1-Piperidineethanol,4-amino- supplier

Name
4-AMINO-1-PIPERIDINE-ETHANOL
EINECS
CAS No. 89850-72-6
Article Data5
CAS DataBase
Density 1.028 g/cm³
Solubility at 25 deg C (mg/L): 1e+006
Melting Point
Formula C₇H₁₆N₂O
Boiling Point 250.4 °C at 760 mmHg
Molecular Weight 144.217
Flash Point 105.3 °C
Transport Information
Appearance
Safety 26-39
Risk Codes 22-37/38-41
Molecular Structure
Hazard Symbols Xn
Synonyms 2-(4-Aminopiperidin-1-yl)ethanol;4-Amino-1-piperidineethanol;
PSA 49.49000
LogP 0.04000

Synthetic route

: 558443-53-1
[1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With trifluoroacetic acid at 20℃; for 1h;	95%
With hydrogenchloride In ethanol; water for 2h; Reflux;	95%
With hydrogenchloride In ethanol for 2h; Reflux;	95%
Stage #1: [1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester With trifluoroacetic acid Stage #2: With hydrogenchloride In methanol at 20℃; for 0.5h; Stage #3: With sodium hydroxide In water at 20℃; for 0.25h; pH=> 10; Cooling with ice;	87%

: 51527-83-4
Br(1-)*C7H11N2O(1+)

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Stage #1: Br(1-)*C7H11N2O(1+) With hydrogen; sodium; rhodium contaminated with carbon In methanol at 60℃; under 7240.26 Torr; Stage #2: In methanol Reflux;	69%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / K2CO3 / acetonitrile / 5 h / Heating 2: 95 percent / TFA / 1 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 5 h / Reflux 2.1: trifluoroacetic acid 2.2: 0.5 h / 20 °C 2.3: 0.25 h / 20 °C / pH > 10 / Cooling with ice View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile / 5 h / Reflux 2: hydrogenchloride / ethanol; water / 2 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile / 5 h / Reflux 2: hydrogenchloride / ethanol / 2 h / Reflux View Scheme

: 504-24-5
4-aminopyridine

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: toluene / 3.5 h / Reflux 2.1: hydrogen; sodium / rhodium contaminated with carbon / methanol / 60 °C / 7240.26 Torr 2.2: Amberlyst 15 resin / Reflux View Scheme

: 1421000-02-3
2,6-dichloro-N-(2-ethylhexyl)nicotinamide

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1420999-78-5
6-chloro-N-(2-ethylhexyl)-2-{[1-(2-hydroxyethyl)piperidin-4-yl]amino}nicotinamide

Conditions

Conditions	Yield
With potassium carbonate In o-xylene for 24h; Reflux;	77.9%
With potassium carbonate In o-xylene for 24h; Reflux;	77.9%

: 619-58-9
4-iodobenzoic acid

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: C14H19IN2O2

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h;	50%

: 586-76-5
4-Bromobenzoic acid

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 4-bromo-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h;	40%

: (R)-1-(3-((3'-(3-bromopropoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: (R)-1-(3-((3'-(3-((1-(2-hydroxyethyl)piperidin-4-yl)amino)propoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol at 65℃; for 72h; Inert atmosphere;	34%

: 89891-65-6
7-bromo-2-chloroquinoxaline

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1345444-82-7
C15H19BrN4O

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 24h;	32%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 24h;	32%

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1H-1,2,3-benzotriazol-1-yl 4-amino-3-methoxybenzoate

: 1201694-09-8
4-amino-N-[1-(2-hydroxy-ethyl)-piperidin-4-yl]-3-methoxy-benzamide

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide

: 89891-65-6
7-bromo-2-chloroquinoxaline

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1345437-78-6
C30H29F2N7O3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 100 °C 2: N-ethyl-N,N-diisopropylamine; copper(l) iodide / [Pd0(1,1’-bis(diphenylphosphino)ferrocene)] / dimethyl sulfoxide / 3 h / 90 °C View Scheme
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 100 °C 2: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; copper(l) iodide / dimethyl sulfoxide / 3 h / 90 °C View Scheme

: 4774-14-5
2,6-dichloropyrazine

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1401732-37-3
2-(4-((6-chloropyrazin-2-yl)amino)piperidin-1-yl)ethanol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; Inert atmosphere;

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1401732-38-4
2-(4-((6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)piperidin-1-yl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere 2: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere View Scheme

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 1401731-27-8
2-(4-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)piperidin-1-yl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere 2.1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere 3.1: trifluoroacetic acid / chloroform / 50 °C 3.2: pH 8 View Scheme

: 1025068-57-8
3,3-dimethyl-5-oxo-5-(((1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-(2-oxoethyl)-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)pentanoic acid

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 5-(((1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(2-((1-(2-hydroxyethyl)piperidin-4-yl)amino)ethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃;

: 1025068-57-8
3,3-dimethyl-5-oxo-5-(((1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-(2-oxoethyl)-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)pentanoic acid

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 76-05-1
trifluoroacetic acid

: (3β)-17-[2-[[1-(2-hydroxyethyl)piperidin-4-yl]amino]ethyl]-28-norIup-20(29)-en-3-ol 3-(hydrogen 3,3-dimethyIpentanedioate) bis(trifluoroacetate)

Conditions

Conditions	Yield
Stage #1: 3,3-dimethyl-5-oxo-5-(((1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-(2-oxoethyl)-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)pentanoic acid; 4-amino-1-(2-hydroxyethyl)piperidine With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane for 18h; Stage #2: trifluoroacetic acid

...Expand

: phenyl ((1R,4R)-4-((4-((5-cyclopentyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)cyclohexyl)carbamate

: 89850-72-6
4-amino-1-(2-hydroxyethyl)piperidine

: 76-05-1
trifluoroacetic acid

: 1-((1R,4R)-4-((4-((5-cyclopentyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)cyclohexyl)-3-(1-(2-hydroxyethyl)piperidin-4-yl)urea 2,2,2-trifluoroacetate

Conditions

Conditions	Yield
Stage #1: phenyl ((1R,4R)-4-((4-((5-cyclopentyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)cyclohexyl)carbamate With triethylamine In N,N-dimethyl-formamide at 85℃; for 1h; Stage #2: 4-amino-1-(2-hydroxyethyl)piperidine In N,N-dimethyl-formamide at 95℃; for 16h; Stage #3: trifluoroacetic acid	25 mg

...Expand

1-Piperidineethanol,4-amino- Specification

The 1-Piperidineethanol, 4-amino-, with the CAS registry number of 89850-72-6, is also known as 2-(4-Amino-1-piperidinyl)ethanol. This chemical's molecular formula is C₇H₁₆N₂O and molecular weight is 144.21. What's more, its IUPAC name is 2-(4-Aminopiperidin-1-yl)ethanol.

Physical properties about 1-Piperidineethanol, 4-amino- are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 3; (6)#H bond donors: 3; (7)#Freely Rotating Bonds: 4; (8)Polar Surface Area: 49.49 Å²; (9)Index of Refraction: 1.497; (10)Molar Refractivity: 41.03 cm³; (11)Molar Volume: 140.1 cm³; (12)Surface Tension: 39.6 dyne/cm; (13)Density: 1.028 g/cm³; (14)Flash Point: 105.3 °C; (15)Enthalpy of Vaporization: 56.66 kJ/mol; (16)Boiling Point: 250.4 °C at 760 mmHg; (17)Vapour Pressure: 0.00344 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: OCCN1CCC(N)CC1
(2) InChI: InChI=1/C7H16N2O/c8-7-1-3-9(4-2-7)5-6-10/h7,10H,1-6,8H2
(3) InChIKey: NMWIFNPFFNFXPB-UHFFFAOYAK

Product Name

4-AMINO-1-PIPERIDINE-ETHANOL

Synthetic route

1-Piperidineethanol,4-amino- Specification

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