131860-97-4Relevant articles and documents
Method for improving conversion rate of azoxystrobin
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, (2021/03/31)
The invention discloses a method for improving the conversion rate of azoxystrobin. The method comprises the following steps: preparing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate; preparing o-hydroxybenzonitrile; mixing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate, o-hydroxybenzonitrile, potassium carbonate and ketene chloride according to a molar ratio of 30: 35: 50: 1.1, and dissolving the obtained mixture in dimethylformamide to obtain a mixed product; and heating the prepared mixed product, keeping the mixed product at a certain temperature, conducting filtering, carrying out reduced-pressure distillation, performing cooling, separating out crystals, carrying out filtering and washing and performing drying to obtain azoxystrobin. On the basis of the prior art, the synthesis of azoxystrobin is improved in the invention, so the yield of azoxystrobin is effectively increased, the conversion rate of the raw materials including methyl(E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate and o-hydroxybenzonitrile for azoxystrobin in the process of preparing azoxystrobin is effectively improved, and the production benefit of azoxystrobin is improved.
PROCESS FOR THE PREPARATION OF FUNGICIDALLY ACTIVE STROBILURIN COMPOUNDS AND INTERMEDIATES THEREOF
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Page/Page column 48; 49, (2020/10/28)
The present invention relates to a process for the preparation of strobilurin of compounds of Formula (I) of and its intermediates using 1,5,7-triazabicyclo[4.4.0]dec-5-ene or salts thereof, or derivatives thereof as a catalyst. The present invention provides the compounds of formula (I) in high yield and high purity.
Preparation method of azoxystrobin compound
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Paragraph 0061-0066, (2019/12/02)
The present invention relates to the field of chemical synthesis, and discloses a preparation method of azoxystrobin compounds, which comprises steps that a compound represented by a formula (II) is adopted as a raw material to carry out a reaction, wherein R is halogen, a hydroxyl group or a 2-cyanophenoxy group. According to the method disclosed by the invention, the pure azoxystrobin compound can be simply and conveniently obtained, a complex separation and purification process is avoided, the waste of raw materials is reduced, and the atom utilization rate is improved.