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Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am

Carvedilol EP8/USP39 CAS72956-09-3

Cas:72956-09-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% Carvedilol powder CAS 72956-09-3

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $50.0 / 800.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Carvedilol CAS NO.72956-09-3

Cas:72956-09-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:Store at +4°C Package:1kg/foil bag; 1kg/

Chinese manufacturer supply Carvedilol CAS 72956-09-3 with favorable price

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $300.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Carvedilol

Cas:72956-09-3

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Carvedilol 72956-09-3 ISO Producer

Cas:72956-09-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality carvedilol

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Carvedilol

Cas:72956-09-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Carvedilol

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Carvedilol Basic information Product Name: Carvedilol Synonyms: 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano;CARVEDILOL;COREG;DIMITONE;DQ-2466;DILATREND;BM-1419

TIANFU-CHEM CAS:72956-09-3 Carvedilol

Cas:72956-09-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

High Quality Carvedi Lol CAS 72956-09-3

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $25.0 / 55.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

CAS No. [72956-09-3] Chemical Name 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]- 2-Propanol Packing 1-5kgs/ fiber carton(drum) Packing as the need of customer Stan

Carvedilol

Cas:72956-09-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Carvedilol 72956-09-3

Cas:72956-09-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hefei TNJ chemical industry co.,ltd

1. One of the domestic largest manufacturers of API; 2. High quality,competitive price and delivery in time; 3. Supplier of safe and ecofriendly products ; 4. Stable supply and efficient service; 5. Cooperate with scientific

Manufacturer of Carvedilol at Factory Price

Cas:72956-09-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antibacterial drugs Carvedilol/CAS:72956-09-3

Cas:72956-09-3

Min.Order:100 Gram

FOB Price: $32.0 / 46.9

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Carvedilol CAS:72956-09-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Carvedilol CAS:72956-09-3

Cas:72956-09-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Carvedilol

Cas:72956-09-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name: Carvedilol Certificates: GMP, DMF CAS No.: 72956-09-3 Chemical name: 1-(9H-carbazol-4-yloxy)-3-{2-(2-methoxyphenoxy)ethylamino}propan-2-ol DQ-2466 Formula: C24H26N2O4 Structure: Appearance:White or off white powder Storage:Store

Carvedilol

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Carvedilol

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $20.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Carvedilol

Cas:72956-09-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for ma

CAS.72956-09-3 CARVEDILOL USP

Cas:72956-09-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Carvedilol

Cas:72956-09-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

Carvedilol

Cas:72956-09-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Carvedilol CAS 72956-09-3 with Fast Shipment

Cas:72956-09-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Carvedilol

Cas:72956-09-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Carvedilol

Cas:72956-09-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Carvedilol

Cas:72956-09-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Carvedilol

Cas:72956-09-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:colourless crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Carvedilol is a

Carvedilol

Cas:72956-09-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate
787598-91-8

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate

A

C39H39N3O6
918903-20-5

C39H39N3O6

B

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium hydroxide In water; isopropyl alcohol at 50 - 70℃; for 0.75h;A n/a
B 91.21%
Stage #1: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate With triethylamine In ethyl acetate at 10 - 35℃; for 1h;
Stage #2: With sodium chloride In water; ethyl acetate for 0.5h;
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium hydroxide In propan-1-ol at 60℃; for 4h; Solvent; Temperature;89.11%
With sodium hydroxide In ethanol Reflux; Inert atmosphere;70%
With ethanol; sodium hydroxide Inert atmosphere; Reflux;70%
(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol tolsylate
1016214-10-0

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol tolsylate

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate Product distribution / selectivity;88%
With sodium carbonate In water; ethyl acetate80%
With sodium hydroxide; water In isopropyl alcohol Product distribution / selectivity;
1-[benzyl[2(2-methoxyphenoxy)ethyl]amino]-3-(9H-carbazol-4-yloxy)propan-2-ol
72955-94-3

1-[benzyl[2(2-methoxyphenoxy)ethyl]amino]-3-(9H-carbazol-4-yloxy)propan-2-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In water; ethyl acetate at 20 - 50℃; for 8h;84%
With hydrogen; palladium 10% on activated carbon In methanol at 70℃; under 2942.29 - 4413.43 Torr;76.7%
With hydrogen; 5%-palladium/activated carbon In ethyl acetate at 60 - 70℃; under 2574.5 - 3310.08 Torr; for 10h;
1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol
143412-40-2, 143412-41-3, 72955-96-5

1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol

1-(2-chloroethoxy)-2-methoxybenzene
53815-60-4

1-(2-chloroethoxy)-2-methoxybenzene

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With potassium carbonate In toluene at 80 - 85℃;83%
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

4-(2,3-epoxypropoxy)carbazole
51997-51-4

4-(2,3-epoxypropoxy)carbazole

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
In isopropyl alcohol for 5h; Inert atmosphere; Reflux;81%
With N-ethyl-N,N-diisopropylamine In 1,2-dimethoxyethane at 80 - 85℃;36.26%
With sulfuric acid; potassium carbonate In isopropyl alcohol at 80℃; for 6h;
4-[2-(tert-butyldiphenylsilyloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propyloxy]carbazole

4-[2-(tert-butyldiphenylsilyloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propyloxy]carbazole

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30 - 40℃; for 17h;67%
(+/-) 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]amino-2-propanol oxalate
72956-09-3

(+/-) 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]amino-2-propanol oxalate

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With ammonia In dichloromethane; water at 20℃; for 1h; pH=9.0 - 9.3;63.2%
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

4-(2,3-epoxypropoxy)carbazole
51997-51-4

4-(2,3-epoxypropoxy)carbazole

A

C39H39N3O6
918903-20-5

C39H39N3O6

B

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
In dimethyl sulfoxide at 68 - 72℃; for 18 - 20h;A n/a
B 58%
2-[(2-methoxy)phenoxy]ethylamine hydrochloride
64464-07-9

2-[(2-methoxy)phenoxy]ethylamine hydrochloride

4-(2,3-epoxypropoxy)carbazole
51997-51-4

4-(2,3-epoxypropoxy)carbazole

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With sodium hydroxide In water at 20℃; pH=9 - 9.5;
Stage #2: 4-(2,3-epoxypropoxy)carbazole In water at 80 - 85℃; for 0.75 - 1h; Product distribution / selectivity;
45.99%
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With sodium hydroxide In water; isopropyl alcohol at 20℃; pH=9 - 9.5;
Stage #2: 4-(2,3-epoxypropoxy)carbazole In water; isopropyl alcohol for 4 - 5h; Product distribution / selectivity; Heating / reflux;
43.05%
With potassium carbonate In i-Amyl alcohol at 80 - 85℃; for 7h;41%
With calcium carbonate In isopropyl alcohol at 80℃; for 4h;
4-(2,3-epoxypropoxy)carbazole
51997-51-4

4-(2,3-epoxypropoxy)carbazole

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With potassium carbonate In isopropyl alcohol at 35℃; for 0.25h;
Stage #2: 4-(2,3-epoxypropoxy)carbazole In isopropyl alcohol at 83℃; for 5h;
45%
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 140 °C
2: methylamine / water / 2 h / 80 °C
3: potassium carbonate / toluene / 80 - 85 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / water; methanol / 0 - 30 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 - 95 °C
3: methylamine / water / 2 h / 80 °C
4: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: 4-methoxypyridine N-oxide; sodium sulfate / dichloromethane / 60 h / 20 °C
2: potassium carbonate / toluene / 60 h / Reflux
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 30 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1: water; hydrogen bromide / isopropyl alcohol / 25 - 60 °C
2: triethylamine / isopropyl alcohol / 60 °C
View Scheme
(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate
787598-91-8

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol Product distribution / selectivity;
(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate
374779-43-8

(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate Product distribution / selectivity;
C27H34N2O4Si
1187921-88-5

C27H34N2O4Si

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Stage #1: C27H34N2O4Si With phosphoric acid; water In ethyl acetate at 20 - 25℃;
Stage #2: With ammonia In water; ethyl acetate pH=~ 9.5; Product distribution / selectivity;
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

1-(9H-carbazol-4-yloxy)-3-bromopropan-2-ol
1187921-94-3

1-(9H-carbazol-4-yloxy)-3-bromopropan-2-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 60℃; Product distribution / selectivity;
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol
1187921-93-2

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
With potassium carbonate In toluene at 80 - 85℃; for 13h; Product distribution / selectivity;
9H-carbazol-4-ol
52602-39-8

9H-carbazol-4-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; dimethyl sulfoxide / 12 h / 25 - 45 °C
2: 1,2-dimethoxyethane; ethyl acetate
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / isopropyl alcohol / 0.17 h / Inert atmosphere
1.2: 16 h / 15 - 20 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 12 h / 5 - 20 °C / Inert atmosphere
3.1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
4.1: 100 - 110 °C / Inert atmosphere
5.1: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / isopropyl alcohol / 0.17 h / Inert atmosphere
1.2: 16 h / 15 - 20 °C / Inert atmosphere
2.1: dichloromethane / 4 h / 0 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
4.1: 100 - 110 °C / Inert atmosphere
5.1: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol
1187921-93-2

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 12 h / 5 - 20 °C / Inert atmosphere
2: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
3: 100 - 110 °C / Inert atmosphere
4: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 4 steps
1: dichloromethane / 4 h / 0 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
3: 100 - 110 °C / Inert atmosphere
4: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 - 95 °C
2: methylamine / water / 2 h / 80 °C
3: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux
View Scheme
3-((9H-carbazol-4-yloxy)methyl)-3-chloropropane-2-yl phenyl carbonate
1392322-33-6

3-((9H-carbazol-4-yloxy)methyl)-3-chloropropane-2-yl phenyl carbonate

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol chloroformate

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol chloroformate

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one
1218777-33-3

5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one

1-(2-chloroethoxy)-2-methoxybenzene
53815-60-4

1-(2-chloroethoxy)-2-methoxybenzene

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere
2: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere
View Scheme
1-(9H-carbazol-4-yloxy)-3-(benzhydrylamino)propan-2-ol
1392100-68-3

1-(9H-carbazol-4-yloxy)-3-(benzhydrylamino)propan-2-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon / methanol / 6 h / 3102.97 - 3620.13 Torr / Inert atmosphere
2: 0 °C / Reflux; basic condition; Inert atmosphere
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere
4: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere
View Scheme
1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol
143412-40-2, 143412-41-3, 72955-96-5

1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 0 °C / Reflux; basic condition; Inert atmosphere
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere
3: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere
View Scheme
5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one
1218777-33-3

5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one

1-(2-iodoethoxy)-2-methoxybenzene
1187921-84-1

1-(2-iodoethoxy)-2-methoxybenzene

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
2: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
2-methoxy-phenol
90-05-1

2-methoxy-phenol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutylammomium bromide; sodium hydroxide / water / 5 h / 80 °C
2: sodium iodide / acetone / 48 h / Reflux
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
4: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 30 °C
1.2: 20 - 70 °C
2.1: sodium hydroxide / toluene / 0.17 h / 25 - 30 °C
2.2: 25 - 30 °C
3.1: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide; sodium hydroxide / 16 h / Reflux
2: water; sodium hydroxide / 13 h / 130 °C
3: ethyl acetate / 24 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: tetrabutylammomium bromide; sodium hydroxide / 16 h / Reflux
2: tetrabutylammomium bromide / 180 - 185 °C
3: water; potassium hydroxide / 13 h / 130 °C
4: ethyl acetate / 24 h / Reflux
View Scheme
1-(2-chloroethoxy)-2-methoxybenzene
53815-60-4

1-(2-chloroethoxy)-2-methoxybenzene

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium iodide / acetone / 48 h / Reflux
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
3: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: water; sodium hydroxide / 13 h / 130 °C
2: ethyl acetate / 24 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide / 180 - 185 °C
2: water; potassium hydroxide / 13 h / 130 °C
3: ethyl acetate / 24 h / Reflux
View Scheme
sodium salt of 9H-carbazol-4-ol
1207276-96-7

sodium salt of 9H-carbazol-4-ol

carvedilol
72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 100 °C
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
3: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
carvedilol
72956-09-3

carvedilol

C24H22(2)H4N2O4

C24H22(2)H4N2O4

Conditions
ConditionsYield
With deuterium In tetrahydrofuran under 1500.15 Torr; for 24h; Glovebox; Heating;99%
carvedilol
72956-09-3

carvedilol

1-(carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)ethyl]amino]-2-propanol dihydrogen phosphate

1-(carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)ethyl]amino]-2-propanol dihydrogen phosphate

Conditions
ConditionsYield
With phosphoric acid In acetonitrile at 20℃; for 0.5h; Product distribution / selectivity;98%
With phosphoric acid In acetone Product distribution / selectivity;98%
With phosphoric acid In methanol Product distribution / selectivity;98%
carvedilol
72956-09-3

carvedilol

1-(9H-carbazole-4-oxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanolphosphate
374779-45-0

1-(9H-carbazole-4-oxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanolphosphate

Conditions
ConditionsYield
With phosphoric acid In water; acetonitrile at 20 - 70℃; Product distribution / selectivity;97%
With phosphoric acid In water; N,N-dimethyl-formamide; isopropyl alcohol at 20℃; Product distribution / selectivity;96%
With phosphorus pentoxide In water; acetone at 0 - 45℃; Product distribution / selectivity;95%
carvedilol
72956-09-3

carvedilol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C29H34N2O6

C29H34N2O6

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 1h;96%
carvedilol
72956-09-3

carvedilol

carvedilol dihydrogen phosphate hemihydrate

carvedilol dihydrogen phosphate hemihydrate

Conditions
ConditionsYield
With phosphorus pentoxide In water; acetone at 0 - 45℃; for 1h; Product distribution / selectivity;95%
With hydrogenchloride; dipotassium hydrogenphosphate In water; acetone at 0 - 45℃; for 1h; pH=4.5 - 5; Product distribution / selectivity;94.49%
With PPA In water; acetone at 0 - 45℃; for 1h; Product distribution / selectivity;93.3%
carvedilol
72956-09-3

carvedilol

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;93%
With triethylamine In dichloromethane at 20℃;
carvedilol
72956-09-3

carvedilol

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol sulfate salt

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol sulfate salt

Conditions
ConditionsYield
With sulfuric acid In ethanol; water92.1%
With sulfuric acid In water; acetone at 17 - 35℃; for 10 - 24h;
carvedilol
72956-09-3

carvedilol

2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid
320401-51-2

2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid

A

6(5H)-phenanthridinone
1015-89-0

6(5H)-phenanthridinone

B

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{[3-(9H-carbazol-4-yloxy)-2-hydroxy-propyl]-[2-(2-methoxy-phenoxy)-ethyl]-carbamoyloxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{[3-(9H-carbazol-4-yloxy)-2-hydroxy-propyl]-[2-(2-methoxy-phenoxy)-ethyl]-carbamoyloxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethaneA n/a
B 92%
carvedilol
72956-09-3

carvedilol

(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate
374779-43-8

(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate

Conditions
ConditionsYield
With sulfuric acid In ethanol; water89.6%
With sulfuric acid In dichloromethane; water pH=4.0 - 4.5;
With sulfuric acid In water; acetone at 17 - 35℃; for 10 - 24h;
carvedilol
72956-09-3

carvedilol

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

C26H26N2O5

C26H26N2O5

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; for 18h;77%
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; for 18h; Product distribution / selectivity;75%
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃;
carvedilol
72956-09-3

carvedilol

4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate

4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate

C31H29N3O4

C31H29N3O4

Conditions
ConditionsYield
Stage #1: carvedilol With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: 4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere; Schlenk technique;
71%
carvedilol
72956-09-3

carvedilol

trifluoroacetic acid
76-05-1

trifluoroacetic acid

8-chlorocarvedilol

8-chlorocarvedilol

Conditions
ConditionsYield
With glucose dehydrogenase; alpha-D-glucopyranose; maltose binding protein-RebF; RebH variant 4-V; nicotinamide adenine dinucleotide; flavin adenine dinucleotide; sodium chloride In methanol at 25℃; for 72h; pH=7.4; Enzymatic reaction;69%
carvedilol
72956-09-3

carvedilol

citric acid
77-92-9

citric acid

carvedilol monocitrate monohydrate
623113-70-2

carvedilol monocitrate monohydrate

Conditions
ConditionsYield
With water In acetone at 20 - 40℃; Product distribution / selectivity;67%
With water In acetone at 20 - 40℃; for 24 - 48h; Product distribution / selectivity;67%
With water
With water Product distribution / selectivity;
carvedilol
72956-09-3

carvedilol

Diethyl carbonate
105-58-8

Diethyl carbonate

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: carvedilol In methanol
Stage #2: With methanol; sodium In methanol
Stage #3: Diethyl carbonate In methanol for 12h; Product distribution / selectivity; Heating / reflux;
65%
carvedilol
72956-09-3

carvedilol

trifluoromethyl trifluoromethanesulfonate
3582-05-6

trifluoromethyl trifluoromethanesulfonate

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
ConditionsYield
In acetonitrile at 20℃; for 1h; Sealed tube;61%
carvedilol
72956-09-3

carvedilol

carvedilol mandelate
852995-78-9

carvedilol mandelate

Conditions
ConditionsYield
In methanol; water; acetone at 17 - 35℃; for 10 - 24h;54.5%
In methanol; water; acetone at 17 - 35℃; for 10 - 24h;54.5%
carvedilol
72956-09-3

carvedilol

methyl iodide
74-88-4

methyl iodide

1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]methylamino}-2-propanol
72956-35-5

1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]methylamino}-2-propanol

Conditions
ConditionsYield
Stage #1: carvedilol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; for 4h;
54%
With sodium hydride In tetrahydrofuran at 20℃; for 4h;54%
In tetrahydrofuran at 20℃;
carvedilol
72956-09-3

carvedilol

methyl iodide
74-88-4

methyl iodide

C26H30N2O4

C26H30N2O4

Conditions
ConditionsYield
Stage #1: carvedilol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 4h;
49%
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