

diethyl-N-(β-hydroxypivaloyl)-aminomalonate
88143-81-1

diethyl-N-(β-hydroxypivaloyl)-aminomalonate

B

N-[Di-(ethoxycarbonyl)methyl]-3,3-dimethyl-2-azetidinone
88143-97-9

N-[Di-(ethoxycarbonyl)methyl]-3,3-dimethyl-2-azetidinone

Conditions
ConditionsYield
A 88%
B n/a
2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl ortho-(hex-1-ynyl)benzoate
1221151-98-9

2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl ortho-(hex-1-ynyl)benzoate

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

C39H36O12
1221152-17-5

C39H36O12

Conditions
ConditionsYield
With trifluoromethanesulfonyloxy(triphenylphosphine)gold(I); boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; Molecular sieve; Inert atmosphere; chemoselective reaction;88%
triethylsilyl chloride
994-30-9

triethylsilyl chloride

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2,2-dimethyl-3-((triethylsilyl)oxy)propanoic acid

2,2-dimethyl-3-((triethylsilyl)oxy)propanoic acid

Conditions
ConditionsYield
With pyridine at 60℃; for 8h; Inert atmosphere; Sealed tube;88%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

N-benzyloxyamine
622-33-3

N-benzyloxyamine

O-benzyl-2,2-dimethyl-3-hydroxypropano hydroxamate
49640-44-0

O-benzyl-2,2-dimethyl-3-hydroxypropano hydroxamate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water pH 4-5;87%
With diisopropyl-carbodiimide In tetrahydrofuran
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

N-(6-(5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3- yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide hydrochloride

N-(6-(5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3- yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide hydrochloride

N-(6-(5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)pyridin-2-yl)-2-(3-hydroxy-2,2-dimethylpropanoyl)-6-methoxy-1,2,3,4- tetrahydroisoquinoline-7-carboxamide

N-(6-(5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)pyridin-2-yl)-2-(3-hydroxy-2,2-dimethylpropanoyl)-6-methoxy-1,2,3,4- tetrahydroisoquinoline-7-carboxamide

Conditions
ConditionsYield
Stage #1: 3-Hydroxy-2,2-dimethylpropanoic acid With HATU In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: N-(6-(5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3- yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;
87%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
7524-50-7

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

methyl (S)-2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-3-phenylpropanoate

methyl (S)-2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-3-phenylpropanoate

Conditions
ConditionsYield
With triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 20℃;86%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2-benzyl-2-methyl-3-(N-methyl-N-phenylamino)-2H-azirine
155129-91-2

2-benzyl-2-methyl-3-(N-methyl-N-phenylamino)-2H-azirine

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)-2-phenylethyl]propanamide

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)-2-phenylethyl]propanamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 28h;84%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

[N,N'-dimethyl-N,N'-bis(2-oxido-5-(di(4-methoxyphenyl)amino)benzyl)ethylenediamine]titanium(IV) diisopropoxide

[N,N'-dimethyl-N,N'-bis(2-oxido-5-(di(4-methoxyphenyl)amino)benzyl)ethylenediamine]titanium(IV) diisopropoxide

[N,N'-dimethyl-N,N'-bis(2-oxido-5-(di(4-methoxyphenyl)amino)benzyl)ethylenediamine](2,2-dimethyl-3-oxidopropanoato)titanium(IV)

[N,N'-dimethyl-N,N'-bis(2-oxido-5-(di(4-methoxyphenyl)amino)benzyl)ethylenediamine](2,2-dimethyl-3-oxidopropanoato)titanium(IV)

Conditions
ConditionsYield
In chloroform a soln. of ligand added dropwise to a soln. of Ti complex, stirred for 15 min; evapd. (vac.), suspended in hexanes, filtered, vac.-dried overnight; elem. anal.;84%
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

2-tert-butoxypyridine
83766-88-5

2-tert-butoxypyridine

tert-butyl 3-hydroxy-2,2-dimethylpropanoate
25307-76-0

tert-butyl 3-hydroxy-2,2-dimethylpropanoate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In toluene at 20℃; for 2h;84%
2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl ortho-(hex-1-ynyl)benzoate
1221151-98-9

2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl ortho-(hex-1-ynyl)benzoate

3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

C39H36O12
1221152-20-0

C39H36O12

Conditions
ConditionsYield
With 2,6-di-tert-butyl-pyridine; trifluoromethanesulfonyloxy(triphenylphosphine)gold(I) In dichloromethane at 20℃; Molecular sieve; Inert atmosphere; chemoselective reaction;82%

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