(R)-Lactate supplier | CasNO.10326-41-7

Name
(R)-Lactate
EINECS 233-713-2
CAS No. 10326-41-7
Article Data179
CAS DataBase
Density 1.276 g/cm³
Solubility Soluble in water (50mg/ml)
Melting Point 52.8°
Formula C₃H₆O₃
Boiling Point 227.6 °C at 760 mmHg
Molecular Weight 90.0788
Flash Point 109.9 °C
Transport Information
Appearance
Safety 26-39
Risk Codes 38-41
Molecular Structure
Hazard Symbols Xi
Synonyms Lacticacid, D- (8CI);Propanoic acid, 2-hydroxy-, (R)-;(-)-Lactic acid;(2R)-2-Hydroxypropanoic acid;(R)-(-)-Lacticacid;(R)-2-Hydroxypropanoic acid;(R)-2-Hydroxypropionic acid;(R)-Lactic acid;(R)-a-Hydroxypropionic acid;D-(-)-Lactic acid;D-Lacticacid;
PSA 57.53000
LogP -0.54820

Synthetic route

: 127-17-3
2-oxo-propionic acid

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With phosphonic Acid; lactate dehydrogenase V152R mutant; phosphorous dehydrogenase I151R mutant; NAD In aq. buffer at 30℃; for 12h; pH=7.5; Reagent/catalyst; Time; Enzymatic reaction;	100%
With phosphate buffer; ADH (EC 1.1.1.2); MV2+; nicotinamide adenine dinucleotide phosphate In water; tert-butyl alcohol for 30h; electrolysis' other reaction system;	8.3E-6 mol
With Leuconostoc lactis ketoacid reductase; NADH In aq. phosphate buffer at 35℃; for 10h; pH=7; Enzymatic reaction; enantioselective reaction;	65.2 %Chromat.

: 4254-14-2
(2R)-propane-1,2-diol

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
Stage #1: (2R)-propane-1,2-diol With Rh(OTf)(trop2NH)(PPh3); water; cyclohexanone; sodium hydroxide at 20℃; for 5h; Inert atmosphere; Stage #2: With hydrogenchloride In water Inert atmosphere; chemoselective reaction;	91%

: 232944-80-8
1-dodecyl L-lactate

A: 10326-41-7
D-Lactic acid

B: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With 2C33H37N*H2O7S2; water at 80℃; for 4h;	A 80% B 87%

: 547-64-8
methyl lactate

A: 10326-41-7
D-Lactic acid

B: 27871-49-4
(S)-Methyl lactate

Conditions

Conditions	Yield
With Dactylosporangium aurantiacum esterase WDEst9 In aq. buffer at 30℃; for 3h; pH=8.5; Catalytic behavior; Concentration; pH-value; Reagent/catalyst; Solvent; Temperature; Time; Green chemistry; Enzymatic reaction; enantioselective reaction;	A n/a B 86.7%

: 338-69-2
D-Alanine

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite	82%
With trifluoroacetic acid; sodium nitrite In water at 20℃; for 6h;	62%
With sulfuric acid; sodium nitrite In water at 0℃; for 2h;

: 61597-96-4
Isobutyl (R)-lactate

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; water at 0 - 20℃; for 48h; Inert atmosphere;	77%

: 338-69-2
D-Alanine

A: 10326-41-7
D-Lactic acid

B: 4511-42-6
D-lactide

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water at 0 - 20℃; stereoselective reaction;	A 58% B < 3 %Spectr.

: 57-55-6
propylene glycol

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With phosphate buffer; Gluconobacter oxydans DSM 2003 cells at 28℃; for 20h; pH=6.0;	48%

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

A: 79-33-4
L-Lactic acid

B: 10326-41-7
D-Lactic acid

C: 7699-00-5
(R)-Ethyl lactate

Conditions

Conditions	Yield
With ammonium hydroxide at 30℃; pH=6.9;	A n/a B n/a C 34.5%

...Expand

: 77-92-9
citric acid

A: 328-42-7
Oxalacetic acid

B: 79-33-4
L-Lactic acid

C: 10326-41-7
D-Lactic acid

D: 513-86-0, 52217-02-4
3-hydroxy-2-butanon

E: 64-19-7
acetic acid

F: 127-17-3
2-oxo-propionic acid

Conditions

Conditions	Yield
With Leuconostoc mesenteroides at 30℃; for 1h; potassium phosphate buffer, pH 5.0; other conditions also investigated; several substrates investigated;	A 0.66% B 0.06% C 1.77% D 6.86% E 15.5% F 0.05%

...Expand

: 77-92-9
citric acid

A: 328-42-7
Oxalacetic acid

B: 79-33-4
L-Lactic acid

C: 10326-41-7
D-Lactic acid

D: 64-19-7
acetic acid

E: 127-17-3
2-oxo-propionic acid

F: 431-03-8
dimethylglyoxal

Conditions

Conditions	Yield
With Leuconostoc mesenteroides at 30℃; for 1h; potassium phosphate buffer, pH 5.0; other conditions also investigated; several substrates investigated;	A 0.66% B 0.06% C 1.77% D 15.5% E 0.05% F 1.72%

...Expand

: 849585-22-4
LACTIC ACID

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
mit Hilfe von Chinin;
mit Hilfe von Morphin;
With MORPHIN
mit Hilfe von Strychnin;

: 57-48-7
D-Fructose

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
bei der Vergaerung durch Bacterium coli communis (zu mehr als 75prozent aus l-Milchsaeure besteht);
bei der Vergaerung durch Lactobacillus Leichmanni;

: 53651-68-6
pyruvic acid menthyl ester

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With aluminium amalgam und Verseifung der Produkte mit alkoholischem Kaliumhydroxyd;

: 7474-05-7
(R)-2-chloropropionic acid

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With water; silver(l) oxide

: 32644-15-8
(S)-2-bromopropanoic acid

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 10009-70-8
R-(+)-2-bromopropionic acid

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With water; silver carbonate

: 18791-44-1
(S)-2-iodo-propionic acid

: furan-2,3,5(4H)-trione pyridine (1:1)

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
Hydrolysis;

: 18791-44-1
(S)-2-iodo-propionic acid

A: 849585-22-4
LACTIC ACID

B: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With sodium hydroxide Hydrolysis;

: 69-65-8
mannitol

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
bei der Vergaerung durch eine auf Birnen gefundene Mikrobe;
bei der Vergaerung durch Bacterium formicicum;
durch Vergaerung mit Pneumokokkus(Friedlaender);

: 69-65-8
mannitol

A: 64-17-5
ethanol

B: 10326-41-7
D-Lactic acid

C: 64-19-7
acetic acid

D: 71-36-3
butan-1-ol

Conditions

Conditions	Yield
bei der Vergaerung durch Clostridium thermocellum;Produkt 5:Buttersaeure;

...Expand

: 50-70-4
D-sorbitol

A: 57-48-7
D-Fructose

B: 10326-41-7
D-Lactic acid

C: 50-99-7
D-glucose

Conditions

Conditions	Yield
beim Durchleiten von sorbithaltigem Rinderblut durch isolierte Hundeleber;

...Expand

: 5328-37-0
L-arabinose

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
durch Vergaerung mit Pneumokokkus(Friedlaender);

: 3416-24-8
2-amino-2-deoxyglucose

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
bei der Einw. von Bac. subtilis und Bac. prodigiosus;

: 50-99-7
D-glucose

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
bei der Gaerung der alkalischen Loesungen durch den Bacillus acidi laevolactici;
at 36℃; bei der Gaerung der alkalischen Loesungen durch den Bacillus acidi laevolactici;
bei der Vergaerung durch eine auf Birnen gefundene Mikrobe;

: 59-23-4
D-Galactose

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
durch Vergaerung mit Pneumokokkus(Friedlaender);
bei der Vergaerung durch Lactobacillus Leichmanni;

: 50-99-7, 59-23-4, 921-60-8, 1949-88-8, 1990-29-0, 2152-76-3, 2595-97-3, 2595-98-4, 3458-28-4, 4205-23-6, 5934-56-5, 5978-95-0, 5987-68-8, 6027-89-0, 6038-51-3, 7635-11-2, 10030-80-5, 15572-79-9, 19163-87-2, 23567-25-1, 26566-61-0, 30077-17-9, 31103-86-3, 39665-52-6, 40866-07-7, 58367-01-4, 58407-05-9, 58407-06-0, 83198-69-0, 83198-70-3, 83198-71-4, 93780-23-5, 145920-48-5
glucose

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
bei der Gaerung der alkalischen Loesungen durch den Typhusbazillus;
durch Vergaerung mit Pneumokokkus(Friedlaender);
durch den Pilz Rhizopus chinensis;
beim Vergaeren durch Betacoccus arabinosaceus;
Vergaerung durch Lactobacillus leichmannii sowie Reinigung ueber das Zinksalz und durch folgende Einw. eines Ionenaustausch-Harzes;

: 3646-68-2
D-glucosaminic acid

A: 10326-41-7
D-Lactic acid

B: 110-15-6
succinic acid

Conditions

Conditions	Yield
durch Escherishia Coli;

: 3646-68-2
D-glucosaminic acid

A: 10326-41-7
D-Lactic acid

B: 144-62-7
oxalic acid

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
nach Verabreichung an Hunde und Kaninchen im Harn ausscheiden;

...Expand

: 488-69-7
fructose-1,6-bisphosphate

: 10326-41-7
D-Lactic acid

Conditions

Conditions	Yield
With GLUTATHIONE; toluene bei der Vergaerung durch Hefe;
With GLUTATHIONE; toluene bei der Vergaerung durch Hefe; in diesen Gaerensaetzen entsteht vielleicht intermediaer Methylglyoxal durch einen nichtfermentativen Prozess;

: 10326-41-7
D-Lactic acid

: 127-17-3
2-oxo-propionic acid

Conditions

Conditions	Yield
With oxygen at 100℃; under 75.0075 Torr; for 8h; Temperature; Pressure; Autoclave;	94.3%
With mutant 3-isopropylmalate dehydrogenase(Gly89-Gly-Leu90); nicotinamide adenine dinucleotide In water at 60℃; for 2h; pH=7.8; Enzyme kinetics;
With nicotinamide flucytosine dinucleotide at 25℃; pH=7.5; aq. buffer; Enzymatic reaction;
With D-lactate dehydrogenase of Planctomyces brasiliensis at 25℃; for 1h; pH=7; Concentration; pH-value; Reagent/catalyst; Temperature; Enzymatic reaction;
With D-lactate oxidase from Saccharomyces cerevisiae; oxygen; catalase In aq. buffer at 30℃; pH=7.4; Reagent/catalyst; Enzymatic reaction;

: 10326-41-7
D-Lactic acid

: 7173-51-5
didecyldimethylammonium chloride

: 1308889-80-6
didecyldimethylammonium L-lactate

Conditions

Conditions	Yield
Stage #1: D-Lactic acid With potassium hydroxide In water Reflux; Stage #2: didecyldimethylammonium chloride In water at 20℃; for 5h;	94%

: 10326-41-7
D-Lactic acid

: 271247-18-8
((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

: (R)-2-Hydroxy-1-{4-[5-[2-((S)-1-phenyl-ethylamino)-pyrimidin-4-yl]-6-(3-trifluoromethyl-phenyl)-pyridazin-3-yl]-piperidin-1-yl}-propan-1-one

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide	93%

: 10326-41-7
D-Lactic acid

: 10401-59-9
9-anthryldiazomethane

: (R)-2-Hydroxy-propionic acid anthracen-9-ylmethyl ester

Conditions

Conditions	Yield
In diethyl ether for 0.5h; Ambient temperature;	90%
In diethyl ether for 0.5h; Ambient temperature;
In methanol at 20℃; for 0.5h;

: 10326-41-7
D-Lactic acid

: 100-51-6
benzyl alcohol

: 2051-96-9, 56777-24-3, 74094-05-6
benzyl (R)-Lactate

Conditions

Conditions	Yield
Stage #1: benzyl alcohol With toluene-4-sulfonic acid In benzene for 0.5h; Reflux; Stage #2: D-Lactic acid In benzene Reflux;	88%
With salicylaldehyde In toluene at 100℃; for 18h; Inert atmosphere; chemoselective reaction;	85%
With hydrogenchloride for 18h;	51.3%

: 10326-41-7
D-Lactic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129919-88-6
(2S)-2-<(tert-Butyldimethylsilyl)oxy>lactic acid

Conditions

Conditions	Yield
With dmap; triethylamine	87%

: 64-17-5
ethanol

: 10326-41-7
D-Lactic acid

: 7699-00-5
(R)-Ethyl lactate

Conditions

Conditions	Yield
With salicylaldehyde at 80℃; for 28h; Inert atmosphere; chemoselective reaction;	85%
With sulfuric acid at 120℃; for 8h; Molecular sieve;	25%
With hydrogenchloride
With sulfuric acid; benzene durch azeotrope Destillation;

: 10326-41-7
D-Lactic acid

: 9-(6-methoxypyridin-3-yl)-3-methyl-1-(piperidin-4-yl)-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one hydrochloride salt

: (R)-1-[1-(2-hydroxypropionyl)piperidine-4-yl]-9-(6-methoxypyridin-3-yl)-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 9-(6-methoxypyridin-3-yl)-3-methyl-1-(piperidin-4-yl)-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one hydrochloride salt With triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: D-Lactic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h;	81.4%
Stage #1: 9-(6-methoxypyridin-3-yl)-3-methyl-1-(piperidin-4-yl)-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one hydrochloride salt With triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: D-Lactic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h;	88mg
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; water at 20℃; for 2h;	88 mg

: 10326-41-7
D-Lactic acid

: 1292317-84-0
methyl 4-({4-[3-cyano-4-(piperidin-4-yloxy)phenyl]pyrimidin-2-yl}amino)benzoate

: 76-05-1
trifluoroacetic acid

: methyl 4-({4-[3-cyano-4-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)phenyl]pyrimidin-2-yl}amino)benzoate trifluoroacetate

Conditions

Conditions	Yield
Stage #1: D-Lactic acid; methyl 4-({4-[3-cyano-4-(piperidin-4-yloxy)phenyl]pyrimidin-2-yl}amino)benzoate With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 16h; Stage #2: trifluoroacetic acid In water; acetonitrile	81%

...Expand

: 66-71-7
1,10-Phenanthroline

: malachite

: 10326-41-7
D-Lactic acid

: [copper(II)-di(lactato)-(1,10-phenanthroline)]*4H2O

Conditions

Conditions	Yield
In ethanol suspn. of Cu compd. and lactic acid in EtOH refluxed for 4 h at 75°C, 1,10-phenanthroline added, refluxed for 2 h, then stirred for several d; filtered, washed with EtOH, dried over CaCl2; elem. anal.;	80%

...Expand

: 10326-41-7
D-Lactic acid

: vanadia

: 21050-13-5
bis(triphenylphosphine)iminium chloride

: [VO2(lac)]2(Ph3P=NPPh3)2

Conditions

Conditions	Yield
With tetraethylammonium hydroxide In water; acetonitrile V2O5 was added to aq. soln. Et4NOH and warmed to 60°C, soln. was filtered, lactic acid was added with stirring, pH was raised from 3.0 to6.3 by Et4NOH, soln. was concd. in air stream, soln. PPNCl in MeCN was added and left overnight; product was filtered, washed with MeCN, and dried in vacuo; elem. anal.;	78%

...Expand

: 10326-41-7
D-Lactic acid

: 1428651-87-9
(rac)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-amine

: 1469979-88-1
(R)-N-((R,S)-4-bromo-5,6,7,8-tetrahydro-isoquinolin-8-yl)-2-hydroxy-propionamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	77%

: 10326-41-7
D-Lactic acid

: 1222104-79-1
5-{9-(cyclopropylmethyl)-8-[(3R)-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9H-purin-2-yl}pyrimidin-2-amine

: 1222104-99-5
(2R)-1-{(2R)-4-[2-(2-Aminopyrimidin-5-yl)-9-(cyclopropylmethyl)-6-morpholin-4-yl-9H-purin-8-yl]-2-methylpiperazin-1-yl}-1-oxopropan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20 - 40℃; for 40.5h;	76%

: 10326-41-7
D-Lactic acid

: 100-39-0
benzyl bromide

: 2051-96-9, 56777-24-3, 74094-05-6
benzyl (R)-Lactate

Conditions

Conditions	Yield
Stage #1: D-Lactic acid With caesium carbonate In methanol; water pH=7; Stage #2: benzyl bromide In methanol; water; N,N-dimethyl-formamide at 20℃; for 6h;	75%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 80 - 100℃; for 1h;	68%
With potassium carbonate In N,N-dimethyl-formamide for 14h; Ambient temperature;
In N,N-dimethyl-formamide at 50℃; for 6h; Inert atmosphere; Glovebox; Sealed tube;

: 10326-41-7
D-Lactic acid

: 1428651-83-5
(rac)-6-(8-amino-5,6,7,8-tetrahydroisoquinolin-4-yl)-1-methyl-3,4-dihydroquinolin-2(1H)-one

: 1428652-31-6
(2R)-2-hydroxy-N-[(4R,S)-4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	75%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Inert atmosphere;	75%

: 10326-41-7
D-Lactic acid

: 3-(((1R,2R)-2-((4-(6-fluorobenzo[d]isoxazole-3-yl)piperidin-1-yl)methyl)cyclohexyl)methyl)oxazolidine-2-one

: 3-(((1R,2R)-2-((4-(6-fluorobenzo[d]isoxazole-3-yl)piperidin-1-yl)methyl)cyclohexyl)methyl)oxazolidine-2-one lactic acid salt

Conditions

Conditions	Yield
In ethanol Reflux;	74.1%

: 10326-41-7
D-Lactic acid

: (R)-3-iodo-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: (R)-1-((R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-hydroxypropan-1-one

Conditions

Conditions	Yield
Stage #1: D-Lactic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (R)-3-iodo-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine In N,N-dimethyl-formamide at 20℃; for 5h;	73.3%

: 10326-41-7
D-Lactic acid

: 1222105-31-8
5-(9-isobutyl-6-morpholin-4-yl-8-piperazin-1-yl-9H-purin-2-yl)pyrimidin-2-amine

: 1222104-78-0
(2R)-1-{4-[2-(2-Aminopyrimidin-5-yl)-9-isobutyl-6-morpholin-4-yl-9H-purin-8-yl]piperazin-1-yl}-1-oxopropan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 96h;	73%

: 10326-41-7
D-Lactic acid

: 5-bromo-3-fluoro-N1-(propan-2-yl)benzene-1,2-diamine

: (1R)-1-[6-bromo-4-fluoro-1-(propan-2-yl)-1H-benzimidazol-2-yl]ethan-1-ol

Conditions

Conditions	Yield
for 44h; Time; Heating;	71%

: 10326-41-7
D-Lactic acid

: 1422470-13-0
5-amino-N-(4-(azepan-4-yloxy)pyrimidin-5-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

: C20H20F2N6O2S*C3H6O3

Conditions

Conditions	Yield
In methanol; dichloromethane at 20 - 30℃; for 0.5h;	67.8%

: 10326-41-7
D-Lactic acid

: 32315-10-9
bis(trichloromethyl) carbonate

: 91049-50-2
L-lactic acid O-carboxyanhydride

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 0 - 20℃; for 8h;	65%

: 10326-41-7
D-Lactic acid

: 5-chloro-N-[3,5-dimethyl-1-(4-piperidinyl)-1H-pyrazol-4-yl]-4-(pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinamine

: (2R)-1-[4-(4-{[5-chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}-3,5-dimethyl-1H-pyrazol-1-yl)-1-piperidinyl]-2-hydroxy-1-propanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	64%

: 10326-41-7
D-Lactic acid

: 3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-(4-piperidin-3-yl)phenyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one hydrochloride

: 1-(4-(1-((R)-2-hydroxypropionyl)piperidin-3-yl)phenyl)3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-2-(3H)-one

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;	63.4%

: 10326-41-7
D-Lactic acid

: 1607590-13-5
tert-butyl 4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-3-fluoropiperidine-1-carboxylate

: 1607590-14-6
tert-butyl 3-fluoro-4-[(6-{[(2R)-2-hydroxypropanoyl]amino}thieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃;	62%

(R)-Lactate Chemical Properties

Molecular Structure of Propanoic acid,2-hydroxy-, (2R)- (CAS NO.10326-41-7):

Molecular Formula: C₃H₆O₃
Molecular Weight: 90.0779
IUPAC Name: (2R)-2-Hydroxypropanoic acid
Synonyms of Propanoic acid,2-hydroxy-, (2R)- (CAS NO.10326-41-7): D-Lactic acid ; (-)-Lactic acid ; (D)-(-)-Lactic acid ; (R)-(-)-Lactic acid ; (R)-2-Hydroxypropanoic acid ; (R)-2-Hydroxypropionsaeure ; (R)-Lactic acid ; (R)-Milchsaeure ; (R)-alpha-Hydroxypropionic acid ; 1-Lactic acid ; D-Milchsaeure ; EINECS 233-713-2 ; Lactic acid (D) ; Propanoic acid, 2-hydroxy-, (2R)- ; Propanoic acid, 2-hydroxy-, (R)-
CAS NO: 10326-41-7
Classification Code: TSCA Flag P [A commenced PMN (Premanufacture Notice) substance]
Index of Refraction: 1.451
Molar Refractivity: 19 cm³
Molar Volume: 70.5 cm³
Surface Tension: 49.7 dyne/cm
Density: 1.276 g/cm³
Flash Point: 109.9 °C
Enthalpy of Vaporization: 53.96 kJ/mol
Boiling Point: 227.6 °C at 760 mmHg
Vapour Pressure: 0.015 mmHg at 25°C

(R)-Lactate Safety Profile

Hazard Codes of Propanoic acid,2-hydroxy-, (2R)- (CAS NO.10326-41-7): Irritant Xi
Risk Statements: 38-41
R38: Irritating to skin.
R41: Risk of serious damage to the eyes.
Safety Statements: 26-39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39: Wear eye / face protection.
WGK Germany: 3
F: 3-10

Product Name

(R)-Lactate

Synthetic route

(R)-Lactate Chemical Properties

(R)-Lactate Safety Profile

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