As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:74103-06-3
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiryUnique advantages of Ketorolac Cas 74103-06-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow solid Storage:cool dry place Package:1kg/foil bag;25kg/drum Application
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:74103-06-3
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:74103-06-3
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
Cas:74103-06-3
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:74103-06-3
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:74103-06-3
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:74103-06-3
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inquiryKetorolac CAS:74103-06-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:74103-06-3
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Appearance:white crystalline or white powder Storage:R.T Package:25kg/drum Application:Ketorlac is an NSAIDs with strong analgesic and anti-inflammatory effects, which is suitable for the short-term treatment of more severe acute pain, usually for p
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci
Cas:74103-06-3
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:74103-06-3
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Superior quality, moderate price & quick delivery. Appearance:white crystalline or white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Applicatio
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Name: Ketorolac Synonyms: 3-dihydro-5-benzoyl-(+-)-1h-pyrrolizine-1-carboxylicaci;rs37619;5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid;KETOROLAC;KETOROLAC-D5;KETOROLAC TROMETHAMINE, USP STANDARD;5-(phenylcarbonyl)-2,3-dihyd
Cas:74103-06-3
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:74103-06-3
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Ketorolac Basic information Product Name: Ketorolac Synonyms: Ketorolac Solution, 100ppm;Ketorolac, >=98%;(1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]ammonium;5-benzoyl-2,3-dihydr
Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
Ketorolac
Conditions | Yield |
---|---|
With sodium hydroxide In methanol Ambient temperature; | 99% |
Ketorolac
Conditions | Yield |
---|---|
With hydrogenchloride In water | 98% |
With hydrogenchloride In water at 0 - 20℃; | 83.6% |
With hydrogenchloride In water |
diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
Ketorolac
Conditions | Yield |
---|---|
Stage #1: diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate With sodium hydroxide In diethyl ether; water for 24h; Reflux; Stage #2: With hydrogenchloride In ethyl acetate at 70℃; for 4h; | 80% |
With sodium hydroxide In tetrahydrofuran for 9h; Time; Reflux; Green chemistry; | 47.5% |
With hydrogenchloride; sodium hydroxide 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h; Yield given. Multistep reaction; |
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
Ketorolac
Conditions | Yield |
---|---|
With potassium carbonate In methanol; water for 0.5h; Heating; | 64% |
With water In methanol; aq. phosphate buffer at 37℃; pH=8; Kinetics; pH-value; |
5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
Ketorolac
Conditions | Yield |
---|---|
With hydrogen; magnesium oxide; palladium on activated charcoal In methanol; water under 760 Torr; for 2h; Ambient temperature; Yield given; |
2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester
Ketorolac
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
ketorolac acid ethyl ester
Ketorolac
Conditions | Yield |
---|---|
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures; |
Ketorolac
Conditions | Yield |
---|---|
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures; |
phenyl chloroformate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
(1H-pyrrol-2-yl)acetic acid isopropyl ester
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h 2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 4: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 40 h 2: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h 3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 4: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
Methyl isopropyl 2-pyrrolylmalonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
Isopropyl (5-benzoylpyrrol-2-yl)acetate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 2: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h 2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating View Scheme |
N,N-dimethylbenzamide
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h 2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h 3: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C 4: 95 percent / HCl / 0.5 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h 2: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C 3: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h 4: 95 percent / HCl / 0.5 h / Heating View Scheme |
phenyl(1H-pyrrol-2-yl)methanone
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 75 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C 2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C 3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 4 steps 1: 57 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C 2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C 3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 3 steps 1: 86 percent / triethylborane, O2 / hexane; benzene / 3 h / Ambient temperature 2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 83 percent / NaOC2H5 / dimethylformamide / 2 h / Ambient temperature 2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 2 steps 1: 80 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(2-chloroethyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 80 percent / NaI / acetonitrile / 24 h / Heating 2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 3: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t. 4: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 5: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 4 steps 1: 80 percent / NaI / acetonitrile / 24 h / Heating 2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 3: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(2-iodoethyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 2: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t. 3: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 3 steps 1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 2: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
diethyl 2-(5-benzoyl-1H-pyrrol-2-yl)malonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t. 2: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 2 steps 1: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C 2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
phenyl(1H-pyrrol-2-yl)methanone
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 77 percent / bromine / CH2Cl2 / 0 deg C to RT, 2.5 h 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h 3: HCl / 5 h / 0 deg C to RT 5: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature View Scheme |
2,3-dibromo-5-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h 2: HCl / 5 h / 0 deg C to RT 4: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature View Scheme |
2-(methylthio)-5-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h 2: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C 3: 95 percent / HCl / 0.5 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C 2: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h 3: 95 percent / HCl / 0.5 h / Heating View Scheme |
2-(methylsulfonyl)-5-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h 2: 95 percent / HCl / 0.5 h / Heating View Scheme |
5-[2-(2-Benzoyl-5-methylsulfanyl-pyrrol-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C 2: 95 percent / HCl / 0.5 h / Heating View Scheme |
Conditions | Yield |
---|---|
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 95% |
Conditions | Yield |
---|---|
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 94% |
Ketorolac
butan-1-ol
5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid butyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 3h; Heating; | 89% |
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h; |
Conditions | Yield |
---|---|
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Stage #2: (L)-phenylalanine ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃; | 88% |
Conditions | Yield |
---|---|
Stage #1: (S)-alanine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 83% |
chloromethyl n-butyrate
Ketorolac
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetone at 20℃; | 83% |
With potassium carbonate; potassium iodide In acetone at 20℃; |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 82% |
1-bromoethyl acetate
Ketorolac
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; | 80% |
With potassium carbonate In acetone at 20℃; | 76% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 79% |
Ketorolac
isopropyl alcohol
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; Cooling with ice; | 76% |
With thionyl chloride | 76% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 75% |
Ketorolac
Conditions | Yield |
---|---|
With iron(III) chloride; oxygen In N,N-dimethyl-formamide at 110℃; for 12h; Catalytic behavior; Mechanism; Temperature; Solvent; Reagent/catalyst; | 74% |
methanol
Ketorolac
5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With thionyl chloride for 14h; Inert atmosphere; Reflux; | 73% |
With sulfuric acid Reflux; | |
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h; |
Conditions | Yield |
---|---|
Stage #1: L-leucine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 71% |
Ketorolac
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 17h; | 71% |
L-tryptophan ethyl ester hydrochloride
Ketorolac
C28H27N3O4
Conditions | Yield |
---|---|
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Stage #2: L-tryptophan ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃; | 70% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 69% |
Conditions | Yield |
---|---|
Stage #1: Ketorolac; diethyl L-aspartate hydrochloride With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 63% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h; | 63% |
With dmap In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 20℃; for 5h; | 63% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h; | 63% |
Conditions | Yield |
---|---|
Stage #1: L-Valine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 62% |
Conditions | Yield |
---|---|
In ethanol at 70℃; for 0.5h; Temperature; | 60% |
Conditions | Yield |
---|---|
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Stage #2: diethyl-L-glutamate hydrochloride With triethylamine In dichloromethane at 0 - 20℃; | 59% |
Conditions | Yield |
---|---|
With ammonia In ethanol; water at 20℃; for 0.25h; pH=8; Darkness; | 58% |
Ketorolac
Conditions | Yield |
---|---|
Stage #1: Ketorolac With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl acetamide at 20℃; for 0.166667h; Stage #2: 3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃; | 58% |
Ketorolac
(R)-fluoxetine
[1-{[methyl{(R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}-amino]methyl}-2,3-dihydro-1H-pyrrolizin-5-yl](phenyl)methanone
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 18h; | 56% |
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