We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am
Cas:72956-09-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $50.0 / 800.0
Type:Trading Company
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:72956-09-3
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:Store at +4°C Package:1kg/foil bag; 1kg/
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $300.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:72956-09-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryCarvedilol Basic information Product Name: Carvedilol Synonyms: 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano;CARVEDILOL;COREG;DIMITONE;DQ-2466;DILATREND;BM-1419
Cas:72956-09-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $25.0 / 55.0
Type:Trading Company
inquiryCAS No. [72956-09-3] Chemical Name 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]- 2-Propanol Packing 1-5kgs/ fiber carton(drum) Packing as the need of customer Stan
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:72956-09-3
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:72956-09-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. One of the domestic largest manufacturers of API; 2. High quality,competitive price and delivery in time; 3. Supplier of safe and ecofriendly products ; 4. Stable supply and efficient service; 5. Cooperate with scientific
Cas:72956-09-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:72956-09-3
Min.Order:100 Gram
FOB Price: $32.0 / 46.9
Type:Trading Company
inquiryCarvedilol CAS:72956-09-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:72956-09-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
API name: Carvedilol Certificates: GMP, DMF CAS No.: 72956-09-3 Chemical name: 1-(9H-carbazol-4-yloxy)-3-{2-(2-methoxyphenoxy)ethylamino}propan-2-ol DQ-2466 Formula: C24H26N2O4 Structure: Appearance:White or off white powder Storage:Store
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $20.0 / 50.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for ma
Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio
Cas:72956-09-3
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:72956-09-3
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:72956-09-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:colourless crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Carvedilol is a
(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate
A
C39H39N3O6
B
carvedilol
Conditions | Yield |
---|---|
With sodium hydroxide In water; isopropyl alcohol at 50 - 70℃; for 0.75h; | A n/a B 91.21% |
Stage #1: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate With triethylamine In ethyl acetate at 10 - 35℃; for 1h; Stage #2: With sodium chloride In water; ethyl acetate for 0.5h; |
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
carvedilol
Conditions | Yield |
---|---|
With sodium hydroxide In propan-1-ol at 60℃; for 4h; Solvent; Temperature; | 89.11% |
With sodium hydroxide In ethanol Reflux; Inert atmosphere; | 70% |
With ethanol; sodium hydroxide Inert atmosphere; Reflux; | 70% |
(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol tolsylate
carvedilol
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate Product distribution / selectivity; | 88% |
With sodium carbonate In water; ethyl acetate | 80% |
With sodium hydroxide; water In isopropyl alcohol Product distribution / selectivity; |
1-[benzyl[2(2-methoxyphenoxy)ethyl]amino]-3-(9H-carbazol-4-yloxy)propan-2-ol
carvedilol
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In water; ethyl acetate at 20 - 50℃; for 8h; | 84% |
With hydrogen; palladium 10% on activated carbon In methanol at 70℃; under 2942.29 - 4413.43 Torr; | 76.7% |
With hydrogen; 5%-palladium/activated carbon In ethyl acetate at 60 - 70℃; under 2574.5 - 3310.08 Torr; for 10h; |
1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol
1-(2-chloroethoxy)-2-methoxybenzene
carvedilol
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 80 - 85℃; | 83% |
2-(2-methoxy-phenoxy)-ethylamine
4-(2,3-epoxypropoxy)carbazole
carvedilol
Conditions | Yield |
---|---|
In isopropyl alcohol for 5h; Inert atmosphere; Reflux; | 81% |
With N-ethyl-N,N-diisopropylamine In 1,2-dimethoxyethane at 80 - 85℃; | 36.26% |
With sulfuric acid; potassium carbonate In isopropyl alcohol at 80℃; for 6h; |
carvedilol
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30 - 40℃; for 17h; | 67% |
(+/-) 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]amino-2-propanol oxalate
carvedilol
Conditions | Yield |
---|---|
With ammonia In dichloromethane; water at 20℃; for 1h; pH=9.0 - 9.3; | 63.2% |
2-(2-methoxy-phenoxy)-ethylamine
4-(2,3-epoxypropoxy)carbazole
A
C39H39N3O6
B
carvedilol
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 68 - 72℃; for 18 - 20h; | A n/a B 58% |
2-[(2-methoxy)phenoxy]ethylamine hydrochloride
4-(2,3-epoxypropoxy)carbazole
carvedilol
Conditions | Yield |
---|---|
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With sodium hydroxide In water at 20℃; pH=9 - 9.5; Stage #2: 4-(2,3-epoxypropoxy)carbazole In water at 80 - 85℃; for 0.75 - 1h; Product distribution / selectivity; | 45.99% |
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With sodium hydroxide In water; isopropyl alcohol at 20℃; pH=9 - 9.5; Stage #2: 4-(2,3-epoxypropoxy)carbazole In water; isopropyl alcohol for 4 - 5h; Product distribution / selectivity; Heating / reflux; | 43.05% |
With potassium carbonate In i-Amyl alcohol at 80 - 85℃; for 7h; | 41% |
With calcium carbonate In isopropyl alcohol at 80℃; for 4h; |
4-(2,3-epoxypropoxy)carbazole
carvedilol
Conditions | Yield |
---|---|
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With potassium carbonate In isopropyl alcohol at 35℃; for 0.25h; Stage #2: 4-(2,3-epoxypropoxy)carbazole In isopropyl alcohol at 83℃; for 5h; | 45% |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 140 °C 2: methylamine / water / 2 h / 80 °C 3: potassium carbonate / toluene / 80 - 85 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride / water; methanol / 0 - 30 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 - 95 °C 3: methylamine / water / 2 h / 80 °C 4: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: 4-methoxypyridine N-oxide; sodium sulfate / dichloromethane / 60 h / 20 °C 2: potassium carbonate / toluene / 60 h / Reflux 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 30 - 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: water; hydrogen bromide / isopropyl alcohol / 25 - 60 °C 2: triethylamine / isopropyl alcohol / 60 °C View Scheme |
(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate
carvedilol
Conditions | Yield |
---|---|
With sodium hydroxide; water In isopropyl alcohol Product distribution / selectivity; |
(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate
carvedilol
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate Product distribution / selectivity; |
C27H34N2O4Si
carvedilol
Conditions | Yield |
---|---|
Stage #1: C27H34N2O4Si With phosphoric acid; water In ethyl acetate at 20 - 25℃; Stage #2: With ammonia In water; ethyl acetate pH=~ 9.5; Product distribution / selectivity; |
2-(2-methoxy-phenoxy)-ethylamine
1-(9H-carbazol-4-yloxy)-3-bromopropan-2-ol
carvedilol
Conditions | Yield |
---|---|
With triethylamine In isopropyl alcohol at 60℃; Product distribution / selectivity; |
2-(2-methoxy-phenoxy)-ethylamine
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol
carvedilol
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 80 - 85℃; for 13h; Product distribution / selectivity; |
9H-carbazol-4-ol
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water; dimethyl sulfoxide / 12 h / 25 - 45 °C 2: 1,2-dimethoxyethane; ethyl acetate View Scheme | |
Multi-step reaction with 5 steps 1.1: pyridine / isopropyl alcohol / 0.17 h / Inert atmosphere 1.2: 16 h / 15 - 20 °C / Inert atmosphere 2.1: pyridine / dichloromethane / 12 h / 5 - 20 °C / Inert atmosphere 3.1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere 4.1: 100 - 110 °C / Inert atmosphere 5.1: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: pyridine / isopropyl alcohol / 0.17 h / Inert atmosphere 1.2: 16 h / 15 - 20 °C / Inert atmosphere 2.1: dichloromethane / 4 h / 0 °C / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere 4.1: 100 - 110 °C / Inert atmosphere 5.1: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme |
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine / dichloromethane / 12 h / 5 - 20 °C / Inert atmosphere 2: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere 3: 100 - 110 °C / Inert atmosphere 4: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 4 steps 1: dichloromethane / 4 h / 0 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere 3: 100 - 110 °C / Inert atmosphere 4: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 - 95 °C 2: methylamine / water / 2 h / 80 °C 3: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux View Scheme |
3-((9H-carbazol-4-yloxy)methyl)-3-chloropropane-2-yl phenyl carbonate
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere 2: 100 - 110 °C / Inert atmosphere 3: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme |
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere 2: 100 - 110 °C / Inert atmosphere 3: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme |
2-(2-methoxy-phenoxy)-ethylamine
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere 2: 100 - 110 °C / Inert atmosphere 3: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere 2: 100 - 110 °C / Inert atmosphere 3: ethanol; sodium hydroxide / Inert atmosphere; Reflux View Scheme |
5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one
1-(2-chloroethoxy)-2-methoxybenzene
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere 2: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere View Scheme |
1-(9H-carbazol-4-yloxy)-3-(benzhydrylamino)propan-2-ol
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon / methanol / 6 h / 3102.97 - 3620.13 Torr / Inert atmosphere 2: 0 °C / Reflux; basic condition; Inert atmosphere 3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere 4: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere View Scheme |
1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 0 °C / Reflux; basic condition; Inert atmosphere 2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere 3: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere View Scheme |
5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one
1-(2-iodoethoxy)-2-methoxybenzene
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C 2: water; sodium hydroxide / ethanol / 12 h / Reflux View Scheme |
2-methoxy-phenol
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrabutylammomium bromide; sodium hydroxide / water / 5 h / 80 °C 2: sodium iodide / acetone / 48 h / Reflux 3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C 4: water; sodium hydroxide / ethanol / 12 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 30 °C 1.2: 20 - 70 °C 2.1: sodium hydroxide / toluene / 0.17 h / 25 - 30 °C 2.2: 25 - 30 °C 3.1: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: tetrabutylammomium bromide; sodium hydroxide / 16 h / Reflux 2: water; sodium hydroxide / 13 h / 130 °C 3: ethyl acetate / 24 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: tetrabutylammomium bromide; sodium hydroxide / 16 h / Reflux 2: tetrabutylammomium bromide / 180 - 185 °C 3: water; potassium hydroxide / 13 h / 130 °C 4: ethyl acetate / 24 h / Reflux View Scheme |
1-(2-chloroethoxy)-2-methoxybenzene
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium iodide / acetone / 48 h / Reflux 2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C 3: water; sodium hydroxide / ethanol / 12 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: water; sodium hydroxide / 13 h / 130 °C 2: ethyl acetate / 24 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: tetrabutylammomium bromide / 180 - 185 °C 2: water; potassium hydroxide / 13 h / 130 °C 3: ethyl acetate / 24 h / Reflux View Scheme |
sodium salt of 9H-carbazol-4-ol
carvedilol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 100 °C 2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C 3: water; sodium hydroxide / ethanol / 12 h / Reflux View Scheme |
carvedilol
Conditions | Yield |
---|---|
With deuterium In tetrahydrofuran under 1500.15 Torr; for 24h; Glovebox; Heating; | 99% |
carvedilol
Conditions | Yield |
---|---|
With phosphoric acid In acetonitrile at 20℃; for 0.5h; Product distribution / selectivity; | 98% |
With phosphoric acid In acetone Product distribution / selectivity; | 98% |
With phosphoric acid In methanol Product distribution / selectivity; | 98% |
carvedilol
1-(9H-carbazole-4-oxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanolphosphate
Conditions | Yield |
---|---|
With phosphoric acid In water; acetonitrile at 20 - 70℃; Product distribution / selectivity; | 97% |
With phosphoric acid In water; N,N-dimethyl-formamide; isopropyl alcohol at 20℃; Product distribution / selectivity; | 96% |
With phosphorus pentoxide In water; acetone at 0 - 45℃; Product distribution / selectivity; | 95% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 1h; | 96% |
carvedilol
Conditions | Yield |
---|---|
With phosphorus pentoxide In water; acetone at 0 - 45℃; for 1h; Product distribution / selectivity; | 95% |
With hydrogenchloride; dipotassium hydrogenphosphate In water; acetone at 0 - 45℃; for 1h; pH=4.5 - 5; Product distribution / selectivity; | 94.49% |
With PPA In water; acetone at 0 - 45℃; for 1h; Product distribution / selectivity; | 93.3% |
carvedilol
1,1'-carbonyldiimidazole
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 5h; | 93% |
With triethylamine In dichloromethane at 20℃; |
carvedilol
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; water | 92.1% |
With sulfuric acid In water; acetone at 17 - 35℃; for 10 - 24h; |
carvedilol
2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid
A
6(5H)-phenanthridinone
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane | A n/a B 92% |
carvedilol
(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; water | 89.6% |
With sulfuric acid In dichloromethane; water pH=4.0 - 4.5; | |
With sulfuric acid In water; acetone at 17 - 35℃; for 10 - 24h; |
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; for 18h; | 77% |
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; for 18h; Product distribution / selectivity; | 75% |
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; |
Conditions | Yield |
---|---|
Stage #1: carvedilol With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 0.166667h; Inert atmosphere; Schlenk technique; Stage #2: 4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere; Schlenk technique; | 71% |
Conditions | Yield |
---|---|
With glucose dehydrogenase; alpha-D-glucopyranose; maltose binding protein-RebF; RebH variant 4-V; nicotinamide adenine dinucleotide; flavin adenine dinucleotide; sodium chloride In methanol at 25℃; for 72h; pH=7.4; Enzymatic reaction; | 69% |
Conditions | Yield |
---|---|
With water In acetone at 20 - 40℃; Product distribution / selectivity; | 67% |
With water In acetone at 20 - 40℃; for 24 - 48h; Product distribution / selectivity; | 67% |
With water | |
With water Product distribution / selectivity; |
carvedilol
Diethyl carbonate
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: carvedilol In methanol Stage #2: With methanol; sodium In methanol Stage #3: Diethyl carbonate In methanol for 12h; Product distribution / selectivity; Heating / reflux; | 65% |
carvedilol
trifluoromethyl trifluoromethanesulfonate
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 1h; Sealed tube; | 61% |
carvedilol
MANDELIC ACID
carvedilol mandelate
Conditions | Yield |
---|---|
In methanol; water; acetone at 17 - 35℃; for 10 - 24h; | 54.5% |
In methanol; water; acetone at 17 - 35℃; for 10 - 24h; | 54.5% |
carvedilol
methyl iodide
1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]methylamino}-2-propanol
Conditions | Yield |
---|---|
Stage #1: carvedilol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; for 4h; | 54% |
With sodium hydride In tetrahydrofuran at 20℃; for 4h; | 54% |
In tetrahydrofuran at 20℃; |
Conditions | Yield |
---|---|
Stage #1: carvedilol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 4h; | 49% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View