Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:53617-35-9
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inquiry4-(Piperidin-4-yl)morpholine CAS No.:53617-35-9 Name: 4-(Piperidin-4-yl)morpholine Molecular Structure
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:53617-35-9
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:53617-35-9
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:53617-35-9
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inquiryName:4-Piperidin-4-ylmorpholine CAS No. :53617-35-9 Place of Origin: China (Mainland) Grade Standard: Medicine Grade Appearance powder Grade Phamaceutical Grade PSA 24.50000
Cas:53617-35-9
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:53617-35-9
Min.Order:1 Kilogram
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inquiryBeluga chemical professional supply 4-(4-Piperidinyl)morpholine dihydrochloride CAS 53617-35-9 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support a
Cas:53617-35-9
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:53617-35-9
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:53617-35-9
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
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inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:53617-35-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantages: 1. owerful R & D team; 2. Mature technical support 3.Best quality in your requirement 4. Competitive price in china market . 5. The ability of quantized production,from grams to tons; 6. Efficient and safe logistic plans for c
Cas:53617-35-9
Min.Order:1 Gram
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:53617-35-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:53617-35-9
Min.Order:0 Metric Ton
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inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
Cas:53617-35-9
Min.Order:0
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:53617-35-9
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:53617-35-9
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:53617-35-9
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryCompany Profile SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD is a high-tech enterprise dedicated to the fields of fine chemical products.The scope of products covers pharmaceutical intermediates, plant extracts, chemical reagent, animal p
Cas:53617-35-9
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:53617-35-9
Min.Order:1 Kilogram
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inquiry4-Morpholinopiperidine Chemical Properties Melting point 40-43 °C(lit.) Boiling point 100-115 °C0.15-0.20 mm Hg(lit.) density 1.033±0.06 g/cm3(Predicted) Fp >230 °F storage temp. Keep in dark place,Sealed in
Cas:53617-35-9
Min.Order:1 Gram
FOB Price: $66.0
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:53617-35-9
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:53617-35-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:53617-35-9
Min.Order:1 Metric Ton
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Type:Trading Company
inquiry4-(1-benzyl-piperidin-4-yl)-morpholine
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In isopropyl alcohol at 80℃; under 3750.38 Torr; for 7h; Reagent/catalyst; Autoclave; | 100% |
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 3750.38 Torr; for 6h; | 97.6% |
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; under 2585.81 Torr; for 18h; | 93% |
With hydrogenchloride; Pd(OH)2 In methanol | 932 mg (91%) |
With hydrogenchloride; Pd(OH)2 In methanol | 932 mg (91%) |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Stage #1: 4-(1-benzylpiperidin-4-yl)morpholine dihydrochloride With potassium carbonate In tert-butyl alcohol at 60℃; for 0.5h; pH=>11; Stage #2: With palladium 10% on activated carbon In tert-butyl alcohol at 50℃; for 8h; pH=>11; | 91.6% |
Stage #1: 4-(1-benzylpiperidin-4-yl)morpholine dihydrochloride With potassium carbonate In water; tert-butyl alcohol at 45℃; Industrial scale; Stage #2: With hydrogen In tert-butyl alcohol at 60℃; under 3000.3 Torr; Industrial scale; | 88% |
tert-butyl 4-(morpholin-4-yl)piperidine-1-carboxylate
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 6h; | 79% |
With trifluoroacetic acid In dichloromethane at 20℃; for 2h; | |
With hydrogenchloride In methanol at 40℃; for 12h; | 1.52 g |
With trifluoroacetic acid In dichloromethane at 20℃; | 3 g |
morpholine
1-phenylmethyl-4-piperidone
A
4-(piperidin-4-yl)morpholine
B
4-(1-benzyl-piperidin-4-yl)-morpholine
Conditions | Yield |
---|---|
With 10 wt% Pd(OH)2 on carbon; hydrogen at 80℃; under 3750.38 Torr; for 4h; Reagent/catalyst; Time; Autoclave; | A 19.7% B 77.5% |
morpholine
N-tert-butyloxycarbonylpiperidin-4-one
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 74% |
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 74% |
Stage #1: morpholine; N-tert-butyloxycarbonylpiperidin-4-one With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium cyanoborohydride In tetrahydrofuran; ethanol at 20℃; Stage #3: With water In tetrahydrofuran; ethanol for 0.5h; |
4-morpholinopyridine
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With hydrogen; ruthenium(IV) oxide |
morpholine
isopropyl alcohol
N-ethoxycarbonyl-4-piperidone
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With potassium hydroxide; sodium borohydrid; toluene-4-sulfonic acid In ethanol; toluene |
4-(4-morpholinopiperidin-1-yl)benzonitrile
A
4-fluorobenzonitrile
B
4-(piperidin-4-yl)morpholine
benzyl 4-morpholin-4-ylpiperidine-1-carboxylate
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With hydrogen |
1-phenylmethyl-4-piperidone
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: toluene / 110 °C / Industrial scale 1.2: Raney nickel / 60 °C / 3000.3 Torr / Industrial scale 1.3: 50 °C / Industrial scale 2.1: potassium carbonate / water; tert-butyl alcohol / 45 °C / Industrial scale 2.2: 60 °C / 3000.3 Torr / Industrial scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen; platinum on activated charcoal / 8 h / 80 °C / 3750.38 Torr / Autoclave 2: hydrogen; palladium on activated charcoal / isopropyl alcohol / 7 h / 80 °C / 3750.38 Torr / Autoclave View Scheme | |
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 3750.38 Torr View Scheme |
N-tert-butyloxycarbonylpiperidin-4-one
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C / Cooling 2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C 1.2: 20 °C 2.1: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
4-HYDROXYPIPERIDINE
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydroxide; water / 1,4-dioxane / 0 - 20 °C 2.1: pyridinium chlorochromate; SiO2 / dichloromethane / 2 h / 20 °C 3.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C 3.2: 20 °C 4.1: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
t-butyl 4-hydroxy piperidine-1-carboxylate
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridinium chlorochromate; SiO2 / dichloromethane / 2 h / 20 °C 2.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C 2.2: 20 °C 3.1: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
benzyl 4-oxo-1-piperidinecarboxylate
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: titanium(IV) isopropylate 2: hydrogen View Scheme |
5-(3-benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazole-3-carboxylic acid
4-(piperidin-4-yl)morpholine
[5-(3-Benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(4-morpholin-4-yl-piperidin-1-yl)-methanone
Conditions | Yield |
---|---|
Stage #1: 5-(3-benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazole-3-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h; Stage #2: 4-(piperidin-4-yl)morpholine With triethylamine In dichloromethane at 0℃; for 3h; | 100% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
In tert-Amyl alcohol at 110℃; Inert atmosphere; | 100% |
trifluoroacetic acid
4-(piperidin-4-yl)morpholine
4-piperidin-4-yl-morpholine bis-trifluoroacetate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1h; | 98% |
trifluoro-methane sulfonic acid 9-bromo-3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester
4-(piperidin-4-yl)morpholine
6,6-dimethyl-9-bromo-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 120℃; for 3h; | 98% |
With N-methylcyclohexylamine at 80 - 90℃; Temperature; Reagent/catalyst; Large scale; | 78.6% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium methylate In 1,4-dioxane at 90℃; for 18h; Solvent; Temperature; Reagent/catalyst; | 97% |
methyl 3-(bromomethyl)-6-chloro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
4-(piperidin-4-yl)morpholine
methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: 4-(piperidin-4-yl)morpholine With potassium carbonate In dichloromethane at 20℃; for 0.5h; Stage #2: methyl 3-(bromomethyl)-6-chloro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate In dichloromethane at 20℃; for 24h; | 96% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium methylate In N,N-dimethyl-formamide at 100℃; for 12h; Concentration; Temperature; Reagent/catalyst; Solvent; Green chemistry; | 96% |
4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine
4-(piperidin-4-yl)morpholine
4-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 95% |
methyl 3-(bromomethyl)-7-[(2-methylpropyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
4-(piperidin-4-yl)morpholine
methyl 7-[(2-methylpropyl)oxy]-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 3h; | 95% |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; 4-(piperidin-4-yl)morpholine In acetonitrile at 80℃; for 1h; Stage #2: 2-cyano-6-hydroxybenzothiazole In acetonitrile at 80℃; | 95% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium t-butanolate In toluene at 90℃; for 18h; Solvent; Temperature; Reagent/catalyst; | 95% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With triethylamine In ethanol at 80℃; for 0.25h; Microwave irradiation; Sealed tube; | 95% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With triethylamine In ethanol at 80℃; for 0.25h; Microwave irradiation; | 95% |
1-[4-(2-bromoethyl)phenyl]ethanone
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With potassium tert-butylate In dimethyl sulfoxide at 5 - 80℃; Microwave irradiation; | 94.9% |
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-benzyloxy-3,5-dimethyl-phenyl)-1-carboxy-ethyl ester
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In tetrahydrofuran; ethyl acetate at 0 - 20℃; for 1h; | 94% |
3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; chloroform at 20℃; | 94% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; chloroform at 20℃; | 94% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium methylate In N,N-dimethyl-formamide at 100℃; for 8h; Reagent/catalyst; Solvent; Temperature; | 92.3% |
1-bromomethyl-4-bromobenzene
4-(piperidin-4-yl)morpholine
4-(1-(4-bromobenzyl)piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 44h; | 92% |
4-(piperidin-4-yl)morpholine
CH5424802
Conditions | Yield |
---|---|
With sodium methylate In N,N-dimethyl-formamide at 100℃; for 12h; Reagent/catalyst; Temperature; | 92% |
With sodium methylate In toluene at 100℃; for 10h; Reagent/catalyst; Solvent; | 89% |
With potassium tert-butylate; L-proline In 1,4-dioxane at 120℃; for 24h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 10.3 g |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 60℃; for 1h; | 91.39% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium ethanolate In toluene at 110℃; for 6h; Reagent/catalyst; Solvent; Temperature; | 91% |
With iron(III)-acetylacetonate; caesium carbonate; copper(II) oxide In N,N-dimethyl-formamide at 90℃; for 20h; Reagent/catalyst; Solvent; Temperature; Sealed tube; Inert atmosphere; Green chemistry; | 82% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium methylate In N,N-dimethyl-formamide at 100℃; for 8h; Solvent; Temperature; Reagent/catalyst; | 91% |
methyl 3-(bromomethyl)-6-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
4-(piperidin-4-yl)morpholine
methyl 3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-6-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 5h; Reflux; | 90% |
methyl 3-(bromomethyl)-6-chloro-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
4-(piperidin-4-yl)morpholine
methyl 6-chloro-7-(methyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 3h; | 90% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With sodium isopropylate In 1,4-dioxane at 90℃; for 12h; Temperature; Reagent/catalyst; Solvent; | 90% |
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
Stage #1: (Z)-5-(3-phenoxybenzylidene)-2-(methylthio)-3H-imidazol-4(5H)-one; 4-(piperidin-4-yl)morpholine at 120 - 130℃; for 0.25h; Stage #2: In ethanol Reflux; Stage #3: With hydrogenchloride | 89.26% |
1-bromo-3-{[(4-methoxybenzyl)oxy]methyl}benzene
4-(piperidin-4-yl)morpholine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 1h; Buchwald-Hartwig Coupling; Inert atmosphere; | 89% |
methyl 3-(bromomethyl)-6-(ethylsulfonyl)-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
4-(piperidin-4-yl)morpholine
methyl 6-(ethylsulfonyl)-7-(methyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 3h; | 87% |
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