2,2'-Biphenol supplier | CasNO.1806-29-7

Name
2,2'-Biphenol
EINECS 217-303-0
CAS No. 1806-29-7
Article Data66
CAS DataBase
Density 1.228 g/cm³
Solubility insoluble in water
Melting Point 108-110 °C
Formula C₁₂H₁₀O₂
Boiling Point 314.999 °C at 760 mmHg
Molecular Weight 186.21
Flash Point 160.803 °C
Transport Information
Appearance Beige to greyish-beige powder
Safety 26-39-36/37/39
Risk Codes 36/37/38-41-22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 2,2'-Biphenyldiol(8CI);1,1'-Bi-2-phenol;2,2'-Dihydroxy-1,1'-biphenyl;2,2'-Dihydroxybiphenyl;2,2'-Dihydroxydiphenyl;2'-Hydroxy-1,1'-biphenyl-2-ol;NSC 37068;o,o'-Biphenol;o,o'-Dihydroxybiphenyl;o,o'-Diphenol;[1,1'-Biphenyl]-2,2'-diol;
PSA 40.46000
LogP 2.76480

Synthetic route

: 1227735-80-9
6,6-diisopropyldibenzo[d,f][1,3,2]dioxasilepine

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	100%

: 6390-69-8
3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 98-51-1
4-tert-butyltoluene

Conditions

Conditions	Yield
With Nafion-H; toluene for 2h; Heating;	A 98% B 98 % Chromat.

: 6390-69-8
3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol

: 108-88-3
toluene

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 98-51-1
4-tert-butyltoluene

Conditions

Conditions	Yield
With Nafion-H for 2h; Heating;	A 98% B 98 % Chromat.

...Expand

: 533-58-4
2-Iodophenol

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With palladium 10% on activated carbon; potassium carbonate In water at 80℃; for 2.5h; Suzuki-Miyaura Coupling; Inert atmosphere;	98%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 160℃; for 0.5h; Suzuki Coupling; Microwave irradiation;
With palladium on activated charcoal; potassium carbonate In water at 80℃; Suzuki Coupling;

: 2,2'-dihydroxy-4,4'-biphenyldisulfonic acid

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 2h;	98%

: 4877-93-4
2,2'-Dimethoxybiphenyl

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With aluminium trichloride In ethanethiol for 0.5h; Ambient temperature;	97.5%
With aluminium trichloride In ethanethiol for 0.5h; Ambient temperature;	97.5%

: 1196786-63-6
C30H50O2Si2

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With potassium fluoride In Tetraethylene glycol at 20℃; for 0.5h; Inert atmosphere;	96%
With potassium fluoride; Tetraethylene glycol at 20℃; for 0.5h;	96%

: 1114567-49-5
2,2'-biphenol bis(tert-butyldimethylsilyl) ether

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With lithium acetate In water; N,N-dimethyl-formamide at 70℃; for 6h; Inert atmosphere;	92%

: 220-11-1
dibenzo[d,f][1,3]dioxepin

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 50℃;	92%
With hydrogenchloride; water In ethanol at 50℃;	92%

: 95-57-8
2-monochlorophenol

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water at 20℃; for 12h; Ullmann Condensation;	92%

: 95-56-7
2-hydroxybromobenzene

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With palladium 10% on activated carbon; potassium hydroxide at 150℃; for 0.5h; Suzuki-Miyaura Coupling; Microwave irradiation; Inert atmosphere;	83%
With palladium 10% on activated carbon; potassium hydroxide In water at 150℃; for 0.5h; Suzuki-Miyaura Coupling; Inert atmosphere; Microwave irradiation;	83%

: 90-43-7
2-Phenylphenol

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; palladium diacetate; caesium carbonate; Trimethylacetic acid In water; acetonitrile at 80℃; for 18h; Reagent/catalyst; Time; Sealed tube; regioselective reaction;	76%
With palladium diacetate; caesium carbonate; Trimethylacetic acid In acetonitrile at 80℃; for 24h;	74%

: 95-56-7
2-hydroxybromobenzene

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With palladium 10% on activated carbon; potassium acetate; bis(pinacol)diborane In ethanol at 60℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;	75.5%
With NaH-t-AmONa-Ni(OAc)2-bpy-KI In tetrahydrofuran; benzene at 63℃; for 0.5h;	63%
Multi-step reaction with 5 steps 1: sodium hydride / N,N-dimethyl-formamide 2: sulfuryl dichloride / dichloromethane 3: potassium carbonate / N,N-dimethyl-formamide 4: 1,10-Phenanthroline; potassium tert-butylate / pyridine / 2 h / 120 °C / Microwave irradiation; Inert atmosphere 5: hydrogenchloride / ethanol; water / 50 °C View Scheme

: 2-(2-benzylsulfonyloxyphenyl)phenyl benzylsulfonate

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With 4,4'-di-tert-butylbiphenyl; lithium In tetrahydrofuran at 0℃; for 4h;	70%

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With nano-CuO-grafted triazine-functionalized covalent organic framework In methanol at 60℃; Catalytic behavior;	68%

: 928642-45-9
6-diazo-2-cyclohexen-1-one

: 184368-89-6
1-iodo-2-(tert-butyldimethylsilyloxy)benzene

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 50℃; for 36h; Inert atmosphere;	64%

: 352-33-0
1-Chloro-4-fluorobenzene

: 95-56-7
2-hydroxybromobenzene

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 398-23-2
4,4'-difluorobiphenyl

C: 80254-62-2
4'-fluoro-[1,1'-biphenyl]-2-ol

Conditions

Conditions	Yield
With NaH-t-AmONa-Ni(OAc)2-bpy-KI In tetrahydrofuran; benzene at 63℃; for 3h; Yields of byproduct given;	A n/a B n/a C 43%

...Expand

: 95-56-7
2-hydroxybromobenzene

: 98-56-6
4-chlorobenzotrifluoride

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 581-80-6
4,4'-bis(trifluoromethyl)biphenyl

C: 122801-61-0
4′-(trifluoromethyl)[1,1′-biphenyl]-2-ol

Conditions

Conditions	Yield
With NaH-t-AmONa-Ni(OAc)2-bpy-KI In tetrahydrofuran; benzene at 63℃; for 2h; Yields of byproduct given;	A n/a B n/a C 40%

...Expand

: 95-56-7
2-hydroxybromobenzene

: 88-16-4
1-chloro-2-(trifluoromethyl)benzene

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 567-15-7
2,2’-bis(trifluoromethyl)-1,1’-biphenyl

C: 122801-60-9
2-(trifluoromethyl)-2'-hydroxybiphenyl

Conditions

Conditions	Yield
With NaH-t-AmONa-Ni(OAc)2-bpy-KI In tetrahydrofuran; benzene at 63℃; for 3.5h; Yields of byproduct given;	A n/a B n/a C 35%

...Expand

: 348-51-6
1-chloro-2-fluorobenzene

: 95-56-7
2-hydroxybromobenzene

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 388-82-9
2,2'-difluorobiphenyl

C: 439-80-5
2'-fluoro-[1,1'-biphenyl]-2-ol

Conditions

Conditions	Yield
With NaH-t-AmONa-Ni(OAc)2-bpy-KI In tetrahydrofuran; benzene at 63℃; for 3h; Yields of byproduct given;	A n/a B n/a C 34%

...Expand

: 65109-75-3
N-(phenoxy)-4-methylbenzenesulfonamide

: 108-95-2
phenol

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 92-88-6
4,4'-Dihydroxybiphenyl

C: 611-62-1
2,4'-dihydroxybiphenyl

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; trifluoroacetic acid at 0℃; for 1h;	A 9.2% B 27.6 % Chromat. C 32.7%
With trifluorormethanesulfonic acid; trifluoroacetic acid at 0℃; for 1h;	A 9.2 % Chromat. B 27.6 % Chromat. C 32.7 % Chromat.

...Expand

: 39227-53-7
1-chlorodibenzo-p-dioxin

A: 6-chloro-[1,1'-biphenyl]-2,2'-diol

B: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
In methanol at 20℃; for 3h; Irradiation;	A 11.7% B 18.8%

: 54536-18-4
1,2-dichlorodibenzo-p-dioxin

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
In methanol at 20℃; for 1h; Irradiation;	13%
Multi-step reaction with 2 steps 1: 58.5 percent / acetophenone / methanol / 1 h / 20 °C / Irradiation 2: 18.8 percent / methanol / 3 h / 20 °C / Irradiation View Scheme

: 108-95-2
phenol

A: 1806-29-7
2,2'-dihydroxybiphenyl

B: 120-80-9
benzene-1,2-diol

C: 123-31-9
hydroquinone

Conditions

Conditions	Yield
With 3,10-di-n-butylisoalloxazine N-oxide In acetonitrile for 6h; Irradiation; Yields of byproduct given;	A 2% B n/a C n/a

...Expand

: 132-64-9
dibenzofuran

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide at 400 - 410℃; im Eisenrohr;
With potassium hydroxide; 9H-carbazole at 250 - 275℃;
With potassium hydroxide; 9H-fluorene at 250 - 275℃;
With indole; potassium hydroxide at 250 - 275℃;
With potassium hydroxide; phenanthrene at 200 - 230℃;

: 4783-30-6
6,6'-dihydroxy-1,1'-biphenyl-3,3'-dicarboxylic acid

A: 132-64-9
dibenzofuran

B: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With hydrogenchloride at 270℃;

: 108-95-2
phenol

: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With potassium permanganate; sulfuric acid
coupling;

: 262-12-4
dioxin

A: 33483-06-6
1-hydroxydibenzofuran

B: 2417-10-9
2-Phenoxyphenol

C: 1806-29-7
2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
In acetonitrile at 12℃; Mechanism; Irradiation; also 2,3,7,8-tetrachlorodibenzo-1,4-dioxin (TCDD), also with NaBH4 in aq. MeCN;

...Expand

: 2122-46-5, 55748-05-5
phenoxy radical

A: 2417-10-9
2-Phenoxyphenol

B: 1806-29-7
2,2'-dihydroxybiphenyl

C: 92-88-6
4,4'-Dihydroxybiphenyl

D: 611-62-1
2,4'-dihydroxybiphenyl

E: 831-82-3
4-Phenoxyphenol

Conditions

Conditions	Yield
Product distribution; Irradiation; effect of abs. dose of irrad.;

...Expand

: 108-95-2
phenol

: 94-36-0
dibenzoyl peroxide

A: 2005-10-9
6H-benzo[c]chromen-6-one

B: 93-99-2
benzoic acid phenyl ester

C: 1806-29-7
2,2'-dihydroxybiphenyl

D: 5876-92-6
2-hydroxyphenyl benzoate

Conditions

Conditions	Yield
at 60℃; for 3h; Product distribution;	A 0.1 % Chromat. B 8 % Chromat. C 6 % Chromat. D 82 % Chromat.
at 60℃; for 3h;	A 0.1 % Chromat. B 8 % Chromat. C 6 % Chromat. D 82 % Chromat.

...Expand

: 1806-29-7
2,2'-dihydroxybiphenyl

: 16611-68-0
6-chloro-dibenzo[d,f][1,3,2]-dioxaphosphepin

Conditions

Conditions	Yield
With phosphorus trichloride for 2h; Inert atmosphere; Reflux;	100%
With trichlorophosphate at 20 - 50℃; under 150.015 - 675.068 Torr; Inert atmosphere;	99%
With phosphorus trichloride In toluene at 20℃; under 525.053 - 675.068 Torr; for 0.25h; Inert atmosphere;	99%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 21987-62-2
3,3′,5,5′-tetrabromo-[1,1′-biphenyl]-2,2′-diol

Conditions

Conditions	Yield
With bromine; acetic acid	100%
With bromine In methanol at 0 - 20℃; for 8h;	90%
With bromine In methanol for 1h;	76%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 358-23-6
trifluoromethylsulfonic anhydride

: 17763-95-0
2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;	99%
With pyridine	97%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 2627-86-3
(S)-1-phenyl-ethylamine

: 175790-44-0
((S)-1-Phenyl-ethyl)-(6-thioxo-5,7-dioxa-6λ5-phospha-dibenzo[a,c]cyclohepten-6-yl)-amine

Conditions

Conditions	Yield
With pyridine; trichlorothiophosphine	100%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 107-30-2
chloromethyl methyl ether

: 121169-22-0
2,2'-bis(methoxymethoxy)-1,1'-biphenyl

Conditions

Conditions	Yield
With sodium hydride	100%
Stage #1: 2,2'-dihydroxybiphenyl With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice; Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;	100%
Stage #1: 2,2'-dihydroxybiphenyl With sodium hydride In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water at 0℃; for 0.166667h; Stage #2: chloromethyl methyl ether In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 8h;	97%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 34261-55-7
5,5'-dibromo-2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With bromine In dichloromethane at -78℃;	99%
With bromine In chloroform Bromination;	97%
With bromine In dichloromethane	95%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 106-95-6
allyl bromide

: 73429-23-9
2,2′-di(allyloxy)-biphenyl

Conditions

Conditions	Yield
With potassium carbonate In acetone at 63℃; for 24h;	99%
With potassium carbonate In toluene at 60 - 70℃;	99%
With potassium carbonate In acetone for 8h; Heating;	98%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 214050-01-8
4,6-(bis[bis-diethylamido]phosphonito)-2,8-dimethyl-phenoxathiine

: 214050-02-9
4,6-bis(dibenzo[d,f][1,3,2]dioxaphosphino-1-yl)-2,8-dimethylphenoxathiine

Conditions

Conditions	Yield
In toluene at 109.9℃; for 15h;	99%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 35466-83-2
allyl methyl carbonate

: 73429-23-9
2,2′-di(allyloxy)-biphenyl

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran at 25℃; for 24h; Condensation;	99%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 335206-52-5
5-bromo-2,2'-dihydroxybiphenyl

Conditions

Conditions	Yield
With Diethyl 2-bromomalonate at 100℃; for 48h; Product distribution; Further Variations:; Reagents;	99%
With bromine In dichloromethane at 20℃; for 24h;	40%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 107-82-4
i-pentyl bromide

: 900522-60-3
2'-(isopentyloxy)-[1,1'-biphenyl]-2-ol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 19.5h; Heating / reflux;	99%
With potassium carbonate In acetone Reflux;	99%
With potassium carbonate In acetone at 56℃; for 24h;	89%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 1795-48-8
Isopropyl isocyanate

: 1032476-99-5
2,2'-bis(isopropylcarbamoyloxy)biphenyl

Conditions

Conditions	Yield
With dmap In tetrahydrofuran at 60℃; for 24h;	99%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 1285820-28-1
C24H18O2P2Se4

: 6-phenyl-dibenzo[d,f][1,3,2]dioxaphosphepine-6-selenide

Conditions

Conditions	Yield
In toluene for 7h; Reflux; Inert atmosphere;	99%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 6390-69-8
3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol

: 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-dibenzo [d,f][1,3,2]-dioxaphosphepine

Conditions

Conditions	Yield
Stage #1: 2,2'-dihydroxybiphenyl With pyridine; 1-methyl-1H-imidazole; phosphorus trichloride In tetrahydrofuran at 90℃; for 5h; Stage #2: 3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol In tetrahydrofuran at 100℃; for 11h; Reagent/catalyst; Time;	99%
Stage #1: 2,2'-dihydroxybiphenyl With 1-methyl-1H-imidazole; phosphorus trichloride In toluene at 90℃; for 3h; Stage #2: 3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol With pyridine In toluene at 100℃; for 11h; Reagent/catalyst; Solvent; Temperature;	99%
Stage #1: 2,2'-dihydroxybiphenyl With pyridine; phosphorus trichloride In toluene at 0 - 35℃; for 18h; Stage #2: 3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol In toluene at 5 - 35℃;

: 1806-29-7
2,2'-dihydroxybiphenyl

: 628-89-7
2-(2-Chloroethoxy)ethanol

: 91859-84-6
2,2'-bis(5-hydroxy-3-oxa-1-pentyloxy)-1,1'-biphenyl

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 24h;	98%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 14078-41-2
2,2'-dihydroxy-3,3'-di-tert-butyl-5,5'-dimethoxy-1,1'-biphenyl

: 121627-17-6
6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin)

Conditions

Conditions	Yield
Stage #1: 2,2'-dihydroxybiphenyl With pyridine; phosphorus trichloride In tetrahydrofuran for 6h; Stage #2: 2,2'-dihydroxy-3,3'-di-tert-butyl-5,5'-dimethoxy-1,1'-biphenyl In tetrahydrofuran at 100℃; for 11h; Concentration;	98%

: 617-86-7
triethylsilane

: 1806-29-7
2,2'-dihydroxybiphenyl

: 2,2'-bis((triethylsilyl)oxy)-1,1'-biphenyl

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride In acetonitrile at 20℃; for 16h; Irradiation;	98%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 1493-27-2
ortho-nitrofluorobenzene

: 65811-04-3
2,2'-bis-(2-nitrophenoxy)-biphenyl

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran for 72h; Heating;	97.2%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 77-78-1
dimethyl sulfate

: 4877-93-4
2,2'-Dimethoxybiphenyl

Conditions

Conditions	Yield
Stage #1: 2,2'-dihydroxybiphenyl With potassium carbonate In acetone at 20℃; for 0.166667h; Inert atmosphere; Stage #2: dimethyl sulfate In acetone at 20℃; for 12h; Inert atmosphere;	97%
With potassium carbonate at 60℃; for 1.5h; Williamson synthesis;	95%
With sodium hydroxide	95%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 2,2'-bis(dibenzo[a,c]-1,3,2-dioxaborepin-2-yloxy)biphenyl

Conditions

Conditions	Yield
With dimethylsulfide borane complex In dichloromethane at 20℃;	97%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 16523-54-9
chlorodicyclohexylphosphane

: 872217-45-3
(C6H4OP(cyclohexyl)2)2

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 60℃;	97%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 563-68-8
thallium(I) acetate

: 159766-95-7
(Tl[μ-O(C6H4)(C6H4)OH])2

Conditions

Conditions	Yield
With NH3 In ethanol; water bubbling NH3 through soln. of Tl-salt (in aq. EtOH), addn. of ligand (in EtOH); crystn. (24 h), filtration, washing (EtOH), drying (vac.); may be recrystallized from hot water;	97%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 13292-87-0
dimethylsulfide borane complex

: 2,2'-bis(dibenzo[a,c]-1,3,2-dioxaborepin-2-yloxy)biphenyl

Conditions

Conditions	Yield
In dichloromethane under N2 atm. BH3*SMe2 was added dropwise at 0°C soln. 2,2'-dihydroxybiphenyl in CH2Cl2, soln. was allowed to warm to room temp. and stirred for 14 h; volatiles were evapd., residue was washed with Et2O, dried in vacuo, andcrystd. from CH2Cl2-hexane (1:1); elem. anal.;	97%

: 1806-29-7
2,2'-dihydroxybiphenyl

: germanium tetramethoxide

: Ge(4+)*2C12H8O2(2-)

Conditions

Conditions	Yield
In toluene Heating;	97%

2,2'-Biphenol Chemical Properties

Molecular Structure of 2,2'-Biphenyldiol (CAS NO.1806-29-7):

IUPAC Name: 2-(2-Hydroxyphenyl)phenol
Canonical SMILES: C1=CC=C(C(=C1)C2=CC=CC=C2O)O
InChI: InChI=1S/C12H10O2/c13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14/h1-8,13-14H
InChIKey: IMHDGJOMLMDPJN-UHFFFAOYSA-N
Molecular Weight: 186.2066 [g/mol]
Molecular Formula: C₁₂H₁₀O₂
XLogP3: 3
H-Bond Donor: 2
H-Bond Acceptor: 2
EINECS: 217-303-0
Water Solubility: insoluble
Appearance: Beige to greyish-beige powder
Melting Point: 108-110 °C
Index of Refraction: 1.639
Molar Refractivity: 54.6 cm³
Molar Volume: 151.5 cm³
Surface Tension: 53.8 dyne/cm
Density: 1.228 g/cm³
Flash Point: 160.8 °C
Enthalpy of Vaporization: 57.84 kJ/mol
Boiling Point: 315 °C at 760 mmHg
Vapour Pressure: 0.000243 mmHg at 25 °C
Classification Code: Mutation data
Product Categories: Aromatic Phenols; Biphenyls (for High-Performance Polymer Research); Color Former & Related Compounds; Developer; Functional Materials; Reagent for High-Performance Polymer Research

2,2'-Biphenol Uses

2,2'-Biphenyldiol (CAS NO.1806-29-7) is used as pharmaceutical intermediates.

2,2'-Biphenol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)		National Technical Information Service. Vol. AD691-490,
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07870,

2,2'-Biphenol Consensus Reports

Reported in EPA TSCA Inventory.

2,2'-Biphenol Safety Profile

Poison by intraperitoneal and intravenous routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Hazard Codes : Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-41-22
R22: 2,2'-Biphenyldiol (CAS NO.1806-29-7) is harmful if swallowed.
R41:Risk of serious damage to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 2
RTECS: DV4200000
F: 8-9-23

2,2'-Biphenol Specification

2,2'-Biphenyldiol (CAS NO.1806-29-7), its Synonyms are 2,2'-Biphenol ; 2,2'-Dihydroxybiphenyl ; 2,2'-Dihydroxydiphenyl ; O,O'-Biphenol ; o,o'-Biphenol ; o,o'-Dihydroxybiphenyl ; o,o'-Diphenol ; o-Dihydroxydiphenyl ; (1,1'-Biphenyl)-2,2'-diol ; Biphenyl-2,2'-diol .

Product Name

2,2'-Biphenol

Synthetic route

2,2'-Biphenol Chemical Properties

2,2'-Biphenol Uses

2,2'-Biphenol Toxicity Data With Reference

2,2'-Biphenol Consensus Reports

2,2'-Biphenol Safety Profile

2,2'-Biphenol Specification

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