Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:2380-94-1
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiry4-Hydroxyindole Product Name: 4-Hydroxyindole Molecular Weight: 133.15 CAS NO: 2380-94-1 EC NO: 219-177-2 Molecular Formula: C8H7NO
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:2380-94-1
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Product Description Product website: http://www.finerchem.com Product Name 4-Hydroxyindole CAS No. 2380-94-1
Cas:2380-94-1
Min.Order:1 Gram
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inquiryName: 4-Hydroxyindole CAS No.: 2380-94-1 Molecular Formula: C8H7NO Molecular Weight: 133.14728 EINEC No.: 219-177-2 Appearance:White Powder Storage:Store in cool and dry place,
TIANFUCHEM--2380-94-1--High purity 4-Hydroxyindole factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busine
Cas:2380-94-1
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:2380-94-1
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Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:2380-94-1
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:2380-94-1
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Type:Trading Company
inquiry4-Hydroxyindole CAS:2380-94-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
Cas:2380-94-1
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:2380-94-1
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
PRODUCT DETAILS
Cas:2380-94-1
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryProduct Name: 4-Hydroxyindole Synonyms: 1H-INDOL-4-OL;1H-INDOLE-4-OL;4-HYDROXY-1H-INDOLE;4-INDOLOL;4-HYDROXYINDOLE;INDOL-4-OL;4-Hydroxy Indole (4-Indolol);4-Hydroxxyindole CAS: 2380-94-1 MF: C8H7NO MW: 133.15 EINECS: 219-177-2 Product C
Cas:2380-94-1
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white powder Storage:Room Temperature Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,DHL/TNT/FEdex/UPS/EMS Port:QINGDAO
Cas:2380-94-1
Min.Order:10 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E
Cas:2380-94-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:2380-94-1
Min.Order:0 Metric Ton
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:2380-94-1
Min.Order:10 Kilogram
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Type:Trading Company
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Factory price 1,3-Dichloro-4-fluorobenzene CAS 1435-48-9 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw materi
Cas:2380-94-1
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Type:Trading Company
inquiry3-nitro-2-vinylphenol
1H-indol-4-ol
Conditions | Yield |
---|---|
With carbon monoxide; triphenylphosphine; palladium diacetate In acetonitrile under 3040 Torr; Heating; | 96% |
With carbon monoxide; palladium diacetate; triphenylphosphine In acetonitrile at 90℃; under 3051.25 Torr; for 50h; | 96% |
(4-Hydroxy-indol-1-yl)-phenyl-methanone
1H-indol-4-ol
Conditions | Yield |
---|---|
With potassium hydroxide at 0 - 20℃; for 2h; | 96% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With sodium hydroxide at 0℃; for 1h; | 95% |
4-benzyloxy-1H-indole
1H-indol-4-ol
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 775.743 Torr; for 12h; | 89.4% |
With methanol; magnesium hydrosilicate; palladium Hydrogenation; |
4-hydroxyindoline
1H-indol-4-ol
Conditions | Yield |
---|---|
With palladium on activated charcoal In o-xylene for 2.3h; Heating; | 88% |
A
1H-indol-4-ol
B
4-benzyloxy-1H-indole
Conditions | Yield |
---|---|
With hydrogen; 5% rhodium-on-charcoal; nickel(II) nitrate In tetrahydrofuran; water at 20℃; for 32h; | A 6% B 88% |
With hydrogen; 5% rhodium-on-charcoal; iron(II) acetate In tetrahydrofuran at 20℃; for 31h; | A 5% B 83% |
With hydrogen; 5% rhodium-on-charcoal; tris(acetylacetonato)cobalt In tetrahydrofuran at 20℃; for 38h; | A 3% B 80% |
4-acetoxy-N-tosylindole
1H-indol-4-ol
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 12h; Heating; | 83% |
2-(2-benzyloxy-6-nitrophenyl)acetonitrile
1H-indol-4-ol
Conditions | Yield |
---|---|
With hydrogen; acetic acid; 10% palladium on active carbon In ethanol under 2280 Torr; for 2h; Ambient temperature; | 81% |
With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol | 78% |
Conditions | Yield |
---|---|
With ethene; 5%-palladium/activated carbon; ammonium acetate In acetonitrile at 90℃; under 760.051 Torr; for 15h; Reagent/catalyst; Schlenk technique; | A 11% B 80% |
ethyl 4-hydroxy-1H-indole-1-carboxylate
1H-indol-4-ol
Conditions | Yield |
---|---|
palladium on activated charcoal | 75% |
4-hydroxy-1-methoxycarbonylindole
1H-indol-4-ol
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 10h; Heating; | 74.9% |
1,5,6,7-tetrahydro-indol-4-one
1H-indol-4-ol
Conditions | Yield |
---|---|
palladium on activated charcoal In various solvent(s) Heating; | 69% |
With diisobutyl ketone; palladium 10% on activated carbon at 190℃; for 48h; Inert atmosphere; | 49% |
With palladium on activated charcoal; hydrogen In 1,3,5-trimethyl-benzene at 160 - 161℃; for 48h; | 67 % Chromat. |
2-benzyloxy-6-nitrophenyl acetaldehyde
1H-indol-4-ol
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide; palladium on activated charcoal In methanol at 60℃; under 52956.6 Torr; for 15h; | 67.7% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal under 3102.9 Torr; for 6h; | 55% |
indole
A
6-hydroxy-1H-indole
B
indol-5-ol
C
7-Indolol
D
1H-indol-4-ol
Conditions | Yield |
---|---|
With dihydrogen peroxide; edetate disodium; iron(II) sulfate; ascorbic acid phosphate buffer (pH=7.2); | A 10% B 30% C 10% D 50% |
1-(p-toluenesulphonyl)-4-hydroxyindole
1H-indol-4-ol
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 10h; Heating; | 42.1% |
Conditions | Yield |
---|---|
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -20℃; for 0.05h; | A 10% B 20% C 5% |
Conditions | Yield |
---|---|
With methanol; ammonia |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite 1.) water and methanol, 5 deg C, 5 min, 2.) water, 97 deg C, 50 min; Yield given. Multistep reaction; |
1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol
A
1H-indol-4-ol
Conditions | Yield |
---|---|
With hydrogenchloride at 98℃; for 504h; |
2-bromo-3-hydroxy-1-nitrobenzene
1H-indol-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 30 percent / PPh3 / Pd(dba)2 / toluene / 17 h / Heating 2: 96 percent / PPh3, CO / Pd(OAc)2 / acetonitrile / 3040 Torr / Heating View Scheme | |
Multi-step reaction with 6 steps 1: 44 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / Ambient temperature 2: 93 percent / iron / ethanol; acetic acid / 3.5 h / Heating 3: 60 percent / pyridine / 6 h / Ambient temperature 4: 36 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / Heating 5: 58 percent / bis(acetonitrile)palladium chloride, p-benzoquinone, lithium chloride / dimethylformamide / 28 h / 100 - 110 °C 6: 83 percent / 20percent aq. NaOH / methanol / 12 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / Et4NOTs / dimethylformamide / 0.83 h / Ambient temperature; 3.3 mAcm-2 2: 86 percent / H2 / Raney Ni (W-2) / methanol / 2 h / 55 - 65 °C / 3800 - 6840 Torr 3: 90 percent / aq. 70percent H3PO4 / 24 h / 220 °C 4: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 94 percent / Et4NOTs / dimethylformamide / 0.83 h / Ambient temperature; 3.3 mAcm-2 2: 86 percent / H2 / Raney Ni (W-2) / methanol / 2 h / 55 - 65 °C / 3800 - 6840 Torr 3: 92 percent / aq. 30percent H2SO4 / 24 h / 170 °C 4: 86 percent / aq. 30percent H3PO4 / 24 h / 220 °C 5: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme |
2-(2,6-dinitrophenyl)ethanol
1H-indol-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / H2 / Raney Ni (W-2) / methanol / 2 h / 55 - 65 °C / 3800 - 6840 Torr 2: 90 percent / aq. 70percent H3PO4 / 24 h / 220 °C 3: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 86 percent / H2 / Raney Ni (W-2) / methanol / 2 h / 55 - 65 °C / 3800 - 6840 Torr 2: 92 percent / aq. 30percent H2SO4 / 24 h / 170 °C 3: 86 percent / aq. 30percent H3PO4 / 24 h / 220 °C 4: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme |
4-aminoindoline
1H-indol-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / aq. 30percent H3PO4 / 24 h / 220 °C 2: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme |
2-(2,6-diaminophenyl)ethanol
1H-indol-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / aq. 70percent H3PO4 / 24 h / 220 °C 2: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 92 percent / aq. 30percent H2SO4 / 24 h / 170 °C 2: 86 percent / aq. 30percent H3PO4 / 24 h / 220 °C 3: 88 percent / 10percent Pd/C / o-xylene / 2.3 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: anhydrous K2CO3 / dimethylformamide 2: 63 percent / tBuOK / dimethylformamide / 0.5 h / -20 - -10 °C 3: 81 percent / H2, acetic acid / Pd/C (10percent Pd) / ethanol / 2 h / 2280 Torr / Ambient temperature View Scheme |
3-(benzyloxy)nitrobenzol
1H-indol-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 63 percent / tBuOK / dimethylformamide / 0.5 h / -20 - -10 °C 2: 81 percent / H2, acetic acid / Pd/C (10percent Pd) / ethanol / 2 h / 2280 Torr / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / N,N-dimethyl-formamide / 4 h 3: sodium hydroxide / methanol / 10 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydride / N,N-dimethyl-formamide / 4 h 2: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature 3: hydrogenchloride; sodium nitrite / 1.) water and methanol, 5 deg C, 5 min, 2.) water, 97 deg C, 50 min 4: sodium hydroxide / methanol / 10 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydride / N,N-dimethyl-formamide; benzene / 17 h 2: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature 3: hydrogenchloride; sodium nitrite / 1.) water and methanol, 5 deg C, 5 min, 2.) water, 97 deg C, 20 min 4: sodium hydroxide / methanol / 10 h / Heating View Scheme |
1-hydroxy-4-nitroindole
1H-indol-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / methanol / 16 h / Ambient temperature 2: sodium hydride / N,N-dimethyl-formamide / 4 h 4: sodium hydroxide / methanol / 10 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / methanol / 43 h / Ambient temperature 2: sodium hydride / N,N-dimethyl-formamide / 4 h 4: sodium hydroxide / methanol / 10 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: ethyl bromoacetate; triethylamine / methanol / 92.5 h / Ambient temperature 2: sodium hydride / N,N-dimethyl-formamide / 4 h 4: sodium hydroxide / methanol / 10 h / Heating View Scheme |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; | 100% |
With potassium carbonate In acetone for 20h; Ambient temperature; | 95% |
With potassium carbonate In acetone for 72h; Heating; | 94% |
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide at 45℃; for 4h; | 100% |
Stage #1: 1H-indol-4-ol; epichlorohydrin With potassium hydroxide In dimethyl sulfoxide at 45℃; for 4h; Stage #2: With ammonium chloride In water | 99% |
With potassium hydroxide In dimethyl sulfoxide at 45℃; for 4h; | 99% |
1H-indol-4-ol
tert-butyldimethylsilyl chloride
4-((tert-butyldimethylsilyl)oxy)-1H-indole
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 5h; | 99% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; | 91% |
1H-indol-4-ol
4-hydroxyindoline
Conditions | Yield |
---|---|
Stage #1: 1H-indol-4-ol With sodium cyanoborohydride; acetic acid at 15 - 20℃; for 1.5h; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate | 100% |
With sodium cyanoborohydride In acetic acid at 15 - 20℃; for 1.5h; | 100% |
With sodium cyanoborohydride In acetic acid at 15 - 20℃; | 99% |
Conditions | Yield |
---|---|
In N-methyl-acetamide | 100% |
Conditions | Yield |
---|---|
With potassium fluoride In ethanol at 60℃; for 6h; | 100% |
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 25℃; Inert atmosphere; Large scale; | 99.2% |
With pyridine at 25 - 32℃; | 98% |
With pyridine In dichloromethane at 20℃; for 2h; | 34 g |
1H-indol-4-ol
methyl(2-hydroxyethyl)carbamic acid tert-butyl ester
N-methyl-N-[2-(1H-indol-4-yloxy)-ethyl]-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; for 14h; | 99% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 16h; Ambient temperature; | 77% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 16h; | |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 72h; | |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; Schlenk technique; | 873.5 mg |
1H-indol-4-ol
triisopropylsilyl chloride
4-((triisopropylsilyl)oxy)-1H-indole
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane at 20℃; for 7h; | 99% |
With 1H-imidazole In dichloromethane at 20℃; | 80% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; |
Conditions | Yield |
---|---|
With potassium carbonate In acetone Reflux; | 99% |
With potassium carbonate In acetonitrile at 90℃; for 6h; | 92% |
Conditions | Yield |
---|---|
With 3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione In toluene at 25℃; for 12h; Friedel-Crafts Alkylation; enantioselective reaction; | 99% |
1H-indol-4-ol
tert-butyl (1-benzyl-5,7-dimethyl-2-oxoindolin-3-ylidene)carbamate
Conditions | Yield |
---|---|
With 3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione In toluene at 25℃; for 12h; Friedel-Crafts Alkylation; enantioselective reaction; | 99% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With C32H28F6N4O3 In dichloromethane at -30℃; for 35h; Solvent; Temperature; Concentration; Friedel-Crafts Alkylation; enantioselective reaction; | 99% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; Friedel-Crafts Alkylation; enantioselective reaction; | 99% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; for 18h; Reagent/catalyst; Solvent; Temperature; Friedel-Crafts Alkylation; enantioselective reaction; | 99% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; Friedel-Crafts Alkylation; enantioselective reaction; | 99% |
1H-indol-4-ol
bromoacetic acid methyl ester
methyl 2-((1H-indol-4-yl)oxy)acetate
Conditions | Yield |
---|---|
With potassium carbonate In acetone | 98% |
With caesium carbonate In acetonitrile at 20℃; for 0.583333h; | 78% |
With potassium carbonate In acetone at 20℃; |
1H-indol-4-ol
(3-bromopropyl)({ [2-chloro-3-(trifluoromethyl)phenyl]methyl})(2,2-diphenylethyl)amine
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 90℃; | 98% |
With potassium carbonate In acetonitrile at 90℃; Product distribution / selectivity; | 98% |
Conditions | Yield |
---|---|
With potassium fluoride In ethanol at 60℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Time; Green chemistry; | 98% |
Stage #1: 4-chlorobenzaldehyde; malononitrile With guanine-functionalized mesoporous silica In ethanol at 20℃; for 0.333333h; Knoevenagel Condensation; Green chemistry; Stage #2: 1H-indol-4-ol In ethanol at 80℃; for 3.5h; Michael Addition; Green chemistry; | 76% |
1H-indol-4-ol
tert-butyl (1-benzyl-6-chloro-2-oxoindolin-3-ylidene)carbamate
Conditions | Yield |
---|---|
With 3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione In toluene at 25℃; for 12h; Friedel-Crafts Alkylation; enantioselective reaction; | 98% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With C32H28F6N4O3 In dichloromethane at -30℃; for 72h; Friedel-Crafts Alkylation; enantioselective reaction; | 98% |
Conditions | Yield |
---|---|
In water at 80℃; for 5h; | 98% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; Friedel-Crafts Alkylation; enantioselective reaction; | 98% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; Friedel-Crafts Alkylation; enantioselective reaction; | 98% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; Friedel-Crafts Alkylation; enantioselective reaction; | 98% |
1H-indol-4-ol
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 20℃; Friedel-Crafts Acylation; | 97% |
Conditions | Yield |
---|---|
With potassium fluoride In ethanol at 60℃; for 6h; Green chemistry; | 97% |
1H-indol-4-ol
1-benzyl-5-chloroisatin
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In diethyl ether at 20 - 25℃; enantioselective reaction; | A n/a B 97% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane at 0℃; Friedel-Crafts Alkylation; enantioselective reaction; | 97% |
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