1,4-Benzodioxan supplier | CasNO.493-09-4

Name
1,4-Benzodioxan
EINECS 207-775-6
CAS No. 493-09-4
Article Data47
CAS DataBase
Density 1.15 g/cm³
Solubility insoluble in water
Melting Point 213-217 °C
Formula C₈H₈O₂
Boiling Point 248.138 °C at 760 mmHg
Molecular Weight 136.15
Flash Point 87.778 °C
Transport Information
Appearance clear colourless to very slightly yellow liquid
Safety 23-24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 1,4-Benzodioxan(6CI,7CI,8CI);1,2-(Ethylenedioxy)benzene;2,3-Dihydro-1,4-benzodioxin;2,3-Dihydrobenzo[1,4]dioxine;Benzene, 1,2-[1,2-ethanediylbis(oxy)]-;Ethyleneo-phenylene dioxide;NSC 406705;Pyrocatechol ethylene ether;
PSA 18.46000
LogP 1.45780

Synthetic route

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane for 3h; Reflux;	97%
With 1,4-diaza-bicyclo[2.2.2]octane; carbonic acid dimethyl ester at 90℃; for 2h; Reagent/catalyst; Time;	92%
With phosphorus pentoxide
Multi-step reaction with 2 steps 1: pyridine; PBr3 2: aqueous alkaline solution View Scheme

: 120-80-9
benzene-1,2-diol

: 106-93-4
ethylene dibromide

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With sodium hydroxide; (C16H33CH3)2NCH2CH2N(CH3)2C16H33)(2+)Br(1-)Br(1-) In water Heating;	89%
With sodium hydroxide; (C16H33N(CH3)2CH2CH=CHCH2(CH3)2NC16H33)(2+)Br(1-)Br(1-) In water Heating;	84%
With potassium carbonate In ethylene glycol; ethyl acetate Reflux;	81%

: 34743-89-0
2-(2-bromophenoxy)ethan-1-ol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With palladium diacetate; 9-di(2-tert-butylphosphinophenyl)phenanthrene; caesium carbonate In toluene at 70℃; for 40h;	88%
With palladium diacetate; caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine In toluene at 70℃; for 40h;	88%
With (4,4′-di-tert-butyl-2,2′-dipyridyl)Ni(o-tolyl)(Br); 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 80℃; for 24h; Inert atmosphere; Sealed tube; UV-irradiation;	86%

: 96-49-1
[1,3]-dioxolan-2-one

: 120-80-9
benzene-1,2-diol

A: 493-09-4
benzo-1,4-dioxane

B: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 170℃; for 1h; Inert atmosphere; Schlenk technique;	A 5% B 84%

...Expand

: 52287-51-1
6-bromo-1,4-benzodioxane

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate; triethylamine In tetrahydrofuran; acetonitrile at 20℃; for 4.4h; Inert atmosphere; Electrolysis;	83%
With isopropyl alcohol for 20h; Schlenk technique; Inert atmosphere; Irradiation; Heating;	65%

: 120-80-9
benzene-1,2-diol

: (vinylselenonyl)benzene

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
Stage #1: benzene-1,2-diol With caesium carbonate In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: (vinylselenonyl)benzene In dichloromethane at 0 - 20℃; for 24h; Reagent/catalyst; Temperature; Time; Inert atmosphere;	80%

: 3663-82-9
2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With chlorobis(cyclooctene)-iridium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium chloride In water; 1,3,5-trimethyl-benzene at 170℃; for 60h; Schlenk technique; Inert atmosphere;	79%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium chloride In water; 1,3,5-trimethyl-benzene for 60h; Reflux;	79%

: 107-21-1
ethylene glycol

: 583-53-9
1,2-dibromobenzene

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With caesium carbonate; triphenylphosphine; palladium dichloride In toluene at 50℃; for 24h;	65%

: 107-21-1
ethylene glycol

: 95-50-1
1,2-dichloro-benzene

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With caesium carbonate; triphenylphosphine; palladium dichloride In toluene at 50℃; for 24h;	63%

: 120-80-9
benzene-1,2-diol

: 107-06-2
1,2-dichloro-ethane

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide	57%
With sodium hydroxide In N,N-dimethyl-formamide at 90℃;	2.1 g
With sodium hydroxide In dimethyl sulfoxide at 80 - 85℃; for 5.45h;	115 g

: 367-12-4
2-fluorophenol

: 107-07-3
2-chloro-ethanol

A: 493-09-4
benzo-1,4-dioxane

B: 4792-79-4
2-hydroxyphenyl 2-chloroethyl ether

Conditions

Conditions	Yield
With <(η-C6H6)Rh(η-C5EtMe4)>(2+)*2 In nitromethane at 80℃; for 48h; Title compound not separated from byproducts;	A 50% B 10 % Chromat.

...Expand

: 122-99-6
2-Phenoxyethanol

A: 493-09-4
benzo-1,4-dioxane

B: 57744-67-9
6-iodo-1,4-benzodioxane

C: 29639-77-8
2-(4-iodophenoxy)ethanol

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; iodine In 1,2-dichloro-ethane at 60 - 70℃; Irradiation;	A 39% B 12% C n/a
With [bis(acetoxy)iodo]benzene; iodine In 1,2-dichloro-ethane at 60 - 70℃; Irradiation;	A 6% B 22% C n/a

...Expand

: 122-99-6
2-Phenoxyethanol

A: 493-09-4
benzo-1,4-dioxane

B: 57744-67-9
6-iodo-1,4-benzodioxane

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; iodine In 1,2-dichloro-ethane at 60 - 70℃; for 2h; Irradiation;	A 39% B 12%
With [bis(acetoxy)iodo]benzene; iodine In 1,2-dichloro-ethane at 60 - 70℃; for 2h; Irradiation;	A 6% B 22%

: 2924-65-4
2-(2-fluorophenoxy)ethan-1-ol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
(η5-ethyltetramethylcyclopentadienyl)(η6-benzene)rhodium(III) tetrafluoroborate In nitromethane; acetone at 80℃; for 312h;	35%

: 51974-48-2
2-(2-bromo-ethoxy)-phenol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With alkaline solution
With potassium hydroxide In water; dimethyl sulfoxide at 25℃;	92 % Spectr.
With potassium hydroxide In water; dimethyl sulfoxide at 25℃; Rate constant;	92 % Spectr.

: 154582-47-5
1-(benzyloxy)-2-(2-bromoethoxy)benzene

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With hydrogenchloride; ethanol

: 75-21-8
oxirane

: 17333-73-2
phenylium

A: 271-89-6
1-benzofurane

B: 496-16-2
2,3-Dihydrobenzofuran

C: 493-09-4
benzo-1,4-dioxane

D: 766-94-9
vinyl phenyl ether

Conditions

Conditions	Yield
With oxygen; trimethylamine under 244 Torr; for 8760h; Ambient temperature; dark;	A 4 % Chromat. B 15 % Chromat. C 3 % Chromat. D 78 % Chromat.
With oxygen; trimethylamine under 244 Torr; for 8760h; Product distribution; Mechanism; Ambient temperature; arylation of various cyclic ethers in the dark and effects of base;	A 4 % Chromat. B 15 % Chromat. C 3 % Chromat. D 78 % Chromat.

...Expand

: 75-21-8
oxirane

: 17333-73-2
phenylium

A: 271-89-6
1-benzofurane

B: 496-16-2
2,3-Dihydrobenzofuran

C: 493-09-4
benzo-1,4-dioxane

D: 108-95-2
phenol

Conditions

Conditions	Yield
With oxygen under 34 Torr; for 8760h; Ambient temperature; dark;	A 2 % Chromat. B 21 % Chromat. C 61 % Chromat. D 15 % Chromat.

...Expand

: 75-21-8
oxirane

: 17333-73-2
phenylium

A: 271-89-6
1-benzofurane

B: 496-16-2
2,3-Dihydrobenzofuran

C: 493-09-4
benzo-1,4-dioxane

D: 766-94-9
vinyl phenyl ether

E: 108-95-2
phenol

Conditions

Conditions	Yield
With oxygen under 34 Torr; for 8760h; Product distribution; Mechanism; Ambient temperature; arylation of various cyclic ethers in the dark;	A 2 % Chromat. B 21 % Chromat. C 61 % Chromat. D 1 % Chromat. E 15 % Chromat.

...Expand

: 75-21-8
oxirane

: 17333-73-2
phenylium

A: 496-16-2
2,3-Dihydrobenzofuran

B: 493-09-4
benzo-1,4-dioxane

C: 108-95-2
phenol

Conditions

Conditions	Yield
With oxygen under 224 Torr; for 8760h; Ambient temperature; dark;	A 37 % Chromat. B 33 % Chromat. C 30 % Chromat.

...Expand

: 107-21-1
ethylene glycol

: 765-87-7
cyclohexane-1,2-dione

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With bis(benzonitrile)palladium(II) dichloride In benzene Heating;	50 % Chromat.

: 367-12-4
2-fluorophenol

: 107-07-3
2-chloro-ethanol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With <(η-C6H6)Rh(η-C5EtMe4)>(2+)*2; triethylamine 1) CH3NO2, 80 deg C, 2 d, 2) room temperature, 24 h; Yield given. Multistep reaction. Title compound not separated from byproducts;

: 1072-53-3
ethyleneglycol sulfate

: 120-80-9
benzene-1,2-diol

aqueous alkali: aqueous alkali

: 493-09-4
benzo-1,4-dioxane

...Expand

: 110851-22-4
1,10-Dimethyl-2,9,11,12,13-pentaoxa-tricyclo[8.2.1.03,8]trideca-3,5,7-triene

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH2Cl2 / 1 h / -78 °C / Irradiation 2: potassium carbonate / ethane-1,2-diol / 4 h / 120 °C View Scheme

: 110851-16-6
2,9,11,12,13-Pentaoxa-tricyclo[8.2.1.03,8]trideca-3,5,7-triene

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 51 percent / CH2Cl2 / 1 h / -78 °C / Irradiation 2: potassium carbonate / ethane-1,2-diol / 4 h / 120 °C View Scheme

: 120-80-9
benzene-1,2-diol

1,2-bis<2-(-p-toluenesulfonyloxy)ethoxy>amine: 1,2-bis<2-(-p-toluenesulfonyloxy)ethoxy>amine

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH 2: phosphorus (V)-oxide View Scheme
Multi-step reaction with 3 steps 1: sodium ethylate; ethanol 2: pyridine; PBr3 3: aqueous alkaline solution View Scheme

: 67470-89-7
2,3-dibromo-2,3-dihydro-benzo[1,4]dioxin

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With sodium iodide In acetone for 2h; Heating / reflux;

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 616-38-6
carbonic acid dimethyl ester

A: 493-09-4
benzo-1,4-dioxane

B: C10H12O5

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane at 90℃; for 24h;	A 10 %Chromat. B 90 %Chromat.

...Expand

: 120-80-9
benzene-1,2-diol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 150 °C / Autoclave 2: 1,4-diaza-bicyclo[2.2.2]octane / 3 h / Reflux View Scheme

: 493-09-4
benzo-1,4-dioxane

: 52287-51-1
6-bromo-1,4-benzodioxane

Conditions

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃;	100%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 24h;	100%
With N-Bromosuccinimide In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 24h;	100%

: 493-09-4
benzo-1,4-dioxane

: 100-51-6
benzyl alcohol

: 6-Benzyl-2,3-dihydro-benzo[1,4]dioxine

Conditions

Conditions	Yield
With sulfuric acid; sodium perchlorate In chloroform Heating; or KClO4;	100%

: 493-09-4
benzo-1,4-dioxane

: 75-65-0
tert-butyl alcohol

: 93591-46-9
6-tert-Butyl-2,3-dihydro-benzo[1,4]dioxine

Conditions

Conditions	Yield
With sulfuric acid; sodium perchlorate In chloroform Heating; or KClO4;	100%

: 493-09-4
benzo-1,4-dioxane

: 1261570-98-2
2-bromo-5-iodobenzoyl chloride

: 1291094-64-8
(2-bromo-5-iodophenyl)-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; for 3h; Temperature;	100%
With aluminum (III) chloride In dichloromethane at -5 - 20℃; for 4h; Inert atmosphere;	90%
In dichloromethane at 0 - 20℃;

: 281652-58-2
2-chloro-5-iodobenzoylchloride

: 493-09-4
benzo-1,4-dioxane

: (2-chloro-5-iodophenyl)-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; for 16h;	98.7%

: 493-09-4
benzo-1,4-dioxane

: 127461-51-2
2,3-dihydro-benzo[1,4]dioxin-6-sulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide In 1,4-dioxane-d8 at 15℃; for 0.25h; other time; other temp; other reagent: cc H2SO4;	98%
With sulfuric acid at 125℃;

: 493-09-4
benzo-1,4-dioxane

: 2,3-Dihydro-benzo[1,4]dioxine-5,7-disulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide In nitromethane at 10℃; for 0.25h; other reagent;	98%

: 493-09-4
benzo-1,4-dioxane

: 21900-41-4
5-bromo-2-methylbenzoyl chloride

: (5-bromo-2-methylphenyl)-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; Inert atmosphere;	96%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 12h;	95%

: 493-09-4
benzo-1,4-dioxane

: 103-72-0
phenyl isothiocyanate

: 1556673-47-2
2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)benzo[d]thiazole

Conditions

Conditions	Yield
With di-tert-butyl peroxide; copper diacetate In acetonitrile at 120℃; for 6h; Inert atmosphere;	94%

: 493-09-4
benzo-1,4-dioxane

: 75-00-3
chloroethane

: 6-ethylbenzodioxane

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 1.5h;	93.1%

: 493-09-4
benzo-1,4-dioxane

: 98-88-4
benzoyl chloride

: 93637-87-7
2,3-dihydro-1,4-benzodioxin-6-yl(phenyl)methanone

Conditions

Conditions	Yield
With aluminium trichloride In nitrobenzene at 5℃; for 6h;	92.9%
With aluminium trichloride In 1,2-dichloro-ethane at 20℃; for 10h;	88%
With aluminium trichloride In dichloromethane at 0℃; for 1h;	85%
With aluminium trichloride In dichloromethane at 15℃; for 1h;
With aluminium trichloride In benzene at 55 - 60℃; for 2.5h; Friedel-Crafts reaction;

: 493-09-4
benzo-1,4-dioxane

: 75-36-5
acetyl chloride

: 2879-20-1
1,4-benzodioxan-6-yl methyl ketone

Conditions

Conditions	Yield
	92%
With aluminium trichloride In carbon disulfide for 10h; Ambient temperature;	91%
With aluminium trichloride In benzene at 55 - 60℃; for 2.5h; Friedel-Crafts reaction;

: 493-09-4
benzo-1,4-dioxane

: 507-20-0
tertiary butyl chloride

: 93591-46-9
6-tert-Butyl-2,3-dihydro-benzo[1,4]dioxine

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 1.5h;	91.2%

: 493-09-4
benzo-1,4-dioxane

: 25812-80-0
6,7-dibromo-2,3-dihydrobenzo[b][1,4]dioxine

Conditions

Conditions	Yield
With bromine In dichloromethane at 20℃;	90%
With bromine In dichloromethane at 20℃; Inert atmosphere;	83%
With iodine pentoxide; potassium bromide In water at 20℃; for 23h; regioselective reaction;	78%

: 493-09-4
benzo-1,4-dioxane

: 403-43-0
4-fluorobenzoyl chloride

: 101018-97-7
(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(4-fluoro-phenyl)-methanone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 15℃; for 1h;	90%

: 493-09-4
benzo-1,4-dioxane

: 586-75-4
4-chlorobenzoyl chloride

: 101018-99-9
(4-Bromo-phenyl)-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-methanone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 15℃; for 1h;	90%

: 493-09-4
benzo-1,4-dioxane

: 592-42-7
1,5-Hexadien

: C20H28O2

Conditions

Conditions	Yield
With C19H16*C24BF20; C23H40NScSi2 In chlorobenzene at 70℃; for 2h; stereoselective reaction;	90%

: 493-09-4
benzo-1,4-dioxane

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 126382-18-1
6-(3,4,5-trimethoxybenzoyl)-2,3-dihydro-1,4-benzodioxin

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane for 24h; Ambient temperature;	88%

: 493-09-4
benzo-1,4-dioxane

: 2,3,10,11-tetrahydro[1,4]dioxino[2',3':8,9][1,2,5,6]benzotetrathiocino[3,4-g][1,4]benzodioxine

Conditions

Conditions	Yield
With disulfur dichloride; acetic acid at 20℃; for 120h; Inert atmosphere; Schlenk technique; Glovebox;	88%
With disulfur dichloride In acetic acid for 18h;	52%
Stage #1: benzo-1,4-dioxane With disulfur dichloride In acetic acid at 20℃; for 48h; Stage #2: With tin(ll) chloride In methanol; acetic acid
With disulfur dichloride; acetic acid at 20℃; Inert atmosphere; Schlenk technique;	2.45 g

: 493-09-4
benzo-1,4-dioxane

: 109-69-3
n-Butyl chloride

: C12H16O2

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 1.5h;	87.5%

: 493-09-4
benzo-1,4-dioxane

: 16498-20-7
6-nitro-2,3-dihydrobenzo[b][1,4]dioxine

Conditions

Conditions	Yield
With nitric acid at 60℃;	87%
With tert.-butylnitrite In acetonitrile at 20℃; for 1h;	80%
With nitric acid In water at 20 - 80℃; for 6h;	76.7%

: 493-09-4
benzo-1,4-dioxane

: 498-66-8
norbornene

: 5,8-bis(bicyclo[2.2.1]hept-2-yl)-2,3-dihydro-1,4-benzodioxine

Conditions

Conditions	Yield
With (C5H5)Y(CH2C6H4NMe2-o)2; trityl tetrakis(pentafluorophenyl)borate In toluene at 70℃; for 24h; Inert atmosphere; Glovebox; regioselective reaction;	87%

: 493-09-4
benzo-1,4-dioxane

: 50-00-0
formaldehyd

: 6,7-bis(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine

Conditions

Conditions	Yield
Stage #1: benzo-1,4-dioxane; formaldehyd With acetic acid at 0℃; for 0.5h; Inert atmosphere; Stage #2: With hydrogen bromide; acetic acid at 0 - 20℃; Inert atmosphere;	87%

: 493-09-4
benzo-1,4-dioxane

: 57744-67-9
6-iodo-1,4-benzodioxane

Conditions

Conditions	Yield
With Iron(III) nitrate nonahydrate; carbon dioxide; iodine; oxygen In ethylene glycol at 100℃; under 5250.53 - 9000.9 Torr; for 10h; Autoclave; Green chemistry; regioselective reaction;	86%
With iodine; periodic acid In ethanol for 0.75h; Heating;	73%

: 493-09-4
benzo-1,4-dioxane

: 762-04-9
phosphonic acid diethyl ester

: (2,3-dihydro-1,4-benzodioxin-6-yl)phosphonic diethylester

Conditions

Conditions	Yield
With manganese(III) triacetate dihydrate In acetic acid at 60℃; for 5h;	85%

: 493-09-4
benzo-1,4-dioxane

: 1122-91-4
4-bromo-benzaldehyde

: C23H19BrO4

Conditions

Conditions	Yield
With Amberlyst-15 In neat (no solvent) at 60℃; for 0.666667h; Friedel-Crafts Alkylation; Green chemistry;	85%

: 493-09-4
benzo-1,4-dioxane

: 645-45-4
hydrocinnamic acid chloride

: 130396-94-0
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-phenylpropan-1-one

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 30℃; for 1h;	84%
With aluminium trichloride In dichloromethane at 15 - 20℃; for 3h;	78%

1,4-Benzodioxan Chemical Properties

Molecular Formula: C₈H₈O₂

Formula Weight: 136.15
bp of 1,4-Benzodioxan (493-09-4): 103 ^°C 6 mm Hg(lit.)
density : 1.142 g/mL at 25 ^°C(lit.)
refractive index : n20/D 1.549(lit.)
Fp of 1,4-Benzodioxan (493-09-4): 190 ^°F
Solubility: Insoluble in water; soluble in all typical organic solvents
Appearance: Colorless to light yellow liquid
Odor of 1,4-Benzodioxan (493-09-4): Aromatic odor

1,4-Benzodioxan Uses

1,4-Benzodioxan (493-09-4) can be used as the intermediate of doxazosin.

1,4-Benzodioxan Toxicity Data With Reference

LD₅₀/LC₅₀: RTECS: Not available
Carcinogenicity: 1,4-Benzodioxan (493-09-4) - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

1,4-Benzodioxan Safety Profile

Hazard Codes : Xi (Irritant)
Safety Statements : 23-24/25 (Toxic by inhalation; Toxic in contact with skin and if swallowed)
WGK Germany : 3
RTECS : DF4728000
Hazard Note : Irritant
HS Code : 29329995

1,4-Benzodioxan Standards and Recommendations

Purity: 98.0%

1,4-Benzodioxan Specification

Storage: Store in a tightly closed container. Store in a cool, dry place. Keep away from sources of ignition.
Handling: Avoid contact with skin and eyes. Avoid breathing dust, vapor, mist, or gas. Keep container tightly closed. Wash thoroughly after handling. Mechanical exhaust required.

Product Name

1,4-Benzodioxan

Synthetic route

1,4-Benzodioxan Chemical Properties

1,4-Benzodioxan Uses

1,4-Benzodioxan Toxicity Data With Reference

1,4-Benzodioxan Safety Profile

1,4-Benzodioxan Standards and Recommendations

1,4-Benzodioxan Specification

Related Products

Hot Products