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Zhejiang Haizhou Pharmaceutical Co., Ltd.

Quality Standard: USP 41, EP 9.4 Certification: US-FDA, CEP, GMP Guaifenesin is used to try to help with coughing up thick mucous and is sometimes combined with dextromethorphan, an antitussive (cough medicine), such as in Mucinex DM or Robitus

Guaifenesin

Cas:93-14-1

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Guaifenesin Manufacturer/High quality/Best price/In stock

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Purity99% Guaifenesin CAS no 93-14-1 manufacturer/supplier

Cas:93-14-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White crystalline powder Storage:Refrigerator Package:25kg/dr

USP standard Guaifenesin CAS 93-14-1 with factory price

Cas:93-14-1

Min.Order:25 Kilogram

FOB Price: $10.0 / 65.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Guaifenesin

Cas:93-14-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Guaifenesin 93-14-1 ISO Producer

Cas:93-14-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Guaifenesin

Cas:93-14-1

Min.Order:10 Metric Ton

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:guaifenesin CAS NO:93-14-1 Grade:Medical scientific research and export Molecular formula:C10H14O4  Molecular weight:198.21 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data s

guaifenesin /cas:93-14-1/Raw material spot

Cas:93-14-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

Guaifenesin CAS: 93-14-1

Cas:93-14-1

Min.Order:20 Metric Ton

FOB Price: $299.0 / 399.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 93-14-1 with best quality

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Guaifenesin

Cas:93-14-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Guaifenesin Synonyms: 3-(2-Methoxyphenoxy)-1,2-propanediol CAS: 93-14-1 MF: C10H14O4 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package: 25KG/Barrel Application:APIs Transportation:By sea or by air Por

Guaifenesin CAS:93-14-1

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White Solid Storage:R.T Package:25kg/drum Application:3-(2-Methoxyphenoxy)-1,2-propanediol is an expectorant and antitussive drug, suitable for expectorant cough, chronic bronchitis, bronchiectasis and other diseases. Transportation:Expre

Factory price high quality 3-(2-Methoxyphenoxy)-1,2-propanediol

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Guaifenesin 93-14-1

Cas:93-14-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Guaifenesin CAS:93-14-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Guaifenesin CAS:93-14-1

Cas:93-14-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

Guaifenesin CAS: 93-14-1 Specification Appearance & Physical State White Solid Density 1.195 g/cm3 Boiling Point 215ºC (19 mmHg) Melting Point 77-81ºC Flash Point 169.6º

Factory supply Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Leader Biochemical Group

PRODUCT DETAILS

China Largest Factory Manufacturer sales Guaifenesin CAS 93-14-1

Cas:93-14-1

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

minimum order qty. 10 gram

Guaifenesin 93-14-1 CAS NO.93-14-1

Cas:93-14-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Guaifenesin

Cas:93-14-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Guaifenesin

Cas:93-14-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Guaifenesin Synonyms: 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane;1,2-Propanediol, 3-(2-methoxyphenoxy)-;1,2-Propanediol, 3-(o-methoxyphenoxy)-;2/G;2-G;3-(2-Methoxyphenosy)-1,2-propamediol;3-(2-methoxyphenoxy)-2-propanediol;3-(o-meth

Guaifenesin 99% Manufactuered in China best quality

Cas:93-14-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Guaifenesin

Cas:93-14-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Guaifenesin CAS 93-14-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,

Guaifenesin CAS 93-14-1

Cas:93-14-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Guaifenesin

Cas:93-14-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

oxiranyl-methanol
556-52-5

oxiranyl-methanol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

A

2-(2-methoxyphenoxy)-1,3-propanediol
14007-09-1

2-(2-methoxyphenoxy)-1,3-propanediol

B

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With calcined hydrotalcite In tetrahydrofuran at 120℃; for 4h; Kinetics; Reagent/catalyst; Temperature; Autoclave;A 5%
B 95%
oxiranyl-methanol
556-52-5

oxiranyl-methanol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 65 - 70℃; for 12h;90%
With sodium hydroxide at 90 - 95℃;56%
With tetrabutylammomium bromide; potassium carbonate; palladium dichloride In water at 60℃; for 5h;55%
Stage #1: 2-methoxy-phenol With potassium hydroxide at 64.84℃; Inert atmosphere;
Stage #2: oxiranyl-methanol With hydrogenchloride Inert atmosphere;
2-(2-methoxy-phenoxymethyl)-oxirane
2210-74-4

2-(2-methoxy-phenoxymethyl)-oxirane

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With perchloric acid81%
With perchloric acid In water at 80℃;80%
With sulfuric acid; water at 70℃; for 2h;59.1%
2-methoxy-phenol
90-05-1

2-methoxy-phenol

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 210℃; for 0.25h; Microwave irradiation;75%
Stage #1: 2-methoxy-phenol With sodium hydroxide In ethanol; water for 0.5h; Heating;
Stage #2: 3-monochloro-1,2-propanediol In ethanol; water for 8h; Heating;
61%
With sodium hydroxide
3-Amino-1,2-propanediol
616-30-8, 13552-31-3

3-Amino-1,2-propanediol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
Stage #1: 2-methoxy-phenol With potassium chloride; sodium sulfite at 50℃; for 3h; Reflux;
Stage #2: 3-Amino-1,2-propanediol at 90℃; for 5h; Temperature; Concentration;
72%
4-hydroxymethyl-1,3-dioxolan-2-one
931-40-8

4-hydroxymethyl-1,3-dioxolan-2-one

2-methoxy-phenol
90-05-1

2-methoxy-phenol

A

1,3-bis(2-methoxyphenoxy)propan-2-ol
16929-60-5

1,3-bis(2-methoxyphenoxy)propan-2-ol

B

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 160℃; for 9.5h; Inert atmosphere; Schlenk technique;A 9%
B 64%
sodium 2-methoxyphenolate
13052-77-2

sodium 2-methoxyphenolate

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With ethanol
methocarbamol
532-03-6

methocarbamol

A

3-(2-methoxyphenoxy)propanediol 2-carbamate
10488-39-8

3-(2-methoxyphenoxy)propanediol 2-carbamate

B

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With water at 70℃; Product distribution; Rate constant; further temperatures, pH 8.0-10.0;
methyl bromide
74-83-9

methyl bromide

3-(2-hydroxy-phenoxy)-propane-1,2-diol
19826-87-0

3-(2-hydroxy-phenoxy)-propane-1,2-diol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With potassium carbonate In acetone
2-methoxy-phenol
90-05-1

2-methoxy-phenol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 43 percent / NaOH / 16 h / 80 °C
2: 81 percent / perchloric acid
View Scheme
Multi-step reaction with 2 steps
1: 2.) 50percent aq. NaOH / 1.) 80 deg C, 2.) 4 h
2: 80 percent / 72percent HClO4 / H2O / 80 °C
View Scheme
benzene-1,2-diol
120-80-9

benzene-1,2-diol

1,2-bis<2-(-p-toluenesulfonyloxy)ethoxy>amine

1,2-bis<2-(-p-toluenesulfonyloxy)ethoxy>amine

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOEt / ethanol
2: K2CO3 / acetone
View Scheme
2-methoxy-phenol
90-05-1

2-methoxy-phenol

epichlorohydrin
106-89-8

epichlorohydrin

A

1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol
25772-81-0

1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol

B

1,3-bis(2-methoxyphenoxy)propan-2-ol
16929-60-5

1,3-bis(2-methoxyphenoxy)propan-2-ol

C

guaifenesin
93-14-1

guaifenesin

D

2-(2-methoxy-phenoxymethyl)-oxirane
2210-74-4

2-(2-methoxy-phenoxymethyl)-oxirane

Conditions
ConditionsYield
With sodium hydroxide In toluene at 25 - 30℃; Solvent; Concentration;
2-methoxy-phenol
90-05-1

2-methoxy-phenol

glycerol
56-81-5

glycerol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With potassium carbonate; Diethyl carbonate at 105 - 110℃; for 8h;78 %Spectr.
methocarbamol
532-03-6

methocarbamol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With ethanol In water at 80℃;
C14H16O7

C14H16O7

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C14H18O7

C14H18O7

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C15H20O7

C15H20O7

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C22H26O10

C22H26O10

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C18H18O10

C18H18O10

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C22H30O10

C22H30O10

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
guaifenesin
93-14-1

guaifenesin

tannic acid
5424-20-4

tannic acid

guaifenesin tannate

guaifenesin tannate

Conditions
ConditionsYield
In water at 35 - 50℃; for 1h; Product distribution / selectivity;96.15%
guaifenesin
93-14-1

guaifenesin

2(2-methoxyphenoxy)ethanale
18167-91-4

2(2-methoxyphenoxy)ethanale

Conditions
ConditionsYield
With sodium periodate In water at 10℃; for 1h;95%
chromium(III) chloride hexahydrate

chromium(III) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

[Cr(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]Cl

[Cr(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]Cl

Conditions
ConditionsYield
In ethanol for 3h; Reflux;94%
guaifenesin
93-14-1

guaifenesin

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3-(2-methoxyphenoxy)-1,2-bis(tert-butyldimethylsiloxy)propane

3-(2-methoxyphenoxy)-1,2-bis(tert-butyldimethylsiloxy)propane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;94%
guaifenesin
93-14-1

guaifenesin

acetic anhydride
108-24-7

acetic anhydride

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate
92865-65-1

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate

Conditions
ConditionsYield
With pyridine at 4℃; for 4h;90%
2,2-dimethylsuccinic anhydride
17347-61-4

2,2-dimethylsuccinic anhydride

guaifenesin
93-14-1

guaifenesin

C22H30O10

C22H30O10

Conditions
ConditionsYield
Stage #1: guaifenesin With sodium hydride In tetrahydrofuran; mineral oil for 0.5h;
Stage #2: 2,2-dimethylsuccinic anhydride In tetrahydrofuran; mineral oil at 20℃;
90%
guaifenesin
93-14-1

guaifenesin

butyraldehyde
123-72-8

butyraldehyde

4-(2-methoxy-phenoxymethyl)-2-propyl-[1,3]dioxolane

4-(2-methoxy-phenoxymethyl)-2-propyl-[1,3]dioxolane

Conditions
ConditionsYield
With phosphorus pentoxide; silica gel In acetonitrile at 20℃;88%
carbon monoxide
201230-82-2

carbon monoxide

guaifenesin
93-14-1

guaifenesin

rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one
2049-21-0

rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; oxygen; sodium acetate; potassium iodide In 1,2-dimethoxyethane at 100℃; under 10343.2 Torr; for 3h; Autoclave; Inert atmosphere;86%
guaifenesin
93-14-1

guaifenesin

cyclohexanone
108-94-1

cyclohexanone

2-(2-methoxy-phenoxymethyl)-1,4-dioxa-spiro[4.5]decane

2-(2-methoxy-phenoxymethyl)-1,4-dioxa-spiro[4.5]decane

Conditions
ConditionsYield
With phosphorus pentoxide; silica gel In acetonitrile at 20℃;85%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

glycine
56-40-6

glycine

[Fe(guaifenesin)(2-aminoacetic acid(H-))(Cl)]*3H2O

[Fe(guaifenesin)(2-aminoacetic acid(H-))(Cl)]*3H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;83%
N-methylsulfamoyl chloride
10438-96-7

N-methylsulfamoyl chloride

guaifenesin
93-14-1

guaifenesin

1-[(2-Methoxyphenoxy)methyl]-1,2-ethanediol bis(methylsulfamate) (ester)
136166-31-9

1-[(2-Methoxyphenoxy)methyl]-1,2-ethanediol bis(methylsulfamate) (ester)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 2h; Ambient temperature;82%
guaifenesin
93-14-1

guaifenesin

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose
14215-97-5

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)propane-1,2-diol
664994-56-3

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)propane-1,2-diol

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 4h;82%
manganese(II) chloride dihydrate

manganese(II) chloride dihydrate

guaifenesin
93-14-1

guaifenesin

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]*3H2O

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]*3H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;82%
guaifenesin
93-14-1

guaifenesin

1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose
99395-04-7

1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)propane-1,2-diol
664994-58-5

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)propane-1,2-diol

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 5h;80%
cadmium(II) chloride dihydrate

cadmium(II) chloride dihydrate

guaifenesin
93-14-1

guaifenesin

[Gd(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]

[Gd(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]

Conditions
ConditionsYield
In ethanol for 3h; Reflux;80%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(H2O)3]Cl2

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(H2O)3]Cl2

Conditions
ConditionsYield
In ethanol for 3h; Reflux;80%
guaifenesin
93-14-1

guaifenesin

water
7732-18-5

water

glycine
56-40-6

glycine

platinum(II) chloride

platinum(II) chloride

[Pt(guaifenesin)2(Gly)]Cl*H2O

[Pt(guaifenesin)2(Gly)]Cl*H2O

Conditions
ConditionsYield
In ethanol; N,N-dimethyl-formamide at 70℃; for 1.5h; Reflux;80%
maleic anhydride
108-31-6

maleic anhydride

guaifenesin
93-14-1

guaifenesin

C18H18O10

C18H18O10

Conditions
ConditionsYield
Stage #1: guaifenesin With sodium hydride In tetrahydrofuran; mineral oil for 0.5h;
Stage #2: maleic anhydride In tetrahydrofuran; mineral oil at 20℃;
80%
guaifenesin
93-14-1

guaifenesin

acetic anhydride
108-24-7

acetic anhydride

A

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate
92865-65-1

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate

B

1-O-acetyl-3-(2-methoxyphenoxy)propane-1,2-diol
333381-39-8

1-O-acetyl-3-(2-methoxyphenoxy)propane-1,2-diol

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;A 10%
B 78%
cadmium(II) chloride dihydrate

cadmium(II) chloride dihydrate

guaifenesin
93-14-1

guaifenesin

glycine
56-40-6

glycine

[Cd(guaifenesin)(2-aminoacetic acid(H-))(H2O)]*H2O

[Cd(guaifenesin)(2-aminoacetic acid(H-))(H2O)]*H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;75%
1-benzoylimidazole
10364-94-0

1-benzoylimidazole

guaifenesin
93-14-1

guaifenesin

A

2-hydroxy-3-(2-methoxyphenoxy)propyl benzoate

2-hydroxy-3-(2-methoxyphenoxy)propyl benzoate

B

3-(2-methoxyphenoxy)propane-1,2-diyl dibenzoate

3-(2-methoxyphenoxy)propane-1,2-diyl dibenzoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 8h; regioselective reaction;A 75%
B 15%
guaifenesin
93-14-1

guaifenesin

water
7732-18-5

water

zinc(II) chloride
7646-85-7

zinc(II) chloride

[Zn(glyceryl guaiacolate)(H2O)2]

[Zn(glyceryl guaiacolate)(H2O)2]

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 70℃; pH=8 - 9;74%
guaifenesin
93-14-1

guaifenesin

CVT-4786
13057-65-3

CVT-4786

Conditions
ConditionsYield
Stage #1: guaifenesin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; toluene at 25℃; for 0.0833333h; pH=6.8;
Stage #2: With sodium hypochlorite; sodium chlorite In aq. phosphate buffer; water; toluene at 50℃; for 24h; pH=6.8;
73%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite In water; acetonitrile at 35℃; aq. phosphate buffer; chemoselective reaction;37.4%
guaifenesin
93-14-1

guaifenesin

A

(2-methoxyphenoxy)acetic acid
1878-85-9

(2-methoxyphenoxy)acetic acid

B

CVT-4786
13057-65-3

CVT-4786

Conditions
ConditionsYield
Stage #1: guaifenesin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; toluene at 25℃; pH=6.8;
Stage #2: With sodium hypochlorite; sodium chlorite In aq. phosphate buffer; toluene at 50℃; for 24h; chemoselective reaction;
A 10 %Spectr.
B 73%
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

water
7732-18-5

water

[Ni(glyceryl guaiacolate)(H2O)4]*3H2O

[Ni(glyceryl guaiacolate)(H2O)4]*3H2O

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 70℃; pH=8 - 9;73%
2,3-Dimethylmaleic anhydride
766-39-2

2,3-Dimethylmaleic anhydride

guaifenesin
93-14-1

guaifenesin

C22H26O10

C22H26O10

Conditions
ConditionsYield
Stage #1: guaifenesin With sodium hydride In tetrahydrofuran; mineral oil for 0.5h;
Stage #2: 2,3-Dimethylmaleic anhydride In tetrahydrofuran; mineral oil at 20℃;
73%
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