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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Newest Batch Best Quality CantharidinCAS:56-25-7

Cas:56-25-7

Min.Order:1 Gram

FOB Price: $48.0 / 51.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Cantharidin Manufacturer/High quality/Best price/In stock

Cas:56-25-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Cantharidin supplier in China

Cas:56-25-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Cantharidin

Cas:56-25-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

56-25-7

Cas:56-25-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name:Cantharidin Part Used:Shell Latin Name:Mylabris cichorii L. Specification:99% Appearance:White Powder CAS No.:56-25-7 MF:C6H9NO)n EINECS No.:200-263-3 Appearance:White powder Storage:Store in cool and dry place, away fro

Cantharidin

Cas:56-25-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Jilin Artel New Materials Co., LTD

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo

BEST PRICE/Cantharidin

Cas:56-25-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Cantharidin

Cas:56-25-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Cantharidin

Cas:56-25-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4,7-Epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-

Cas:56-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Cantharidin

Cas:56-25-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

4,7-Epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-

Cas:56-25-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Cantharidin

Cas:56-25-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

CantharidinCAS NO.: 56-25-7

Cas:56-25-7

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

shanghai Tauto Biotech Co., Ltd

The quality is guaranteed. If you find the product is wrong compared with COA, we promise 100% refund or change product. COA and HPLC will be shipped out with goods. You can also inform your analysis method and we will follow your analysis me

E-0142 Cantharidin

Cas:56-25-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-

Cas:56-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in yo

Cantharidin

Cas:56-25-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

Product Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard

factory supply CAS 56-25-7 with competitive price

Cas:56-25-7

Min.Order:1 Kilogram

FOB Price: $112.0

Type:Trading Company

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4,7-Epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-

Cas:56-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

High quality, good effectAppearance:fine powder Storage:cool, dry place Package:1kg/bag, 25kg/drum Application:health supplement Transportation:DHL,TNT,FEDEX,EMS, by air, by sea Port:seed, root,whole plant

High quality Cantharidin in bulk supply

Cas:56-25-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Other

inquiry

Josun International Limited

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Other

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aktin Chemicals, Inc.

Cantharidin

Cas:56-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

furan
110-00-9

furan

2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride
75532-25-1

2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Stage #1: furan; 2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride With 1-butyl-3-methylimidazolium Tetrafluoroborate at 50℃; for 19h;
Stage #2: In ethyl acetate for 4h; Reagent/catalyst; Temperature; Reflux;
90%
C10H10O4S
75538-64-6

C10H10O4S

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
With hydrogen In ethyl acetate under 760.051 Torr; Reflux;59%
With hydrogen In ethyl acetate at 50℃; under 1551.49 - 2585.81 Torr; for 20h;17%
With nickel In ethyl acetate Heating;
furan
110-00-9

furan

2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride
75532-25-1

2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride

A

epi-catharidin
80558-50-5

epi-catharidin

B

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
nickel 1.) 7000 bar, 24 h, 2.) ethyl acetate, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
1,2t-dimethyl-3,6-dioxo-cyclohexane-1r,2c-dicarboxylic acid diethyl ester

1,2t-dimethyl-3,6-dioxo-cyclohexane-1r,2c-dicarboxylic acid diethyl ester

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
With aluminum isopropoxide; isopropyl alcohol Behandeln des Reaktionsprodukts mit konz. Schwefelsaeure;
1-<(Ξ)-benzylidene>-3a,7a-dimethyl-(3ar,7ac)-3a,4,5,6,7,7a-hexahydro-4t,7t-epoxido-indene

1-<(Ξ)-benzylidene>-3a,7a-dimethyl-(3ar,7ac)-3a,4,5,6,7,7a-hexahydro-4t,7t-epoxido-indene

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
With ozone; ethyl acetate at -40℃; Erhitzen des Reaktionsprodukts mit Essigsaeure und wss. Wasserstoffperoxid;
hydrogenchloride
7647-01-0

hydrogenchloride

2-methoxy-3a,7a-dimethyl-hexahydro-4,7-epoxido-isoindole-1,3-dione

2-methoxy-3a,7a-dimethyl-hexahydro-4,7-epoxido-isoindole-1,3-dione

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
at 150℃; im Rohr;
(+/-)-1-((Ξ)-benzylidene)-3a,7a-dimethyl-(3ar,7ac)-3a,4,5,6,7,7a-hexahydro-4t,7t-epoxido-indene

(+/-)-1-((Ξ)-benzylidene)-3a,7a-dimethyl-(3ar,7ac)-3a,4,5,6,7,7a-hexahydro-4t,7t-epoxido-indene

ethyl acetate
141-78-6

ethyl acetate

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
at -40℃; Erhitzen des Reaktionsprodukts mit Essigsaeure und wss. Wasserstoffperoxid;
cantharidene

cantharidene

cantharidin
56-25-7

cantharidin

hydrogenchloride
7647-01-0

hydrogenchloride

2-hydroxy-3a,7a-dimethyl-hexahydro-4,7-epoxido-isoindole-1,3-dione
853200-58-5

2-hydroxy-3a,7a-dimethyl-hexahydro-4,7-epoxido-isoindole-1,3-dione

A

hydroxylamine
7803-49-8

hydroxylamine

B

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
at 150℃; im Rohr;
(-)-2-bromo-1,8-dimethyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-8-carboxylic acid

(-)-2-bromo-1,8-dimethyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-8-carboxylic acid

A

cantharidin
56-25-7

cantharidin

B

dextrorotatory cantharic acid

dextrorotatory cantharic acid

C

<3.6-dibromo-1.2-dimethyl-hexahydrophthalic acid >-anhydride

<3.6-dibromo-1.2-dimethyl-hexahydrophthalic acid >-anhydride

Conditions
ConditionsYield
at 215 - 225℃;
hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

acetic acid
64-19-7

acetic acid

(+)-2-bromo-1,8-dimethyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-8-carboxylic acid

(+)-2-bromo-1,8-dimethyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-8-carboxylic acid

A

cantharidin
56-25-7

cantharidin

B

<3.6-dibromo-1.2-dimethyl-hexahydrophthalic acid >-anhydride

<3.6-dibromo-1.2-dimethyl-hexahydrophthalic acid >-anhydride

C

levorotatory cantharic acid

levorotatory cantharic acid

Conditions
ConditionsYield
at 150 - 155℃;
C10H8O4S
75532-26-2

C10H8O4S

A

cantharidin
56-25-7

cantharidin

B

concentrated aqueous methylamine solution

concentrated aqueous methylamine solution

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / 10percent Pd-C
2: Raney Ni / ethyl acetate / Heating
View Scheme
C10H8O4S
75532-26-2

C10H8O4S

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
With hydrogen In water; ethyl acetate for 4h; Reflux;50 mg
Multi-step reaction with 2 steps
1: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
2: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
3-cyano-3-hydroxy-tetrahydrothiophene-4-carboxylic acid methyl ester
155251-30-2

3-cyano-3-hydroxy-tetrahydrothiophene-4-carboxylic acid methyl ester

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine; trichlorophosphate / benzene / 5 h / 20 - 52 °C
2.1: hydrogenchloride; water; acetic acid / Reflux
3.1: thionyl chloride / Reflux
4.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 19 h / 50 °C
4.2: Raney-Ni / 4 h / Reflux
View Scheme
methyl 4-oxotetrahydrothiophene-3-carboxylate
2689-68-1

methyl 4-oxotetrahydrothiophene-3-carboxylate

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydrogensulfite / water; methanol / 16 h / 20 °C / pH 7 - 8
2.1: pyridine; trichlorophosphate / benzene / 5 h / 20 - 52 °C
3.1: hydrogenchloride; water; acetic acid / Reflux
4.1: thionyl chloride / Reflux
5.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 19 h / 50 °C
5.2: Raney-Ni / 4 h / Reflux
View Scheme
Multi-step reaction with 7 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -30 - -20 °C / Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 24 h / 50 °C / 2068.65 Torr
3: sodium hydroxide; water / tetrahydrofuran / 2.5 h
4: acetyl chloride / toluene / 4 h / Reflux
5: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
6: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
7: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
3-cyano-2,5-dihydrothiophene-4-carboxylic acid methyl ester
96307-21-0

3-cyano-2,5-dihydrothiophene-4-carboxylic acid methyl ester

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water; acetic acid / Reflux
2.1: thionyl chloride / Reflux
3.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 19 h / 50 °C
3.2: Raney-Ni / 4 h / Reflux
View Scheme
dimethyl-3-thiaadipate
7400-45-5

dimethyl-3-thiaadipate

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: methanol; lithium / 7 h / 20 °C / Inert atmosphere; Reflux
2: hydrogenchloride / water / pH Ca. 5
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -30 - -20 °C / Inert atmosphere
4: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 24 h / 50 °C / 2068.65 Torr
5: sodium hydroxide; water / tetrahydrofuran / 2.5 h
6: acetyl chloride / toluene / 4 h / Reflux
7: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
8: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
9: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
C6H7O3S(1-)*Li(1+)

C6H7O3S(1-)*Li(1+)

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: hydrogenchloride / water / pH Ca. 5
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -30 - -20 °C / Inert atmosphere
3: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 24 h / 50 °C / 2068.65 Torr
4: sodium hydroxide; water / tetrahydrofuran / 2.5 h
5: acetyl chloride / toluene / 4 h / Reflux
6: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
7: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
8: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
methyl 4-{[(trifluoromethyl)sulfonyl]oxy}-2,5-dihydrothiophene-3-carboxylate
170945-21-8

methyl 4-{[(trifluoromethyl)sulfonyl]oxy}-2,5-dihydrothiophene-3-carboxylate

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 24 h / 50 °C / 2068.65 Torr
2: sodium hydroxide; water / tetrahydrofuran / 2.5 h
3: acetyl chloride / toluene / 4 h / Reflux
4: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
5: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
6: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
3,4-dimethyl 2,5-dihydrothiophene-3,4-dicarboxylate
20946-32-1

3,4-dimethyl 2,5-dihydrothiophene-3,4-dicarboxylate

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide; water / tetrahydrofuran / 2.5 h
2: acetyl chloride / toluene / 4 h / Reflux
3: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
4: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
5: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid
20688-07-7

2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetyl chloride / toluene / 4 h / Reflux
2: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
3: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
4: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride
75532-25-1

2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride

cantharidin
56-25-7

cantharidin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1-methyl-pyrrolidin-2-one / 48 h / 45 °C
2: hydrogen; 20 mol% Pd/C / ethyl acetate / 760.05 Torr
3: hydrogen / ethyl acetate / 760.05 Torr / Reflux
View Scheme
Cyclopropylamine
765-30-0

Cyclopropylamine

cantharidin
56-25-7

cantharidin

(1S,2R,6S,7R)-4-Cyclopropyl-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-4-Cyclopropyl-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;96%
methylamine
74-89-5

methylamine

cantharidin
56-25-7

cantharidin

7-oxabicyclo<2.2.1>heptane-2,3-dimethyl-2,3-dicarboxylic acid methylimide

7-oxabicyclo<2.2.1>heptane-2,3-dimethyl-2,3-dicarboxylic acid methylimide

Conditions
ConditionsYield
In water 1.) reflux, 4 h, 2.) 200 deg C, 1 h;93%
2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

cantharidin
56-25-7

cantharidin

(1R,2S,6R,7S)-4-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1R,2S,6R,7S)-4-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;93%
2-(5-methoxyindol-3-yl)ethylamine
608-07-1

2-(5-methoxyindol-3-yl)ethylamine

cantharidin
56-25-7

cantharidin

(1R,2S,6R,7S)-4-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1R,2S,6R,7S)-4-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;92%
Nδ-(tert-butoxycarbonyl)-L-ornithine
13650-49-2

Nδ-(tert-butoxycarbonyl)-L-ornithine

cantharidin
56-25-7

cantharidin

(S)-5-tert-Butoxycarbonylamino-2-((1S,2R,6S,7R)-2,6-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-pentanoic acid
849355-19-7

(S)-5-tert-Butoxycarbonylamino-2-((1S,2R,6S,7R)-2,6-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-pentanoic acid

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 48h;92%
cantharidin
56-25-7

cantharidin

7-oxabicyclo<2.2.1>heptane-2,3-dimethyl-2,3-dicarboxylic acid imide
76970-77-9

7-oxabicyclo<2.2.1>heptane-2,3-dimethyl-2,3-dicarboxylic acid imide

Conditions
ConditionsYield
With ammonium hydroxide at 180℃; for 2h;91%
With ammonium hydroxide 1.) reflux, 2 h, 2.) 200 deg C, 1 h;66%
(i) aq. NH3, (ii) (heating); Multistep reaction;
With ammonia
2-amino-4-phenyl-1,3,5-thiadiazole
17467-15-1

2-amino-4-phenyl-1,3,5-thiadiazole

cantharidin
56-25-7

cantharidin

N-[5-(3-phenyl-1,2,4-thiadiazolyl)]cantharidinimide

N-[5-(3-phenyl-1,2,4-thiadiazolyl)]cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;91%
1-amino-2-propene
107-11-9

1-amino-2-propene

cantharidin
56-25-7

cantharidin

(1R,2S,6R,7S)-4-Allyl-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1R,2S,6R,7S)-4-Allyl-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;90%
5-methyl-2-thiazol-2-amine
7305-71-7

5-methyl-2-thiazol-2-amine

cantharidin
56-25-7

cantharidin

N-[2-(5-methylthiazolyl)]cantharidinimide

N-[2-(5-methylthiazolyl)]cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;89%
1,4-diaminobutane
110-60-1

1,4-diaminobutane

cantharidin
56-25-7

cantharidin

bis[(1S,2R,3S,6R)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboximido]-tetramethylene

bis[(1S,2R,3S,6R)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboximido]-tetramethylene

Conditions
ConditionsYield
With triethylamine In methanol at 180℃; for 24h;89%
4-tert-Butylaniline
769-92-6

4-tert-Butylaniline

cantharidin
56-25-7

cantharidin

C20H25NO3

C20H25NO3

Conditions
ConditionsYield
With acetic acid Sealed tube;89%
tyrosamine
51-67-2

tyrosamine

cantharidin
56-25-7

cantharidin

(1R,2S,6R,7S)-4-[2-(4-Hydroxy-phenyl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1R,2S,6R,7S)-4-[2-(4-Hydroxy-phenyl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;88%
2-thiazolylamine
96-50-4

2-thiazolylamine

cantharidin
56-25-7

cantharidin

N-(2-thiazolyl)cantharidinimide

N-(2-thiazolyl)cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;87%
4-methylthiazol-2-ylamine
1603-91-4

4-methylthiazol-2-ylamine

cantharidin
56-25-7

cantharidin

N-[2-(4-methylthiazolyl)]cantharidinimide

N-[2-(4-methylthiazolyl)]cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;86%
1,5-diaminopentane
462-94-2

1,5-diaminopentane

cantharidin
56-25-7

cantharidin

bis[(1S,2R,3S,6R)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboximido]-pentamethylene

bis[(1S,2R,3S,6R)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboximido]-pentamethylene

Conditions
ConditionsYield
With triethylamine In methanol at 180℃; for 24h;86%
Trimethylenediamine
109-76-2

Trimethylenediamine

cantharidin
56-25-7

cantharidin

bis[(1S,2R,3S,6R)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboximido]-trimethylene

bis[(1S,2R,3S,6R)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboximido]-trimethylene

Conditions
ConditionsYield
With triethylamine In methanol at 180℃; for 24h;85%
3,4-methylenedioxyphenylethylamine
1484-85-1

3,4-methylenedioxyphenylethylamine

cantharidin
56-25-7

cantharidin

(1R,2S,6R,7S)-4-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1R,2S,6R,7S)-4-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;84%
2-(aminoethyl)pyridine
2706-56-1

2-(aminoethyl)pyridine

cantharidin
56-25-7

cantharidin

(1S,2R,6S,7R)-2,6-Dimethyl-4-(2-pyridin-2-yl-ethyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-2,6-Dimethyl-4-(2-pyridin-2-yl-ethyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;83%
6-methoxy-pyridin-3-ylamine
6628-77-9

6-methoxy-pyridin-3-ylamine

cantharidin
56-25-7

cantharidin

N-(6-methoxypyridyl-3)cantharidinimide

N-(6-methoxypyridyl-3)cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;83%
ethanolamine
141-43-5

ethanolamine

cantharidin
56-25-7

cantharidin

N-hydroxyethyl exo-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboximide

N-hydroxyethyl exo-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboximide

Conditions
ConditionsYield
In ethanol at 20℃; for 2.5h; Acylation; Heating;80.1%
2-amino-3-hydroxypyridine
16867-03-1

2-amino-3-hydroxypyridine

cantharidin
56-25-7

cantharidin

N-(3-hydroxypyridyl-2)cantharidinimide

N-(3-hydroxypyridyl-2)cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;79%
With triethylamine In toluene at 200℃; for 2h;52%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

cantharidin
56-25-7

cantharidin

C19H23NO3

C19H23NO3

Conditions
ConditionsYield
With acetic acid at 135℃; for 12h; Sealed tube;79%
tryptamine
61-54-1

tryptamine

cantharidin
56-25-7

cantharidin

(1R,2S,6R,7S)-4-[2-(1H-Indol-3-yl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1R,2S,6R,7S)-4-[2-(1H-Indol-3-yl)-ethyl]-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;77%
6-amino-3,4-benzodioxane
22013-33-8

6-amino-3,4-benzodioxane

cantharidin
56-25-7

cantharidin

3,4-diethyleneoxyphenylcantharidinimide

3,4-diethyleneoxyphenylcantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;76%
1,4-diaminobutane
110-60-1

1,4-diaminobutane

cantharidin
56-25-7

cantharidin

(1S,2R,6S,7R)-4-(4-Amino-butyl)-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-4-(4-Amino-butyl)-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;74%
6-methoxybenzothiazol-2-ylamine
1747-60-0

6-methoxybenzothiazol-2-ylamine

cantharidin
56-25-7

cantharidin

4-(6-methoxy-benzothiazol-2-yl)-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

4-(6-methoxy-benzothiazol-2-yl)-2,6-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With triethylamine In toluene at 180℃; for 5h;73%
2-Amino-4,6-dimethylpyridine
5407-87-4

2-Amino-4,6-dimethylpyridine

cantharidin
56-25-7

cantharidin

N-(4,6-dimethylpyridyl-2)cantharidinimide

N-(4,6-dimethylpyridyl-2)cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;72%
With triethylamine In toluene at 200℃; for 2h;62%
2-amino-5-nitro-1,3-thiazole
121-66-4

2-amino-5-nitro-1,3-thiazole

cantharidin
56-25-7

cantharidin

N-[2-(5-nitrothiazolyl)]cantharidinimide

N-[2-(5-nitrothiazolyl)]cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;69%
cantharidin
56-25-7

cantharidin

6-methyl-4-phenyl-benzothiazol-2-ylamine

6-methyl-4-phenyl-benzothiazol-2-ylamine

N-[2-(4-phenyl-6-methylbenzothiazolyl)]cantharidinimide

N-[2-(4-phenyl-6-methylbenzothiazolyl)]cantharidinimide

Conditions
ConditionsYield
With triethylamine In toluene at 200℃; for 2h;69%
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