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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ketorolac Manufacturer/High quality/Best price/In stock

Cas:74103-06-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ketorolac supplier in China

Cas:74103-06-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Ketorolac manufacturer/supplier

Cas:74103-06-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Ketorolac Cas 74103-06-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow solid Storage:cool dry place Package:1kg/foil bag;25kg/drum Application

Manufacturer high quality Ketorolac Cas 74103-06-3 with good price and fast delivery

Cas:74103-06-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ketorolac

Cas:74103-06-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ketorolac

Cas:74103-06-3

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Ketorolac 74103-06-3 GMP Manufacturer

Cas:74103-06-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Ketorolac Manufacturer/High quality/Best price/In stock CAS NO.74103-06-3

Cas:74103-06-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ketorolac

Cas:74103-06-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

Ketorolac CAS:74103-06-3

Cas:74103-06-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 74103-06-3 with best quality

Cas:74103-06-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ketorolac

Cas:74103-06-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ketorolac 74103-06-3

Cas:74103-06-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Non-steroidal anti-inflammatory drugs, Ketorolac CAS:74103-06-3

Cas:74103-06-3

Min.Order:1 Gram

FOB Price: $16.0 / 20.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ketorolac CAS:74103-06-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Ketorolac CAS:74103-06-3

Cas:74103-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ketorolac

Cas:74103-06-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white crystalline or white powder Storage:R.T Package:25kg/drum Application:Ketorlac is an NSAIDs with strong analgesic and anti-inflammatory effects, which is suitable for the short-term treatment of more severe acute pain, usually for p

Factory price ready stock Ketorolac

Cas:74103-06-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Ketorolac

Cas:74103-06-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

KETOROLAC

Cas:74103-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ketorolac

Cas:74103-06-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Ketorolac CAS 74103-06-3

Cas:74103-06-3

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Ketorolac

Cas:74103-06-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Ketorolac

Cas:74103-06-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline or white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Applicatio

Ketorolac

Cas:74103-06-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Ketorolac

Cas:74103-06-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Ketorolac Synonyms: 3-dihydro-5-benzoyl-(+-)-1h-pyrrolizine-1-carboxylicaci;rs37619;5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid;KETOROLAC;KETOROLAC-D5;KETOROLAC TROMETHAMINE, USP STANDARD;5-(phenylcarbonyl)-2,3-dihyd

TIANFU-CHEM 74103-06-3 Ketorolac

Cas:74103-06-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ketorolac Manufacturer/High quality/Best price/In stock CAS NO.74103-06-3

Cas:74103-06-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

high purityKetorolac

Cas:74103-06-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Ketorolac

Cas:74103-06-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Ketorolac Basic information Product Name: Ketorolac Synonyms: Ketorolac Solution, 100ppm;Ketorolac, >=98%;(1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]ammonium;5-benzoyl-2,3-dihydr

Ketorolac

Cas:74103-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
157071-66-4

Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With sodium hydroxide In methanol Ambient temperature;99%
ketorolac tromethamine

ketorolac tromethamine

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With hydrogenchloride In water98%
With hydrogenchloride In water at 0 - 20℃;83.6%
With hydrogenchloride In water
diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
140947-23-5

diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Stage #1: diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate With sodium hydroxide In diethyl ether; water for 24h; Reflux;
Stage #2: With hydrogenchloride In ethyl acetate at 70℃; for 4h;
80%
With sodium hydroxide In tetrahydrofuran for 9h; Time; Reflux; Green chemistry;47.5%
With hydrogenchloride; sodium hydroxide 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h; Yield given. Multistep reaction;
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
66635-74-3

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With potassium carbonate In methanol; water for 0.5h; Heating;64%
With water In methanol; aq. phosphate buffer at 37℃; pH=8; Kinetics; pH-value;
5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
84023-60-9

5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With hydrogen; magnesium oxide; palladium on activated charcoal In methanol; water under 760 Torr; for 2h; Ambient temperature; Yield given;
2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester
80965-05-5

2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Yield given. Multistep reaction;
ketorolac acid ethyl ester
108061-03-6

ketorolac acid ethyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;
ketorolac acid <(N,N-dimethylamino)carbonyl>methyl ester

ketorolac acid <(N,N-dimethylamino)carbonyl>methyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;
phenyl chloroformate
1885-14-9

phenyl chloroformate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
(1H-pyrrol-2-yl)acetic acid isopropyl ester
157071-48-2

(1H-pyrrol-2-yl)acetic acid isopropyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h
2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
4: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 40 h
2: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h
3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
4: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Methyl isopropyl 2-pyrrolylmalonate
157071-53-9

Methyl isopropyl 2-pyrrolylmalonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Isopropyl (5-benzoylpyrrol-2-yl)acetate
157071-65-3

Isopropyl (5-benzoylpyrrol-2-yl)acetate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate
157071-60-8

Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
2: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate
66635-71-0

i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h
2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating
View Scheme
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h
2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h
2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h
3: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
4: 95 percent / HCl / 0.5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h
2: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C
3: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h
4: 95 percent / HCl / 0.5 h / Heating
View Scheme
phenyl(1H-pyrrol-2-yl)methanone
7697-46-3

phenyl(1H-pyrrol-2-yl)methanone

alkaline iodine-potassium iodide

alkaline iodine-potassium iodide

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 75 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C
2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C
3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 4 steps
1: 57 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C
2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C
3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 3 steps
1: 86 percent / triethylborane, O2 / hexane; benzene / 3 h / Ambient temperature
2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate
136116-84-2

triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / NaOC2H5 / dimethylformamide / 2 h / Ambient temperature
2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 2 steps
1: 80 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(2-chloroethyl)-2-benzoylpyrrole
87549-01-7

1-(2-chloroethyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / NaI / acetonitrile / 24 h / Heating
2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
3: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t.
4: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
5: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 4 steps
1: 80 percent / NaI / acetonitrile / 24 h / Heating
2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
3: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(2-iodoethyl)-2-benzoylpyrrole
141031-77-8

1-(2-iodoethyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
2: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t.
3: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 3 steps
1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
2: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
diethyl 2-(5-benzoyl-1H-pyrrol-2-yl)malonate
144710-35-0

diethyl 2-(5-benzoyl-1H-pyrrol-2-yl)malonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole
141031-81-4

1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole
141031-78-9

1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t.
2: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 2 steps
1: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate
144710-34-9

diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C
2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
phenyl(1H-pyrrol-2-yl)methanone
7697-46-3

phenyl(1H-pyrrol-2-yl)methanone

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / bromine / CH2Cl2 / 0 deg C to RT, 2.5 h
2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h
3: HCl / 5 h / 0 deg C to RT
5: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
2,3-dibromo-5-benzoylpyrrole
50372-61-7

2,3-dibromo-5-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h
2: HCl / 5 h / 0 deg C to RT
4: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
2-(methylthio)-5-benzoylpyrrole
80965-00-0

2-(methylthio)-5-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h
2: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
3: 95 percent / HCl / 0.5 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C
2: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h
3: 95 percent / HCl / 0.5 h / Heating
View Scheme
2-(methylsulfonyl)-5-benzoylpyrrole
80965-03-3

2-(methylsulfonyl)-5-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h
2: 95 percent / HCl / 0.5 h / Heating
View Scheme
5-[2-(2-Benzoyl-5-methylsulfanyl-pyrrol-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione
83727-08-6

5-[2-(2-Benzoyl-5-methylsulfanyl-pyrrol-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
2: 95 percent / HCl / 0.5 h / Heating
View Scheme
4-arm-PEG-20K

4-arm-PEG-20K

Ketorolac
74103-06-3

Ketorolac

4-arm-PEG-20K-ketorolac

4-arm-PEG-20K-ketorolac

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;95%
4-arm-PEG-40K

4-arm-PEG-40K

Ketorolac
74103-06-3

Ketorolac

4-arm-PEG-40K-ketorolac

4-arm-PEG-40K-ketorolac

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;94%
Ketorolac
74103-06-3

Ketorolac

butan-1-ol
71-36-3

butan-1-ol

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid butyl ester
376628-29-4

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid butyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 3h; Heating;89%
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h;
(L)-phenylalanine ethyl ester hydrochloride
3182-93-2

(L)-phenylalanine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C26H26N2O4
1093407-70-5

C26H26N2O4

Conditions
ConditionsYield
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: (L)-phenylalanine ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
88%
(S)-alanine ethyl ester hydrochloride
1115-59-9

(S)-alanine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C20H22N2O4
1093407-68-1

C20H22N2O4

Conditions
ConditionsYield
Stage #1: (S)-alanine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
83%
chloromethyl n-butyrate
33657-49-7

chloromethyl n-butyrate

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-(butyryloxy)methyl ester

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-(butyryloxy)methyl ester

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone at 20℃;83%
With potassium carbonate; potassium iodide In acetone at 20℃;
n-heptan1ol
111-70-6

n-heptan1ol

Ketorolac
74103-06-3

Ketorolac

ketorolac heptyl ester

ketorolac heptyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;82%
1-bromoethyl acetate
40258-78-4

1-bromoethyl acetate

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid-1-(acetoxy)ethyl ester

5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid-1-(acetoxy)ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;80%
With potassium carbonate In acetone at 20℃;76%
Ketorolac
74103-06-3

Ketorolac

tert-butyl alcohol
75-65-0

tert-butyl alcohol

ketorolac tert-butyl ester

ketorolac tert-butyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;79%
Ketorolac
74103-06-3

Ketorolac

isopropyl alcohol
67-63-0

isopropyl alcohol

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
66635-74-3

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester

Conditions
ConditionsYield
With thionyl chloride at 20℃; Cooling with ice;76%
With thionyl chloride76%
1,7-heptandiol
629-30-1

1,7-heptandiol

Ketorolac
74103-06-3

Ketorolac

diketorolac heptyl diester
1571587-90-0

diketorolac heptyl diester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;75%
Ketorolac
74103-06-3

Ketorolac

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one

Conditions
ConditionsYield
With iron(III) chloride; oxygen In N,N-dimethyl-formamide at 110℃; for 12h; Catalytic behavior; Mechanism; Temperature; Solvent; Reagent/catalyst;74%
methanol
67-56-1

methanol

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid methyl ester
80965-09-9

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With thionyl chloride for 14h; Inert atmosphere; Reflux;73%
With sulfuric acid Reflux;
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h;
L-leucine ethyl ester hydrochloride
2743-40-0

L-leucine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C23H28N2O4
1093407-72-7

C23H28N2O4

Conditions
ConditionsYield
Stage #1: L-leucine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
71%
2-(prop-2-yn-1-yl)pent-4-yn-1-yl 3-hydroxybenzoate

2-(prop-2-yn-1-yl)pent-4-yn-1-yl 3-hydroxybenzoate

Ketorolac
74103-06-3

Ketorolac

3-(((2-(prop-2-yn-1-yl)pent-4-yn-1-yl)oxy)carbonyl)phenyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate

3-(((2-(prop-2-yn-1-yl)pent-4-yn-1-yl)oxy)carbonyl)phenyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 17h;71%
L-tryptophan ethyl ester hydrochloride
2899-28-7, 6519-67-1, 61535-49-7, 67557-18-0, 68401-14-9

L-tryptophan ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C28H27N3O4
1093407-69-2

C28H27N3O4

Conditions
ConditionsYield
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: L-tryptophan ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
70%
Ketorolac
74103-06-3

Ketorolac

benzyl alcohol
100-51-6

benzyl alcohol

ketorolac benzyl ester

ketorolac benzyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;69%
Ketorolac
74103-06-3

Ketorolac

diethyl L-aspartate hydrochloride
16115-68-7

diethyl L-aspartate hydrochloride

C23H26N2O6
1093407-74-9

C23H26N2O6

Conditions
ConditionsYield
Stage #1: Ketorolac; diethyl L-aspartate hydrochloride With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
63%
Ketorolac
74103-06-3

Ketorolac

propargyl alcohol
107-19-7

propargyl alcohol

C18H15NO3

C18H15NO3

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h;63%
With dmap In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 20℃; for 5h;63%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h;63%
L-Valine ethyl ester hydrochloride
17609-47-1

L-Valine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C22H26N2O4
1093407-71-6

C22H26N2O4

Conditions
ConditionsYield
Stage #1: L-Valine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
62%
1-deoxy-1-(octylamino)-D-glucitol

1-deoxy-1-(octylamino)-D-glucitol

Ketorolac
74103-06-3

Ketorolac

C15H13NO3*C18H39NO

C15H13NO3*C18H39NO

Conditions
ConditionsYield
In ethanol at 70℃; for 0.5h; Temperature;60%
diethyl-L-glutamate hydrochloride
1118-89-4

diethyl-L-glutamate hydrochloride

Ketorolac
74103-06-3

Ketorolac

C24H28N2O6
1093407-76-1

C24H28N2O6

Conditions
ConditionsYield
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: diethyl-L-glutamate hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
59%
Ketorolac
74103-06-3

Ketorolac

silver nitrate

silver nitrate

C15H12AgNO3

C15H12AgNO3

Conditions
ConditionsYield
With ammonia In ethanol; water at 20℃; for 0.25h; pH=8; Darkness;58%
3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate

3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-N-(3-(4-sulfamoylphenoxy)propyl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide

5-benzoyl-N-(3-(4-sulfamoylphenoxy)propyl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide

Conditions
ConditionsYield
Stage #1: Ketorolac With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl acetamide at 20℃; for 0.166667h;
Stage #2: 3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃;
58%
Ketorolac
74103-06-3

Ketorolac

[1-{[methyl{(R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}-amino]methyl}-2,3-dihydro-1H-pyrrolizin-5-yl](phenyl)methanone
1331729-86-2

[1-{[methyl{(R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}-amino]methyl}-2,3-dihydro-1H-pyrrolizin-5-yl](phenyl)methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 18h;56%
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