(R)-(-)-1-METHOXY-2-PROPANOL supplier

Name
(R)-(-)-1-METHOXY-2-PROPANOL
EINECS 628-460-3
CAS No. 4984-22-9
Article Data14
CAS DataBase
Density 0.912 g/cm³
Solubility
Melting Point -97 °C
Formula C₄H₁₀O₂
Boiling Point 118.5 °C at 760 mmHg
Molecular Weight 90.1222
Flash Point 33.9 °C
Transport Information UN 3092 3/PG 3
Appearance Colorless to light yellow liquid
Safety 24-43-7/8
Risk Codes 10-15
Molecular Structure
Hazard Symbols F, Xn
Synonyms 2-Propanol,1-methoxy-, (R)-;2-Propanol, 1-methoxy-, D-(-)- (8CI);(-)-1-Methoxy-2-propanol;(R)-(-)-1-Methoxy-2-propanol;
PSA 29.46000
LogP 0.01360

Synthetic route

: 124-41-4
sodium methylate

: 15448-47-2
(R)-propylene oxide

: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
In methanol for 13.5h; Reflux;	86.51%

: 67-56-1
methanol

: 15448-47-2
(R)-propylene oxide

: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With sodium hydroxide at 35 - 65℃; for 16h;	86.51%

: 67-56-1
methanol

: 15448-47-2
(R)-propylene oxide

A: 4984-22-9
(R)-1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With sodium hydroxide for 5h; Reflux;	A 79% B n/a

...Expand

: 67-56-1
methanol

: 16088-62-3
(S)-Propylene oxide

A: 4984-22-9
(R)-1-methoxy-2-propanol

B: 6131-59-5
(2R)-2-methoxypropan-1-ol

C: 19141-39-0
(R)-(-)-1-chloro-2-propanol

Conditions

Conditions	Yield
With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 25℃;	A 52% B 42% C 6%

...Expand

: 113429-86-0
(R)-1-bromo-2-propanol

: 124-41-4
sodium methylate

: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With methanol

: 4,6-Dimethyl-2,5,7-trioxanonane

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 67-56-1
methanol

: 15448-47-2
(R)-propylene oxide

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

C: 116422-39-0
(S)-(+)-2-methoxypropanol

D: 6131-59-5
(2R)-2-methoxypropan-1-ol

E: 76946-23-1
(S)-(+)-1,2-dimethoxypropane

F: 76946-22-0
(R)-(-)-1,2-dimethoxypropane

Conditions

Conditions	Yield
With Methyl fluoride at 25℃; under 720 Torr; Product distribution; Mechanism; Irradiation; also in the presence of H2O or CH4;

...Expand

: 67-56-1
methanol

: 16088-62-3
(S)-Propylene oxide

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

C: 116422-39-0
(S)-(+)-2-methoxypropanol

D: 6131-59-5
(2R)-2-methoxypropan-1-ol

E: 76946-23-1
(S)-(+)-1,2-dimethoxypropane

F: 76946-22-0
(R)-(-)-1,2-dimethoxypropane

Conditions

Conditions	Yield
With Methyl fluoride at 25℃; under 720 Torr; Product distribution; Mechanism; Irradiation; also in the presence of H2O or CH4;

...Expand

: 5878-19-3
Methoxyacetone

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With potassium isopropoxide; isopropyl alcohol; dichloro(benzene)ruthenium(II) dimer; (1S,2R)-N-benzylnorephedrine at 20℃; for 0.33h; Title compound not separated from byproducts;
With dichloro(benzene)ruthenium(II) dimer; 2-benzylamino-1-phenyl-propan-1-ol; potassium isopropoxide In isopropyl alcohol at 20℃; for 0.33h; Title compound not separated from byproducts;

: 107-98-2
1-methoxy-2-propanol

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With vinyl acetate; Candida antarctica B lipase on carrier C3 In hexane at 37℃; for 20h; Title compound not separated from byproducts;
With pentyl cage-coated capillary column Resolution of racemate;
With homochiral metal-organic cage [Zn3(deprotonated [3+3] macrocyclic Schiff base of trans-1,2-diaminocyclohexane and 4-tert-butyl-2,6-diformylphenol)2] coated capillary column In dichloromethane at 115℃; Resolution of racemate; enantioselective reaction;

: 107-98-2
1-methoxy-2-propanol

: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With vinyl acetate; Candida antarctica B lipase on carrier B In phosphate buffer at 37℃; for 3.41667h; pH=7.3;

: 108-65-6
propylene glycol methyl ether acetate

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With sodium phosphate buffer; esterase B from Candida antarctica In water at 37℃; for 1h; pH=7.3; Product distribution; Further Variations:; Reagents;

: 5878-19-3
Methoxyacetone

: 67-63-0
isopropyl alcohol

A: 4984-22-9
(R)-1-methoxy-2-propanol

B: 67-64-1
acetone

Conditions

Conditions	Yield
With Lactobacillus brevis dehydrogenase; NADPH; tris hydrochloride In water; dimethyl sulfoxide at 30℃; Kinetics; Enzymatic reaction;

...Expand

: 1001419-94-8
C16H16O5

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1001419-95-9
C20H24O6

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 18h;	100%

: 915949-06-3
methyl 3-(4-cyanophenoxy)-5-hydroxybenzoate

: 4984-22-9
(R)-1-methoxy-2-propanol

: 915949-07-4
methyl 3-(4-cyanophenoxy)-5-[(1S)-2-methoxy-1-methylethoxy]benzoate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 30℃; for 2.5h;	100%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1093966-77-8
2-amino-5-hydroxy-3-(2-pyridin-2-ylethoxy)benzonitrile

: 1093966-84-7
2-amino-5-[(1S)-2-methoxy-1-methylethoxy]-3-(2-pyridin-2-ylethoxy)benzonitrile

Conditions

Conditions	Yield
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 60℃; for 4h;	100%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1576-44-9
N-nosylaniline

: (S)-N-(1-methoxypropan-2-yl)-4-nitro-N-phenylbenzenesulfonamide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 50℃; for 2h; Solvent; Temperature; Mitsunobu Displacement;	99%

: 4984-22-9
(R)-1-methoxy-2-propanol

: N-(2-ethyl-6-methylphenyl)-4-nitrobenzenesulfonamide

: 1-ethyl-2-{(2S)-3-methoxy-2-methyl-1-[(4-nitrophenyl)sulfonyl]propyl}-3-methylbenzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 50℃; for 2h; Mitsunobu Displacement;	99%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 98-59-9
p-toluenesulfonyl chloride

: (R)-1-methoxypropan-2-ol 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With triethylamine hydrochloride; triethylamine In toluene at -5 - 8℃; for 1h; Inert atmosphere;	97%
Stage #1: (R)-1-methoxy-2-propanol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1.5h; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 0 - 20℃;	82%
Stage #1: (R)-1-methoxy-2-propanol With sodium hydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 0 - 32℃;	52%
With pyridine In dichloromethane at 20℃; for 16h;	51%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 1239585-55-7
(1R)-2-methoxy-1-methylethyl 4-(trifluoromethyl)benzenesulfonate

Conditions

Conditions	Yield
With triethylamine hydrochloride; triethylamine In toluene at 5 - 12℃; for 18.83h;	97%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-89-1
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h;	94.5%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran Mitsunobu Displacement;

: 4984-22-9
(R)-1-methoxy-2-propanol

: 134227-45-5
3,4,5-trifluorobenzonitrile

: 864178-51-8
3,5-difluoro-4-(2-methoxy-(1R)-methyl-ethoxy)-benzonitrile

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at -5 - 20℃; for 19h;	94%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 124-63-0
methanesulfonyl chloride

: C5H12O4S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	91.8%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 98-59-9
p-toluenesulfonyl chloride

: C11H16O4S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	91.54%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1352570-95-6
3-hydroxy-5-(4-(methylsulfonyl)phenoxy)benzonitrile

: 3-[(1S)-2-methoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzonitrile

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; Mitsunobu reaction;	90.8%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 610-14-0
2-nitrobenzyl chloride

: 916922-85-5
(1R)-2-methoxy-1-methylethyl 2-nitrobenzoate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 12h;	90%

: 752242-45-8
3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester

: 4984-22-9
(R)-1-methoxy-2-propanol

: 863504-76-1
methyl 3-[(1S)-2-methoxy-1-(methylethyl)oxy]-5-{[4-(methylsulfonyl)phenyl]oxy}benzoate

Conditions

Conditions	Yield
With PS-triphenylphosphine; di-isopropyl azodicarboxylate In tetrahydrofuran at 5 - 20℃;	90%

: 13734-41-3
t-Boc-L-valine

: 4984-22-9
(R)-1-methoxy-2-propanol

: (S)-(R)-1-methoxypropan-2-yl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	90%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 855400-66-7
3-bromo-5-methoxyphenol

: 1177420-51-7
1-Bromo-3-methoxy-5-[(1S)-2-methoxy-1-methylethoxy]benzene

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In toluene at 0 - 20℃; Product distribution / selectivity; Inert atmosphere;	89%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: indomethacin 1‐methoxypropan‐2‐yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere;	88%

: 626-64-2
pyridin-4-ol

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1174044-52-0
(S)-4-(1-methoxypropan-2-yloxy)pyridine

Conditions

Conditions	Yield
Stage #1: pyridin-4-ol; (R)-1-methoxy-2-propanol With triphenylphosphine In tetrahydrofuran for 0.166667h; Stage #2: With di-isopropyl azodicarboxylate In tetrahydrofuran at 25℃; for 1h;	87%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1177420-07-3
3-Bromo-5-[4-(methylsulfonyl)phenoxy]phenol

: 1177420-31-3
1-Bromo-3-[(1S)-2-methoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzene

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In toluene at 0 - 20℃; Inert atmosphere;	86%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 54915-31-0
methyl 3-(benzyloxy)-5-hydroxybenzoate

: 851885-42-2
methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h;	85%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h;	85%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16h;	75%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 15761-38-3
L-N-Boc-Ala

: (R)-1-methoxypropan-2-yl (S)-2-((tert-butoxycarbonyl)amino)propanoic acid

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0 - 20℃; for 72h;	85%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0 - 20℃; for 72h;	85%

: 4984-22-9
(R)-1-methoxy-2-propanol

: methyl 3-(4-(azetidine-1-carbonyl)phenoxy)-5-hydroxybenzoate

: methyl (S)-3-(4--(azetidine-1-carbonyl)phenoxy)-5-((1-methoxypropan-2-yl)oxy)benzoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	83%

: 863504-80-7
methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate

: 4984-22-9
(R)-1-methoxy-2-propanol

: 863504-79-4
methyl (S)-3-(3,5-difluorophenoxy)-5-((1-methoxypropan-2-yl)oxy)benzoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	80%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	75%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 124-63-0
methanesulfonyl chloride

: (R)-1-methoxypropan-2-yl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 16h;	80%
With triethylamine In tetrahydrofuran at 0℃; for 4h;	10.6 g

: 4984-22-9
(R)-1-methoxy-2-propanol

: 2-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-methyl acetate

: [5-bromo-3-((S)-2-methoxy-1-methylethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-methyl acetate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 48h;	78%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1228588-18-8
ethyl-Nα-[4-amino-2-methanesulfonyl-5-nitropyrimidin-6-yl],Nα-[3'-(pyrrolidin-1"-ylmethyl)-benzyl]-glycinate

: 1228588-67-7
C24H34N6O6*ClH

Conditions

Conditions	Yield
With trifluoroacetic acid at 100℃; for 17.5h;	76%

: 4984-22-9
(R)-1-methoxy-2-propanol

: 1177420-08-4
3-[4-(Methylsulfonyl)phenoxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1177420-09-5
2-{3-[(1S)-2-Methoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 20℃; Inert atmosphere;	76%

(R)-(-)-1-METHOXY-2-PROPANOL Chemical Properties

Molecular Formula: C₄H₁₀O₂
Molar mass: 90.12 g/mol
Density: 0.921 g/mL at 20 °C(lit.)
Flash Point: 33 °C
Melting point: -97 °C
storage temp: Flammables area
Boiling Point: 119-121 °C(lit.)
Index of Refraction: n20/D 1.403
Appearance: Colorless to light yellow liqui
Structure of (R)-(-)-1-METHOXY-2-PROPANOL(4984-22-9) :

Synonyms of (R)-(-)-1-METHOXY-2-PROPANOL(4984-22-9) : (R)-(-)-Propylene glycol 1-methyl ether
Product Categories : Chiral Compound

(R)-(-)-1-METHOXY-2-PROPANOL Toxicity Data With Reference

Carcinogenicity of (R)-(-)-1-METHOXY-2-PROPANOL(4984-22-9) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65.And its toxicological properties have not been fully investigated.

(R)-(-)-1-METHOXY-2-PROPANOL Safety Profile

Hazard Note: Irritant Toxic
Hazard Codes: F

,Xn

Risk Statements:
10: Flammable
15: Contact with water liberates extremely flammable gases
Safety Statements:
7: Keep container tightly closed
8: Keep container dry
24: Avoid contact with skin
43: In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add - Never use water)

(R)-(-)-1-METHOXY-2-PROPANOL Specification

(R)-(-)-1-METHOXY-2-PROPANOL(4984-22-9) is hazardous,so the first aid measures and others should be known .Such as:
Skin: Get medical aid. Should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing and shoes.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.
Inhalation: Remove from exposure and move to fresh air immediately. when breathing is difficult, give oxygen.And as soon as to get medical aid.
Ingestion: Wash mouth out with water,and get medical aid immediately.
Notes to Physician: Treat supportively and symptomatically.
Polymerization of the (R)-(-)-1-METHOXY-2-PROPANOL(4984-22-9) can be stable under normal temperature and pressure conditions.It is not compatible with strong oxidizing agents, and you must not take it with ignition sources and incompatible materials.And also prevent it to broken down into hazardous decomposition products: carbon dioxide,carbon monoxide.

Product Name

(R)-(-)-1-METHOXY-2-PROPANOL

Synthetic route

(R)-(-)-1-METHOXY-2-PROPANOL Chemical Properties

(R)-(-)-1-METHOXY-2-PROPANOL Toxicity Data With Reference

(R)-(-)-1-METHOXY-2-PROPANOL Safety Profile

(R)-(-)-1-METHOXY-2-PROPANOL Specification

Related Products

Hot Products