(R)-(-)-3-Chloro-1,2-propanediol supplier

Name
(R)-(-)-3-Chloro-1,2-propanediol
EINECS 435-560-9
CAS No. 57090-45-6
Article Data97
CAS DataBase
Density 1.303 g/cm³
Solubility soluble in water
Melting Point - 40 °C
Formula C₃H₇ClO₂
Boiling Point 213 °C at 760 mmHg
Molecular Weight 110.54
Flash Point 113.3 °C
Transport Information UN 2689 6.1/PG 3
Appearance clear light yellow liquid
Safety 26-28-39-45-36/37/39
Risk Codes 25-41-68-62-36/37/38-23/25-21
Molecular Structure
Hazard Symbols T
Synonyms 1,2-Propanediol,3-chloro-, (R)-;(-)-3-Chloro-1,2-propanediol;(2R)-3-Chloro-1,2-propanediol;(R)-3-Chloro-1,2-propanediol;(R)-a-Chlorohydrin;R-3-chloro-1,2-propanediol;
PSA 40.46000
LogP -0.42160

Synthetic route

: 51594-55-9
(R)-(-)-epichlorohydrin

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With (R)-2-chloropropionic acid In water at 80 - 90℃; for 15h; Reagent/catalyst; Temperature;	95.57%
With (R,R)-Jacobsen catalyst; water In tetrahydrofuran at 4℃; for 24h;	41%
Stage #1: With N,N'-bis(3,5-di-tert-butylsalicylidene)ethylenediaminocobalt(II); camphor-10-sulfonic acid; oxygen In tetrahydrofuran for 1h; Stage #2: (R)-(-)-epichlorohydrin With water In tetrahydrofuran at 20℃; for 20h;	93.7 %Chromat.

: 57044-24-3
(R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With hydrogenchloride	86%

: 82954-65-2
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride; sodium nitrite In water at 10 - 20℃; for 24h; Substitution;	82%

: 95589-30-3
(1S,2R,4R,4'R)-4'-Chloromethyl-4,7,7-trimethylbicyclo<2.2.1>heptane-2-spiro-2'-(1',3'-dioxolan)-3-one

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 95548-92-8, 95589-33-6
C13H21ClO3

C: 95548-92-8, 95589-33-6
C13H21ClO3

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol	A 55% B n/a C n/a

...Expand

: 106-89-8
epichlorohydrin

A: 67843-74-7
(S)-epichlorohydrin

B: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With C72H102Co2F12N4O12P2; water at 0 - 20℃; for 3h; optical yield given as %ee;	A 45% B 53%
With water; (S,S)-(salen)cobalt(III)(OAc) at 0℃; for 19h;	A 46% B 45%
With C114H155Co3N8O14Pol; water; acetic acid at 20℃; for 3h; Resolution of racemate; optical yield given as %ee; enantioselective reaction;	A 46% B n/a

: 106-89-8
epichlorohydrin

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With water In tetrahydrofuran at 4℃; for 24h;	50%
In tetrahydrofuran; water
In tetrahydrofuran; water
With Co(salen) macrocycles 1(OTs) at 20℃; for 0.333333h; optical yield given as %ee; enantioselective reaction;

: 616-23-9
2,3-Dichloro-1-propanol

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

C: (S)-1,3-dichloro-1-propanol

D: 106-89-8
epichlorohydrin

Conditions

Conditions	Yield
With epoxide hydrolase from Agrobacterium radiobacter AD1; halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer In water at 30℃; for 20h; pH=7.5; kinetic resolution; Further byproducts given;	A n/a B n/a C 49.5% D n/a

...Expand

: 106-89-8
epichlorohydrin

A: 67843-74-7
(S)-epichlorohydrin

B: 57090-45-6
(2R)-3-chloro-1,2-propanediol

C: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With water; dimeric chiral (salen)Co complex linked with Al at 20℃; for 5h; Product distribution; Further Variations:; Catalysts;	A 46% B n/a C n/a
With water; Cr(III)-endo,endo-2,5-diaminonorbornane-salen In tetrahydrofuran at 20℃; for 42h;	A 46% B n/a C n/a
With chiral oligo-(salen)Co(OTs) complexes; lutidinium p-toluene sulfonate; water In dichloromethane; acetonitrile at 20℃; for 11h;	A 45% B n/a C n/a

...Expand

: 106-89-8
epichlorohydrin

A: 51594-55-9
(R)-(-)-epichlorohydrin

B: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With water at 20℃; for 8h; optical yield given as %ee;	A 45% B n/a

: 106-89-8
epichlorohydrin

A: 51594-55-9
(R)-(-)-epichlorohydrin

B: 57090-45-6
(2R)-3-chloro-1,2-propanediol

C: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water In tetrahydrofuran at 0 - 20℃;	A 43% B n/a C n/a
With (S,S)-(salen)Co(III)-OTs; water at 0 - 4℃; for 16h;	A 42.3% B n/a C n/a
With poly-salen-Co(III); water In tetrahydrofuran at 10℃; for 12h;
With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water In tetrahydrofuran at 0 - 20℃; Title compound not separated from byproducts;

...Expand

: 106-89-8
epichlorohydrin

A: 67843-74-7
(S)-epichlorohydrin

B: 51594-55-9
(R)-(-)-epichlorohydrin

C: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; (salen)Co(III)-AlCl3; water In tetrahydrofuran at 19.84℃; for 3h; Kinetics; Reagent/catalyst; Solvent; optical yield given as %ee; enantioselective reaction;	A n/a B n/a C 41%
With C8F17COOH; water; (R,R)-Co(III)(salen) In toluene at 20℃; for 15h;	A n/a B n/a C 40%
With chiral oligo-(salen)Co(OTs) complexes; lutidinium p-toluene sulfonate; water In dichloromethane; acetonitrile at 0 - 20℃; for 1.5h;	A n/a B n/a C 40%

...Expand

: 95589-30-3
(1S,2R,4R,4'R)-4'-Chloromethyl-4,7,7-trimethylbicyclo<2.2.1>heptane-2-spiro-2'-(1',3'-dioxolan)-3-one

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With hydrogenchloride; sodium tetrahydroborate 2) MeOH, reflux, 3h; Yield given. Multistep reaction;

: 1-O-β-D-glucosyl-(2R)-3-chloropropylene glycol

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With β-galactosidase In various solvent(s) at 35℃;

: barium D-3-chloropropane-1,2-diol-1-phosphate

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With ethanol Yield given. Yields of byproduct given;

: 96-24-2
3-monochloro-1,2-propanediol

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

C: D-3-chloropropane-1,2-diol-1-phosphate

Conditions

Conditions	Yield
With sodium hydroxide; phospho(enol)pyruvic acid mono potassium salt; ATP; 2-hydroxyethanethiol; magnesium chloride In water at 27℃; for 120h; pH=7.5; Yield given. Yields of byproduct given;

...Expand

: C13H21ClO3

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 3h; Heating; Yield given;

: 869-50-1
1,2-diacetoxy-3-chloro-propane

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With porcine pancreatic lipase; sodium methylate 1) H2O (pH:7), r.t., 2) MeOH, r.t., 4h; Multistep reaction;

: 78692-88-3
(S)-1,2-Diacetoxy-3-chloropropane

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With sulfuric acid for 1h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 107-05-1
3-chloroprop-1-ene

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With potassium dioxotetrahydroxoosmate(VI); potassium carbonate; potassium hexacyanoferrate(III); 1,4-bis(dihydroquinidinyl)anthraquinone In water; tert-butyl alcohol at 0℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With dihydrogen peroxide In acetonitrile at 25℃; for 0.416667h; Title compound not separated from byproducts.;

: 96-24-2
3-monochloro-1,2-propanediol

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With sodium hydroxide; sodium azide; acid phosphatase; pyruvate kinase; phosphoenolpyruvic acid; glycerol kinase from Streptomyces canus; potassium chloride; ATP; 2-hydroxyethanethiol; magnesium chloride 1.) H2O, 25 deg C; Yield given. Multistep reaction. Yields of byproduct given;

: 106-89-8
epichlorohydrin

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With polistyrene-bound (R,R)-N-(3,5-di-t-butyl-6-hydroxy)benzylidene-N'-(3-t-butyl-2,5-dihydroxy)benzylidene-1,2-cyclohexanediamine; water In dichloromethane for 3h; Ambient temperature; Yield given; Yields of byproduct given. Title compound not separated from byproducts;
With water Jacobsen kinetic hydrolytic resolution;
Stage #1: epichlorohydrin With phthalic anhydride; C64H74Al2Cl2N4O4; bis(triphenylphosphine)iminium chloride In toluene at 25℃; for 3h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; methanol at 20℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere; enantioselective reaction;	A n/a B n/a

: 106-89-8
epichlorohydrin

A: 67843-74-7
(S)-epichlorohydrin

B: 51594-55-9
(R)-(-)-epichlorohydrin

C: 57090-45-6
(2R)-3-chloro-1,2-propanediol

D: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With water; poly(Co(III)(OTs)-salen-norbornene) In chlorobenzene at 20℃; for 0.5h; Product distribution; Further Variations:; Catalysts; reaction times;
Co(Salen)/SBA-16-C8 In tetrahydrofuran; water at 24.84℃; for 20h;
With C118H146Co2N4O14S2; water In acetonitrile at 20℃; optical yield given as %ee; enantioselective reaction;

...Expand

: 24423-98-1
3-chloro-1-hydroxypropan-2-one

A: 57090-45-6
(2R)-3-chloro-1,2-propanediol

B: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; D-glucose In water at 30℃; for 24h; pH=5.5; Aqueous phophate buffer; Microbiological reaction;	A n/a B n/a
With potassium dihydrogenphosphate; D-glucose In water at 30℃; for 24h; pH=5.5; Aqueous phophate buffer; Microbiological reaction;	A n/a B n/a
With potassium dihydrogenphosphate; D-glucose In water at 30℃; for 24h; pH=5.5; Aqueous phophate buffer; Microbiological reaction;	A n/a B n/a

: 24423-98-1
3-chloro-1-hydroxypropan-2-one

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With Candida-derived reductase; NADH at 30℃; for 2h; pH=6.5; Aqueous phophate buffer; Enzymatic reaction;	n/a
With potassium dihydrogenphosphate; D-glucose In water at 30℃; for 24h; pH=5.5; Aqueous phophate buffer; Microbiological reaction;	n/a
With potassium dihydrogenphosphate; D-glucose In water at 30℃; for 24h; pH=5.5; Aqueous phophate buffer; Microbiological reaction;	n/a

: 51594-55-9
(R)-(-)-epichlorohydrin

A: 67843-74-7
(S)-epichlorohydrin

B: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With (R,R)-Jacobsen catalyst; water	A n/a B n/a

: 67843-74-7
(S)-epichlorohydrin

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

Conditions

Conditions	Yield
With sulfuric acid In water at 108℃; for 6h;
With sulfuric acid In water at 108℃; for 6h;

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 107-73-3
phosphorylcholine chloride

: 28319-77-9
L-glycero-3-phosphorylcholine

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride With potassium hydroxide In methanol for 1h; Stage #2: (2R)-3-chloro-1,2-propanediol In methanol at 65℃; for 16h; Temperature;	99%
Stage #1: phosphorylcholine chloride With potassium hydroxide In ethanol for 0.5h; Stage #2: (2R)-3-chloro-1,2-propanediol In ethanol at 75 - 85℃; for 6h;	79.6%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 98-59-9
p-toluenesulfonyl chloride

: 83398-53-2
(R)-3-chloro-2-hydroxypropyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With pyridine for 1h; Ambient temperature;	98.6%
With hydrogenchloride	75%
With pyridine
With pyridine at 0 - 20℃; for 1h;

: heptatriaconta-6,9,28,31-tetraen-19-one

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 4-(R)-4-chloromethyl-2,2-di-octadeca-9,12-dienyl-[1,3]dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 72h; Reflux; Water removal;	97%

: 1122-58-3
dmap

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 942209-57-6
(S)-(-)-1-(2,3-dihydroxypropyl)-4-(dimethylamino)pyridinium chloride

Conditions

Conditions	Yield
In acetonitrile at 65℃; for 24h;	96%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 75-50-3
trimethylamine

: (S)-2,3-dihydroxypropyltrimethylammonium chloride

Conditions

Conditions	Yield
In water at 90℃; for 16h;	95.7%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 150710-99-9
2-benzyloxy-3-methylphenol

: 335280-94-9
(R)-2-benzyloxy-3-(2,3-dihydroxypropoxy)toluene

Conditions

Conditions	Yield
Stage #1: 2-benzyloxy-3-methylphenol; cesium fluoride In N,N-dimethyl-formamide for 1h; Stage #2: (2R)-3-chloro-1,2-propanediol In N,N-dimethyl-formamide at 60℃; for 5h; Further stages.;	95%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 431-03-8
dimethylglyoxal

: 149-73-5
trimethyl orthoformate

: (2R,3R)-5-(chloromethyl)-2,3-dimethoxy-2,3-dimethyl-1,4-dioxane

Conditions

Conditions	Yield
With camphor-10-sulfonic acid In methanol at 90℃;	95%
With camphor-10-sulfonic acid In methanol for 2h; Heating;

...Expand

: 34966-51-3
2,4-dichloro-α-oxo-benzeneacetic ethyl ester

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: (1S,5S)-5-(2,4-dichlorophenyl)-3,6,8-trioxabicyclo[3.2.1]octan-4-one

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;	95%

: 136918-14-4
phthalimide

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 119835-88-0
1H-isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 5h; Reagent/catalyst; Temperature; Time; Gabriel Amine Synthesis;	94.9%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 146864-18-8
(R)-4-chloromethyl-[1,3,2]dioxathiolane 2-oxide

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane	94%
With thionyl chloride In tetrachloromethane for 2h; Reflux; Inert atmosphere;	94%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 1126-20-1
2-allyloxyphenol

: 66901-82-4
(R)-2-allyloxy-1-(2,3-dihydroxypropoxy)benzene

Conditions

Conditions	Yield
Stage #1: 2-allyloxyphenol; cesium fluoride In N,N-dimethyl-formamide for 1h; Stage #2: (2R)-3-chloro-1,2-propanediol In N,N-dimethyl-formamide at 60℃; for 5h; Further stages.;	93%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 136984-26-4
(R)-(-)-1-(tert-butylmethylsilanyloxy)-3-chloropropan-2-ol

Conditions

Conditions	Yield
With 1H-imidazole In DMF (N,N-dimethyl-formamide) at 0 - 20℃;	92.4%

: 92736-81-7
2’2’2’-trifluoro-2,4-dichloroacetophenone

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: ((4R)-2-(2,4-dichlorophenyl)-2-trifluoromethyl-1,3-dioxolan-4-yl)methanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	91%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 106-45-6
para-thiocresol

: 127634-04-2
(R)-3-p-Tolylsulfanyl-propane-1,2-diol

Conditions

Conditions	Yield
With sodium hydroxide at 100℃; for 2h;	90%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 67-64-1
acetone

: 57044-24-3
(R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 50℃; for 4h;	90%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 58905-16-1
1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

: C13H12Cl3N3O2

Conditions

Conditions	Yield
With methanesulfonic acid In toluene at 40℃; for 4h;	90%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 506-59-2
N,N-dimethylammonium chloride

: 666234-82-8
(S)-3-(N,N-dimethylamino)propane-1,2-diol

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 18h;	89%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane for 18h; Ambient temperature;	88%
With potassium carbonate In dichloromethane other reagent: Cs2CO3;
With potassium phosphate In dichloromethane for 3h; Product distribution / selectivity; Heating / reflux;
With potassium carbonate In dichloromethane at 20℃; for 24h;
With potassium carbonate In dichloromethane at 20℃; for 20h;

: 2-(4-methylamino-phenyl)-benzofuran-5-ol

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: (R)-3-((2-(4-(methylamino)phenyl)benzofuran-5-yl)oxy)propane-1,2-diol

Conditions

Conditions	Yield
Stage #1: 2-(4-methylamino-phenyl)-benzofuran-5-ol With sodium hydroxide In ethanol; water at 80℃; for 1h; Stage #2: (2R)-3-chloro-1,2-propanediol In ethanol; water at 80℃; for 3h;	87.7%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 4826-71-5
phosphorylcholine chloride, calcium salt

: 34688-34-1
glycerolcholine phosphate

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride, calcium salt With potassium oxalate In water at 20℃; for 2h; Stage #2: (2R)-3-chloro-1,2-propanediol With potassium hydroxide In ethanol for 6h;	86%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 57044-24-3
(R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetone	85%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 58479-61-1
tert-butylchlorodiphenylsilane

: (R)-1-[(tert-butyldiphenylsilyl)oxy]-3-chloropropan-2-ol

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 0 - 20℃; for 4h;	85%

: 1029435-58-2
(2Z,5Z)-5-[(3-chloro-4-hydroxyphenyl)methylene]-3-(o-tolyl)-2-propyliminothiazolidin-4-one

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: Ponesimod

Conditions

Conditions	Yield
With potassium tert-butylate In ethanol at 20 - 88℃; for 24.5h;	84%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 18162-48-6
tert-butyldimethylsilyl chloride

: (R)-5-(chloromethyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃;	84%
With 1H-imidazole In dichloromethane

: 119-61-9
benzophenone

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 139892-51-6
(4R)-4-(chloromethyl)-2,2-diphenyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Reflux;	82%
With toluene-4-sulfonic acid In toluene Heating;
With toluene-4-sulfonic acid In toluene for 18h; Reflux; Dean-Stark;

: 2380-94-1
1H-indol-4-ol

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 74784-71-7
(R)-3-(4-indolyloxy)-propane-1,2-diol

Conditions

Conditions	Yield
Stage #1: 1H-indol-4-ol With potassium carbonate In acetonitrile for 2h; Reflux; Stage #2: (2R)-3-chloro-1,2-propanediol In acetonitrile for 16h; Reflux;	82%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 157396-11-7
7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one

A: (R)-(-)-1-chloro-3-<(1-phenylsulfonyl)-1H-indol-4-yloxy>-2-propanol

B: 4-(4-chlorophenylthio)-1-(phenylsulfonyl)-1H-indole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; copper dichloride In benzene for 1h; Heating;	A 81% B 6%
With toluene-4-sulfonic acid In benzene for 1.5h; Heating;	A 77% B 4%

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(R)-(-)-3-Chloro-1,2-propanediol Specification

The (R)-3-Chloro-1,2-propanediol, with the CAS registry number 57090-45-6, is also known as 1,2-Propanediol, 3-chloro-, (R)-. It belongs to the product categories of Chiral Compounds; Diols; Chiral; Chiral Building Blocks; Simple Alcohols (Chiral); Synthetic Organic Chemistry; Chiral Compound. Its EINECS registry number is 435-560-9. This chemical's molecular formula is C₃H₇ClO₂ and molecular weight is 110.54. Its IUPAC name is called (2R)-3-chloropropane-1,2-diol. This chemical is clear light yellow liquid. The product should be sealed and stored at 2-8 °C.

Physical properties of (R)-3-Chloro-1,2-propanediol: (1)ACD/LogP: -0.76; (2)ACD/LogD (pH 5.5): -0.76; (3)ACD/LogD (pH 7.4): -0.76; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 9.21; (7)ACD/KOC (pH 7.4): 9.21; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.473; (12)Molar Refractivity: 23.82 cm³; (13)Molar Volume: 84.8 cm³; (14)Surface Tension: 45.8 dyne/cm; (15)Density: 1.303 g/cm³; (16)Flash Point: 113.3 °C; (17)Enthalpy of Vaporization: 52.26 kJ/mol; (18)Boiling Point: 213 °C at 760 mmHg; (19)Vapour Pressure: 0.0374 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical that at low levels can cause damage to health. It is harmful in contact with skin. Besides, it is toxic if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(C(CCl)O)O
(2)Isomeric SMILES: C([C@H](CCl)O)O
(3)InChI: InChI=1S/C3H7ClO2/c4-1-3(6)2-5/h3,5-6H,1-2H2/t3-/m0/s1
(4)InChIKey: SSZWWUDQMAHNAQ-VKHMYHEASA-N

Product Name

(R)-(-)-3-Chloro-1,2-propanediol

Synthetic route

(R)-(-)-3-Chloro-1,2-propanediol Specification

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