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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Amino-5-Chloro-2'-Fluoro Benzophenone supplier in China

Cas:784-38-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-Amino-5-chloro-2'-fluorobenzophenone-

Cas:784-38-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 784-38-3 with best quality

Cas:784-38-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name:2-Amino-5-chloro-2'-fluorobenzophenone CAS No.: 784-38-3 Quality standard:99%MIN Properties:mp95-97℃; Yellow powdery crystal Structural formula: Appearance:Yellow powdery crystal Storage:Store in cool and dry place, away from s

2-Amino-5-chloro-2'-fluorobenzophenone CAS:784-38-3

Cas:784-38-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:25 Kilogram

FOB Price: $63.0 / 65.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methanone,(2-amino-5-chlorophenyl)(2-fluorophenyl)- 784-38-3

Cas:784-38-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Methanone,(2-amino-5-chlorophenyl)(2-fluorophenyl)-/ LIDE PHARMA- Factory supply / Best price

Cas:784-38-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Amino-5-chloro-2'-fluorobenzophenone CAS:784-38-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

2-Amino-5-chloro-2'-fluorobenzophenone CAS:784-38-3

Cas:784-38-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:784-38-3

Cas:784-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Amino-5-Chloro-2'-Fluoro Benzophenone

Cas:784-38-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

784-38-3 2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(2-AMINO-5-CHLOROPHENYL)(2-FLUOROPHENYL)METHANONE

Cas:784-38-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-Amino-5-chloro-2’-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Amino-5-Chloro-2'-Fluoro Benzophenone

Cas:784-38-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

2-Amino-5-chloro-2'-fluorobenzophenoneAppearance:White powder Storage:In Shade Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or a

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

784-38-3 2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Amino-5-Chloro-2'-fluorobenzophenone CAS No.:784-38-3 Molecule Formula:C13H9ClFNO Molecule Weight:249.67 Purity: 99.0% Package: 25kg/drum Description:Yellow crystalline powder Manufacture Standards:Enterprise Stand

High Quality 2-Amino-5-Chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Amino-5-chloro-2'-fluorobenzophenone Basic information Product Name: 2-Amino-5-chloro-2'-fluorobenzophenone Synonyms: 2-Amino-5-Chloro-2''-Fluorobenzophenone(CFAB);2-Amino-2'-fluoro-5-chloro-diphenylmethanone;TIMTEC-BB SB

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

784-38-3 2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Amino-5-chloro-2'-fluorobenzophenone

Cas:784-38-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Synthetic route

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique;64%
With [2,2]bipyridinyl; methanesulfonic acid; palladium(II) trifluoroacetate In tetrahydrofuran; water at 80℃; for 36h;
2-amino-5-chloro-α-(2-fluorophenyl)benzenemethanol
74173-87-8

2-amino-5-chloro-α-(2-fluorophenyl)benzenemethanol

(2-amino-5-chlorophenyl)(2-fluorophenyl)methanol

(2-amino-5-chlorophenyl)(2-fluorophenyl)methanol

B

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 80℃; for 18h; optical yield given as %ee;A n/a
B 59%
flurazepam
17617-23-1

flurazepam

A

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

B

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one
2886-65-9

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one

Conditions
ConditionsYield
With hydrogenchloride multistep reaction: biotransformation, acid hydrolysis;
4-chloro-aniline
106-47-8

4-chloro-aniline

2-Fluorobenzoyl chloride
393-52-2

2-Fluorobenzoyl chloride

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
With zinc(II) chloride at 200 - 230℃; for 3h;
Stage #1: 4-chloro-aniline; 2-Fluorobenzoyl chloride With zinc(II) chloride at 180 - 230℃; Friedel Crafts acylation;
Stage #2: With sulfuric acid; acetic acid In water for 0.666667h; Reflux;
tert-butyl 4-chloro-2-(2-fluorobenzoyl)phenylcarbamate

tert-butyl 4-chloro-2-(2-fluorobenzoyl)phenylcarbamate

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water Reflux;
Stage #1: tert-butyl 4-chloro-2-(2-fluorobenzoyl)phenylcarbamate With hydrogenchloride; water In ethanol Reflux;
Stage #2: With sodium hydrogencarbonate In ethanol; water pH=8;
N-(t-butoxycarbonyl)-4-chloroaniline
18437-66-6

N-(t-butoxycarbonyl)-4-chloroaniline

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 1.25 h / -40 °C / Inert atmosphere
2.1: hydrogenchloride; water / ethanol / Reflux
2.2: pH 8
View Scheme
4-chloro-aniline
106-47-8

4-chloro-aniline

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / toluene / 20 °C
2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1.25 h / -40 °C / Inert atmosphere
3.1: hydrogenchloride; water / ethanol / Reflux
3.2: pH 8
View Scheme
o-fluorobromobenzene
1072-85-1

o-fluorobromobenzene

N-methyl-N-methyloxy-2-amino-5-chlorobenzamide
150879-48-4

N-methyl-N-methyloxy-2-amino-5-chlorobenzamide

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
5-Chloroisatoic anhydride
4743-17-3

5-Chloroisatoic anhydride

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / ethanol; water / 0.17 h / 25 °C
1.2: 1.5 h / Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
View Scheme
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

acetylacetone
123-54-6

acetylacetone

1-(6-chloro-4-(2-fluorophenyl)-2-methylquinolin-3-yl)ethan-1-one
57262-00-7

1-(6-chloro-4-(2-fluorophenyl)-2-methylquinolin-3-yl)ethan-1-one

Conditions
ConditionsYield
With magnesium(II) chloride hexahydrate In ethanol at 80℃; for 12h; Reagent/catalyst; Friedlaender Quinoline Synthesis; Schlenk technique;99%
With 1,3-dimethylimidazolium sulfate monomethyl ester; L-proline at 90℃; for 0.5h; Knoevenagel Condensation; Green chemistry;96%
With L-proline In neat (no solvent) for 0.15h; Knoevenagel Condensation; Microwave irradiation; Green chemistry;95%
phenylacetylene
536-74-3

phenylacetylene

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

2-phenyl-4-(2'-fluorophenyl)-6-chloroquinoline

2-phenyl-4-(2'-fluorophenyl)-6-chloroquinoline

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate; 1-hexyl-3-methylimidazolium hexafluorophosphate at 80 - 90℃; for 2.5h; Meyer-Schuster rearrangement; Heating;98%
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 0.583333h;95%
With indium(III) triflate at 110℃; for 0.0583333h; microwave irradiation;92%
With potassium dodeca tungstocobaltate trihydrate; hex-1-yne at 110℃; for 0.166667h; Microwave irradiation; neat (no solvent);90%
Multi-step reaction with 2 steps
1: potassium tert-butylate / neat (no solvent) / 2 h / 20 °C / Inert atmosphere
2: calcium(II) trifluoromethanesulfonate; tert-butylammonium hexafluorophosphate(V) / neat (no solvent) / 2.5 h / 70 °C
View Scheme
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

2-azido-5-chloro-2'-fluorobenzophenone
53878-94-7

2-azido-5-chloro-2'-fluorobenzophenone

Conditions
ConditionsYield
Stage #1: 2-amino-5-chloro-2'-fluorobenzophenone With acetic acid; sodium nitrite In water at 0℃; for 1h; Inert atmosphere;
Stage #2: With sodium azide In water at 0 - 20℃; Inert atmosphere;
98%
dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

dimethyl 6-chloro-4-(2-fluorophenyl)quinoline-2,3-dicarboxylate

dimethyl 6-chloro-4-(2-fluorophenyl)quinoline-2,3-dicarboxylate

Conditions
ConditionsYield
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 0.333333h;98%
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 110℃; for 3h; Green chemistry; regioselective reaction;85%
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

4-n-methylphenylacetylene
766-97-2

4-n-methylphenylacetylene

6-chloro-4-(2-fluorophenyl)-2-(p-tolyl)quinoline
1171312-04-1

6-chloro-4-(2-fluorophenyl)-2-(p-tolyl)quinoline

Conditions
ConditionsYield
With potassium dodeca tungstocobaltate trihydrate at 110℃; for 0.0833333h; Microwave irradiation; neat (no solvent);96%
Multi-step reaction with 2 steps
1: potassium tert-butylate / neat (no solvent) / 2 h / 20 °C / Inert atmosphere
2: calcium(II) trifluoromethanesulfonate; tert-butylammonium hexafluorophosphate(V) / neat (no solvent) / 4.5 h / 70 °C
View Scheme
N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

C23H22ClFN2O2
1347747-95-8

C23H22ClFN2O2

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; N,N-dimethyl-formamide at 90℃; Friedlaender reaction; Microwave irradiation;95%
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

2-amino-5-chloro-α-(2-fluorophenyl)benzenemethanol
74173-87-8

2-amino-5-chloro-α-(2-fluorophenyl)benzenemethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol for 1h; Heating;94%
With sodium tetrahydroborate In methanol at 0℃;88%
With sodium borohydrid In methanol; water; Petroleum ether
With sodium tetrahydroborate
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

6-chloro-4-(2’-fluorophenyl)quinazoline
55075-93-9

6-chloro-4-(2’-fluorophenyl)quinazoline

Conditions
ConditionsYield
With ammonium acetate In neat (no solvent) at 110℃; for 2h; Green chemistry;93%
cyclohexane-1,2-dione
765-87-7

cyclohexane-1,2-dione

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

7-chloro-9-(2'-fluorophenyl)-2,3-dihydro-1H-acridin-4-one

7-chloro-9-(2'-fluorophenyl)-2,3-dihydro-1H-acridin-4-one

Conditions
ConditionsYield
With indium(III) chloride; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 2h;92%
With sulfuric acid; silica gel In methanol for 2.5h; Friedlaender Quinoline Synthesis; Reflux;90%
With eaton’s reagent In neat (no solvent) at 90℃; for 3h;82%
dimethylglyoxal
431-03-8

dimethylglyoxal

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

2-acetyl-6-chloro-4-(2'-fluorophenyl)-quinoline

2-acetyl-6-chloro-4-(2'-fluorophenyl)-quinoline

Conditions
ConditionsYield
With indium(III) triflate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 2h; Friedlaender Quinoline Synthesis; Ionic liquid;92%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

2‑(2‑bromoacetamido)‑5‑chloro‑2'‑fluorobenzophenone
1584-62-9

2‑(2‑bromoacetamido)‑5‑chloro‑2'‑fluorobenzophenone

Conditions
ConditionsYield
In dichloromethane at 0℃; for 4h;90%
In diethyl ether at 10℃; for 2h;
With water In dichloromethane at 20℃;
In acetonitrile chemoselective reaction;
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

4-chlorocarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester
308243-40-5

4-chlorocarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester

4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester
308243-58-5

4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester

Conditions
ConditionsYield
In diethyl ether; chloroform for 0.5h; Heating / reflux;90%
In chloroform Heating;
1-ethynyl-3-methoxybenzene
768-70-7

1-ethynyl-3-methoxybenzene

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

6-chloro-4-(2-fluorophenyl)-2-(3-methoxyphenyl)-quinoline
1093164-46-5

6-chloro-4-(2-fluorophenyl)-2-(3-methoxyphenyl)-quinoline

Conditions
ConditionsYield
With potassium dodeca tungstocobaltate trihydrate at 110℃; for 0.166667h; Microwave irradiation; neat (no solvent);90%
sodium acetate
127-09-3

sodium acetate

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide
57698-59-6

N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide

Conditions
ConditionsYield
With acetic anhydride at 80℃; for 1h;90%
1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

C19H13ClFNO

C19H13ClFNO

Conditions
ConditionsYield
With sulfuric acid; silica gel In methanol for 2.5h; Friedlaender Quinoline Synthesis; Reflux;90%
With hydrogenchloride In water at 20℃; for 5h; Friedlaender Quinoline Synthesis;82%
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

(Z)-2-amino-5-chloro-4-((4-chloro-2-(2-fluoro benzoyl)phenyl)imino)-3-(2-fluorobenzoyl)cyclohexa-2,5-dien-1-one

(Z)-2-amino-5-chloro-4-((4-chloro-2-(2-fluoro benzoyl)phenyl)imino)-3-(2-fluorobenzoyl)cyclohexa-2,5-dien-1-one

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 27 - 30℃; for 0.583333h; chemoselective reaction;87%
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

4-methoxyphenylacetylen
768-60-5

4-methoxyphenylacetylen

6-chloro-4-(2-fluorophenyl)-2-(4-methoxyphenyl)quinoline
1093164-45-4

6-chloro-4-(2-fluorophenyl)-2-(4-methoxyphenyl)quinoline

Conditions
ConditionsYield
With potassium dodeca tungstocobaltate trihydrate at 110℃; for 0.25h; Microwave irradiation; neat (no solvent);86%
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

(R)-2-methylpropane-2-sulfinamide
196929-78-9

(R)-2-methylpropane-2-sulfinamide

C17H18ClFN2OS

C17H18ClFN2OS

Conditions
ConditionsYield
With titanium(IV) isopropylate In tetrahydrofuran at 122℃; for 0.666667h; Microwave irradiation;86%
With titanium(IV) isopropylate In tetrahydrofuran for 2h; Reagent/catalyst; Solvent; Microwave irradiation;85%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

6-chloro-4-(2-fluorophenyl)-2-methylquinazoline

6-chloro-4-(2-fluorophenyl)-2-methylquinazoline

Conditions
ConditionsYield
With ammonium acetate In neat (no solvent) at 110℃; for 2h; Green chemistry;86%
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

4-chloro-2-(1-(2-fluorophenyl)vinyl)aniline
488828-89-3

4-chloro-2-(1-(2-fluorophenyl)vinyl)aniline

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: 2-amino-5-chloro-2'-fluorobenzophenone In tetrahydrofuran at 0 - 20℃; Schlenk technique; Inert atmosphere;
85%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.666667h; Schlenk technique; Inert atmosphere;
Stage #2: 2-amino-5-chloro-2'-fluorobenzophenone In tetrahydrofuran at 0 - 20℃; Schlenk technique; Inert atmosphere;
85%
Stage #1: Methyltriphenylphosphonium bromide With potassium 2-methylbutan-2-olate In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: 2-amino-5-chloro-2'-fluorobenzophenone In tetrahydrofuran at 20℃; Further stages.;
80%
cyclohexanone
108-94-1

cyclohexanone

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

7-chloro-9-(2-fluoro-phenyl)-1,2,3,4-tetrahydro-acridine

7-chloro-9-(2-fluoro-phenyl)-1,2,3,4-tetrahydro-acridine

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate In ethanol at 20℃; for 5.5h;85%
With hydrogenchloride In water at 20℃; for 6h; Friedlaender Quinoline Synthesis;84%
phenylpropynoic acid ethyl ester
2216-94-6

phenylpropynoic acid ethyl ester

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

ethyl 6-chloro-4-(2-fluorophenyl)-2-phenylquinoline-3-carboxylate
1350934-76-7

ethyl 6-chloro-4-(2-fluorophenyl)-2-phenylquinoline-3-carboxylate

Conditions
ConditionsYield
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 110℃; for 4.5h; Green chemistry; regioselective reaction;85%
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 100℃; for 2h; Inert atmosphere;80%
N,N-bis(4-chlorophenacyl)-4-chloroaniline
1426307-47-2

N,N-bis(4-chlorophenacyl)-4-chloroaniline

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

A

[5-chloro-3-(2-fluorophenyl)-1H-2-indolyl](4-chlorophenyl)methanone
1426307-56-3

[5-chloro-3-(2-fluorophenyl)-1H-2-indolyl](4-chlorophenyl)methanone

B

4-chloro-aniline
106-47-8

4-chloro-aniline

Conditions
ConditionsYield
With camphor-10-sulfonic acid In ethanol for 1.6h; Reflux;A 84%
B n/a
2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

orthobenzoic acid trimethyl ester
707-07-3

orthobenzoic acid trimethyl ester

6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline
1283751-57-4

6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline

Conditions
ConditionsYield
With ammonium acetate In neat (no solvent) at 110℃; for 2.5h; Green chemistry;84%
N,N-diphenacylaniline
41120-12-1

N,N-diphenacylaniline

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

A

[5-chloro-3-(2-fluorophenyl)-1H-2-indolyl](phenyl)methanone
1426307-55-2

[5-chloro-3-(2-fluorophenyl)-1H-2-indolyl](phenyl)methanone

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
With camphor-10-sulfonic acid In ethanol for 2h; Reflux;A 82%
B n/a
ethyl acetoacetate
141-97-9

ethyl acetoacetate

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

ethyl 6-chloro-4-(2-fluorophenyl)-2-methyl-3-quinolinecarboxylate

ethyl 6-chloro-4-(2-fluorophenyl)-2-methyl-3-quinolinecarboxylate

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 16h; Friedlaender Quinoline Synthesis;81%
With bismuth(lll) trifluoromethanesulfonate In ethanol at 20℃; for 6h;72%
N,N-bis(4-chlorinephenacyl)aniline
932022-91-8

N,N-bis(4-chlorinephenacyl)aniline

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

A

[5-chloro-3-(2-fluorophenyl)-1H-2-indolyl](4-chlorophenyl)methanone
1426307-56-3

[5-chloro-3-(2-fluorophenyl)-1H-2-indolyl](4-chlorophenyl)methanone

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
With camphor-10-sulfonic acid In ethanol for 2.1h; Reflux;A 81%
B n/a
2,3-Pentanedione
600-14-6

2,3-Pentanedione

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

6-chloro-4-(2'-fluorophenyl)-2-propanoylquinoline

6-chloro-4-(2'-fluorophenyl)-2-propanoylquinoline

Conditions
ConditionsYield
With indium(III) triflate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 2h; Friedlaender Quinoline Synthesis; Ionic liquid;81%
tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

2-amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-amino-5-chloro-2'-fluorobenzophenone

6-chloro-4-(2’-fluorophenyl)quinazoline
55075-93-9

6-chloro-4-(2’-fluorophenyl)quinazoline

Conditions
ConditionsYield
With ammonium acetate; caesium carbonate In water; acetonitrile at 80℃; for 12h;81%

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